Gene ROS (Mouse)

ROS

Species: Mouse
Alias: ROS, Ros1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Sev

Sequence

Name Sequence Type Origin Length Description Download
ROS.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 271 Kinase domain by global Sugen HMM Fasta, JSON
ROS.NA RNA Sugen 7401 None Fasta, JSON
ROS.AA Protein Sugen 2340 None Fasta, JSON

Protein domain

Protein domains of ROS.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FN3 ROS.AA FN3 109-187 21 5.6e-07 30.43 SMART 1-69 (69) Show / Hide 
Range on Protein: 109-187
Range on HMM: 1-69/69
Sequence Identity: 21% (20 aa)

TELPTA---PFASSIGSH------GVTLRWNPANISGVKYIIQWKYAQLPGSWTFTETVSKLSYTVEPLHPF----TEYIFRVVWIFT--AQLH
   |.    . .....|.       |||.|.|        |....                  |||. |.|     ||| |||. .    |   
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-------IVGYR------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
FN3 ROS.AA FN3 205-282 21 4e-12 47.52 SMART 1-69 (69) Show / Hide 
Range on Protein: 205-282
Range on HMM: 1-69/69
Sequence Identity: 21% (20 aa)

ETAPLI---LNMESWSPD------TVEVSWAPPHFPGGPILGYNLRLISKNQKLDSGTQRTSFQFYSTLPN----TTYRFSIAAVNE--VGEG
  .|     |  ......      .|..|| ||      |.||                   . .    |.    |.|.|...|||.  .|||
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
LY ROS.AA LY 369-409 13 0.035512 8.5 SMART 1-51 (51) Show / Hide 
Range on Protein: 369-409
Range on HMM: 1-51/51
Sequence Identity: 13% (7 aa)

LRIFYQGSGLVSS-ISIDWLYQ--RMYFIMDK--------LVYVCELKNCSN
 .|. ..   . . | .||...  |.|..  .          ..| .     
RTIISEDL-WPNGGIAVDWIEGHDRLYWTDWGRDPSHHHPKIERCNMDGTNR
FN3 ROS.AA FN3 568-654 17 1e-06 29.31 SMART 1-69 (69) Show / Hide 
Range on Protein: 568-654
Range on HMM: 1-69/69
Sequence Identity: 17% (18 aa)

PGHPQE---VSVL-FGSR------EALIQWTPPALAIGASPSAWQNWTYEVKVYSQDILEITQVFSNISGTMLNVPELQSS----TKYTVSVRASSP--K
|| |.    ..|   .|.       . ..|.||   .| .                                  |. |.      |.|...||| .   .
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP--IVGYR--------------------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDA

GPG
|.|
GEG
LY ROS.AA LY 775-815 23 0.003533 16.88 SMART 1-51 (51) Show / Hide 
Range on Protein: 775-815
Range on HMM: 1-51/51
Sequence Identity: 23% (12 aa)

TDIVTHVKLLVND-MAVDSVGG--YLYWTTLY--------SVESTRLNGESS
. |...    .|  .||| ..|  .||||  .        . |. ...|   
RTIISEDL-WPNGGIAVDWIEGHDRLYWTDWGRDPSHHHPKIERCNMDGTNR
FN3 ROS.AA FN3 944-1023 20 3e-06 28.0 SMART 1-69 (69) Show / Hide 
Range on Protein: 944-1023
Range on HMM: 1-69/69
Sequence Identity: 20% (19 aa)

PDPVQE---SSFRIEGHTS-----SFQILWNEPPAVDWGIVFYSVEFSTHSKFLIIEQQSLPIFTVEGLEPY----TLFNLSVTPY--TYWGKG
|.|..     ...  . ||     |... |..|      || |.                   .||.||.|.    |  . .|. .  .  | |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR-------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
FN3 ROS.AA FN3 1037-1133 14 0.042729 9.17 SMART 1-69 (69) Show / Hide 
Range on Protein: 1037-1133
Range on HMM: 1-69/69
Sequence Identity: 14% (15 aa)

PSAPENPRIFILSSGRYTKKNE-VVVEFRWNKPKHENGVLTKFEIFYHISKQSGTNRSTEDWMSASVIPPVMSFQLEAVSPE----YTVAFQVRVFTS--
|..|.||... ...   |  .. . |. .|..|          .. |.                         . ..  .|      .  |.||....  
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP----------IVGYR-------------------------YTVTGLKPGQYPWTEYEFRVRAVNGND

KGPG
.|.|
AGEG
FN3 ROS.AA FN3 1440-1532 13 0.046149 8.88 SMART 1-69 (69) Show / Hide 
Range on Protein: 1440-1532
Range on HMM: 1-69/69
Sequence Identity: 13% (14 aa)

SLASDM---VEATILYATNT----SLTLKLPPVKTNLTWHGITHPTSTYLIYYMEANRANSSDRRHKMLESQENVARIEGLQPF----SMYMIQIAVKNY
  .      ...|   .|.|    |.||.  |                  ..|                      ....||.|     . | ......| 
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP----------------IVGYR---------------------YTVTGLKPGQYPWTEYEFRVRAVNG

--YSEP
  . | 
NDAGEG
FN3 ROS.AA FN3 1551-1637 13 0.008194 15.39 SMART 1-69 (69) Show / Hide 
Range on Protein: 1551-1637
Range on HMM: 1-69/69
Sequence Identity: 13% (14 aa)

PGAVCH---INATVLSDT------SLHVFWTESHKPNGPKESVRYQLVMSYLAPIPETPLRQGEFPSAKLSLLITKLSGG----QLYVMKVLAC--HPEE
||.. .   . .|  ..|      |... |..          |.|.                           .| |. |    . |. .| |       
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP--------IVGYR-------------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAG

MW
  
EG
FN3 ROS.AA FN3 1649-1731 17 4e-06 27.7 SMART 1-69 (69) Show / Hide 
Range on Protein: 1649-1731
Range on HMM: 1-69/69
Sequence Identity: 17% (17 aa)

FDTPEK---PSALVPENT------SLQLDWKARSNVNLTGFWFELQKWKYNEFYHVKASCSQGPVYVCNITDLQPY----TSYNIRVVVVYT--TGEN
 . |.    ...    .|      |..| ||.      .|..                         . .|.|.|.    | |..||..|.    || 
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP----IVGYR-------------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
FN3 ROS.AA FN3 1746-1832 12 0.103168 5.85 SMART 1-69 (69) Show / Hide 
Range on Protein: 1746-1832
Range on HMM: 1-69/69
Sequence Identity: 12% (13 aa)

PSKPGI---PKLLEGSKN------SIQ--WEKAEDNGSRLMYYTLEVRKGISNDSQNQSSRWKVVFNGSCSSICTWRSKNLKG------TFQFRAVAANE
|. |.    ... . ...      |..  |..      .. |                                  . ..||       . .|| .| |.
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-----IVGYR--------------------------------YTVTGLKPGQYPWTEYEFRVRAVNG

--IGLG
   | |
NDAGEG
Kinase ROS.AA Sev 1938-2208 76 2.4e-250 837.94 In-house 1-277 (277) Show / Hide 
Range on Protein: 1938-2208
Range on HMM: 1-277/277
Sequence Identity: 76% (211 aa)

LSLRLLLGSGAFGEVYEGTAIDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLGEPQYIILELMEGGDLLSYLRKARGT
|.||..||||||||||||.|.||.|||..|..||.|||.||||||||.||||||||||||.||||..|.||||..||||||.|.|||||||.|||.||.|
LKLRRFLGSGAFGEVYEGQAKDIDGVGEEEQRVAIKTLRKGSTDQEKQEFLKEAHLMSKFKHPNIVCQMGVCLDNEPQYIIMEHMEGGDLLCYLRAARMT

