Gene PRPK (Mouse)

PRPK

Species: Mouse
Alias: PRPK, 5630401H01Rik
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Other
Family: Bud32

Sequence

Name Sequence Type Origin Length Description Download
PRPK.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 220 Kinase domain by global Sugen HMM Fasta, JSON
PRPK.NA RNA Sugen 1044 None Fasta, JSON
PRPK.AA Protein Sugen 244 None Fasta, JSON

Protein domain

Protein domains of PRPK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PRPK.AA Bud32 25-242 45 8.60000000001e-164 528.23 In-house 1-269 (269) Show / Hide 
Range on Protein: 25-242
Range on HMM: 1-269/269
Sequence Identity: 45% (123 aa)

SGLELVQ--------QGAEARVFR--------------GRFQGR------AAVVKHRFPKSYRHPELEARLGRRRTVQEARALLRCRRAGIAAPVVFFVD
..|||..        ||||||||.              ..||||      ....|.||||.||||.|...|...||.||.||..|||.|||..|.|.|.|
MSLELYKDVDIAPISQGAEARVFYTCYLTVSKQKVYTTCNFQGRAKDSHQQCIIKERFPKAYRHPQLDQQLTKHRTKQEVRAMNRCRKAGICVPYVYFCD

YASNCLYMEEIEDS------VTVRDYIQSTMETEK---DPQCLLDLARRMGQVLAGMHDQDLIHGDLTTSNMLLRRPLAQL-----HIVLIDFGLSFVSG
....|.|||.||.|      .||..||....||.|   ..|||.......|.... ||....||||||||||.||.|.|..     ...|||||||..| 
NYNHCIYMEYIEESPGGHGFYTVKNYIWQHQETQKEDQHDQCLREFCKKVGRQIGKMHWNHIIHGDLTTSNMMLRHPYADWTKLYGQMHLIDFGLSYISN

LP-EDKGVDLYVLEKAFLSTHPHTET-----AFEAFLKSYG---ASSKKSSPVLKKLDEVRLRGRKRSM
.. |||||||||||.|||||||..|.     .||.|...|.   ...||...||||..|||||||||.|
SVPEDKGVDLYVLERAFLSTHPKCEQKYNAWIFEHFMENYRKQDTKCKKFKAVLKKFNEVRLRGRKRTM
Kinase PRPK.AA RSK 144-178 38 2.5e-07 23.25 In-house 120-154 (278) Show / Hide 
Range on Protein: 144-178
Range on HMM: 120-154/278
Sequence Identity: 38% (14 aa)

MHDQDLIHGDLTTSNMLLRR-PLAQLHIVLIDFGLS
.|.|. || ||  .|.|.      . ||.|.|||..
LHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFC
Kinase PRPK.AA CAMK-Unique 139-178 30 2.6e-07 19.99 In-house 168-220 (363) Show / Hide 
Range on Protein: 139-178
Range on HMM: 168-220/363
Sequence Identity: 30% (16 aa)

QVLAGMHDQDLIHGDLTTSNMLLRRPLA-------------QLHIVLIDFGLS
...| ||.|| .|.||   | ... ..              ..||.|.||||.
SAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLC
Kinase PRPK.AA TESK 131-182 35 8.4e-07 17.02 In-house 97-149 (292) Show / Hide 
Range on Protein: 131-182
Range on HMM: 97-149/292
Sequence Identity: 35% (19 aa)

LDLARRMGQVLAGMHDQDLIHGDLTTSNMLLR-RPLAQLHIVLIDFGLSFVSG
..||    . .  .|..   | |||  | | | |.  |.  |. ||||  | |
IHLAYDIARGMSYLHSKGVFHRDLTSKNCLVRQRDNNQYEAVVGDFGLARVLG
Kinase PRPK.AA VRK 127-179 33 9e-06 14.98 In-house 129-181 (284) Show / Hide 
Range on Protein: 127-179
Range on HMM: 129-181/284
Sequence Identity: 33% (18 aa)

PQCLLDLARRMGQVLAGMHDQDLIHGDLTTSNMLLRRPLAQLHIVLIDFGLSF
. ..| || ||  ||  .|. .  |||.. .| ||     . . .|.|.||..
MKTVLQLACRMLDVLEYLHENEYVHGDIKAANILLGFEKNPDQVYLVDYGLAY
Kinase PRPK.AA Ciliate-E2 144-178 36 9e-06 15.83 In-house 176-203 (365) Show / Hide 
Range on Protein: 144-178
Range on HMM: 176-203/365
Sequence Identity: 36% (13 aa)

MHDQD-LIHGDLTTSNMLLRRPLAQLHIVLIDFGLS
.| .   || |.  .| |.        | .||||||
LHSKNNIIHRDIKPENILF--------IKIIDFGLS
Kinase PRPK.AA MSK 144-178 40 1.3e-05 14.9 In-house 117-151 (277) Show / Hide 
Range on Protein: 144-178
Range on HMM: 117-151/277
Sequence Identity: 40% (14 aa)

MHDQDLIHGDLTTSNMLLRRPLAQLHIVLIDFGLS
||.   ||.||   | |.     . |..|||||..
MHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFA
Kinase PRPK.AA TKL 144-178 24 1.9e-05 15.59 In-house 148-201 (364) Show / Hide 
Range on Protein: 144-178
Range on HMM: 148-201/364
Sequence Identity: 24% (13 aa)

MHDQD--------LIHGDLTTSNMLLRRPL-----------AQLHIVLIDFGLS
.| ..        .|| ||...| |. . .           |. .. . |||||
LHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLS
S_TKc PRPK.AA S_TKc 24-244 15 2.7e-05 -99.15 SMART 1-220 (231) Show / Hide 
Range on Protein: 24-244
Range on HMM: 1-220/231
Sequence Identity: 15% (40 aa)

LSGLELVQQGAEARVFRGRFQG--RAAVVKHRFPKSYRHPELEARLGRRRTVQEARALLRCRRAGIAAPVVFFVDYASNCLYMEEIE-DSVTVRDYIQST
   |... .|| ..|...|  .  |   .|                  ... .| . | . .   |     .|.|  . .. || .. |  ...|||.. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR

ME----TEKDPQCLLDLARRMGQVLAGMHDQDLIHGDLTTSNMLLRRPLAQLHIVLIDFGLS-----------------FVSGLPEDK-GVDLY------
         ..     ... . . |. .|..  || ||  .| || .     || ..||||.                 .    . .|  .| .      
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQLTTFCGTPWYMAPEVL----GYGKCKCDWWSCGCIL

---VLEKAFLSTHPHTETAFEAFLKSYGASSKKSSPVLKKLD-EVRLRGRKRSMVG
   .  .   .   . .. |.  .     |.   . . | |. . . |        
YEMLCGYPPFP---QMQMMFKKIG-----SPEAKDFIRKCLQKDPEKRPTA-EALQ
Kinase PRPK.AA DAPK 144-178 44 4.5e-05 10.47 In-house 119-154 (264) Show / Hide 
Range on Protein: 144-178
Range on HMM: 119-154/264
Sequence Identity: 44% (16 aa)

MHDQDLIHGDLTTSN-MLLRRPLAQLHIVLIDFGLS
||.    | ||   | ||| |  .. .| .|||||.
MHSKHICHFDLKPENIMLLDRNVPNPRIKIIDFGLA
Kinase PRPK.AA CK1 133-178 25 7.5e-05 12.96 In-house 137-195 (339) Show / Hide 
Range on Protein: 133-178
Range on HMM: 137-195/339
Sequence Identity: 25% (15 aa)

LARRMGQVLAGMHDQDLIHGDLTTSNMLLRR-------------PLAQLHIVLIDFGLS
.| .| ..|  |||   || |.  .|... |                  ....||||..
IAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMA