Gene RHOK (Mouse)

RHOK

Species: Mouse
Alias: RHOK, Rhok
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: AGC
Family: GRK
Subfamily: GRK

Sequence

Name Sequence Type Origin Length Description Download
RHOK.AA Protein Sugen 564 None Fasta, JSON
RHOK.NA RNA Sugen 7462 None Fasta, JSON
RHOK.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 266 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of RHOK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RGS RHOK.AA RGS 57-175 25 3.3e-37 130.85 SMART 1-121 (121) Show / Hide 
Range on Protein: 57-175
Range on HMM: 1-121/121
Sequence Identity: 25% (31 aa)

EFESLCSEQPIGKRLFQQFLKTDERH-VPALELWKDIEDYDTADDDLRPQKAQAILAEYLDPQGTL-FCNFLDQGMVTRVKEGPTGSQDGLFQPLLQATM
 |..||...|||.|.|..|||.   . .. || | ..|.. ...|. |.|||..|  .|..|...  .| ..|. ........ .. . ..|.. .....
SFHHLCDNDPIGRRYFREFLKQEFCEYKENLEFWLACEEFKKMEDEERRQKAREIYDKYISPNAPCEHCVNIDHHTREQCQQCLCNPHPDCFDEAQRHVY

EHLSQAPFQEYLESLYFLRFL
..... .....|.| |..|.|
QLMEKDSYPRFLRSDYYKRYL
RGS RHOK.AA RGS 57-174 26 5.9e-33 110.68 Pfam 1-124 (124) Show / Hide 
Range on Protein: 57-174
Range on HMM: 1-124/124
Sequence Identity: 26% (33 aa)

EFESLCSEQPIGKRLFQQFLKT-DERHVPALELWKDIEDYDTA---DDDLRPQK-AQAILAEYLDPQGTLFCNFLDQGMVTRVKEGPTGSQ--DGLFQPL
 |..||..||||.|||.|||..    . ...| |...||....   .|. ..|| |..|  .|..|. . .| ..|   ....... . .|    .|.. 
SFHHLCNDQPIGRRLFRQFLESEFCEY-ENIEFWLACEDFKKMFSDSDEKMHQKDAREIYNKYIAPDSPCECHNIDHDTREHCQDNLEQAQPTPDCFDEA

LQATMEHLSQAPFQEYLESLYFLRF
 . . ..... .....|.| |..||
QRHIYTLMEKDSYPRFLKSDYYQRF
Kinase RHOK.AA GRK 190-455 63 4.4e-212 710.85 In-house 1-265 (265) Show / Hide 
Range on Protein: 190-455
Range on HMM: 1-265/265
Sequence Identity: 63% (170 aa)

FLDFRVLGKGGFGEVSACQMKATGKMYACKKLNKKRLKKRKGYQGAIVEKRILTKVHSRFIVSLAYAFETKTDLCLVMTIMNGGDVRYHIYNVDEDNPGF
|...|||||||||||.|||..|||||||||||.|||.|||||.|.|..||.||.||||||.||||||.|||..||||||||||||...||||..| ||||
FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEQMALNEKQILEKVHSRFVVSLAYAYETKDALCLVMTIMNGGDLKFHIYNMGE-NPGF

SEPRAIYYTAQIISGLEHLHQRRIVYRDLKPENVLLDNDGNIRISDLGLAVELKEGQNKTKGYAGTPGFMAPELLRGEEYDFSVDYFALGVTLYEMIAAR
.|.|||.|.|.|..||||||..||||||.||||.|||..|.|||||||||||..||| ...|..||.|.||||....|.|.||.|...||...||||..|
DEERAIFYAAEICCGLEHLHRERIVYRDMKPENILLDDHGHIRISDLGLAVEIPEGQ-MIRGRVGTVGYMAPEVVKNERYTFSPDWWGLGCLIYEMIEGR

GPFRARGEKVENKELKQRIISEPVKYP-EKFSQASKDFCEQLLEKDPEKRLGFRDGTCDALRANVLF
.|||.|.|||...|...|....|.||. ||||...||.|..||.||||.|||.|...||..|....|
SPFRQRKEKVKREEVDRRVKEDPEKYSHEKFSEEAKDICRMLLHKDPEQRLGCREEGCDEVRQHPFF
Kinase RHOK.AA GRK 190-455 60 6.30000000001e-212 674.73 In-house 1-272 (272) Show / Hide 
Range on Protein: 190-455
Range on HMM: 1-272/272
Sequence Identity: 60% (166 aa)

FLDFRVLGKGGFGEVSACQMKATGKMYACKKLNKKRLKKRKGYQGAIVEKRILTKVHSR---FIVSLAYAFETKTDLCLVMTIMNGGDVRYHIYNVDEDN
|...|||||||||||.|||..|||||||||.|.|||.|||||...|..||.||.|||||   |||..|||.|||..||||||||||||..|||||... |
FRQYRVLGKGGFGEVCACQVRATGKMYACKCLDKKRIKKRKGETMALNEKQILEKVHSRDCPFIVCMAYAYETKDALCLVMTIMNGGDLHYHIYNMGN-N

-PGFSEPRAIYYTAQIISGLEHLHQRRIVYRDLKPENVLLDNDGNIRISDLGLAVELKEGQNKTKGYAGTPGFMAPELLRGEE-YDFSVDYFALGVTLYE
 |||.|.|...|.|.|..||||.|.||||||||||||.|||..|..||||||||.|..|||....|..||.|.||||.|..|. ||||.|...||...||
EPGFDEERMRFYAAEICCGLEHMHRRRIVYRDLKPENILLDDHGHVRISDLGLACEIPEGQPMIHGRVGTHGYMAPEVLQNERAYDFSPDWWSLGCMIYE

MIAARGPFRARGEKVENKELKQRIISEPVKYPEKFSQASKDFCEQLLEKDPEKRLGFRDGTC--DALRANVLF
||....|||...|||...|...|....|||||.|||...||.||.||.||||.|||.|.|||  ...... .|
MIEGHSPFRQHKEKVKREEVDRRVKEDPVKYPDKFSEEAKDICEMLLQKDPEQRLGCRGGTCGAQEVKEHPFF
Kinase RHOK.AA AGC 190-455 26 4.6e-142 369.9 In-house 1-395 (395) Show / Hide 
Range on Protein: 190-455
Range on HMM: 1-395/395
Sequence Identity: 26% (104 aa)

FLDFRVLGKGGFGEVSACQMK------ATGKMYACKKLNKKR---LKKRKGYQGAIVE------------KRILTKVH----------SRFIVS-LAYAF
|   .|.|||.||.|  ...|      .|||.||.|.|.||.   .||..  . ...|            ..||.|..          . |||. | |.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETKTD--LCLVMTIMN--------GGDVRYHIYNVDE-DNPGFSEPRAIYYTAQ-------IISGLEHLHQ-RRIVYRD-LKPENVLLDNDGNIRISDLG
..|.   |..||  |.        ||.  ..... .  ..  |.|.|| .|.|.       |...||.||. . |..|| |||||.|||.||.|...| |
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LAVELK--------------------------------------------------EGQNKTKGYAG--TPGFMAPELLRGEEYDFSVDYFA--LGVTLY
|. |..                                                  .....|.   |  || .|||| |    |....|. .  ||. .|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMIAARGPFRARG------------EKVENKELKQRIISEPVKYP----------EKFSQASKDFCEQLLEKDPEKRLGFRDGT-----CDALRANVLF
||.. . ||..              |. .. .  ...|...||.|          ..||.  ||....||.|||||||| ....      . ...   |
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase RHOK.AA S_TKc 190-455 31 2.2e-83 284.25 SMART 1-231 (231) Show / Hide 
Range on Protein: 190-455
Range on HMM: 1-231/231
Sequence Identity: 31% (86 aa)

FLDFRVLGKGGFGEVSACQMKATGKMYACKKLNKKRLKKRKGYQGAIVEKRILTKVHSRFIVSLAYAFETKTDLCLVMTIMNG--GDVRYHIYNVDEDNP
.   |..|||.||.|  |. | ||. .|.|...          . .. | .|| | |  .|| | ..|.. ..|..||  ..|  ||.. .| .     .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

G--FSEPRAIYYTAQIISGLEHLHQRRIVYRDLKPENVLLDNDGNIRISDLGLAVELKEGQNKTKGYAGTPGFMAPELLRGEEYDF-SVDYFALGVTLYE
.  |.| .| .|..||...||..|...|..|||||||.|||.  .| |.| ||| .|       . . ||| .||||.|    |.. ..|  ..|..|||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MIAARGPFRARGEKVENKELKQRIISEPVKYPEKFSQASKDFCEQLLEKDPEKRLGFRDGTC--DALRANVLF
|.. . ||.      . ... ..|           |.  ||| ...|.||||||..  .      . ..   |
MLCGYPPFP------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RHOK.AA Akt 190-445 39 4.7e-80 255.57 In-house 1-255 (264) Show / Hide 
Range on Protein: 190-445
Range on HMM: 1-255/264
Sequence Identity: 39% (104 aa)

FLDFRVLGKGGFGEVSACQMKATGKMY-ACKKLNKKRLKKRKGYQGAIVEKRILTKVHSRFIVSLAYAFETKTDLCLVMTIMNGGDVRYHIYNVDEDNPG
|   .||||| || |  .. |.|.|.| | | | |... ...  . .. |..|| .. . |||.| |.| |.. |..||  .|||.  ||..      . 
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQR----KRR

FSEPRAIYYTAQIISGLEHLHQRRIVYRD-LKPENVLLDNDGNIRISDLGLAVEL-KEGQNKTKGYAGTPGFMAPELLRGEEYDFSVDYFA-LGVTLYEM
|||.|| .| |.||...||||.. |.||| |||||.|.|.||.|.. | ||. |  .  . |||   |||  .||| | |  .. .||  . ||. .|||
FSEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEM

IAARGPFRARGEKVENKELKQRIISEPVKYP--EKFSQASKDFCEQLLEKDPEKRLG-FRDGT
.  | || ..     .... . | ..|||.|  ...|.. ||. ..||.|||.|||| . ...
MCGRPPFYNQ----DHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDA
Kinase RHOK.AA SGK 190-444 35 4.4e-79 243.78 In-house 1-273 (283) Show / Hide 
Range on Protein: 190-444
Range on HMM: 1-273/283
Sequence Identity: 35% (100 aa)

FLDFRVLGKGGFGEVSACQMKAT------------------GKMYACKKLNKKRLK-------KRKGYQGAIVEK-RILTKVHSRFIVSLAYAFETKTDL
|    |.|||.||.|   . |..                  .|.|| | |.|.          |.|       |.  || .. . |||.| ||| ||. |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

CLVMTIMNGGDVRYHIYNVDEDNPGFSEPRAIYYTAQIISGLEHLHQRRIVYRDLKPENVLLDNDGNIRISDLGLAVELKEGQNKTKGYAGTPGFMAPEL
 .||  .|||.  ||.         |.|.||  |.|.|.. ||.||   |.||||||||.||| .|.... | ||. |  . ...|.  .|||  .||| 
YFVMDYVNGGEMFYHLQREKH----FPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEV

LRGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRIISEPVKYPEKFSQASKDFCEQLLEKDPEKRLGFRDG
||....| .|| . ||  ||||.    ||    .    ... . ||..| . |  .| . .|  ..||.|||.|||| ...
LRKQPHDRTVDWWCLGCVLYEMMYGLPPF----YSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRD
Kinase RHOK.AA BARK 190-455 42 1.1e-73 251.14 In-house 1-264 (264) Show / Hide 
Range on Protein: 190-455
Range on HMM: 1-264/264
Sequence Identity: 42% (114 aa)

FLDFRVLGKGGFGEVSACQMKATGKMYACKKLNKKRLKKRKGYQGAIVEKRILTKVHSR----FIVSLAYAFETKTDLCLVMTIMNGGDVRYHIYNVDED
|   |..|.||||||  |    |||||| | | |||.| ..|   |. |. .|  |       ||| ..|||.|   || .. .|||||. ||.      
FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGQDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGV-

NPGFSEPRAIYYTAQIISGLEHLHQRRIVYRDLKPENVLLDNDGNIRISDLGLAVELKEGQNKTKGYAGTPGFMAPELL-RGEEYDFSVDYFALGVTLYE
   |||   ..| | || ||||.|.| .||||||| |.|||  | .|||||||| .    . |     || |.|||| | .|  || | |.|.||  || 
---FSEQEMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDENGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLYK

MIAARGPFRARGEKVENKELKQRIISEPVKYPEKFSQASKDFCEQLLEKDPEKRLGFRDGTCDALRANVLF
..    |||    | . .|. .  .   |. |..||.  .|  | ||..| .|||| . .  . ..    |
LLRGHSPFRQHKTK-DKHEIDRMTLTMNVELPDSFSKEMRDLLEGLLQRDVSKRLGCMGRGAQEVKEHPFF
Kinase RHOK.AA RSK 193-440 34 4.3e-72 245.82 In-house 1-263 (278) Show / Hide 
Range on Protein: 193-440
Range on HMM: 1-263/278
Sequence Identity: 34% (93 aa)

FRVLGKGGFGEVSACQMK---ATGKMYACKKLNKKRLKKR-KGYQGAIVEKRILTKVH-SRFIVSLAYAFETKTDLCLVMTIMNGGDVRYHIYNVDE-DN
 .|||.||.|.|. |. .   .||. || | |.|. ...| |    .  | .||  .  . |||.| |||.|.. | |.|  ..||.  .|...      
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFG-

PGFSEPRAIYYTAQIISGLEHLHQRRIVYRDLKPENVLLDN---DGNIRISDLGLAVE-LKEGQNKTKGYAGTPGFMAPELLR----GEEYDFSVDYFAL
  ||| .| .| |.|.. .|||||. |..|||||||.|.|.   .| |...| |.. .   .  ..|. . .|  .||||.|.    .. .| ..|.. |
-CFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSL

GVTLYEMIAARGPFRARGEKVENKELKQRIISEP--VKYP--EKFSQASKDFCEQLLEKDPEKRLG
|| .||| . . ||.. ...   ||. .|| .    .. |  .. ||. ||.  ..|..||.||||
GVLMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLG
Kinase RHOK.AA Pkinase 190-455 29 5.7e-72 250.21 Pfam 1-293 (293) Show / Hide 
Range on Protein: 190-455
Range on HMM: 1-293/293
Sequence Identity: 29% (91 aa)

FLDFRVLGKGGFGEVSACQMKATGKMYACKKLNKKRLKKRKGYQGAIV--EKRILTKVHSRFIVSLAYAFETKTDLCLVMTIMNGG----DVRYHIYNVD
.   |..|.|.||.|  |. | |||..|.|...|.. |. | .. ..   | .|. .... .|| | ..||.|.....||  ..||    |   .|    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQT-HRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--

EDNPGF--SEPRAIYYTAQIISGLEHLHQRRIVYRDLKPENVLLDNDGNI----RISDLGLAVEL-KEGQNKTKGYAGTPGFMAPELLR-GEEYDFSVDY
... .|  ||  .. |  ||..|||..|...|..|||||||.|.||.|.|    .|.| |||  .    .  .....|||..||||..| |..|. .|| 
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

FALGVTLYEMIAARGPFRAR---GEKVENKELKQRIISEPVKYPEKFS---------------------QASKDFCEQLLEKDPEKRLGFRDGTCDALRA
...|..||||.  | ||. .    . .. ... .|| . |.....  .                     .. |||.. .|.|||.||..     .. .  
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQ

NVLF
   |
HPWF
Kinase RHOK.AA AktR 190-445 37 2.5e-69 236.66 In-house 1-259 (268) Show / Hide 
Range on Protein: 190-445
Range on HMM: 1-259/268
Sequence Identity: 37% (99 aa)

FLDFRVLGKGGFGEVSACQMK-ATGKMYACKKLNKKRLKKRKGYQGAIVEKRILT-KVHSRFIVSLAYAFETKTDLCLVMTIMNGGDVRYHIYNVDEDNP
|   ..||||.||.|  .| |  ..|.|| | . || ...|. .. .| |. |.  ..   ||| | |.|.||. | ..| .. ||.  .|. .      
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKK---

GFSEPRAIYYTAQIISGLEHLHQR-RIVYRDLKPENVLLDNDGNIRISDLGLAV-ELKE-GQNKTKGYAGTPGFMAPELLRG-EEYDFSVDYFALGVTLY
 ||| .|  | |||. .||.|||.  |.|||||||| ||| ||...|.| ||.  . ..    |..   |||  |||| ..  . ...|||. |.|. .|
-FSEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIY

EMIAARGPFRARGEKVENKELKQRIISEP---VKYPEKFSQASKDFCE-QLLEKDPEKRLG-FRDGT
||..   || .      .... |.|....   ..||..||.. ||... .|| |.|.|||| .. |.
EMVTGCPPFYHK----NQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGW
Kinase RHOK.AA Delta 190-455 38 1.2e-68 234.33 In-house 1-259 (259) Show / Hide 
Range on Protein: 190-455
Range on HMM: 1-259/259
Sequence Identity: 38% (103 aa)

FLDFRVLGKGGFGEVSACQMKATGKMYACKKLNKKRLKKRKGYQGAIVEKRILT-KVHSRFIVSLAYAFETKTDLCLVMTIMNGGDVRYHIYNVDEDNPG
|   .||||| || |    .| . | || | | |  . .    .  .||.|.|.  ... |.  |  .| ||  |  ||  .||||. ||| ..      
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHR----

FSEPRAIYYTAQIISGLEHLHQRRIVYRDLKPENVLLDNDGNIRISDLGLAVELKEGQNKTKGYAGTPGFMAPELLRGEEYDFSVDYFALGVTLYEMIAA
|.| || .|.. ||.||. ||.. |.||||| .||||| || |.| | |.. |   |..|.. . ||| ..|||...|. | .|||... || .|||.  
FDEKRARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIG

RGPFRARGEKVENKELKQRIISEPVKYPEKFSQASKDFCEQLLEKDPEKRLGFRDGTCDALRANVLF
  ||  ..|     || . |. .   ||   .. .||  ..|.|.||||||| ..     .|. ..|
QSPFHGEDE----DELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKGDIRQHCFF
Kinase RHOK.AA Ciliate-E2-Unclassified 190-441 26 6.6e-67 228.59 In-house 1-343 (352) Show / Hide 
Range on Protein: 190-441
Range on HMM: 1-343/352
Sequence Identity: 26% (93 aa)

FLDFRVLGKGGFGEVSACQMKATGKMYACKKLNKKRLKKRKGYQGA--------IVEKR--------------ILTKVHSRFIVSLAYAFETKTDLCLVM
.   ...|.||||.|  || | ... || | ..|.. .|.| ..          .....              ||    . ||| . |.|..|  ...||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

TIMNGGDVRYHIYNVDEDNPG-----------------FSEPRAI-----YYTAQIISGLEHLHQR-RIVYRDLKPENVLLDNDG---NIRISDLGLAVE
  ..||| ...|    .....                 |.|  |.     .|.|||..|||.||.   |..||.||||.|.||.|   .|.|.|.|.. .
EYCEGGDLWQYI----KKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKK

LKE---------------GQNKTKGYAGTPGFM----APELLRGEEYD----FSVDYFALGVTLYEMIAARGPFRARGEKV------------ENKELKQ
...                |....  .|||..|    |||.|.|..||    ...|...||| ||||.  . || .. ..              .|.|.|
YQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQ

RIISEPVKYPE--------KFSQASKDFCE----QLLEKDPEKRLGF
 |.  ....|.        . |.  |||..    ..|.|.|.||..|
NIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITF
Kinase RHOK.AA TyrKc 190-449 20 1.3e-14 13.52 SMART 1-280 (280) Show / Hide 
Range on Protein: 190-449
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

FLDFRVLGKGGFGEVSACQMKATGKMYACKKLNKKRLKKRKGYQGAIVEKRILTKV--HSRFIVSLAYAFETK-------TDLCLVMTIMNGGDVRYHIY
    ..|| | ||||  ...|    . | |.|..         .  . | ||..|.  |   || |  .  ..         |..||  | .|| . .. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

NVDEDNPGFSEPRAIYYTAQIISGLEHLHQRRIVYRDLKPENVLLDNDGNIRISDLGLAVELKEG-------QNKTKGY-AGTPG-----FMAPELLRGE
.  ..   .. .  ...  || .| |.||..... |||   |.|..... ..||| ||. .....       . ..|    |. .      |||| ..  
KHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

EYDFSVDYFALGVTLYEMIAARGPFRARGEK--VENKELKQRIISE-PVKYPEK--------FSQASKDFCEQLLEKDPEKRLGFRDGTCDAL
.. .  | .. ||...|.    ..     ..  ..|.|. ... .    . |.          ...  .  .|  . |||.|  |..  .. .
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase RHOK.AA S_TK_X 456-535 20 1.8e-10 42.03 SMART 1-79 (79) Show / Hide 
Range on Protein: 456-535
Range on HMM: 1-79/79
Sequence Identity: 20% (18 aa)

KDISWRQLEA--GMLIPPFIPDSRTVYAKNIQDVGAFS--TVKGVVFDKADTEFFQEFASGNCSIPWQEEMIETG----LFGDLNVWR
..| |..|..  ... |||.|. ..||| . .|.. |     ....         . . .. ... ||.| .||.     |.... ..
RGIDWDKLYNQQKEIEPPFKPKIKEVYA-SPTDTSNFDPEFTEETPM-------LTPDDPPLSNSMWQNE-METEIPPDPFRGFTYVF
Kinase RHOK.AA Pkinase_Tyr 284-386 25 2.6e-05 18.6 Pfam 103-208 (270) Show / Hide 
Range on Protein: 284-386
Range on HMM: 103-208/270
Sequence Identity: 25% (27 aa)

EDNPGFSEPRAIYYTAQIISGLEHLHQRRIVYRDLKPENVLLDNDGNIRISDLGLAVEL-KEGQN-KTKGYAGTPGF-MAPELLRGEEYDFSVDYFALGV
||.. .. .. . . .|| .|.|.|...... |||   |.|..... ..|.| |||  . ....  ...| .  | . |||| ..  ..    |  . ||
EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGV

TLYEMI
...|..
LMWEIF