TFHGPS----LTLLDLVELCVDISKGCVYLEQMHFIHRDLAARNCLVSVKDYTS--PRVVKIGDFGLAREIYKNDYYRKRGEGLLPVRWMAPENLMDGIF
||..|.    |||.||||.|.||||||.|||.|||.|||||.|||||||||||.  .||||||||||||.|||||||||.|||||||||||||.||||.|
TFQNPQPTAGLTLMDLVEMCIDISKGCEYLEDMHFVHRDLACRNCLVSVKDYTTHRRRVVKIGDFGLARDIYKNDYYRKEGEGLLPVRWMAPESLMDGYF

TSQSDVWSFGILVWEILTLGHQPYPAHSNLDVLNYVQAGGRLEPPRNCPDDLWNLMSQCWAQEPDQRPTFHNIQNQL
|.|||||.||||.|||.||||||||||||..|||.|||||||..||.||||||..|.|||.|.|.|||.||..||.|
TTQSDVWAFGILCWEIMTLGHQPYPAHSNFEVLNHVQAGGRLQQPRMCPDDLWMMMRQCWRQDPWQRPSFHMCQNML
Kinase ROS.AA Pkinase_Tyr 1938-2208 50 1.6e-148 503.62 Pfam 1-270 (270) Show / Hide 
Range on Protein: 1938-2208
Range on HMM: 1-270/270
Sequence Identity: 50% (140 aa)

LSLRLLLGSGAFGEVYEGTAIDILGVGSGEIKVAVKTLKKGSTDQE--KIEFLKEAHLMSKF-NHPNILKQLGVCL-LGEP--QYIILELMEGGDLLSYL
...   ||.|||||||.||. .    ....|.||||.|| |.....  . .|..|| .|... .||||.. .|||.  |||   ||..|.|..||||.||
ITFGKKLGEGAFGEVYKGTWKG--DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

RKARGTTFHGPSLTLLDLVELCVDISKGCVYLEQMHFIHRDLAARNCLVSVKDYTSPRVVKIGDFGLAREIYKNDYY-RKRGEGLLPVRWMAPENLMDGI
|| |     ...||. ||.. |..|.||. |||....||||||||||||.     ...||||.|||||| ||. ||| ||||.| ||..||||| ...|.
RKHR---EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVT-----ENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK

FTSQSDVWSFGILVWEILTLGHQP-YPAHSNLDVLNYV-QAGGRLEPPRNCPDDLWNLMSQCWAQEPDQRPTFHNIQNQL
||..|||||||.| |||.|.| || ||  || .|..|. . |.|...|.||||.. .|| |||...|..||||  |..||
FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase ROS.AA TyrKc 1938-2208 42 4.1e-148 499.27 SMART 1-280 (280) Show / Hide 
Range on Protein: 1938-2208
Range on HMM: 1-280/280
Sequence Identity: 42% (129 aa)

LSLRLLLGSGAFGEVYEGTAIDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKF--NHPNILKQLGVCLLG-------EPQYIILELMEGGDLL
..|   ||.|||||||.||..         |.||||.||...    . .|..|| .|.|.  .||||.. .|||. .       || .|..|.|..|||.
ITLGKKLGEGAFGEVYKGTWK---------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

SYLRKARGTTFHGPSLTLLDLVELCVDISKGCVYLEQMHFIHRDLAARNCLVSVKDYTSPRVVKIGDFGLAREIYKN-------DYYRK----RGEGLLP
.|||| |..      |.. ||.. |..|..|. ||.....||||||||||||. .      .|||.||||.|.||         |||||     | ..||
DYLRKHRPK------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP

VRWMAPENLMDGIFTSQSDVWSFGILVWEILTLGHQPYPA-----HSNLDVLNYVQAGGRLEPPRN--------CPDDLWNLMSQCWAQEPDQRPTFHNI
.|||||| ...|.||..|||||||.. |||.|.| ||||       || .|..||..|.|...| |        |||.. ..|.|||. .|..|||| .|
IRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI

QNQL
  ..
HECF
Kinase ROS.AA ALK 1938-2210 48 8e-130 437.6 In-house 1-273 (273) Show / Hide 
Range on Protein: 1938-2210
Range on HMM: 1-273/273
Sequence Identity: 48% (134 aa)

LSLRLLLGSGAFGEVYEGTAIDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLGEPQYIILELMEGGDLLSYLRKARGT
. |   || |||||||.|  . . |  | ...||.|||.     |.   |..||  |.||||.|. . .|.|.   | .|.||.|||||..|.||  | .
ITLVRALGHGAFGEVYMGQYSHMPG-DSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPYMIVLEYMEGGDMKSFLRECRPH

TF--HGPSLTLLDLVELCVDISKGCVYLEQMHFIHRDLAARNCLVSVKDYTSPRVVKIGDFGLAREI-YKNDYYRKRGEGLLPVRWMAPENLMDGIFTSQ
       .||  ||  .| |. .|| |||  |||||| |||||| . |   . ||.||.||| ||.| |. ||||| |  ..|| || || .||||||| 
PESLQPSQLTMKDLLQCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKG--PGRVAKIADFGMARDITYRADYYRKGGRAMMPVKWMPPEAFMDGIFTSK

SDVWSFGILVWEILTLGHQPYPAHSNLDVLNYVQAGGRLEPPRNCPDDLWNLMSQCWAQEPDQRPTFHNIQNQLQL
.||||||.| |||. ||  ||| ..| .|.  | .|||..||||||   ...|.|||  .|  ||.|  |  ..| 
TDVWSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEGGRMDPPRNCPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY
Kinase ROS.AA TK 1938-2208 26 3.4e-125 421.92 In-house 1-486 (486) Show / Hide 
Range on Protein: 1938-2208
Range on HMM: 1-486/486
Sequence Identity: 26% (130 aa)

LSLRLLLGSGAFG---EVYEGTAIDILGVGSGE-------------------IKVAVKTLKKG-STDQE-KIE-----------FLKEAHLMSKFN----
. |   ||.|.||   |||.|..... . .. .                   ..||||.||.| ...|| ...           ||.||. |....    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNILKQLGVCLLG------------EPQYIILELMEGGD----LLSYLRKARGTTFHGPS--------------------------------------
 ||||.. .|||. |            || .|..|.|..||    |..|||| |....| ..                                      
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LTLLDLVELCVDISKGCVYLEQM------HFIHRDLAARNCLVSVKDY------TSPRVVKIGDFG---
                               ||. .|.  |..|..|. ||...      .|.|||||||||||. ..        ...|.||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LAREIYKNDYYRKRG------------------------EGLLPVRWMAPENLMDGI---------FTSQSDVWSFGILVWEILTLGHQPYPA-H
     |||.||..|.|....                         | ||.|||||| |.|..         ||..|||||||.|.|||.|.| .||.  .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SN---------LDVLNYVQAGGRL--------------EPPRNCPD-------------DLWNL-MSQCWAQEPDQRPTFHNIQNQL
||          .|..|...||||              ..| .|||             ... . | |||. .|..||||  ...||
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase ROS.AA InsR 1938-2210 44 1.8e-116 392.73 In-house 1-278 (278) Show / Hide 
Range on Protein: 1938-2210
Range on HMM: 1-278/278
Sequence Identity: 44% (127 aa)

LSLRLLLGSGAFGEVYEGTAIDILGVGSGEI--KVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLGEPQYIILELMEGGDLLSYLRKAR
. |   .| |.|| ||||.| .|.  . ...  ..|.||.. . .. |.||||.||  | .||. .. . ||||  |.| |.. |.|. ||| ||||  |
IVLIRECGQGSFGMVYEGIAKGIV-PDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRR

GTTF--HGPSL------TLLDLVELCVDISKGCVYLEQMHFIHRDLAARNCLVSVKDYTSPRVVKIGDFGLAREIYKNDYYRKRGEGLLPVRWMAPENLM
       ..        .| ....   .|  |  ||.   |.|||||.|||.|. .|.|    |||||||..| ||  ||||| | |.||||||||| | 
PEEEFNNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVN-HDFT----VKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLK

DGIFTSQSDVWSFGILVWEILTLGHQPYPAHSNLDVLNYV-QAGGRLEPPRNCPDDLWNLMSQCWAQEPDQRPTFHNIQNQLQL
||.||..|||||||.. ||. ||| |||   ||  ||.|.  .|. |.|| |||. .  || .||.  |  ||||  | . |. 
DGVFTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase ROS.AA UTK 1938-2208 39 5.5e-112 378.33 In-house 1-296 (296) Show / Hide 
Range on Protein: 1938-2208
Range on HMM: 1-296/296
Sequence Identity: 39% (116 aa)

LSLRLLLGSGAFGEVYEGTAIDILGVGSGEIKVAVKTLKKGSTDQEKIE----FLKEAH---LMSKFN-HPNILKQLGVCLLGEPQYIILELMEGGDLLS
. |. .||.||||||..... .. . . .| .||||........| . |    |..||    .|..|. |||.|. .|||. .|| .|..|.||.|||.|
VQLGRQLGQGAFGEVHKARFTQCSEHM-YEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRS

YLRKARGTTF-HGPSLTLLDLVELCVDISKGCVYLEQMHFIHRDLAARNCLVSVK--DYTSPRVVKIGDFG---LAREIY---------KNDYYRKRGEG
|||..| |.. .. .||| .... ..||. |  ||....|.|||||||||||     . .  .|.||.|||   ..|...           .||.... .
YLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQD

LLPVRWMAPENLMDG-IFTSQSDVWSFGILVWEILTLGHQPYPAHSNLDVLNYVQAGG--RLEPPRNCPDDLWNLMSQCWAQEPDQRPTFHNIQNQL
 .|.|||||| | ..  ||..|||||||...|||.| | .||| .|| .|.  | .||  |...|. ||.....|| .||...|. ||.|. .  |.
RWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase ROS.AA TK-Unique 1938-2208 37 1.1e-100 340.81 In-house 1-294 (294) Show / Hide 
Range on Protein: 1938-2208
Range on HMM: 1-294/294
Sequence Identity: 37% (111 aa)

LSLRLLLGSGAFGEVYEGTAIDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFN-HPNILKQLGVCLLG-EPQYIILELMEGGDLLSYLRKAR
| .  ..|.||||.|. |..  | .. .  ..||||.||...||..| .||||. .|..   ||||.. ||.|    ||..||.| ...|.|..|||. |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

GTTFHG----------------PS---LTLLDLVELCVDISKGCVYLEQ--MHFIHRDLAARNCLVSVKDYTSPRVVKIGDFGLAREIYK-NDYYRKRGE
.... .                |.   ... ||.  ...| .|  ||..  ....||||.|||.|..        |.||.|||.||..|. ..| .....
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE-----DKVCKICDFGMARDVYTNGVYSMMCSQ

GLLPVRWMAPENLM--DGIF-TSQSDVWSFGILVWEILTLGHQPYPAHSNLDVLNYVQAGGRLEPPRNC-PDDLWNLMSQCWAQEPDQRPTFHNIQNQL
| .|.|||||| |   .|.. |..|||||||.| |||.||| .|||  .. |... ...| |.. | .| .... |||..||  ||..||.|  | ..|
GRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase ROS.AA SFK-Src 1938-2212 42 2.5e-98 292.03 In-house 1-259 (259) Show / Hide 
Range on Protein: 1938-2212
Range on HMM: 1-259/259
Sequence Identity: 42% (119 aa)

LSLRLLLGSGAFGEVYEGTAIDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLGEPQYIILELMEGGDLLSYLRKARGT
  |.  |||| ||.|.        |.  .   ||||||| |.. .|  |||.|| .| |  |||  .   ||  ||| ||| |||  | || ||.     
IRLEKKLGSGQFGDVWK-------GRWNNTTEVAVKTLKPGAMSAE--EFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEP---

TFHGPSLTLLDLVELCVDISKGCVYLEQMHFIHRDLAARNCLVSVKDYTSPRVVKIGDFGLAREIYKNDY-YRKRGEGLLPVRWMAPENLMDGIFTSQSD
  || ||..  || .  ..  |  |||   |.|||||||| ||         |.|.||||..| . ..|  |  .     |..| |||      |   ||
--HGRSLRMPQLVDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNN-----VCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSD

VWSFGILVWEILTLGHQPYPAHSNLDVLNYVQA--GGRLEPPRNCPDDLWNLMSQCWAQEPDQRPTFHNIQNQLQLFR
|||||||  || |.|  |||  .|  ||  |    | |.. | |||| ....| .|| .||| |||| . . |.  | 
VWSFGILMMEIVTYGRIPYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase ROS.AA Src 1938-2208 44 1.7e-95 323.56 In-house 1-255 (255) Show / Hide 
Range on Protein: 1938-2208
Range on HMM: 1-255/255
Sequence Identity: 44% (121 aa)

LSLRLLLGSGAFGEVYEGTAIDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLGEPQYIILELMEGGDLLSYLRKARGT
. |   ||.| ||||..|.         |..||||||||.|. ..|   ||.|| .| |. |..... . ||  .|| ||. |.|. | || ||.|    
IKLCRKLGQGQFGEVWMGYW-------NGNTKVAVKTLKPGTMSPE--AFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK----

TFHGPSLTLLDLVELCVDISKGCVYLEQMHFIHRDLAARNCLVSVKDYTSPRVVKIGDFGLAREIYK--NDYYRKRGEGLLPVRWMAPENLMDGIFTSQS
.  | .| | .|...   ...|  |||.| .||||||||| ||. .      |.|..|||||| . |   | |  | .  .|..|.||| .  | ||  |
DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENN-----VCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKS

DVWSFGILVWEILTLGHQPYPAHSNLDVLNYVQAGGRLEPPRNCPDDLWN-LMSQCWAQEPDQRPTFHNIQNQL
|||||||| .|| | |  |||  .| .||  |..| |.  |.|||| | . .| ||| ..|.|||||  .|. |
DVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase ROS.AA Fer 1938-2209 34 2.2e-95 323.16 In-house 1-283 (283) Show / Hide 
Range on Protein: 1938-2209
Range on HMM: 1-283/283
Sequence Identity: 34% (100 aa)

LSLRLLLGSGAFGEVYEG--TAIDILGVGSGE--IKVAVKTL-KKGSTDQEKIEFLKEAHLMSK-FNHPNILKQLGVCLLGEPQYIILELMEGGDLLSYL
  |   ||.||||||| |  |   ..|...    ..|.||..   ..|. ...||..|| .| . ..|||. |  ||| . .| .|..|.. ||.|.|||
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

RKARGTTFHGPSLTLLDLVELCVDISKGCVYLEQMHFIHRDLAARNCLVSV-KDYTSPRVVK--IGDFGLARE--IYKNDYYRKRGEGLLPVRWMAPENL
.|  .      .... .... | ....|  ||.... ||||.||||||..  |.     ..|  | |||..|.   |..||. |  .  .|.||.||| .
KKNKNK-----TVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKV-----KKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETW

MDGIFTSQSDVWSFGILVWEILTLGHQPYPA------HSNLD---VLNYVQAGGRLEPPRNCPDDLWNLMS-QCWAQEPDQRPTFHNIQNQLQ
 .||... .||||||.. ||| | | .|||.        |..   . .....| .. .| ..|... ..|  |||...|..|||.  |...| 
QTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase ROS.AA Met 1939-2202 36 5.6e-92 301.84 In-house 1-271 (271) Show / Hide 
Range on Protein: 1939-2202
Range on HMM: 1-271/271
Sequence Identity: 36% (103 aa)

SLRLLLGSGAFGEVYEGTAIDILGVGSGEIKVAVKTLK-KGSTDQEKIE-FLKEAHLMSKFNHPNILKQLGVCLLGEP--QYIILELMEGGDLLSYLRKA
 .   .| | || || |. .|  |    |...|.|.|.    || ..|. ||.|. .|. |.|||.|. .|.||  |    ...|. |..|||... |  
HFDDVIGQGHFGCVYHGMYHDNDGN---EHHCACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKTFIRNP

RGTTFHGPSLTLLDLVELCVDISKGCVYLEQMHFIHRDLAARNCLVSVKDYTSPRVVKIGDFGLAREI-YKNDYYRKRGEGL---LPVRWMAPENLM---
  .      .. .||.| | .. ||  |.   .|.|||||.|||. . .     ..||..||||.| . |   ||  . .     |||.||||| |    
QNN------PCVRDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEH-----FTVKVADFGLCRDMDYDKEYYSQMHHTHPARLPVKWMAPECLQQGV

-----DGI-FTSQSDVWSFGILVWEILTLGHQPYPAHSN-LDVLNYVQAG--GRLEPPRNCPDDLW-NLMSQCWAQEPDQRPTFH
     . . ||..|||||||.. || .| |  |||  .|  |.. . . |   ||  |  ||| |   .| .||  .| .||.| 
CLGCPTYRQFTTKSDVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQPEYCPDHLYTDVMLCCWHANPEDRPQFS
Kinase ROS.AA S_TKc 1938-2211 23 2.7e-47 164.34 SMART 1-231 (231) Show / Hide 
Range on Protein: 1938-2211
Range on HMM: 1-231/231
Sequence Identity: 23% (67 aa)

LSLRLLLGSGAFGEVYEGTAIDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLGEPQYIILELMEG--GDLLSYLRKAR
  .  ..|.||||.|| .. ..         .||.| .|        . ...|  ...| .|||| | ..|.   .  |...|...|  |||..|..| .
YEILRKIGKGAFGKVYKCRHKK------TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

GTTFHGPS--LTLLDLVELCVDISKGCVYLEQMHFIHRDLAARNCLVSVKDYTSPRVVKIGDFGLAREIYKNDYYRKRGEGLLPVRWMAPENLMDGIFTS
.   ||.   ..  .   ..  | ..  |. ....|||||   | |..        ..||.||||||..                 .|||| |    .. 
R---HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGK

-QSDVWSFGILVWEILTLGHQPYPAHSNLDVLNYVQAGGRLEPPRNCPDDLWNLMSQCWAQEPDQRPTFHNIQN------QLQLF
  .|.||.|....| |. |  |.|     ..    .  |        ..........|.  .|..|||   . .      . . |
CKCDWWSCGCILYEMLC-GYPPFP-----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ROS.AA Pkinase 1938-2210 23 4.7e-36 128.55 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1938-2210
Range on HMM: 1-293/293
Sequence Identity: 23% (72 aa)

LSLRLLLGSGAFGEVYEGTAIDILGVGSGEIKVAVKTLKKGSTDQEK-IEFLK--EAHLMSKFNHPNILKQLGVCLLGEPQYIILELMEGG----DLLSY
. .   .|||.||.||... ..         .||||..|| ... .| .. ..  |...| ..|||||.. ....  .   |...|..|||    || .|
YHIGRKIGSGSFGCVYKCHHKGTGK------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

LRKARGTTFHGPSLTLLDLVELCVDISKGCVYLEQMHFIHRDLAARNCLVSVKDYTSPRVVKIGDFGLAREIYKNDYYRKRGEGLLPV----RWMAPENL
..  |...|    ..  ..   .  | .|  |. .| .|||||   |.|.. .... .  |||.|||||. ..       ... .  .    ..|||| .
ISTWRHGCFY---FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMAPEVI

M-DGIFTSQSDVWSFGILVWEILTLGHQPYPAH----SNLDVLNYVQAGGRLEPPRNCP-----------------------DDLWNLMSQCWAQEPDQR
. .   .. .|.||.|....| |. |. |.| |    . .| .  ..  .. ......|                       ...  ... |... | .|
RGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKR

PTFHNIQNQLQL
||.. | .   .
PTAEQILQHPWF