Gene RAF1 (Mouse)
RAF1
Sequence
Protein domains of RAF1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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RBD | RAF1.AA | RBD | 56-131 | 49 | 4.8e-40 | 141.57 | Pfam | 1-77 (77) | Show / Hide |
Range on Protein: 56-131 Range on HMM: 1-77/77 Sequence Identity: 49% (38 aa) NTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLQEHKGKKARLDWNTDAASLIG-EELQVDFL ....|.|||.||.||.||.||...|.|||..|..||.|.||.|.|. .|.|.|..|||.||...| | .||.|..| KFCCVHLPNNQRCVVEVRPGMTVRDMLMKICKRHGLNPMCCHVYRVGDPHEGEKKPLDWHTDISWLPGPQELWVENL |
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RBD | RAF1.AA | RBD | 56-131 | 51 | 2.6e-37 | 131.17 | SMART | 1-76 (76) | Show / Hide |
Range on Protein: 56-131 Range on HMM: 1-76/76 Sequence Identity: 51% (39 aa) NTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLQEHKGKKARLDWNTDAASLIGEELQVDFL ....|.||..|||||.||.||..||.|||..|.|||.||||.|||. .|.|.| .|||......| |.||.|... KFCCVHLPDNQRTVVKVRPGMTVHDMLMKICKKRGLNPECCHVFRRHHPHEGEKKPLDWHQPISYLPGQELWVENR |
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C1_1 | RAF1.AA | C1_1 | 139-187 | 30 | 7.9e-18 | 69.1 | Pfam | 1-55 (55) | Show / Hide |
Range on Protein: 139-187 Range on HMM: 1-55/55 Sequence Identity: 30% (17 aa) HNFARK-TFLKLAFCDICQKFL-----LNGFRCQTCGYKFHEHCSTKVPTMCVDW |.. .. .| . .||. |..|. . |..||.|.|..|..|..|||..| .. HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN |
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C1 | RAF1.AA | C1 | 139-184 | 30 | 6.2e-16 | 60.17 | SMART | 1-61 (61) | Show / Hide |
Range on Protein: 139-184 Range on HMM: 1-61/61 Sequence Identity: 30% (19 aa) HNFARKTFLKLAFCDICQKFLLN---------GFRCQTCGYKFHEHCSTKVPT-------MC |.. ...| | ..|..|.|.. |.||. |.||.|..|..||| || HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC |
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C1_3 | RAF1.AA | C1_3 | 150-177 | 23 | 0.000492 | 11.76 | Pfam | 1-30 (30) | Show / Hide |
Range on Protein: 150-177 Range on HMM: 1-30/30 Sequence Identity: 23% (7 aa) AFCDICQKFLL--NGFRCQTCGYKFHEHCS .|..|.. . ....| .| . .|| | FTCNCCGLPIYRDPFYHCMQCDFMLHEDCA |
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Kinase | RAF1.AA | RAF | 349-608 | 69 | 2.1e-202 | 662.51 | In-house | 1-282 (282) | Show / Hide |
Range on Protein: 349-608 Range on HMM: 1-282/282 Sequence Identity: 69% (195 aa) VMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQA---FRNEVAVLRKTRHVNILLFMGYMTKDN---LAIVTQWCEGSSLYKHLHVQET--KF ||..||||||||||||.|.||||||||.|.|.||||||.|| |.|||||..||||.|||||||||.|.. .||||||||.||||.|.||||| || VMVMTRIGSGSFGTVYRGHWHGDVAVKMLNVNDPTPEQMQADVFFKNEVAVYKKTRHCNILLFMGYMSKPQTNTYAIVTQWCEHSSLYHHIHVQETREKF QMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWS--GSQQVEQPTGSVLWMAPEVIR-----------MQDDNPFSF .|..||||.||..|||||||||||||||.|||||||||..|||||||||.|||.||| |.||.||||...||||||||| |||.||.|| DMHWLIDISRQVCQGMDYLHAKNIIHRDLKSNNIFLHEDMTVKIGDFGLMTVKTRWSPRGNQQFEQPTHWILWMAPEVIRNLMIDWRGDVLMQDENPYSF QSDVYSYGIVLYELMAGELPY-AHINNRDQIIFMVGRGYASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIEL ||||||.|||.||||....|| .||.||||||||.||||..||||.....|||||.||..||.|. .||||||.|||..|.. QSDVYSFGIVMYELMTRHMPYGCHIWNRDQIIFMCGRGYLRPDLSKVRQDCPKAMHRLMEDCWKFQREERPLFQQILKRITV |
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Kinase | RAF1.AA | RAF | 349-606 | 59 | 1.3e-186 | 626.27 | In-house | 1-275 (275) | Show / Hide |
Range on Protein: 349-606 Range on HMM: 1-275/275 Sequence Identity: 59% (163 aa) VMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTP-EQLQAFRNEVAVLRKTRHVNILLFMGYMTKD---NLAIVTQWCEGSSLYKHLHVQET-KFQMF |.. .|||.|.|||||.|.||||||||.|....||| .|||||.|||....||||.||.|||||..|. ..|||||||.||.||.|.|||.| ||.| VQIGERIGQGRFGTVYRGHWHGDVAVKTLNMKYPTPEHQLQAFKNEVMMYKKTRHENIVLFMGYCMKPDNPHYAIVTQWCKGSTLYHHIHVQKTEKFDMN QLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVK-SRWS--GSQQVEQPTGSVLWMAPEVIRMQ---------DDNPFSFQSDV ..|.||.|..|||||||||||||||.||.|||||.|..|.|.||||.||| .||. ..||..||.|...|||||||||. |.||||||||| WTIQIAQQICQGMDYLHAKNIIHRDLKSKNIFLHNGKVVVITDFGLFTVKRCRWCKRRKQQLCQPHGWICWMAPEVIRMMRPDWDEYQCDCNPFSFQSDV YSYGIVLYELMAGELPYAHINNRDQIIFMVGRGYASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSI |..|.|.|||||||.||.||....|||.||.|||...|.|. ...|||.||.|...|... .||||.|.||...| YAFGTVWYELMAGEWPYQHIQWHEQIIWMVCRGYLRMDRSKARVQCPKEMKELLMECWSYQPEERPSFQQIMKMI |
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Kinase | RAF1.AA | TKL | 355-606 | 26 | 1.9e-96 | 326.74 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 355-606 Range on HMM: 1-364/364 Sequence Identity: 26% (100 aa) IGSGSFGTVYKGKWHG-----------DVAVKILKVV------------------------DPTPEQLQAFRNEVA-VLRKTRHVNILLFMG-------- ||||.||.||||||.| |||||..|. ||...... |..|.. .....|| ||..||| IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG -YMTKD-----NLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHA--------KNIIHRDMKSNNIFLHEGLT--------------V .. . .|.||...|.| ||. .|| . |....|...|.||.|||. ..||||| ||.||...| .| . CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC KIGDFGLATVKS------------------RWSGSQQVEQPTGSVLWMAPEVIRMQDD-------------NPFSFQSDVYSYGIVLYELMAGELPYAHI ||.||||....| . ..... . |. ||||||.|.|.. ..| ..||||.||||.|......||... KICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY NNRDQI------IFMVGRGYASPDLSRL----Y-------KNCPKAMKRLVADCVKKVKEERPLFPQILSSI .....| ........ . . . . ..||. ||.| || . |.|| | .||. . PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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Kinase | RAF1.AA | Pkinase | 349-606 | 25 | 7.9e-83 | 286.27 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 349-606 Range on HMM: 1-293/293 Sequence Identity: 25% (77 aa) VMLSTRIGSGSFGTVYKGKWHGD---VAVKILKVVDPTPEQLQAFRN--EVAVLRKTRHVNILLFMGYM-TKDNLAIVTQWCEGS----SLYKHLH-VQE . .|||||||.|||....|. |||||.|... ....|. |. |...... .| ||. . ... .||.. .|. .||| .|. ... .. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH TKF--QMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTV----KIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDDNPFSFQSDV ..| .. .......|...|..|.|...|||||.|. ||.... .. ||.||||| ... . .. ..|. .||||||| .... . .|. GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR--GGQYYGPKVDM YSYGIVLYELMAGELPYAHI----NNRDQIIFMVGRGYASPDLSRLYKNC------------------PKAMKRLVADCVKKVKEERPLFPQILSS--I .|.|..|||.. |..|. . | .||. .. .... .. .. .... ....| .. .| .| ..|| ..||| . . WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | RAF1.AA | KSR | 349-606 | 36 | 1.2e-69 | 236.59 | In-house | 1-272 (272) | Show / Hide |
Range on Protein: 349-606 Range on HMM: 1-272/272 Sequence Identity: 36% (100 aa) VMLSTRIGSGSFGTVYKGKWHGDVAVKILKVV--DPTPEQLQAFRNEVAVLRKTRHVNILLFMGY-MTKDNLAIVTQWCEG-SSLYKHLHVQETKFQMFQ . . .|| | ||.|..| |||.||.|.. . | .|. ||. ...||| || ||||. | .||||. | | .|| |.||. .|..| LKYGECIGQGRFGKVHRGHWHGEVAIKLYYMDHIHDEHHDLEDFKDEVMMYKNTRHENIVLFMGACMNPPHLAIVMSLCKGSQTLYHHIHVRREKLDMNR LIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVK---SRWSGSQQVEQPTGSVLWMAPEVIR--------MQDD-NPFSFQSDVY ..||.| .||| ||||| ||| | || |||. | | |||| .. .. . | | .||| || |.. .||| .|||| TMQIAQQICQGMGYLHAKGIIHKDLKSKNIFYENKGKVVITDFGLFSITRLLHCCQREDHLCIPHGWLCYLAPELIRAMRPNYDEYQCMCLPFSHHSDVY SYGIVLYELMAGELPYAHINNRDQIIFMVGRG-YASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSI ..| ..||...||.|... .||. ...| ..|. . | . || . | ..||| | .|.. . AFGTIWYEMICGEWPFKY-QCAESIIWQMCQGEGMRQVLRNV--QCGREMKEILMMCWSYEPQERPTFQDIMKML |
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Kinase | RAF1.AA | TKL-Unique | 351-606 | 33 | 1.6e-67 | 230.6 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 351-606 Range on HMM: 1-290/290 Sequence Identity: 33% (100 aa) LSTRIGSGSFGTVYKGKWHGD-VAVKILKV-VDPTPEQLQAFRNEVAVLRKTR-HVNILLFMGYMTK-----DNLAIVTQWCEGSSLYKHLH-------- . ||.|..|.||||||.|. ||.|.... |. .| .| |.||| .. | . | ||...||| .. |. ||. |.|.|||..|| FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN -VQETKFQMFQLIDIARQTAQGMDYLHAKN--IIHRDMKSNNIFLHEG-----LTVKIGDFGLATVKSRWSGSQQV-------EQPTGSVLWMAPEVIRM ...|. | | ...|.. ||||.||| .. |||||.|| |. . .. . .|| ||||....|. . . . . || .||||||.|| NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM QDDNPFSFQSDVYSYGIVLYELMAGEL------PYAHINNRDQIIFMVGR--GYASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSI . .| .|||||.||||.|. ... || .. ...|.. || | .. .||| . | .| . ..|| | .|.... NF-CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGM-DQEQWCEMVHYMEENYRPPIP---NHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL |
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Kinase | RAF1.AA | Dicty4 | 349-608 | 34 | 3.5e-63 | 209.6 | In-house | 1-277 (277) | Show / Hide |
Range on Protein: 349-608 Range on HMM: 1-277/277 Sequence Identity: 34% (97 aa) VMLSTRIGSGSFGTVYKGKWHG-DVAVKIL--KVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMT-----KDNLAIVTQWCEGSSLYKHLHV----- |||.||||.||||.| | .||||.| . .. . |..||.||. . | || ||.||||. | . . ||| . .||. || INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ -QETKFQMFQLID---IARQTAQGMDYLHAKN--IIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQ-VEQPTGSVLWMAPEVIRMQDDNPFSFQ |..| . . .|. .|.|| .||. | ||||| || |. . ..||..||||.... . . .. . |...|||||| . | |. QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQ---PYNEK SDVYSYGIVLYELMAGELPYA-HINNRDQIIFMVGRGYASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFPQILSS--IEL .||||.||||.|. .. ||. |. . .|... |.. | .. ..||. |.|...| . . || |..|.. | ADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIP---DWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH |
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Kinase | RAF1.AA | MLK | 349-606 | 31 | 5.4e-61 | 208.95 | In-house | 1-291 (291) | Show / Hide |
Range on Protein: 349-606 Range on HMM: 1-291/291 Sequence Identity: 31% (93 aa) VMLSTRIGSGSFGTVYKGKWHG-D-----VAVKILK----VVDPTPEQLQAFRNEVAVLRKTRHVN----ILLFMGYMTKD-N-LAIVTQWCEGSSLYKH ... ||||||| |.||.|.. | ||||. . . | .. ..|. |. ||. .| | | |.| ... . ..||...|||.||| IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV LHVQETKFQ-------------MFQLIDIARQTAQGMDYLHAKN---IIHRDMKSNNIFLHE------GLTVKIGDFGLATVKSRWSGSQQVEQPTGSVL || ...| . .....| | |.||.|||.. ||||| || || ..| ..|.|| |||... ... . .. |.. LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNA-GTYA WMAPEVIRMQDDNPFSFQSDVYSYGIVLYELMAGELPYAHINNRDQIIFMVGRGYASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSI ||||||| ...| .||.|.|.||.|....|.||. ... .|...|. | . ||. .|.| .| . ..|| | ||.. WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPST---CPEHWKKLMKQCWNQDPHKRPSFRQIVQHL |
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Kinase | RAF1.AA | TK | 349-606 | 16 | 2.1e-60 | 200.91 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 349-606 Range on HMM: 1-486/486 Sequence Identity: 16% (81 aa) VMLSTRIGSGSFG---TVYKGKWHG----------------------------DVAVKILKVV-DPTPEQLQA--------------FRNEVAVLR--KT . | .|.| || .||||.|.| .||||.|| . ..|. .. . .| .... . ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG RHVNILLFMGYMTKDN-------------LAIVTQWCEGSS----LYKHLHVQETK-------------------------------------------- .| ||. . |. |.. . ||. .... . | ..|. | HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY -------------------------------FQMFQLIDIARQTAQGMDYLHAK------NIIHRDMKSNNIFLHEGLT-----------VKIGDFGLAT . | ||. ...| |.|| |||.| |..||| |. ..|... .||.||||. DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR VKS----RWSGSQQVEQPTGS----------------------------VLWMAPEVIRMQD------DNPFSFQSDVYSYGIVLYELMA-G-ELPYAHI ..| | .| . ..| . |||||... . .. |. .|||.|.|....|.. | | .| . QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM NN--------RDQIIFMVGRG-----------YASPDLSRLYKNCP-------------KAMKRLVADCVKKVKEERPLFPQILSSI .| .... .. || . . .. ... .| .| .. |.|| | |... . SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL |
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Kinase | RAF1.AA | S_TKc | 349-609 | 24 | 5.6e-57 | 196.52 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 349-609 Range on HMM: 1-231/231 Sequence Identity: 24% (69 aa) VMLSTRIGSGSFGTVYKGKWHG---DVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEG--SSLYKHLHVQETK---- . ||.|.||.|||..... ||.||.| . .|.|...|.| .| || . ... |.| .|. |.| .|..... . .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF -FQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDDNPFSF-QSDVYSYGIV | . ...|......|.| ..||||| | ||.| | ..||.|||||.. |. .|||||. .... .|..| |.. PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCI LYELMAGELPYAHINNRDQIIFMVGRGYASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFPQILS------SIELL |||...|. |. . .... ..| .. .| .. | .| |.|| ..| . . . LYEMLCGYPPFP---QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | RAF1.AA | STE | 350-597 | 21 | 6e-51 | 175.59 | In-house | 1-346 (359) | Show / Hide |
Range on Protein: 350-597 Range on HMM: 1-346/359 Sequence Identity: 21% (74 aa) MLS-TRIGSGSFGTVYKGKWH----GD--------------VAVKILKVVDPTP---------------EQLQAFRNEVAVLRKTR--HVNILLFMGYMT .||.|.||||||.. | .. .|.|.... . .. |..| . .|. ...| . | || . |. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF KD--------NLAIVTQWCEGSSLYKHLH-VQETKFQM------------FQLIDIARQTAQG-MDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLAT |. .| |. ...| || . .. . ...... |.. |.||. .| ..||| ..||||| |. ||.| ||. |||... KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG --VKSRW------------SGSQQVEQPTGSVLWMAPEVIRMQD---DNPFSFQSDVYSYGIVLYELMAGELPYAHINNRD---QIIFMVGRG------- ..| ...|. .|. |||||||. .. |.. ....|..| |... |. |. |.. .. .|.|. . . QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC ---YASPDLSR----------------LYKNCPKAMKRLVADCVKKVKEERP .| | . ... . .| .. | .| ..|| IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRP |
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Kinase | RAF1.AA | TyrKc | 349-606 | 30 | 3.6e-49 | 170.59 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 349-606 Range on HMM: 1-280/280 Sequence Identity: 30% (88 aa) VMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKT--RHVNILLFMGYMTK--------DNLAIVTQWCEGSSLYKHLHVQET . | .|.| ||.||||.| .|||| || ...|..| ...| .| ||. . |. |. . | ||. ... .| ..|. . ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP KFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRW-----SGSQQVE----QPT--GSVLWMAPEVIRMQDDNPFSF |..| .|.... | |.||.||| ||.|||| |. ..|..||||.||||. |.. . . . |||||.| ... |.. KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NYGKFTT QSDVYSYGIVLYELMA-GELPYAH-----INNRDQIIFMVGRGYASPDLSRLYKN-----CPKAMKRLVADCVKKVKEERPLFPQILSSI .|||.|.|....|.. |. || ..|.. .| | .|| | | ||..| .. .| . |.|| | .| . . KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQE-VIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | RAF1.AA | Src | 349-606 | 31 | 6.2e-48 | 160.91 | In-house | 1-255 (255) | Show / Hide |
Range on Protein: 349-606 Range on HMM: 1-255/255 Sequence Identity: 31% (84 aa) VMLSTRIGSGSFGTVYKGKWHG--DVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKD-NLAIVTQWCEGSSLYKHLH-VQETK-FQMF . | ..|.| || |..|.| | .|||| || . . .|| | .. | || ... ... ||| . || . |. .|.. .. IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGT---MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLP QLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKS----RWSGSQQVEQPTGSVLWMAPEVIRMQDDNPFSFQSDVYSYGIVLY ||||.| | |.||.|| ..|.|||| |. |.. .|..||||| . . .. | . |.||| |. . |. ||| |.|| |. QLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFP---IKWTAPEAINYGR---FTIKSDVWSFGILLT ELMA-GELPYAHINNRDQIIFMVGRGYASPDLSRLYKNCPKAMKR-LVADCVKKVKEERPLFPQILSSI |.. | || .|. . . .| ||| | . ||. . . |..| |.|| | . . EIVTYGRVPYPGMTNH-EVLQQVERGYRMPCPHN----CPDELYEQIMLQCWHKDPEQRPTFEYLQWFL |
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Kinase | RAF1.AA | Pkinase_Tyr | 349-490 | 32 | 9.5e-47 | 158.95 | Pfam | 1-158 (270) | Show / Hide |
Range on Protein: 349-490 Range on HMM: 1-158/270 Sequence Identity: 32% (52 aa) VMLSTRIGSGSFGTVYKGKWH-------GDVAVKILKVVDPTPEQ--LQAFRNEVAVLRKT-RHVNILLFMGYMT--KDN--LAIVTQWCEGSSLYKHLH . . .|.|.||.||||.|. .||||.|| . ..|| ...| .|...... .| ||. ..| | .. . ||. ... .|...|. ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR VQ---ETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLA . . .. | .|.....| |.||.||..||.|||| |. ..|...|||.||||| KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA |
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Kinase | RAF1.AA | Pkinase_Tyr | 511-606 | 30 | 1.8e-16 | 56.4 | Pfam | 180-270 (270) | Show / Hide |
Range on Protein: 511-606 Range on HMM: 180-270/270 Sequence Identity: 30% (30 aa) WMAPEVIRMQDDNPFSFQSDVYSYGIVLYELMA-GELP-YAHINNRDQIIFMV-GRGYASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSI |||||.|. |. .|||.|.|....|.. || | |. . | . .. .. .|| . . .|||. . .| .| .. |.|| | .|.. . WMAPECINYGK---FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEE-VYEYIYEDGYR---MPC-PENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |