Gene RIPK2 (Mouse)

RIPK2

Species: Mouse
Alias: RIPK2, Ripk2
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TKL
Family: RIPK

Sequence

Name Sequence Type Origin Length Description Download
RIPK2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 267 Kinase domain by global Sugen HMM Fasta, JSON
RIPK2.AA Protein Sugen 539 None Fasta, JSON
RIPK2.NA RNA Sugen 1619 None Fasta, JSON

Protein domain

Protein domains of RIPK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase RIPK2.AA RIPK 24-290 42 1.4e-153 516.55 In-house 1-290 (290) Show / Hide 
Range on Protein: 24-290
Range on HMM: 1-290/290
Sequence Identity: 42% (124 aa)

LSRGASGTVSSARHADWRVRVAVKH---LHIHTPLLDSERNDILREAEILHKARFSYILPILGICNEPEF------LGIVTEYMPNGSLNELLHRKTEY-
...|..|.|..|||..|...||.|.   .|.||...|.||.....||...||.|...|.||.|.|...|.      .|||.|||.||||...||.|..| 
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

-PDIAWPLRFRILHEIALGVNYLHNMNPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQS--------RSYKSAPEGGTIIYMPPENYEPGQKS
 ....||||.|..|||..|..|||.||||..|.|||..|||.||.||||||||||..|.|.| |..        .|.||....||..|||||......|.
HHPDPWPLRCRMIHEISCGMCYLHSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKK

R---ASVKHDIYSYAVIMWEVLSRKQPFEEVTNPLQIMYSVSQGHRPDTSEENLPFDI-PHRGLMISLIQSGWAQNPDERPSFLKCLIEL
.   .. |.|.||.|..|||||..|.|.|.......||....|||||...... .... ||.  ||.|.|..|.|.|..||.|. |  . 
PIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase RIPK2.AA TKL 24-290 23 1.3e-85 290.78 In-house 1-364 (364) Show / Hide 
Range on Protein: 24-290
Range on HMM: 1-364/364
Sequence Identity: 23% (89 aa)

LSRGASGTVSSARHADWR--------VRVAVKHLHIH------------------------TPLLDSERNDILREAEILHKARFSYILPILGICNEPEF-
. .|..|.|  ...  |.          |||| ...|                         | .  .|  . .|. .... |   |....|.|..|.. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LGIVTEYMPNGSLNELLHRKTEYPDIAWPLRFRILHEIALGVNYLHNMN------PPLLHHDLKTQNILLDNEFH-------------
            |.||.||.|.||| ..||         |..|.|. ..||.|.||||.||      ||..| |||..|||.|. ..             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-VKIADFGLSKWRMMSLSQSRSY--------------KSAPEGGTIIYMPPENYEPG-------------QKSRASVKHDIYSYAVIMWEVLSRKQPFEE
 .||.|||||..  .| .....               .. ...||. .|.||  .               ... .| |.|.||.....||.|.|..|...
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD

VTNPLQI---------MYSVSQGHRPDTS------EENLPFDIPHRGL--MISLIQSGWAQNPDERPSFLKCLIEL
  .. .|         |. .. |.||         .   .   ..  .  |..|.|  |...|..||||...| .|
YPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHH-K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase RIPK2.AA MLK 18-290 25 1.2e-51 177.41 In-house 1-291 (291) Show / Hide 
Range on Protein: 18-290
Range on HMM: 1-291/291
Sequence Identity: 25% (79 aa)

LADLHYLSRGASGTVSSARHADWR---VRVAVKHLHIHT---PLLDSERNDILREAEIL----HKARFSYILPILGICNEPEF-LGIVTEYMPNGSLNEL
.  ....  |..| | ..|    .     ||||  .. .      ..|. |. .|...|    |.  ...| ...|.|..|.  ..||.||...|||...
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LHRKTEYPD-----------IAWPLRFRILHEIALGVNYLHNMNP-PLLHHDLKTQNILLDN------EFHVKIADFGLSK-WRMM---SLSQSRSYKSA
|| ..  ..           .   . ... . .| |..|||.| | |. |.||| .|||.|.      . ..||.|||.|. |  |     |.       
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSN-------

PEGGTIIYMPPENYEPGQKSRASVKHDIYSYAVIMWEVLSRKQPFE-EVTNPLQIMYSVSQGHRPDTSEENLPFDIPHRGLMISLIQSGWAQNPDERPSF
   || ..| ||  .  . .. | | |..|..|..||.|.|. |.. .. .   ... .  | ||    .     .|..  . .|..  | |.| .||||
--AGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPST-----CPEH--WKKLMKQCWNQDPHKRPSF

LKCLIEL
  .. .|
RQIVQHL
Kinase RIPK2.AA TKL-Unique 20-290 26 2.9e-44 153.36 In-house 1-290 (290) Show / Hide 
Range on Protein: 20-290
Range on HMM: 1-290/290
Sequence Identity: 26% (80 aa)

DLHYLSRGASGTVSSARHADW-RVRVAVKHLHIHTPLLDSERNDILREAEILHKAR-FSYILPILGICN----EPEFLGIVTEYMPNGSLNELLHR----
..  . .|..|.|    .. | .  ||.| .|.   .  ... .  .|  .. | .    |. . |.|      |  . ||.||.| |||...||.    
FWNKIGEGGYGQVY---KGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNN

----KTEYPDIAWPLRFRILHEIALGVNYLHNMNPPLLHHDLKTQNILLDNE-----FHVKIADFGLSKWRMMSLSQSRSYKS----APEGGTIIYMPPE
    . ... . . .| .. . ||.| .|||. .|| .| |||..|.|.||.     . .||.|||||| .  ..  . . ..    . . |....|.||
NNNNNNNCK-LNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPE

NYEPGQKSRASVKHDIYSYAVIMWEVLSRKQ------PFEEVTNPLQIMYSVSQGHRPDTSEENLPFDIPHRGLMI--SLIQSGWAQNPDERPSFLKCLI
  .    .  | | |.||.....|| ..||.      |.... .. |.   | .     . |||..  || .   .   ||| .|...|..||||   . 
VLRMNF-CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGM-DQEQWCEMVHY-----M-EENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIH

EL
.|
RL
Kinase RIPK2.AA TKL-ciliate1 93-290 30 4.9e-42 141.68 In-house 76-279 (279) Show / Hide 
Range on Protein: 93-290
Range on HMM: 76-279/279
Sequence Identity: 30% (64 aa)

IVTEYMPNGSLNELLHRKTE--YPDIAWPLRFRILHEIALGVNYLHNMNPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSYKSA----PE
|..|. . |.. ...|||    |. | |  | |.. .|| |. |||  ..|| | ||| ||||.| ..  || .|.  |     . .  |  .       
IIMEHCHKGTMFDICHRKHSQIYM-IKWQHRMRWCKDIAQGMQYLHMRQNPLIHRDLKMQNILYDEPYQYKICNFPHVKIADFHRIRNCSFQDMQNEMQR

GGTIIYMPPENYE----PGQKSRASVKHDIYSYAVIMWEVLSRKQPFEEVTNPLQIMYSVSQGH-RPDTSEENLPFDIPHRGLMISLIQSGWAQNPDERP
 .|  .| ||       |..    . | |||.|...|..  .|| ||..  . . ||  .. .  ||    . ..|| |    .. |..  | |||  ||
NTTFHWMAPEQMDPHIFPNYP--INEKIDIYAYGIVMYILCFRKTPFQQKMSVINIMCYWCEFPGRPNLGPQFIHFDCPQN--FHNLMMRCWCQNPNKRP

SFLKCLIEL
.|   .  |
NFNEIIQIL
Kinase RIPK2.AA LRRK 65-292 30 6.9e-42 145.47 In-house 106-351 (351) Show / Hide 
Range on Protein: 65-292
Range on HMM: 106-351/351
Sequence Identity: 30% (78 aa)

REAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYP------DIAWPLRFRILHEIALGVNYLHNMNPPLLHHDLKTQNILL---D
.|. |... . ..|....|.| .|  | .|.||.|.|.|...|| | ...      .| | |. .|  .|| |..|||. |||..| |||. ||||   .
HEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSP

---------NEFHVKIADFGLSKWRMMSLSQSRSYK-SAPEGGTIIYMPPENYEPGQKSRASVKHDIYSYAVIMWEVLSRK-QPFEEVTNP--LQIMYSV
         .. ..||||||.|   |    |.  ..     .|....| ||    . ..  . | |.||...|.|| |.|. .||.| . .  .| |. .
QNHSPNYPNAHVCAKIADFGISR--MF---QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQI

SQ----GHRPDTSEE-NLPFDIPHRGLMISLIQSGWAQNPDERPSFLKCLIELEP
..    |.||  ... ..|   .|.  . .|||. |...|..||.| . .  |. 
EDKIIEGLRPTIPQHYCPPCQPWHM--YQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase RIPK2.AA TK 18-290 14 1.1e-38 126.73 In-house 1-486 (486) Show / Hide 
Range on Protein: 18-290
Range on HMM: 1-486/486
Sequence Identity: 14% (71 aa)

LADLHYLSRGASG---TVSSA---RHADWR----------------------VRVAVKHLHIHTPLLDSERND--------------ILREAEILH--KA
.  .. | .|. |   .|  .   .. .|.                      ..|||| |. ...  . |. |               ..|.....  . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RFSYILPILGICNEP------------EFLGIVTEYMPNGS----LNELLHRKTEYPD------------------------------------------
.   |. ..|.| ..            | . ||.||||.|.    | . |... ..                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------IAWPLRFRILHEIALGVNYLHNMNP----PLLHHDLKTQNILLDNEFH-----------VKIADFGLSK
                               .  . .  . . || |  ||| .|      . | || . |.|.... .           .||||||||.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

W----RMMSLSQSRSYKSAPEGGTII-------------------------YMPPENYEPGQ------KSRASVKHDIYSYAVIMWEVLS--RKQPFEEV
     .   . ..  | .. ..||                           .|.||  . ..      . . . | |..|. | |||...  .... ...
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TN--------PLQIMYSVSQG--------------HRPDTSEENLP---FDIPHRG-----LMISL-IQSGWAQNPDERPSFLKCLIEL
.|        . ..|  . .|              .|.   .   .     . | .      .. . .|. |. .|..||.|  .. .|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRM-H-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase RIPK2.AA Pkinase 18-287 20 2e-38 136.96 Pfam 1-288 (293) Show / Hide 
Range on Protein: 18-287
Range on HMM: 1-288/293
Sequence Identity: 20% (61 aa)

LADLHYLSRGASGTVSSARHADWRVRVAVKHLHIHTPLLDSERNDIL-REAEILHKARFSYILPILGICNEPEFLGIVTEYMPNG----SLNELLH--RK
.  .  . .|..|.|  ..| . . .|||| .  ..   . ...... .|..|... .  .|. ..... ..  . .|.||...|    .| ....  |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TEYPDIAWPLRFRILHEIALGVNYLHNMNPPLLHHDLKTQNILLDNEFHV----KIADFGLSKWRMMSLSQSRSYKSAPEGGTIIYMPPENYEPGQKSRA
. .    .    ... .|. |..|.|.|    .| ||| .|||.||. |.    ||.||||.|   ..    ..       ||. ||.||       .  
GCFY-FSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAK--QFD--Y-NNS-MTTFCGTPWYMAPEVIR--GGQYY

SVKHDIYSYAVIMWEVLSRKQPFEEV---TNPLQIMYSVSQGHRPDTSEENLPFDIPHR----------------GLMISLIQSGWAQNPDERPSFLKCL
. | |..|. .|..|.|... || .     | .  |. . .  .|.....    . . .                  ....| . ....| .||..  .|
GPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQIL
Kinase RIPK2.AA S_TKc 18-294 21 2.2e-37 131.44 SMART 1-231 (231) Show / Hide 
Range on Protein: 18-294
Range on HMM: 1-231/231
Sequence Identity: 21% (62 aa)

LADLHYLSRGASGTVSSARHADWRVRVAVKHLHIHTPLLDSERNDILREAEILHKARFSYILPILGICNEPEFLGIVTEYMPN--GSLNELLHRKTEYPD
   |  . .|| |.|  .|| .   .||.| ..          ..|.|| .||.| .  .|  ..... . ..| .|.||...  |.| ......   . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---IAWPLRFRILHEIALGVNYLHNMNPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSYKSAPEGGTIIYMPPENYEPGQKSRASV-KHD
   .      .....|.....|.|...   .| ||| .|||||.  |.||.||||..                  ||  ||.||          .  | |
RFPFPE-HARFYMYQICCALEYCHSHG--IIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL------GYGKCKCD

IYSYAVIMWEVLSRKQPFEEVTNPLQIMYSVSQGHRPDTSEENLPFDIPHRGLMISLIQSGWAQNPDERPSFLKCLI-----ELEPVL
..|  .|..| |... ||.   .. ...  .                      ....|.  .  .|..||.  ..|       . | .
WWSCGCILYEMLCGYPPFP---QMQMMFKKIG------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RIPK2.AA TyrKc 18-290 24 9e-33 116.11 SMART 1-280 (280) Show / Hide 
Range on Protein: 18-290
Range on HMM: 1-280/280
Sequence Identity: 24% (75 aa)

LADLHYLSRGASGTVSSARHADWRVRVAVKHLHIHTPLLDSERNDILREAEILHKA--RFSYILPILGICNEP-------EFLGIVTEYMPNGSLNELLH
.  .. | .|| |.|  ..     . |||| |. ..      | |..|||.|..|   .   |. ..|.| ..       | | ||.||||.|.|.. |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RKTEYPDIAWPLRFRILHEIALGVNYLHNMNPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLS-----QSRSYKS----APEG-GTIIYMPPENY
.. .   . ..    . . || | .||| .  .. | || . |.|......|||.|||||  |           .  |..       .   |  |.||  
KHRPK--LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLS--RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

EPGQKSRASVKHDIYSYAVIMWEVLSR-KQPFEEV----TNPLQIMYSVSQGHRPDTSEENLPFDI----PHRGLMISLIQSGWAQNPDERPSFLKCLIE
   .... . | |..|. | |||.... .|| ...     .. ...  | ||.|..  ....|  .     .  .   .... |. .|..||.|  .  .
---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP--MSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHEC

L
.
F
Kinase RIPK2.AA DRK 61-168 41 4.4e-30 99.1 In-house 42-147 (258) Show / Hide 
Range on Protein: 61-168
Range on HMM: 42-147/258
Sequence Identity: 41% (45 aa)

NDILREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDIAWPLRFRILHEIALGVNYLHNMNPPLLHHDLKTQNILLDNEFHV
|.  ||.... . |   |   .| ||.|    |..|||| |||   ||   |   . |||. ..   .| |..|||. ||  .| |||. | | |  . |
NEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILH--DESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQV

KIADFGLS
|.||||||
KVADFGLS
Kinase RIPK2.AA Dicty4 82-169 39 1.1e-29 96.28 In-house 64-162 (277) Show / Hide 
Range on Protein: 82-169
Range on HMM: 64-162/277
Sequence Identity: 39% (40 aa)

LGICN----EPEFLGIVTEYMPNGSLNELLHR-------KTEYPDIAWPLRFR---ILHEIALGVNYLHNMNPPLLHHDLKTQNILLDNEFHVKIADFGL
.| |.    .|. . ||||||| |.| .|||        ... .   |||. |   .   .|.|.|.||. ||  .| |||. |.| |  . ||..||||
MGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLD---WPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGL

SK
|.
SQ
Kinase RIPK2.AA Pkinase_Tyr 57-169 30 6.3e-24 81.66 Pfam 42-159 (270) Show / Hide 
Range on Protein: 57-169
Range on HMM: 42-159/270
Sequence Identity: 30% (37 aa)

DSE--RNDILREAEILHKA-RFSYILPILGICN-EPEF--LGIVTEYMPNGSLNELLHRK-TEYPDIAWPLRFRILHEIALGVNYLHNMNPPLLHHDLKT
...  | | .|||.|...  .   |.  .|.|  . |   . ||.||||.|.| . |... .. . .  .    . ..|| | .||...|  . | || .
HEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAA

QNILLDNEFHVKIADFGLSK
 |.|......|||.||||..
RNCLVTENNVVKICDFGLAR
Kinase RIPK2.AA HH498 44-168 28 2e-22 67.56 In-house 25-171 (284) Show / Hide 
Range on Protein: 44-168
Range on HMM: 25-171/284
Sequence Identity: 28% (42 aa)

VAVKHLHIHTPLLDSE-----RNDILREAEILHK-ARFSYILPILGICNEPEFLGIVTEYMPNGSLNELL--------------HRKT-EYPDIAWPLRF
||||   . . .  |.     .    ||. |. . . .. .  .   |..|  . |||.|  ||||  .|              |     |  .  . . 
VAVKRYRAMAFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYACCDDPSQFAIVTQYCDNGSLFSILNTIPIGGAGANNNNHNQKNNYRIMDLQSKM

RILHEIALGVNYLHN-MNPPLLHHDLKTQNILLDNEFHVKIADFGLS
.|  ..| | ||||| . .|  | ||  .|||.. . | ..|||| |
TISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGES
Kinase RIPK2.AA HH498 202-290 30 7.9e-13 36.61 In-house 199-284 (284) Show / Hide 
Range on Protein: 202-290
Range on HMM: 199-284/284
Sequence Identity: 30% (29 aa)

QKSRASVKHDIYSYAVIMWEVLSRKQPFEEVTNPLQIMYSVSQGH-RPDTSEENLPFD----IPHRGLMISLIQSGWAQNPDERPSFLKCLIEL
|  . | | |..||| ..|| ..|. ||     |      .   | ||      .|      |||.   ..||| .| ..|..||.|   .  |
QCQKYSIKVDVFSYAMCIWEMHTREVPFHHY-KPAAAAAEMAYHHIRP-----PIPQTPTAQIPHH--WSNLIQMCWHPCPENRPDFDQIVTIL
Kinase RIPK2.AA DRK 209-292 32 1.3e-12 39.11 In-house 182-258 (258) Show / Hide 
Range on Protein: 209-292
Range on HMM: 182-258/258
Sequence Identity: 32% (28 aa)

KHDIYSYAVIMWEVLSRKQPFEEVTNPLQIMYSVSQ-GHRPDTSEENLPFDIPHRGLMISLIQSGWAQNPDERPSFLKCLIELEP
| |.||.|.. ||.. |. |.  . ...|.  || . | || .     |   |     | |..  |  .|  |||.  ||  || 
KADVYSFAIVLWECVTRQDPYFGM-PTFQVVFSVGRHGMRPPM-----PQWCPPK--YIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase RIPK2.AA Dicty4 211-292 27 3.5e-10 30.32 In-house 199-277 (277) Show / Hide 
Range on Protein: 211-292
Range on HMM: 199-277/277
Sequence Identity: 27% (24 aa)

DIYSYAVIMWEVLSRKQPFE-EVTNPLQIMYSVSQ-GHRPDTSEENLPFDIPHRGLMISLIQSGWAQNPDERPSFLKCLIE--LEP
| ||.. . || | |. |.  .  .. |.  .| . . ||  .   .|.        ..|||  |  .|  ||||  .. .  || 
DVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPS-------WKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase RIPK2.AA Pkinase_Tyr 273-290 33 0.003121 11.57 Pfam 253-270 (270) Show / Hide 
Range on Protein: 273-290
Range on HMM: 253-270/270
Sequence Identity: 33% (6 aa)

WAQNPDERPSFLKCLIEL
|...|..||.|  .. .|
WHYDPEDRPTFSEIHEQL
Kinase RIPK2.AA Pkinase_Tyr 211-249 23 0.351895 4.62 Pfam 196-236 (270) Show / Hide 
Range on Protein: 211-249
Range on HMM: 196-236/270
Sequence Identity: 23% (10 aa)

DIYSYAVIMWEVLS-RKQP-FEEVTNPLQIMYSV-SQGHRPD
|..|. | |||...  .|| ....  . ...  .  .|.| .
DVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMP
CARD RIPK2.AA CARD 436-523 27 4.7e-22 81.99 Pfam 1-90 (90) Show / Hide 
Range on Protein: 436-523
Range on HMM: 1-90/90
Sequence Identity: 27% (25 aa)

QQWIQSKREAIVSQMTEACLNQSLDALLSRDLIMKEDYELIST--KPTRTSKVRQLLDTSDIQGEEFAKVVVQKLKDNKQLGLQPYPEVP
.......|.|.|...|..|... ||.|....... |.||.|.   ..|| .|.|.|||.   .|.. ... .| |....|  |... |  
WHFLRKHRMALVQRLTMECVDGLLDHLREKNVLTWEEYEEIKCAYCTTRMDKARELLDMVQKKGPWACQIFLQCLCETGQPHLADDLEHQ
CARD RIPK2.AA CARD 434-522 13 0.000897 14.77 SMART 1-96 (96) Show / Hide 
Range on Protein: 434-522
Range on HMM: 1-96/96
Sequence Identity: 13% (13 aa)

IAQ---QWIQSKREAIVSQMTEACLNQSLDALLSRDLIMKEDYELISTKPTRTSK--VRQLLDTSDIQGEEFAKVVVQKLKD--NKQLGLQPYPEV
 ..   . . ..| ..... .   | . ||.|....... . .|.|....|....  .|...|.   .|.  . .  . | .  ... .|    ..
MCERDCRNHRRNRMRLCEHLQCDFLHELLDYLVEKNVLTWKHHEHIKYCMTKSRDDKCREMIDSVQKRGDQAFDMFICCLQEFPWNHCHLADFLWH