Gene PYK2 (Mouse)

PYK2

Species: Mouse
Alias: Ptk2b, PYK2
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: FAK

Sequence

Name Sequence Type Origin Length Description Download
PYK2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 260 Kinase domain by global Sugen HMM Fasta, JSON
PYK2.AA Protein Sugen 1009 None Fasta, JSON
PYK2.NA RNA Sugen 3881 None Fasta, JSON

Protein domain

Protein domains of PYK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B41 PYK2.AA B41 35-265 20 5.5e-48 166.65 SMART 1-232 (232) Show / Hide 
Range on Protein: 35-265
Range on HMM: 1-232/232
Sequence Identity: 20% (49 aa)

KEDVRILKVCFYSNSFNPGKNFKLVKCTVQTEIQEIITSILLSGRIGPNIQLAECYGLRLKHMKSDEIHWLHPQMTVGEVQDKYECLHVEAEWRYDLQIR
..  | ..|.|. ..  . . .   ..|.|  ....  .. .      ...  ...||.......|  |||..  |....  |.   | ...|.. . ..
SPKPRFCRVYFMDGT--TLEFEVDSSTTGQDLCDHVCRHCGI------SPREHWYFGLWYEDPHED-RHWLDHWKTIMKQDVKW---HKSEPWTLHFRVK

YLPEDF---MESLKEDRTTLLYFYQQLRNDYMQRYASKVSEGMALQLGCLELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQ---------MQENL
. |.|.    ..|.|| |.. |||.|.|.|..| ..   .|  .|||..| ... ..|.. .....|.... ..|..... |.|||         |....
FYPPDWHGFPNQLQEDPTRYNYFYLQCRHDILQGRHPCPHEEECLQLAALQVQIEYGDYDPEETNNKKMTKHVQKYKSYKRFLPKQWIDSIKQSFMHYQM

KPKQFRKMIQQTFQQYASLREEECVMKFFNTLAGFA-NIDQETY
..|..||.|.. .........||. .|.....   .     | .
HHKEWRKRIMEWHKNHCGMTPEEAKLKYLQICQRWPPMYGVEHF
FERM_M PYK2.AA FERM_M 139-250 14 5.9e-16 56.12 Pfam 1-156 (171) Show / Hide 
Range on Protein: 139-250
Range on HMM: 1-156/171
Sequence Identity: 14% (23 aa)

DFMESLKEDRTTLLYFYQQLRNDYMQRYASKVSEGMALQLGCLELRRFFK-DMP-HNALDKKS-NFELLEKE------------VGLDLFFP--------
|. . ...|  |...||.|...|... .  ..|| .||.|... ..  |  |.. ...  ...  .|. | .            . .. ..|        
DPNR-DIQDEVTRHQFYLQAKWDILEGRY-PCSEEEALMLAAYQCQIEFGSDYNPPQKHKSDYMEKEWWE-QQEGMEVWLRCDNEQQERYWPAHCRLASK

-----------------------KQMQENLKPKQFRKMIQQTFQQYASL-REEECVMKF
                       ..... .| ||... | . ..... .  .||. ...
GRTMADSSYSEVSIRINPHCYVSPWYCKKMKQKQWEQRILEQHKNHRGMCSPEEAMLQY
Kinase PYK2.AA FAK 425-684 66 7.2e-213 713.46 In-house 1-285 (285) Show / Hide 
Range on Protein: 425-684
Range on HMM: 1-285/285
Sequence Identity: 66% (189 aa)

VVLNRILGEGFFGEVYEGVYTNHKG------------------------EKINVAVKTCKKDCTQDNKEKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWI
..|||..|||.||.||.|||||||.                        .||.||.|||||.|..|||||||.||.|||..|||||||||||.||.|.||
ITLNRCIGEGQFGDVYQGVYTNHKNGKGKNLAGNGKNSNSDQRNADSRPDKIQVAIKTCKKCCDDDNKEKFMQEAYIMKQFDHPHIVKLIGICEEMPIWI

IMELYPYGELGHYLERNKNSLKVPTLVLYTLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKAS-VTRLPIKWMSPESINF
||||..||||.|||.|||||||..||.||..|.|.|||||||...||||||.||.||.||.|||||||||||...|..||||| ...|||||||||||||
IMELCKYGELRHYLQRNKNSLKHATLILYCYQLCMAMAYLESKKFVHRDIAARNVLVSSPDCVKLGDFGLSRWMHDHSYYKASPKGKLPIKWMSPESINF

RRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPELCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSDIYQ
||||||||||||.|||||||..|..||.|..|.||||..|.|.|||.|..|||.||.||||||.||||.||||.||.|.|.||||
RRFTTASDVWMFGVCMWEILMYGVKPFQWVKNNDVIGRIENGERLPMPPNCPPTLYSLMTRCWAYDPSKRPRFKELKCQLKDIYQ
Kinase PYK2.AA TyrKc 425-679 41 4.6e-142 479.16 SMART 1-280 (280) Show / Hide 
Range on Protein: 425-679
Range on HMM: 1-280/280
Sequence Identity: 41% (119 aa)

VVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTQDNKEKFMSEAVIMKNL--DHPHIVKLIGIIEE--------EPTWIIMELYPYGELGHYL
..|...||||.|||||.|...      |.||||..|.|.    .| ||.|| ||..|  .||.||.|.|.. .        || .|.||. |.| | .||
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

ERNKNSLKVPTLVLYTLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDE-------DYYKAS---VTR--LPIKWMSPESINFRRF
 .... |....|. . .||.. |.||.| ||.|||.| ||.||... .|| .||||||.|.|.       |||...    ..  |||.||.||.||...|
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TTASDVWMFAVCMWEILSFGKQPFFW-----LENKDVIGVLEKGDRLPKPEL--------CPPVLYTLMTRCWDYDPSDRPRFTELVCSL
||.||||.| ||||||...|.||        ..|..||  ...|.|.|.|.         ||. .|..|..||..||.|||.|.|..  .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase PYK2.AA Pkinase_Tyr 425-679 46 1.9e-141 479.69 Pfam 1-270 (270) Show / Hide 
Range on Protein: 425-679
Range on HMM: 1-270/270
Sequence Identity: 46% (125 aa)

VVLNRILGEGFFGEVYEGVYT-NHKGEKINVAVKTCKKDCTQDN--KEKFMSEAVIMKNL-DHPHIVKLIGIIE--EEP--TWIIMELYPYGELGHYLER
..... |||| |||||.|...  ....|| ||||..| ......  .|.||.|| |||.| .||.||.|.|..   .||   .|.||. |.| | .|| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

N---KNSLKVPTLVLYTLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYY--KASVTRLPIKWMSPESINFRRFTTASDVWMF
.   |..|....|. . .||.|.|.||||.||.|||.| ||.||... .|| .||||.|.|...|||  |.. ..||||||.||.||...|||.||||.|
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

AVCMWEILSFGKQP-FFWLENKDVIGVL-EKGDRLPKPELCPPVLYTLMTRCWDYDPSDRPRFTELVCSL
 |.||||...|.|| .  . | .|.  . |.| |.|.||.||. .|.||..||.|||.|||.|.|..  |
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase PYK2.AA TK 425-679 24 6.30000000001e-115 386.89 In-house 1-486 (486) Show / Hide 
Range on Protein: 425-679
Range on HMM: 1-486/486
Sequence Identity: 24% (117 aa)

VVLNRILGEGFFG---EVYEGVYTNHK----------------------GEKINVAVKTCKKDCTQDNKEKFM-------------SEAVIMKNLD----
..| . |||| ||   |||.| . ...                      |.|. ||||..|...... .|.|.             .|| .|| ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPHIVKLIG-IIEE------------EPTWIIMELYPYGE----LGHYLERNKNS--------------------------------------------
 ||.||.|.| . ..            || .|.||. |.|     | .|| ....                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LKVPTLVLYTLQICKAMAYLESI------NCVHRDIAVRNILVASPEC-----------VKLGDFG---
                               | ...|. . .||...|.||.|       |.||||.| ||.||..              .|..|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSRYI-EDEDYYKAS------------------------VTRLPIKWMSPESIN---------FRRFTTASDVWMFAVCMWEILSFGKQPFFW-L
     |.|.| .|.|||..|                         ..|||.||.||..|         ...|||.||||.| |.||||...|..|. . .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

EN---------KDVIGVLEKGDRL--------------PKPELCP--------------PVLYTLMTRCWDYDPSDRPRFTELVCSL
 |         ..|.  |..| ||              |.|..||              ...| ||..||.|||.|||.|..|.  |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase PYK2.AA Ack 425-679 38 8.3e-97 327.07 In-house 1-266 (266) Show / Hide 
Range on Protein: 425-679
Range on HMM: 1-266/266
Sequence Identity: 38% (103 aa)

VVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTQDN--KEKFMSEAVIMKNLDHPHIVKLIGIIEEEPT-WIIMELYPYGELGHYLERNKN--
. |.  ||.| || |  |. ||  |. |.||||  . |  | .   . |. |. || .|||||.|.| |.    |    ..|| | | |   |   .   
ITLCEKLGDGCFGVVWRGEWTNPGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLRKHCRTA

SLKVPTLVLYTLQICKAMAYLESINCVHRDIAVRNILVASPE-CVKLGDFGLSRYI-EDEDYYKASVTR---LPIKWMSPESINFRRFTTASDVWMFAVC
 . ..||  . .||...|.|||. .|.||| | ||||..|..  || .||||.|   . ||||. . .|   .|. |. ||....|.|. ||||||| |.
FFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMFGVT

MWEILSFGKQPFFWLENKDVIGVLE-KGDRLPKPELCPPVLYTLMTRCWDYDPSDRPRFTELVCSL
.||  |.| .|.  .   ...  .. .| |||.|..||. .|..| .||. .| |||.| ...  |
LWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase PYK2.AA UTK 425-679 35 4e-90 305.71 In-house 1-296 (296) Show / Hide 
Range on Protein: 425-679
Range on HMM: 1-296/296
Sequence Identity: 35% (105 aa)

VVLNRILGEGFFGEVYEGVYTNHK--GEKINVAVKTCK-KDCTQDNKE---KFMSEAV---IMKNLD-HPHIVKLIGI-IEEEPTWIIMELYPYGELGHY
| | | ||.| ||||... .|. .  ...  ||||.|. .. .|...|   .|| ||    .||... ||....|.|.   |||..|..|... | | .|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LERNKNSLK-----VP--TLVLYTLQICKAMAYLESINCVHRDIAVRNILVASP-------ECVKLGDFG---LSRYIE---------DEDYYKAS-VTR
| |.. ..      .   ... . ..|  .|.||.| ..||||.| ||.||..        . .|..|||   .||..          . .||.|. ..|
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

LPIKWMSPESINFR-RFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGD--RLPKPELCPPVLYTLMTRCWDYDPSDRPRFTELVCSL
.||.||.||... . ||||.|||| | | .|||...|..|.  . | .|.  ...|.  |.|.|. ||  .|.||.||| |||..||.| .||  .
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase PYK2.AA TK-Unique 425-679 32 2.3e-86 293.23 In-house 1-294 (294) Show / Hide 
Range on Protein: 425-679
Range on HMM: 1-294/294
Sequence Identity: 32% (96 aa)

VVLNRILGEGFFGEVYEGVYTNHK---GEKINVAVKTCKKDCTQDNKEKFMSEAVIMKNLD-HPHIVKLIGI-IEE-EPTWIIMELYPYGELGHYLERNK
.......||| ||.|. | ... .   .....||||..|.. |.  | .|..|. .||.|. ||.||...|. ..  ||. |||| .|.| | ||| ...
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

NS-------------------------LKVPTLVLYTLQICKAMAYLES--INCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVT--RLPI
                           ..  .|. .  ||...|.||.|   ..||||.. ||.|...   .|..|||..|.....  |  . .  |.||
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

KWMSPESIN--FRRF-TTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPELC-PPVLYTLMTRCWDYDPSDRPRFTELVCSL
.||.|||.    . . || ||||.|.| ||||...|..|.  . .||..  ...|.|.|.|| | .. .| || .|| ..|..|| |....  |
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase PYK2.AA Src 425-679 39 3.3e-86 292.71 In-house 1-255 (255) Show / Hide 
Range on Protein: 425-679
Range on HMM: 1-255/255
Sequence Identity: 39% (104 aa)

VVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTQDNKEKFMSEAVIMKNLDHPHIVKLIGIIEEE-PTWIIMELYPYGELGHYLE--RNKNSL
. | | ||.| ||||..|.. ..    ..||||| |..      | |  || |||.|.|...|.|  .  .| |  |. |.   | |  ||   .   .|
IKLCRKLGQGQFGEVWMGYWNGN----TKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHL

KVPTLVLYTLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIE--DEDYYKASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEIL
..|.|.  . |. . |||||| | .||| | ||.||    ..| .|||| | |.  |. |   .  ..||||. || ||..|||. |||| | . ..|| 
HLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIV

SFGKQPFFWLENKDVIGVLEKGDRLPKPELCPPVLYT-LMTRCWDYDPSDRPRFTELVCSL
..|. |    .|..|.  .|.| |.|.|. ||. ||  .|..||. || .|| |  |   |
TYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase PYK2.AA EGFR 425-680 38 8.2e-85 281.52 In-house 1-258 (258) Show / Hide 
Range on Protein: 425-680
Range on HMM: 1-258/258
Sequence Identity: 38% (100 aa)

VVLNRILGEGFFGEVYEGVYTNHKGE--KINVAVKTCKKDCTQDNKEKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLK
. . ..|| | || || |..    ||  || ||.|  ..   .  .| .. || .|  .||||.|.|.|.  ..   ..  . ||| |  |.  .|. . 
LKKVKVLGSGAFGTVYKGIWIPE-GENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQMQLVTQYMPYGCLLDYVRQHKDNIG

VPTLVLYTLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIE-DEDYYKASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSF
   |... .|| | | |||    |||| | ||.|| ||. ||  ||||..  | ||. |.|.  ..|||||  |.| .|..| .|||| . | .||.. |
SQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQGGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWELMTF

GKQPFFWLENKDVIGVLEKGDRLPKPELCPPVLYTLMTRCWDYDPSDRPRFTELVCSLS
|..|.  .. ...   ||||.||| |. |   .| .| .||  |.  ||.| ||.  ..
GQKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase PYK2.AA Eph 425-679 39 4.5e-84 282.29 In-house 1-264 (264) Show / Hide 
Range on Protein: 425-679
Range on HMM: 1-264/264
Sequence Identity: 39% (104 aa)

VVLNRILGEGFFGEVYEGVYTNHKGEKIN----VAVKTCKKDCTQDNKEKFMSEAVIMKNLDHPHIVKLIGII-EEEPTWIIMELYPYGELGHYLERNKN
. . ...|.| ||||..|     .|..      ||.|| |. .|   .  | ||| ||   |||.|..| |..   .|  |. |    | |  .| ..  
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHDG

SLKVPTLVLYTLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDED----YYKASVTRLPIKWMSPESINFRRFTTASDVWMFAVCM
 ..|  ||     |  .| || . | |||| | ||||| |  . |  |||||| .||..     |  .  . ||.|  || | .|.||.||||| . . |
QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVM

WEILSFGKQPFFWLENKDVIGVLEKGDRLPKPELCPPVLYTLMTRCWDYDPSDRPRFTELVCSL
||..|.|  |.  . |.|||   |.| ||| |  ||. |. ||  || .|...||.|...|  |
WEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase PYK2.AA Syk 425-673 37 1.9e-83 283.52 In-house 1-257 (257) Show / Hide 
Range on Protein: 425-673
Range on HMM: 1-257/257
Sequence Identity: 37% (96 aa)

VVLNRILGEGFFGEVYEGVYTNH----KGEKINVAVKTCKKDCTQDN-KEKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKN
.|. . .| | || | .|.|        .  | ||.|. | | .| . |. || || .|  ||||.||..||| . |.   .||. . | .  ||  ...
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGICHAEMMMMVMEMAELGPMHKYLQQHRH

SLKV-PTLVLYTLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYI-EDEDYYKASVT-RLPIKWMSPESINFRRFTTASDVWMFAVCMW
. ..   | |   |.   | |||. . |||| | ||.|       |  |||.|.    |..||.|    . |.||  ||.|... |  .|||| | | ||
EITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGVTMW

EILSFGKQPFFWLENKDVIGVLEKGDRLPKPELCPPVLYTLMTRCWDYDPSDRPRFT
| .| |..|     . .|.  .|.|.|...|..||. .| || .|| |.. ||| | 
EMFSYGQKPYGEMKGQEVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase PYK2.AA Fer 425-680 34 3.1e-82 279.52 In-house 1-283 (283) Show / Hide 
Range on Protein: 425-680
Range on HMM: 1-283/283
Sequence Identity: 34% (99 aa)

VVLNRILGEGFFGEVYEG-------VYTNHKGEKINVAVKTCKKDCTQDN-KEKFMSEAVIMKN-LDHPHIVKLIGII-EEEPTWIIMELYPYGELGHYL
|.|. .|||| ||||| |         ..| ..|. |.||.|| . ...  ...|| || ||.| .|||..||..|..  |.|  |.||. . | |  ||
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

ERNKN-SLKVPTLVLYTLQICKAMAYLESINCVHRDIAVRNILVASPECVK---LGDFGLSRY--IEDEDYYKA-SVTRLPIKWMSPESINFRRFTTASD
  ||| .... ... ...|... |.||.| ||.||||| ||.|.   . .|   . |||.||    . .||...   ...||.|..||..... .....|
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTD

VWMFAVCMWEILSFGKQPFFW----LENKDV----IGVLEK-GDRLPKPELCPPVLYTLMT-RCWDYDPSDRPRFTELVCSLS
|| | | .||| . |..|...    . .. |    . . .| | ..| |. .|| .. .|. .||..||.||| ..|..  | 
VWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase PYK2.AA S_TKc 425-683 22 3.1e-48 167.49 SMART 1-231 (231) Show / Hide 
Range on Protein: 425-683
Range on HMM: 1-231/231
Sequence Identity: 22% (62 aa)

VVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTQDNKEKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIIMELYPY--GELGHYLERNKNS--
  . |..|.| ||.|| .. ..    .  ||.|  |        |....|  |.|. .||.||||.......  ...||. .   |.| .|.....    
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LKVPTLVLYTLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFRRFTT-ASDVWMFAVCMW
   .   .   |. |||.|..|. | . .|||.   |||. .  ..|..||||.| .        .       .|.|| .    ... ..|.| . ....
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EILSFGKQPFFWLENKDVIGVLEKGDRLPKPELCPPVLYTLMTRCWDYDPSDRPRFTELVC-----SLSDIY
| |. |. ||   . . .. ..            .| .  .. .|...||..||   |.        .    
EMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PYK2.AA Pkinase 425-679 23 1.3e-43 155.24 Pfam 1-293 (293) Show / Hide 
Range on Protein: 425-679
Range on HMM: 1-293/293
Sequence Identity: 23% (71 aa)

VVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTQDNKEKFMS-----EAVIMKNLDHPHIVKLIGIIE-EEPTWIIMELYPYG----ELGHYL
 .. |..|.| ||.||...   |||. . ||||. ||.   ....| ..     |. |||.|.||.||.|... | .   ...||. . |    .| .|.
YHIGRKIGSGSFGCVYKCH---HKGTGKIVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

E-RNKNSL--KVPTLVLYTLQICKAMAYLESINCVHRDIAVRNILVA-SPEC---VKLGDFGLSR---YIEDEDYYKASVTRLPIKWMSPESIN-FRRFT
. ......     ..  | .||.....|. | ...|||.   |||.   ...   ||..||||..   |  .. ..   .|.    .|.|| |.  .  .
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW---YMAPEVIRGGQYYG

TASDVWMFAVCMWEILSFGKQPFFWL----ENKDVIGVLEKGDR----LPKPELCP-------------------PVLYTLMTRCWDYDPSDRPRFTELV
...|.| . . ..| |. |. ||       .  | . ....  .     . |..|.                   . .  ....|...||..|| .....
PKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQIL

CS--L
..  .
QHPWF
Focal_AT PYK2.AA Focal_AT 870-1008 62 6.1e-97 333.17 Pfam 1-139 (139) Show / Hide 
Range on Protein: 870-1008
Range on HMM: 1-139/139
Sequence Identity: 62% (87 aa)

TANLDRTDDLVYHNVMTLVEAVLELKNKLGQLPPEDYVVVVKNVGLNLRKLIGSVDDLLPSLPASSRTEIEGTQKLLNKDLAELINKMKLAQQNAVTSLS
|||.||.||.||.|||..|..|.|.|||. .||.|.||..||||||.||||..|||...|||||....|||...|.||||..|||.||.||||.|.|.|.
TANMDRSDDYVYCNVMQVVKSVMEMKNKVHKLPSEEYVNMVKNVGLELRKLLQSVDEIYPSLPAQCHREIEMAHKVLNKDMHELISKMRLAQQYAMTTLD

EDCKRQMLTASHTLAVDAKNLLDAVDQAKVVANLAHPPA
..||.|||||.|.||.||||||||||||.|....||.|.
QECKKQMLTAAHVLAMDAKNLLDAVDQARVRMQHAHMPH