Gene ROR2 (Mouse)

ROR2

Species: Mouse
Alias: ROR2, Ror2
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Ror

Sequence

Name Sequence Type Origin Length Description Download
ROR2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 307 Kinase domain by global Sugen HMM Fasta, JSON
ROR2.AA Protein Sugen 944 None Fasta, JSON
ROR2.NA RNA Sugen 3987 None Fasta, JSON

Protein domain

Protein domains of ROR2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
I-set ROR2.AA I-set 62-152 30 2.8e-22 78.09 Pfam 1-92 (92) Show / Hide 
Range on Protein: 62-152
Range on HMM: 1-92/92
Sequence Identity: 30% (28 aa)

LNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRVIIRKTE-YGSRLRIQDLDTTDTGYYQCVATNGLKTITATGVLYV
  |. .  ....  |.|| . |.| |.||| | |.|...|. .  .|. .. .. . ..|.|.. .  |.| | ||||| . . ..|  | |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 ROR2.AA IGc2 74-142 30 2.8e-18 67.98 SMART 1-56 (56) Show / Hide 
Range on Protein: 74-142
Range on HMM: 1-56/56
Sequence Identity: 30% (21 aa)

VQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRVIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGLK
 .||...| |...||| ||..|.| . |.             ....|.|..    | |||.|.|.|   
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG ROR2.AA IG 68-153 18 4.8e-12 47.27 SMART 1-58 (58) Show / Hide 
Range on Protein: 68-153
Range on HMM: 1-58/58
Sequence Identity: 18% (17 aa)

VNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRVIIRKTEYGSRLRIQDLDTTDT---GYYQCVATNGLKTITA--TGVLYVR
   .| . |.|. |.| |.     ...|.                       |.| ..   |.   | |.|.||   .....  .  |.|.
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
V-set ROR2.AA V-set 23-152 13 5.8e-07 25.83 Pfam 1-128 (128) Show / Hide 
Range on Protein: 23-152
Range on HMM: 1-128/128
Sequence Identity: 13% (23 aa)

ALLLWT------PWTAGEVEDSEAIDTLGQPDGPDSPLPTLKGYFLNFLEPVNNITIVQGQTAILHCKVAGNP----PP-NVRWLKNDAPVVQEPRRVI-
.. ...      ||                                        .| ..||.. |.|..  ..    ..  . | .   |  | |. .| 
QSQVTQHPPRGCPW---------------------------------------WVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIIS

------------IRKTEY-GSR------------LRIQDLDTTDTGYYQCVATNG-LKTITATGVLYV
              . .. |..            |.|..|   |.| | |...|.   .  .   | |
YYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
Fz ROR2.AA Fz 174-301 25 1.8e-50 155.79 Pfam 1-143 (143) Show / Hide 
Range on Protein: 174-301
Range on HMM: 1-143/143
Sequence Identity: 25% (36 aa)

CQPYR--GIACARFIGNRTIYVDSLQM----QGEIENR----ITAAFTMIGTSTQLSDQCSQFAIPSFCHFVFPLCDARSRAPKPRELCRDECEVLENDL
|||.|  .  | ....|.|..  .|..    |.|.|.     |.. .....||| ||..|...... .|.. || |. . ..|.|. .||. || .... 
CQPIRNDIPMCHGMPYNMTWMPNLLHHETGTQKEAELQWEMMIHQWWPLVHTSTHLSPKCHPHIQFFLCSMYFPMCTDGFHHPPPIPPCRSMCEAVKEQG

CRQEYTI------ARSNPLILMRLQLPKCEALPMPESPDAANCM
|.... .      .|..| .........|. .|.... |...||
CEPVMQMMEDKKHRRMYPFGFHWPEMLNCNKFPHHHD-DRHMCM
KR ROR2.AA KR 314-396 47 2.4e-47 164.54 SMART 1-90 (90) Show / Hide 
Range on Protein: 314-396
Range on HMM: 1-90/90
Sequence Identity: 47% (43 aa)

HQCYNG--SGADYRGMASTTKSGHQCQPWALQHPHSHRLSSTEFPELG----GGHAYCRNPGGQVEGPWCFTQNKNVR-VELCDVPPCSP
..||.|  .| .|||...||.|||.||.|. |.|| |. ... ||..|    ..|.|||||.|. |||||.| . ||| .| ||.|.|. 
RDCYWGDDNGESYRGTVNTTWSGHPCQRWDSQYPHLHWFYPEWFPCAGQLGLLEHNYCRNPDGDSEGPWCYTMDPNVRDWEYCDIPQCED
Kringle ROR2.AA Kringle 316-394 49 5.1e-34 118.93 Pfam 1-85 (85) Show / Hide 
Range on Protein: 316-394
Range on HMM: 1-85/85
Sequence Identity: 49% (42 aa)

CYNGSGADYRGMASTTKSGHQCQPWALQHPHSHRL-SSTEFPELG---GGHAYCRNPGGQVEGPWCFT-QNKNVRVELC-DVPPC
|| | |  |||..|||.||..||.|. |.|| |.    . ||  |   |.|.||||| |. .||||.|  .  ||.| | |.| |
CYHGNGENYRGTWSTTESGRPCQRWDSQTPHRHPFYTPENFPCKGLGEGKHNYCRNPDGDERGPWCYTQTDPRVRWEYCSDIPRC
Kinase ROR2.AA Ror 473-779 70 1.3e-266 892.04 In-house 1-308 (308) Show / Hide 
Range on Protein: 473-779
Range on HMM: 1-308/308
Sequence Identity: 70% (217 aa)

VRFMEELGEDRFGKVYKGHLFGPAPGEPTQAVAIKTLKDKAEGPLREEFRQEAMLRARLQHPNIVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHS
|||||||||..|||||||||.||.......||||||.|..|.......||||.||.|.|.||||||||||.|.|||..|.|.|..||||||||.||||||
VRFMEELGECQFGKVYKGHLMGPNFMYHCMAVAIKTCKHDASPAQWQDFRQEIMLMATLHHPNIVCLLGVCTMDQPYCMLFEYMNHGDLHEFLIMRSPHS

DVG-STDDDRTVKSALEPPDFVHVVAQIAAGMEFLSSHHVVHKDLATRNVLVYDKLNVRISDLGLFREVYSADYYKLMGNSLLPIRWMSPEAVMYGKFSI
|.| |.||||.|||.|..|||.|...|||||||.|||||.||.|||.||.||.....|.|||.||.|..||.|||.....|..|||||||||.||||||.
DHGCSSDDDRMVKSSLDHPDFLHIAIQIAAGMEYLSSHHFVHRDLAARNCLVGEHHHVKISDFGLMRDIYSSDYYRMQHKSWMPIRWMSPEAIMYGKFSE

DSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRSRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRSWGNLSNYNSSAQTSGASNTTQTS
||||||.||||||..|||.|||.|||||.|.||||.|..||||..||.|.|.||||||.|.|||||||||||||||||.||||.|||.|||||.|||||.
DSDIWSFGVVLWEIWSYGMQPYYGYSNQEVIEMIRNRHLLPCPHNCPTWIYSLMIECWHEIPSRRPRFKDIHSRLRSWDNLSNHNSSTQTSGANNTTQTT

SLSTSPVS
||||||||
SLSTSPVS
Kinase ROR2.AA Pkinase_Tyr 473-746 41 2.8e-134 455.39 Pfam 1-270 (270) Show / Hide 
Range on Protein: 473-746
Range on HMM: 1-270/270
Sequence Identity: 41% (118 aa)

VRFMEELGEDRFGKVYKGHLFGPAPGEPTQAVAIKTLKDKAEGPL--REEFRQEAMLRARL-QHPNIVCLLGVVT-KDQP--LSMIFSYCSHGDLHEFLV
..|...|||  ||.||||...|  |..... ||.|.||..|  .   ||.| .|| .   | .|||||.|.||.| ...|  . ... |. ||||...| 
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

MRSPHSDVGSTDDDRTVKSALEPPDFVHVVAQIAAGMEFLSSHHVVHKDLATRNVLVYDKLNVRISDLGLFREVYSADYY-KLMGNSLLPIRWMSPEAVM
 ..            . | .| ..| ..  .|||.|||.|.|.. .| |||.||.|| ... |.|.| || | .|. ||| .  |.. |||.||.||. .
KHR------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECIN

YGKFSIDSDIWSYGVVLWEVFSYGLQP-YCGYSNQDVVEMI-RSRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRL
||||.. ||.||.||..||.|.|| || | | ||..|.|.| .... .|||..||. .| || .||.. |..||.|..||..|
YGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase ROR2.AA TyrKc 473-746 37 6e-116 392.41 SMART 1-280 (280) Show / Hide 
Range on Protein: 473-746
Range on HMM: 1-280/280
Sequence Identity: 37% (116 aa)

VRFMEELGEDRFGKVYKGHLFGPAPGEPTQAVAIKTLKDKAEGPLREEFRQEAMLRARL--QHPNIVCLLGVVTKD-------QPLSMIFSYCSHGDLHE
... ..|||  ||.||||..         . ||.|.||. |    ||.|..|| .  .|  .|||||.|.||.|..       .|| ... |..||||..
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FLVMRSPHSDVGSTDDDRTVKSALEPPDFVHVVAQIAAGMEFLSSHHVVHKDLATRNVLVYDKLNVRISDLGLFREVYSA-------DYYKL----MGNS
.|  . |.               | ..|...   |||.|||.|.|....| |||.||.|| ... |.||| || |..|.        |||.      |..
YLRKHRPK---------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKT

LLPIRWMSPEAVMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCG-----YSNQDVVEMIRSRQVLPCPDD--------CPAWVYALMIECWNEFPSRRPRF
.||||||.||. .||||.. ||.||.||..||.|.|| ||| |      |||.|.| ....  .|.|..        ||. .| .| .||.| |. ||.|
MLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTF

KDIHSRL
..||...
SEIHECF
Kinase ROR2.AA TK 473-746 23 2.8e-108 364.23 In-house 1-486 (486) Show / Hide 
Range on Protein: 473-746
Range on HMM: 1-486/486
Sequence Identity: 23% (113 aa)

VRFMEELGEDRFG---KVYKGHLFGPAPGEPTQ--------------------AVAIKTLKDKAEGPLREEFR-------------QEAMLRARLQ----
... ..|||  ||   .|||| ..|. |.....                     ||.|.||....   .|.|              .||. .. ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNIVCLLGVVTKD------------QPLSMIFSYCSHGD----LHEFLVMRSPHSDVGSTDDD-----------------------------------
 ||||| |.||.|..            .|. ..  |..|||    |...|  ..|.    .   |                                   
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-----RTVKSALEPPDFVH-------------------VVAQIAAGMEFLSSH------HVVHKDLATRNVLVYDKLN-----------VRISDLG----
     ... ..|   |...                     .|||.|||.|.|.      ..|| |||.||.|| ....           ..|.| |    
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----LFREVYSADYYKLMG------------------------NSLLPIRWMSPEAVM---------YGKFSIDSDIWSYGVVLWEVFSYG-LQPYCGYS
    | |..|| |.|  ..                        .  ||||||.||...         ||||.. ||.||.||..||.|.||  ..| | |
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

N---------QDVVEMIRS--------------RQVLPCPDDCP--------------AWVYALMIECWNEFPSRRPRFKDIHSRL
|         |.|.|..|.              |  .|.|..||              . .| || .||.. |..||.|...|..|
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase ROR2.AA Trk 473-746 42 1.2e-105 357.31 In-house 1-275 (275) Show / Hide 
Range on Protein: 473-746
Range on HMM: 1-275/275
Sequence Identity: 42% (117 aa)

VRFMEELGEDRFGKVYKGHLFGPAPGEPTQAVAIKTLKDKAEGPLREEFRQEAMLRARLQHPNIVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHS
...  ||||  ||||. .      | .    ||.||||| .|   |..|. || |   |||..|| . || | ..|| |.| |  |||| ..|  . |  
IVLKWELGEGAFGKVFLAECYNLCPEQDKMMVAVKTLKDASE-NARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQHGPDA

DVGSTDDDRTVKSALEPPDFVHVVAQIAAGMEFLSSHHVVHKDLATRNVLVYDKLNVRISDLGLFREVYS-ADYYKLMGNSLLPIRWMSPEAVMYGKFSI
..    ..|  .  |   .  ... |||.|| .. | |.|| |.|||| || ..| |.|.| |. |.|||  |||.. .   |||||| ||..|| ||..
MCYAQYQPRQAPGPLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMPPESIMYRKFTY

DSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRSRQV-LPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRL
.||.||.|||.||.|.|| ||. . ||. |.| |   .. | .|  ||  ||..|. ||   | .|   |||| ..
ESDVWSFGVVMWECFTYGKQPWYQLSNHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase ROR2.AA Musk 473-746 41 6.30000000001e-103 340.99 In-house 1-282 (282) Show / Hide 
Range on Protein: 473-746
Range on HMM: 1-282/282
Sequence Identity: 41% (118 aa)

VRFMEELGEDRFGKVYKGHLFGPAPGEPTQAVAIKTLKDKAEGPLREEFRQEAMLRARLQHPNIVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHS
. .  ..||  || |.     |  |.|.   ||.| ||| |.  . . |  || . |.  ||||| ||||    .|. . | | . ||| |||  .||| 
IIYVRDIGEGAFGRVFQARAPGLVPYEEETMVAVKMLKDDASKQMQMDFQREACMMAEFDHPNIVKLLGVCFVGRPMCLLFEYMAYGDLNEFLHSCSPHR

DVGSTDDDRT--------VKSALEPPDFVHVVAQIAAGMEFLSSHHVVHKDLATRNVLVYDKLNVRISDLGLFREVYSADYYKLMGNSLLPIRWMSPEAV
    | .||           . |.  .   . .|||.|| .||    || |||||| |. ..  |.|.| || |..|..||||  .|   ||||| ||..
TCSRTHQDRGMRAQVSSPGPPQLKCYHQLCMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYKGHENDHIPIRWMPPESI

MYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRSRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRL
.| .|...||.|.|||.|||.|||.|||| | .  .|.  ||   .| ||. ||  ||.|| .||.  |. || |..||  .
WYNQFTYESDVWAYGVCLWEIFSYALQPYYGMTHEEVIYYIRQGNILSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI
Kinase ROR2.AA UTK 473-746 30 3.7e-89 302.49 In-house 1-296 (296) Show / Hide 
Range on Protein: 473-746
Range on HMM: 1-296/296
Sequence Identity: 30% (94 aa)

VRFMEELGEDRFGKVYKGHLFGPAPGEPTQAVAIKTLKDKAEGPLREE----FRQEAM---LRARLQ-HPNIVCLLGVVTKDQPLSMIFSYCSHGDLHEF
|.....||. .|| |.|...  ... .....||.|... .| ..  .|    |. ||    ...... |||.. |.||.|...|. ..  |.. |||  .
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LVMRSPHSDVGSTDDDRTVKSALEPPDFVH------VVAQIAAGMEFLSSHHVVHKDLATRNVLVYDK-------LNVRISDLG---LFREVY-------
|   .|  .              ..|...        ...||.||..|.|...|| ||| ||.|| .        . ..|.|.|   . |.|.       
LRRHRPTPP--------------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNR

--SADYYKLMGNSLLPIRWMSPEAVMYG-KFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRSR--QVLPCPDDCPAWVYALMIECWNEFPSRR
  ...||.  ..  .|||||.|||. .. .|.. ||.||.|||.||....| .|| |.||..|.. .. .  . .|||.|||. || || .||.  |..|
YWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQER

PRFKDIHSRL
|.|.|. ...
PDFEDLVQQM
Kinase ROR2.AA TK-Unique 473-746 34 3.5e-81 276.03 In-house 1-294 (294) Show / Hide 
Range on Protein: 473-746
Range on HMM: 1-294/294
Sequence Identity: 34% (101 aa)

VRFMEELGEDRFGKVYKGHLFGPAPGEPTQ-AVAIKTLKDKAEGPLREEFRQEAMLRARLQ-HPNIVCLLGVVTKDQ-PLSMIFSYCSHGDLHEFLV-MR
... ...|| .|| |..| ..|.  ..  |  ||.|.|||.| .  . .| .|. .   |  ||||| .||. ||.. |  .|. ||. |.|  .|  .|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

SPHSDV-------GSTDDDRTVKS--ALEPPDFVHVVAQIAAGMEFLSS--HHVVHKDLATRNVLVYDKLNVRISDLGLFREVY-SADYYKLMGNSLLPI
 .....        ... ..  ..  .. | |..|   ||| |||.|.|  ...||.||..||||. ..... |.|.|. |.||   .| .  . . .||
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

RWMSPEAVM--YGKF-SIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRSRQVLPCPDDC-PAWVYALMIECWNEFPSRRPRFKDIHSRL
|||.||.    .| . .. ||.||.||..||.|..| .|| |... |..|.||    .| |. | .  .| ||..||.. |. || | .| .||
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase ROR2.AA CTKA 473-746 34 6.8e-78 261.3 In-house 1-290 (290) Show / Hide 
Range on Protein: 473-746
Range on HMM: 1-290/290
Sequence Identity: 34% (99 aa)

VRFMEELGEDRFGKVYKGHLFGPAP-----GEPTQAVAIKTLKDKAEGPLREEFRQEAMLRA--RLQHPNIVCLLGVVTKDQPLSMIFSYCSHGDLHEFL
   | ..|| ..| |..  | .  .         . ||.| ||| |    |..|  || ...   . |||.. ||||.|...|. ||  . . |||| .|
HCIMFKIGEGHYGQVFRAWLMPDPDDFKAQRKKGKDVAVKMLKDHATEEDRRAFLHEAFVLSSEHFHHPNVLRLLGVCTQHKPWHMIMEHMQYGDLHCYL

VMRSPHS-DVGSTDDDRTVK-----SALEPPDFVHVVAQIAAGMEFLSSHHVVHKDLATRNVLVYDKLNVRISDLGLFREVYSA-DYYKLMGNSLLPIRW
    | .  |      | .       ..  .  |   .||||||..|..   || ||| ||.|.     . |.|.|. |   .   || .   ...|.||
RACRPADGQVCPARARRSIPRSFHPIEVHAHEQVYMAMQIAAGMNYLAEMGFVHRDLACRNCLLGQYCHIKIADFGHGRTLRTESQYYYVSSQRVMPVRW

MSPEAVMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRSR--QVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRL
|.|||.  ||||  ||.|..||.|||..| |  |. . | | |.. . |   . || |  ||  .| .| |||   |  || |  .   |
MAPEALCFGKFSCASDVWAFGVLLWEIMSMGEKPWRHMSDQEVCQAYTSHGMRRLPVPRNCPQVLYHCMQECWKFEPNQRPTFETLQRML
Kinase ROR2.AA InsR 473-748 35 1.8e-76 256.36 In-house 1-278 (278) Show / Hide 
Range on Protein: 473-748
Range on HMM: 1-278/278
Sequence Identity: 35% (100 aa)

VRFMEELGEDRFGKVYKGHLFGPAPGEPTQ--AVAIKTLKDKAEGPLREEFRQEAMLRARLQHPNIVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSP
.    |.|.  ||.|| | . |  |.|.    ..||||....|    | || .||    .  . ..| ||||... ||   .     .|||  .|  || 
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYL--RSR

HSDVGSTDDDRT-VKSALEPPDFVHVVAQIAAGMEFLSSHHVVHKDLATRNVLVYDKLNVRISDLGLFREVYSADYYKLMGNSLLPIRWMSPEAVMYGKF
  ...  . ...  ..   . ...  .|.|. || .| .   || ||| || .| . . | | | |. | .|  |||.. | ..||.|||.|| .  |.|
RPEEEFNNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLKDGVF

SIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMI-RSRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRS
.  ||.||.||||||. . | ||| | ||  | . | . . ||  |. ||  ...||  ||   |. || |.|| . |. 
TTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase ROR2.AA Eph 473-746 37 8.5e-76 254.07 In-house 1-264 (264) Show / Hide 
Range on Protein: 473-746
Range on HMM: 1-264/264
Sequence Identity: 37% (105 aa)

VRFMEELGEDRFGKVYKGHLFGPAPGEPT--QAVAIKTLKDKAEGPLREEFRQEAMLRARLQHPNIVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSP
..  . .|. .|| |..|.|  | . . .  ..|||||||. .    | .|  || .    .||||. | ||||| .|.  .  |  .| | .||  .  
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHDG

HSDVGSTDDDRTVKSALEPPDFVHVVAQIAAGMEFLSSHHVVHKDLATRNVLVYDKLNVRISDLGLFREVYSAD----YYKLMGNSLLPIRWMSPEAVMY
                . .   |     ||.|| .||..  || ||| ||.||  .|   .||.|| |.. . .     |  .| .  ||||  |||. |
---------------QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTRGGK-IPIRWTAPEAIAY

GKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRSRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRL
.||.  ||.||||.|.||| |||  ||   |||||.. |     || | |||.  . || .||   ...||.|..|.| |
RKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase ROR2.AA Src 473-746 33 9.1e-76 256.88 In-house 1-255 (255) Show / Hide 
Range on Protein: 473-746
Range on HMM: 1-255/255
Sequence Identity: 33% (92 aa)

VRFMEELGEDRFGKVYKGHLFGPAPGEPTQAVAIKTLKDKAEGPLREEFRQEAMLRARLQHPNIVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHS
... ..||.  || |..|   |      .  ||.|||| .      | | ||| .   |.|...| |. |.... |   .  | ||| | ..|       
IKLCRKLGQGQFGEVWMGYWNG------NTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK-----

DVGSTDDDRTVKSALEPPDFVHVVAQIAAGMEFLSSHHVVHKDLATRNVLVYDKLNVRISDLGLFREVYS--ADYYKLMGNSLLPIRWMSPEAVMYGKFS
        ..  ..|. |. .   ||.|.||..|.|  ..| ||| ||||| ... . . | || | .     | |     . .||.|. |||. ||.|.
--------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYGRFT

IDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRSRQVLPCPDDCPAWVYA-LMIECWNEFPSRRPRFKDIHSRL
| || ||.|. |.|...||  || | .|..|....     .|||. ||. .|  .| .||.. | .|| |. ... |
IKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase ROR2.AA Pkinase 473-737 21 2e-27 98.03 Pfam 1-282 (293) Show / Hide 
Range on Protein: 473-737
Range on HMM: 1-282/293
Sequence Identity: 21% (65 aa)

VRFMEELGEDRFGKVYKGHLFGPAPGEPTQA-VAIKTLKDKAEGP--LREEFR-QEAMLRARLQHPNIVCLLGVVTKDQPLSMIFSYCSHG----DLHEF
 .. . .|.  ||.|||.|         |.  ||.|..| . | .  ... .| .|. . .||.||||| |..... .. . |.. || .|    ||...
YHIGRKIGSGSFGCVYKCHH------KGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

LVMRSPHSDVGSTDDDRTVKSAL--EPPDFVHVVAQIAAGMEFLSSHHVVHKDLATRNVLVYDKLNV----RISDLGLFREVYSADYYKLMGNSLLPIRW
.                  . ..  .. .  ... ||. |.|.. |. ..| ||   |.|. .. ..    .|.| || . ..    .  |      ...
IST--------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWY

MSPEAVM-YGKFSIDSDIWSYGVVLWEVFSYGLQPYCGY----SNQDVVEMIRSRQV----LPCPDDCP-------------------AWVYALMIECWN
|.|| .. . . .  .|.||.|..|.|... |  |..|     .  |  .||. .       ..| .|.                    .   ..  |..
MAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLC

EFPSRRP
  |..||
KDPKKRP
Kinase ROR2.AA S_TKc 473-750 22 6.7e-25 89.96 SMART 1-231 (231) Show / Hide 
Range on Protein: 473-750
Range on HMM: 1-231/231
Sequence Identity: 22% (64 aa)

VRFMEELGEDRFGKVYKGHLFGPAPGEPTQAVAIKTLKDKAEGPLREEFRQEAMLRARLQHPNIVCLLGVVTKDQPLSMIFSYCSH--GDLHEFLVMRSP
 ......|.  ||||||..  .       . |||| .|        | .|.|  .  . .||||| |..|    . | |.. ||..  |||..... | .
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

HSDVGSTDDDRTVKSALEPPDFVHVVAQIAAGMEFLSSHHVVHKDLATRNVLVYDKLNVRISDLGLFREVYSADYYKLMGNSLLPIRWMSPEAVMYGKFS
|            .. . . .  ....||. ..|.. ||...| ||   |.|. .  .. |.| || |..                 .|.|| .   ...
H----------GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYG

I-DSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRSRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHS-----RLRSWG
   .|.|| |..|.| .. |  |..    | . ..|.           .  .  ..  |..  |..||   ..       ..  | 
KCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF