Gene RSK1 (Mouse)
RSK1
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
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RSK1.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 260 | Kinase domain by global Sugen HMM | Fasta, JSON |
RSK1.AA | Protein | Sugen | 741 | None | Fasta, JSON |
RSK1.NA | RNA | Sugen | 3004 | None | Fasta, JSON |
RSK1.kin_dom2 | Protein Kinase Domain | Sugen global kinase HMM prediction | 258 | Kinase domain by global Sugen HMM | Fasta, JSON |
Protein domains of RSK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | RSK1.AA | AGC | 68-327 | 34 | 3.6e-189 | 494.52 | In-house | 1-395 (395) | Show / Hide |
Range on Protein: 68-327 Range on HMM: 1-395/395 Sequence Identity: 34% (137 aa) FELLKVLGQGSFGKVFLVRKVTRP---DSGHLYAMKVLKKAT---LKVR-DRVRTKME------------RDILADVN----------HPFVVK-LHYAF ||.|||.|.||||||.||||.... |.|..||||||||.. .| . . .|. | |.||. .| |||.|| |||.| FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF QTEGK--LYLILDFLR---------GG-DLFTRLS---KEVMFTEEDVKFYLAE-------LALGLDHLHS-LGIIYRD-LKPENILLDEEGHIKLTDFG |.. . ||...... || .||..| || |.|| ..||.|| ..|.|..||| .|||.|| ||||||||||.||||||||| QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG LSKEAIDHE--------------------------------------------------KKAYSFCG--TVEYMAPEVVNRQGHTHSADWWS--YGVLMF |.|| .. . .....||| | ||||||.. .....|||| .|.||. LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY EMLTGSLPFQGK----------DRKETMTLIL------KAKLGMP----------QFLSTEAQSLLRALFKRNPANRLGSGPD-----GAEEIKRHIFY ||||| ||.|. ...|.. .|. . |. .| ...| ||..|.. |....|..|||.|.. ||||||.| . EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF |
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Kinase | RSK1.AA | RSK | 68-327 | 53 | 2.5e-186 | 625.29 | In-house | 1-271 (271) | Show / Hide |
Range on Protein: 68-327 Range on HMM: 1-271/271 Sequence Identity: 53% (146 aa) FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTE .||....|||||.||....|....|....||||..||||..|.|||....||.||....|||.|||||.||.|||.|.|.||.||||||.||.|..||.| YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSE EDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEE----GHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHTHSADWWSYGVLMFEMLT ..||||.||.|| ...|||.||..|||||||||.|.| ||||..|||..|...|.......||.|..||||||..||||....||||.||||.|||| REVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLT GSLPFQGKDRKETMTLILKAKLGM-------PQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHIFY | .|||.|.|...|..|...|||| ..|.| ||..|||....|.|.||||.||.|.|.||.| .. GCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF |
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Kinase | RSK1.AA | RSK | 71-327 | 55 | 5.70000000001e-170 | 570.95 | In-house | 1-278 (278) | Show / Hide |
Range on Protein: 71-327 Range on HMM: 1-278/278 Sequence Identity: 55% (154 aa) LKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDR-VRTKM-ERDILADVN-HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVM--- |||||||..|||||.||.|. |.|..|||||||||....|.. .|..| ||.||.... |||.|.||||||||||||||....|||.|||.|.||.. LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC FTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDE---EGHIKLTDFGLSKE-AIDHEKKAYSFCGTVEYMAPEVVN----RQGHTHSADWWSYGV |.|....||.||..| ..|||..|||.|||||||||.|. ||||||||||..|. .||......||.|.||||||... . ||....|||| || FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV LMFEMLTGSLPFQG---KDRKETMTLILKAK--LGMP--QFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHIFY ||.||||| .|||| ..|||.|. |.|.| |.|| |.||.||..|.|....|.|..|||.||..|||||.| . LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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Kinase | RSK1.AA | Akt | 68-327 | 49 | 1.2e-144 | 465.35 | In-house | 1-264 (264) | Show / Hide |
Range on Protein: 68-327 Range on HMM: 1-264/264 Sequence Identity: 49% (131 aa) FELLKVLGQGSFGKVFLVRKVTRPDSGHLY-AMKVLKKATLKVRDRVR-TKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMF |..|||||.|||||||||.| |.. .| ||||||| . .. |. || || || .||||.|.|||.|||. |||...|. ||.||. |... | FDFLKVLGKGSFGKVFLVKKK---DTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRF TEEDVKFYLAELALGLDHLHSLGIIYRD-LKPENILLDEEGHIKLTDFGLSKEA-IDHEKKAYSFCGTVEYMAPEVVNRQGHTHSADWWS-YGVLMFEML .|. .|| ||. |...|||| .||||| |||||||.|..|||.||||||.|| | . |...|||| ||.|||. | .||| ..|||. |..|.||. SEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMM TGSLPFQGKDRKETMTLILKAKLGMP--QFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHIFY .| .|| .|... . .|. ... .| ..| |...|.. | ...| .|||.||..|.||||| .. CGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF |
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Kinase | RSK1.AA | p70 | 68-327 | 47 | 1.9e-138 | 466.26 | In-house | 1-299 (299) | Show / Hide |
Range on Protein: 68-327 Range on HMM: 1-299/299 Sequence Identity: 47% (142 aa) FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKA--TLKVRDRVRTK-------------------------MERDILADVNHPFVVKLHYAFQTE ||||||||.| .||||.||||| |.| .||||||.|| . .| |. || || |.|||...|||||||. FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN GKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKK----------AYSFCG |||||||..| || ||. | .. .. |. ..|||.| . | |||..|||||||||||..|.. ||..||||||.|| | .. ..||| GKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCG TVEYMAPEVVNRQGHTHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAK--LGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHIFY | ||||||.. | || | |||| |.||. ||||. || | ||.|. |||.| | .| |. |. |...| ||.|. |.|.||. |..|..| |. TIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF |
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Kinase | RSK1.AA | AktR | 68-327 | 45 | 7.69999999999e-122 | 411.08 | In-house | 1-268 (268) | Show / Hide |
Range on Protein: 68-327 Range on HMM: 1-268/268 Sequence Identity: 45% (124 aa) FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKK-ATLKVRDRVRTKMERDILA-DVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMF |...|.||.| ||||.||.| | |.. .||||..|| . . . .| .||.|.. .|||| |||||.|||. ||..|... .||.||. |.|. | FHVYKCLGKGAFGKVYLVQKK-R-DNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKF TEEDVKFYLAELALGLDHLHSL-GIIYRDLKPENILLDEEGHIKLTDFGLSK-EAID-HEKKAYSFCGTVEYMAPEVVNR-QGHTHSADWWSYGVLMFEM .||...|| |. |.|..||. |||||||||||||||.||.|.||||||| . .. . ||||||||.||||||.... .||. |.|||. |.. .|| SEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEM LTGSLPFQGKDRKETMTLILKAK-LGMPQF--LSTEAQSLLR-ALFKRNPANRLGSGPDGAEEIKRHIFY .|| ||. |.... .|.. . |. .| ....|. |...|| .|||.. |.||||.| . VTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF |
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Kinase | RSK1.AA | MSK | 71-322 | 40 | 2.5e-107 | 362.86 | In-house | 1-277 (277) | Show / Hide |
Range on Protein: 71-322 Range on HMM: 1-277/277 Sequence Identity: 40% (112 aa) LKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTK--MERDILADV-NHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTE |||||.|. ||.|..||... |.| |||||.|.|||. . .. || .| .. .||..|.||||||.. ..||......|| |||...| |.| LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE EDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEE---GHIKLTDFGLSKEAIDH-EKKAYSFCGTVEYMAPEVVN----RQG-HTHSADWWSYGVLM . . ....|| . .||.|..|||.|||||||||.|.| ||.||.|||.... |....|.|.| .|||||... .| . . |||| ||.. SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVIL FEMLTGSLPFQ--GKDRK-------ETMTLILKAKLGMP----QFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIK ..|||| ||| ..||. | | |.|.. | | |..|. |.. | ..|. ||| .. .|.|.| YTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK |
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Kinase | RSK1.AA | S_TKc | 68-327 | 34 | 3.9e-106 | 359.81 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 68-327 Range on HMM: 1-231/231 Sequence Identity: 34% (93 aa) FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRG--GDLFTRLSKEVM- .|.|...|.|.||||...|.. .|...|.|..| ... |..|| .||..|||...||. ..||...... | ||||... | YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH -----FTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHTH-SADWWSYGVLM |.| ...||.......|...||.|||.|||||||||||| |||..||||... ..|||| .||||||. |... ..|||| |... GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL FEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGA--EEIKRHIFY .|||.| ||. .| ...| . | || ...| .....|..|.. . ..|| | . YEMLCGYPPFP------QMQMMFKKIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | RSK1.AA | Pkinase | 68-325 | 30 | 5.5e-96 | 329.98 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 68-325 Range on HMM: 1-293/293 Sequence Identity: 30% (91 aa) FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKM--ERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGG----DLFTRLS- .......|.||||.| .| .. ..|...|.|..|| . | ... | |.. .|||..|.|...|......|.......|| |||...| YHIGRKIGSGSFGCV---YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST -KEVMF--TEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHI----KLTDFGLSKEA-IDHEKKAYSFCGTVEYMAPEVVN-RQGHTHSADW .. | .|...|||. ... ||...|| |||.|||||||||.|..||| |..||||.| . . . ...|||| .||||||.. .|......|. WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM WSYGVLMFEMLTGSLPFQGK------DRKETMTLILKAKLGMPQFLS---------------------TEAQSLLRALFKRNPANRLGSGPDGAEEIKRH ||.|....|||.| .||.|. | .. . .|....| . . . |...... .....|. |.. ||.|. | WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQH --I . PWF |
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Kinase | RSK1.AA | Ciliate-E2 | 68-327 | 23 | 4.4e-87 | 295.6 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 68-327 Range on HMM: 1-365/365 Sequence Identity: 23% (91 aa) FELLKVLGQGSFGKVFLVRKVTRP--------------------DSGHLYAMKVLKKATLKVRDRVRTKM-----------ERDILADVNHPFVVKLHYA ....|..|||.||.|..... . . . .||||..|| .. .. | |. || .|||...|.... YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FQ--TEGKLYLILDFLRGGDLFTRLS------------------KEVM-FTEEDVK-------FYLAELALGLDHLHSLG-IIYRDLKPENILLDEEGHI || .. ..||..... ||||| .. ||. .... .. ||.|.. |.| .||| . ||.||.||||||. | FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I KLTDFGLSKEAIDHEK-------------------------------KAYSFCGTVEYMAPEVVNRQG---------HTHSADWWSYGVLMFEMLTGSLP |..||||||.. | .. ....||| .|||||..|... .....|.|| ||...|||.| .| KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP FQGKDRKETMTLILKAKLGMPQF------------------LSTEAQSLLRA----LFKRNPANRLGSGPDGAEEIKRHIFY | . |.. |. |.. .| |.. |.. .....| .|.. |.|.|. | . F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF |
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Kinase | RSK1.AA | CAMK | 73-327 | 21 | 1.8e-83 | 268.72 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 73-327 Range on HMM: 1-425/425 Sequence Identity: 21% (93 aa) VLGQGSFGKVFLVRKV-TR---------PDSGHLYAMKVLKKATLK--------------------------VRDRVRTKMERDILAD-------VNHPF .||.||||||.|.. | . |. .|.|...| || .|| . . | .|. ..|| TLGRGSFGKVKLCIHKNTTGKERVHHIYTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN VVKLHYAFQ------------TEGK--------LYLIL---DFLRGG----DLFTRLSKE---------------VMFTEEDVKFYLAELALGLDHLHSL ..||. ... | | .|... .. || ||| .. . |||.....| .. .....||. IIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH GIIYRDLKPENILLDEE-----------------GHIKLTDFGLSKEAIDHE-----------------------KKAYSFCGTVEYMA-PEVVNR---- .|. |||||||||||. . ||..|||.... .. | .| . |||| |||| |||.|. NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC ----------QGHTHSADWWSYGVLMFEMLTGSLPFQGK-------------DRKETMTLILKAKLG-MPQFLST-----------------------EA .... ..| || ||... ||.| .||.|. . .|.. |.|.| | ..|. |. NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC QSLLRALFKRNPANRLGSGPDGAEEIKRHIFY ..|.| . ...| .|. .|....| .. KDLIRKMLQVDPEKRM-----TIEQCLNHPWM |
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Kinase | RSK1.AA | CAMK1 | 68-311 | 29 | 5.2e-64 | 184.94 | In-house | 1-265 (276) | Show / Hide |
Range on Protein: 68-311 Range on HMM: 1-265/276 Sequence Identity: 29% (79 aa) FELLKVLGQGSFGKVFLVRKVTR-PDSGHLYAMKVLK-KATLKVRDR---VRTKMERDILADV---NHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRL .|. |..| |.|..|.|. . |. ||.|... | .| |. . ..| .|. | .||...|.. .... ..||... . ||.|| | YEFGKEIGRGAFSEVYLCTHKETQT-NGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRI SKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILL---DEEGHIK--LTDFGLSKEAIDHEK-KAYSFCGTVEYMAPEVVNR---QGHTHSAD . .||.| ... . ..||.|| |||||||.|. ||. || . |||||| .||. . . ||| .|.||||... ... . | VEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSK-IFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACD WWSYGVLMFEMLTGSLPFQGKD-RKETMTLILKAKLGMPQF----LSTE-AQSLLRALFKRNPANRL || || . .|.| ||.... .| . .|.|.....| . | . | ... . . .| .|. MWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRY |
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Kinase | RSK1.AA | S_TK_X | 328-389 | 39 | 3.6e-25 | 90.88 | SMART | 1-79 (79) | Show / Hide |
Range on Protein: 328-389 Range on HMM: 1-79/79 Sequence Identity: 39% (31 aa) STIDWNKLYR--REIKPPFKPAVA----QPDDTFYFDTEFTSRTPRDSPGIPPSAGAHQL-----------FRGFSFVA . |||.|||. .||.||||| . | || .||.|||. ||...| ||. .... ||||..|. RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF |
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Kinase | RSK1.AA | Pkinase_Tyr | 68-289 | 28 | 9.1e-22 | 74.34 | Pfam | 1-237 (270) | Show / Hide |
Range on Protein: 68-289 Range on HMM: 1-237/270 Sequence Identity: 28% (68 aa) FELLKVLGQGSFGKVFLVRKVTRPDSGHLY-AMKVLKKATLKVRD--RVRTKMERDILADV-NHPFVVKLHYAFQ-TEGK--LYLILDFLRGGDLFTRLS ...|.||.|.||.|.. . ||.... | |.| | . .. | | |. .|| .|.|. . .. .|... . .||| . | ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR K----EVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAY-SFCG----TVEYMAPEVVNRQGHTHSADW | . .| .| . .. | |...|.| ..| ||| |.|..|....| .||||.. ... | | . ||||. | |. | KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI--YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV WSYGVLMFEMLT-GSLP-FQGKDRKETMTLILKAKLGMPQ ||.||||.|..| | | ..| . | . .| . ||. WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPC |
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Kinase | RSK1.AA | TyrKc | 68-325 | 23 | 7.8e-18 | 65.63 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 68-325 Range on HMM: 1-280/280 Sequence Identity: 23% (71 aa) FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADV--NHPFVVKLHYAFQTE-------GKLYLILDFLRGGDLFTR .|.|.|| | ||.|.. . | |.||. . | | |. . .|| .|.|. . .. . |.... . .||| . ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY LSKEVM-FTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDH-----EKKAYSF----CGT----VEYMAPEVVNRQG | | .. .| . | | ..||| ..| ||| |.|..|....| .|||||.. |. .|. |. .| . ||||. | LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK HTHSADWWSYGVLMFEMLT-GSLPFQG-----KDRKETMTLILKAKLGMPQFL---------STEAQSLLRALFKRNPANRLGSGPDGAEEIKRHI |. | ||.||.|.|..| | | | .. .| . .. . . .. ..| .. . ...|..| .||.. . FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP-----TFSEIHECF |
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Kinase | RSK1.AA | Pkinase_C | 347-391 | 40 | 1.4e-13 | 51.01 | Pfam | 1-46 (46) | Show / Hide |
Range on Protein: 347-391 Range on HMM: 1-46/46 Sequence Identity: 40% (19 aa) AVAQPDDTFYFDTEFTSRTPRDSP--GIPPSAGAHQLFRGFSFVATG | |.|| .||.|||. .|.|.| . |.|.. .||||..|. QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD |
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Kinase | RSK1.AA | RSK | 424-681 | 56 | 4.6e-192 | 644.34 | In-house | 1-271 (271) | Show / Hide |
Range on Protein: 424-681 Range on HMM: 1-271/271 Sequence Identity: 56% (154 aa) YVVKETIGVGSYS---VCKRCVHKATNMEYAVKVIDKSKRDPS-----EEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSE | ..| ||.||.| |||.|.||.||..||.|.|.|..||.. ||..|.||||.||.|..|..|..|...||.....||||.|.|..|.||.||| YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSE REASFVLHTISKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLA ||..|....| ...|||||||.|||||||.||||.||||||....|||||||||||.|||.|||.|||||..|||||||||.|. ||.||.|.|.|.||. REVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLT GYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTA-----KQVLQHPWI |.|||.|.| |||..|. ||..|.|....|||...|..||||...|||.|||.||.| .|..||||. GCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF |
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Kinase | RSK1.AA | RSK | 426-681 | 43 | 2.1e-160 | 539.17 | In-house | 1-278 (278) | Show / Hide |
Range on Protein: 426-681 Range on HMM: 1-278/278 Sequence Identity: 43% (123 aa) VKET--IGVGSYSVCKRCVHKATNMEYAVKVIDKSKRDPS--------EEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKF--- .|. .|.|....|..|.|..|...||.||..|.|.... .|..||.|..|||.|.||..........||..|..|||||.......|. LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC FSEREASFVLHTISKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAE-NGLLMTPCYTANFVAPEVLK----RQGYDEGCDIWSLG |||.||.|.. .|...||.||.||..||||||.|||| ||| |.. ....||||.||.|.. |...||.|||....|||.|| . |.|. ||.|||| FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG ILLYTMLAGYTPFANGPSD-TPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLT-----AKQVLQHPWI .|.|.||.|..||.. | | ...||..||..|||.|...||...|..||||..||||.|||.||. |....||||. VLMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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Kinase | RSK1.AA | CAMK1 | 424-681 | 38 | 1.3e-118 | 346.41 | In-house | 1-276 (276) | Show / Hide |
Range on Protein: 424-681 Range on HMM: 1-276/276 Sequence Identity: 38% (107 aa) YVVKETIGVGSYSVCKRCVHKAT---NMEYAVKVIDKSKRDPSE-----------EIEILLRYG--QHPNIITLKDVYDDGKHVYLVTELMRGGELLDKI |.....|| |. |. ..|.|| | . .||.|.||| |. .. ||||. . . .||||| ....|.. .|.|||.||. ||||.|.| YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDK-KKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRI LRQKFFSEREASFVLHTISKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLR-ICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKR---QGYDEGCDI . ....|..|. . . | . |||.||.|.||||||| |.||.|.. . . | |.||| .|.. ...|. |.| | .||||||.. ..|| ||. VEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDM WSLGILLYTMLAGYTPFANGPSDT-PEEILTRIGSGKFTLSGGNWNTVSET-AKDLVSKMLHVDPHQRLTAKQVLQHPWI || |. .|..| || || ... .|.. | ..... |. .|. |||....|| ||| .|.|..|.|.|||| WSIGVITYILLCGYPPFY---DENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI |
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Kinase | RSK1.AA | Pkinase | 424-681 | 35 | 2.3e-114 | 391.07 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 424-681 Range on HMM: 1-293/293 Sequence Identity: 35% (104 aa) YVVKETIGVGSYSVCKRCVHKATNMEYAVKVIDKSKRDPSE--------EIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGG----ELLDKIL--R |.....|| ||......|.|| |. ..|||.|.|....... ||.|..| .||||..|.|.. |..|.|.|.|...|| .| | | | YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR QKFF--SEREASFVLHTISKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQL-RAENGLLMTPCYTANFVAPEVLK-RQGYDEGCDIWS .. | ||.|. |.. | . .||.||.|..||||||.|||.... ...|..|||||.|||. |. ..|.| | ...||||.. .|.|. .|.|| HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS LGILLYTMLAGYTPFANG----PSDTPEEILTRIGSGKFTLSGGNWNTVS-----------------ETAKDLVSKMLHVDPHQRLTAKQVLQHPWI .|..|| || |..|| . . ... ... ||..... . .|...| |..||.....|..||..|.||.|.|||||. CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | RSK1.AA | AGC | 424-681 | 23 | 1.6e-109 | 283.79 | In-house | 1-395 (395) | Show / Hide |
Range on Protein: 424-681 Range on HMM: 1-395/395 Sequence Identity: 23% (94 aa) YVVKETIGVGSYSVCKRCVHK------ATNMEYAVKVIDKSK---------RDPS-------------EEIEILLRYGQ---------HPNIIT-LKDVY . .. .|| ||.. . . .| .|. ||.||..|.. . || .|| .. . ||.|. |. . FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF DDGKH--VYLVTELMR---------GG-ELLDKIL---RQKFFSEREASFVLHT-------ISKTVEYLHS-QGVVHRD-LKPSNILYVDESGNPECLRI | .| .|.| |.| || ||. . ... |.| .| | . | .||||| .|..||| ||| ||| .. ... QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED----GHIKL CDFGFAKQLRAE-----------------------------------------------------NGLLMTPCYTANFVAPEVLKRQGYDEGCDIWS--L .|||..|... . . . || |....|||.| |. ||.|| | TDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPC-TPEYMAPEIL----YGKACDWWSFGL GILLYTMLAGYTPFANGPSD-------TPEEILTRIGSGKFTLSGGNWNT------------VSETAKDLVSKMLHVDPHQRLT----------AKQVLQ |.|.| ||.||.|| . . . .|.|. .| .|..... . .|. ||||..|.|..|| .||. |... . GCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKN HPWI ||| HPWF |
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Kinase | RSK1.AA | S_TKc | 424-681 | 36 | 6.30000000001e-107 | 362.44 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 424-681 Range on HMM: 1-231/231 Sequence Identity: 36% (100 aa) YVVKETIGVGSYSVCKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRG--GELLDKILRQKF------FSE | . ..|| |.......|.|| |. ..|.|.|. .. ||.|| . .||||..|.||..| .|.|.|.|.. | |.|.| | ... |.| YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE REASFVLHTISKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDE-GCDIWSLGILLYTML .| |... | . .||.||.|..||||||.||| . .. |||||.|.|| .| | | ...||||| ||. ||.||.|..|| || -HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML AGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQ-------HPWI .||.|| ...... .|| |. |||...|.|..|| .|.|| ..|| |||. CGYPPFP-----QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | RSK1.AA | CAMK | 429-681 | 25 | 5e-106 | 342.71 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 429-681 Range on HMM: 1-425/425 Sequence Identity: 25% (108 aa) TIGVGSYSVCKRCVHKATN------------MEYAVKVIDKS--------------------------------KRDPSEEIEILLRYG------QHPNI |.| ||... |.|.|| |. ..|.|.|||. .. ||||. . .|||| TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI ITLKDVYDDGKH-------------------VYLVT---ELMRGGEL----LDKILRQKF---------------FSEREASFVLHTISKTVEYLHSQGV | | .||.|... .|.|. |.. |||| .|.| ... |.||||... . | |.|.||... IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI VHRDLKPSNILYVDESGNPE-------------CLRICDFGFAKQLRA-----------------------ENGLLMTPCYTANFVA-PEVLKR------ ||||||| |||..| ... . . |.|||||.... |. .. |.| | ..| ||||.. VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM --------QGYDEGCDIWSLGILLYTMLAGYTPFANGPSD----------TPEEILTRIGSGKFTLSGGN------------WNTVSET--------AKD ..|.. ||.||.|..||.|| || || . ...|.. .| .||.. |. .|. .|| QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD LVSKMLHVDPHQRLTAKQVLQHPWI |..||| ||| .|.|..|.|.|||. LIRKMLQVDPEKRMTIEQCLNHPWM |
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Kinase | RSK1.AA | MSK | 426-681 | 36 | 3.8e-92 | 311.79 | In-house | 3-277 (277) | Show / Hide |
Range on Protein: 426-681 Range on HMM: 3-277/277 Sequence Identity: 36% (100 aa) VKETIGVGSYSVCKRCVHKATNMEYAVKVID-----KSKRDPSE---EIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSERE |. |.| |....|..|||. |. .||.|.. ... ... |. .|.. ||||| .|.... | | ||| |. .||||. .| . . |.| | VLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDESE ASFVLHTISKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAE-NGLLMTPCYTANFVAPEVLK----RQG-YDEGCDIWSLGILLY ..... . |...|. |..|||||| |||. ||. | . ... |||||. . .. . . .||.| . |||.|. .| ||| ||.||||..|| CRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGH-VKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVILY TMLAGYTPFA-NGPSDT-----PEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWI ||| | ||. |... || || |.| . | |...|. ||||....| .|| ||.. ..| |. TMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK |
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Kinase | RSK1.AA | Ciliate-E2 | 424-681 | 24 | 5.9e-82 | 278.58 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 424-681 Range on HMM: 1-365/365 Sequence Identity: 24% (93 aa) YVVKETIGVGSYSVCKRCVH-----------------------KATNMEYAVKVIDKS--KRDPSEEIEI--------------LLRYGQHPNIITLKDV | . . || |.... ..| . |.....||.|.. |. . .|. .. .|. .||||| .... YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC YD--DGKHVYLVTELMRGGELLD--KILRQKF---------FSEREASFVLHTISK---------------TVEYLHSQG-VVHRDLKPSNILYVDESGN . | ...|||.|. ||.|.| |. ..|. |.|.|.... | . .|||||.. ..|||.||.|||. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------ PECLRICDFGFAKQLRAENG-------------------------------LLMTPCYTANFVAPEVLKRQG---------YDEGCDIWSLGILLYTMLA . |.|||..|.. .| . | |.|....|||.|.... ||. |||||||..|| || ---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF GYTPFANGPSDTPEEILTRIGSGKFTLSGG--------------NWNTVSETAKDLVSK----MLHVDPHQRLT-AKQVLQHPWI |..|| . | .|. .. .|. .|. .||| .| || .|| .|.| ..|.|.|||. GKPPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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Kinase | RSK1.AA | p70 | 474-681 | 29 | 3.6e-35 | 123.18 | In-house | 86-299 (299) | Show / Hide |
Range on Protein: 474-681 Range on HMM: 86-299/299 Sequence Identity: 29% (67 aa) QHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTISKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAE .||.|. | . .. ||. | . |||| |. . | |.| | |. |.||..|.. ||||| |.. .. | . ||| |. . KHPFICDLHYAFQTNGKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCM-LNQQG---HVVLTDFGLCKESIHD NGL----------LMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGK--FTLSGGNWNTVSETAKDLVSKM . | | | . |||.| | |.. .| ||||.|.| || | || ... .. | || .| .. ..||. |. GAVDEEDPENVNATHTFCGTIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFT---GENRKKTIDKILKGKQGLKL----PPYLTHEMRDLIKKL LHVDPHQRLT-----AKQVLQHPWI | .| ||.. |... .||. LKRHPTQRWGAGPEDAADIQEHPFF |
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Kinase | RSK1.AA | Akt | 492-620 | 36 | 2.4e-29 | 90.92 | In-house | 76-203 (264) | Show / Hide |
Range on Protein: 492-620 Range on HMM: 76-203/264 Sequence Identity: 36% (48 aa) YLVTELMRGGELLDKILRQKFFSEREASFVLHTISKTVEYLHSQGVVHRD-LKPSNILYVDESGNPECLRICDFGFAKQL-RAENGLLMTPCYTANFVAP |.|.. . |||| . |...||| .| | |. |.|||.... || ||| ||| .|. |. ....||| .|. .. .| | |. || YFVMDYCNGGELFYHLQRKRRFSEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENIL-MDKDGH---ICLTDFGLCKENIIKDHDKTKTFCGTPEYLAP EVLKRQGYDEGCDIWS-LGILLYTMLAGYTPF |.|. .|.. .|.|. ||...| |. | || EILNGNGHTKAVDWWGSLGCVMYEMMCGRPPF |
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Kinase | RSK1.AA | AktR | 474-620 | 33 | 1.3e-25 | 91.38 | In-house | 59-205 (268) | Show / Hide |
Range on Protein: 474-620 Range on HMM: 59-205/268 Sequence Identity: 33% (51 aa) QHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTISKTVEYLHSQ-GVVHRDLKPSNILYVDESGNPECLRICDFGFAK--QL .|| |. |.. . .. ... | ..||||.. . ..|.||| .| | | .||||.. .. ||||| ||| || |. ..| ||| .| NHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSEEQARFYFAQILLALEYLHQHMNIIYRDLKPENIL-LDEDGH---VKITDFGLSKLQFM RAENGLLMTPCYTANFVAPEVLKR-QGYDEGCDIWSLGILLYTMLAGYTPF .... . . | | .|||.... .|.. .|.|..||..| |..|..|| MHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPF |
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Kinase | RSK1.AA | Pkinase_Tyr | 424-611 | 25 | 1.2e-17 | 60.4 | Pfam | 1-205 (270) | Show / Hide |
Range on Protein: 424-611 Range on HMM: 1-205/270 Sequence Identity: 25% (54 aa) YVVKETIGVGSYSVCKRCVHK----ATNMEYAVKVIDKSKRDPSE--------EIEILLRYGQHPNIITLKDVYD-DGKH--VYLVTELMRGGELLDKIL . ...| |.. . .... | |... |||.. | . .... |..|. .|.||||. | | .|.. .|.|.|.| .| ||| ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR R----QKFFSEREASFVLHTISKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQL-------RAENGLLMTPCYTANFVAPEVLKRQGY . .. .. . . |.| |||.|.. .|||| |.| . . . .||||| |. . |. | . . |||... . KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE----NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM----APECINYGKF DEGCDIWSLGILLY . |.|| |.|.. TTKSDVWSFGVLMW |
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Kinase | RSK1.AA | TyrKc | 424-681 | 19 | 1.9e-15 | 27.09 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 424-681 Range on HMM: 1-280/280 Sequence Identity: 19% (56 aa) YVVKETIGVGSYSVCKRCVHKATNMEYAVKVIDKSKRDPSE---EIEILLRYG-QHPNIITLKDVYDDG-------KHVYLVTELMRGGELLDKILRQK- . ....| | . . ... | .. |||.. ... . |..|. ..| .||||. | | .. . ...|.|.| .| |.| . . . ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP FFSEREASFVLHTISKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAE-----NGLLMTPCY--TANFV------APEVLKRQGYD .. .. . |.. |||||....|||| |.|. .. . .|.||| .. . . .. .. .... |||... . KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT EGCDIWSLGILLYTMLA-GYTPFAN---GPSDTPEEILTRIGSGKFTLSGGN------WNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWI . |.|| |.... .. | .| . ...|.. .. .|. | .| . . .. | ||..| | ... | . TKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF |
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Kinase | RSK1.AA | Akt | 648-681 | 35 | 9.6e-09 | 23.99 | In-house | 226-264 (264) | Show / Hide |
Range on Protein: 648-681 Range on HMM: 226-264/264 Sequence Identity: 35% (14 aa) NTVSETAKDLVSKMLHVDPHQRL-----TAKQVLQHPWI ...| .|||.|..|. ||..|| .|... .||| DWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF |
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Kinase | RSK1.AA | AktR | 650-681 | 31 | 6e-07 | 23.22 | In-house | 231-268 (268) | Show / Hide |
Range on Protein: 650-681 Range on HMM: 231-268/268 Sequence Identity: 31% (12 aa) VSETAKDLVS-KMLHVDPHQRLT-----AKQVLQHPWI .|...|||. | | .| .||. .... ||| FSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF |
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Kinase | RSK1.AA | AktR | 424-459 | 27 | 0.043981 | 4.35 | In-house | 1-37 (268) | Show / Hide |
Range on Protein: 424-459 Range on HMM: 1-37/268 Sequence Identity: 27% (10 aa) YVVKETIGVGSYSVCKRCVHK-ATNMEYAVKVIDKSK ..| . .| | .. . .| .. || |.|.|.| FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKK |