Gene PRP4 (Mouse)

PRP4

Species: Mouse
Alias: PRP4, Prpf4b
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: PRP4

Sequence

Name Sequence Type Origin Length Description Download
PRP4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 313 Kinase domain by global Sugen HMM Fasta, JSON
PRP4.AA Protein Sugen 1007 None Fasta, JSON
PRP4.NA RNA Sugen 4482 None Fasta, JSON

Protein domain

Protein domains of PRP4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PRP4.AA PRP4 687-1003 79 2.4e-264 884.46 In-house 1-320 (320) Show / Hide 
Range on Protein: 687-1003
Range on HMM: 1-320/320
Sequence Identity: 79% (253 aa)

YNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDA--DPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKD
|.||||.||||||||.|.||..|.|..||.|||||||.|.||||.|||.|.|||||  |..|||||.|.||||.|.||.|||||..||||||||||||||
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

VGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYT
||||.||||||.||||||||.||.|||||||||||||||||||..||.||||||||...|.||||||||||||||||||..|||.|||||||||||||||
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNILVNESKNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELYT

GKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGC-QRLPEDQRKKVHQLKDLLDQI
|||.||||||||||||.||.||||||||||||.|||.|||||.||||.||||||||||||||..|.||||....||.| ||.||||.|||||.|||||..
GKIMFPGKTNNHMLKLFMDYKGKMPNKMIRKGQFKDNHFDQNCNFMYQEVDKVTEREKVTVMTYIKPTKDIYQELIECNQRIPEDQMKKVHQFKDLLDKC

LMLDPAKRISINQALQHAFI
|||||.|||..|.||.| ||
LMLDPKKRITCNEALKHPFI
Kinase PRP4.AA DYRK 687-1003 41 2.7e-174 585.32 In-house 1-320 (320) Show / Hide 
Range on Protein: 687-1003
Range on HMM: 1-320/320
Sequence Identity: 41% (136 aa)

YNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVG
| ...|.|.|.|..||...|. . |. ||.||||||. .......|.. |..||..|||||.||......|||..|||.|||.|||||.|.||.......
YEILEYIGKGSFGQVVKCWDH-KTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGF

LHIKAVRSYSQQLFLALKLLKRC-NILHADIKPDNILVNE--SKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELY
.....||.. ||....||.|... ||.|.|.||.||....  .|  .|..||||...... .|..|..||||||||.|.|  |.| |||||.||.|.||.
FSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQ-RIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELF

TGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKG--VFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTI---NPTKDLLADLIGCQR--LPEDQRKKVHQL
||..||||......|.. |...|..|..||.||   .|...||.   ||| |.|..|...|.|... .   .|||.    .....|   |..| ...||.
TGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC---FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQF

KDLLDQILMLDPAKRISINQALQHAFI
||.... |..||.|||. .||||| ..
KDFIKKCLQWDPHKRITPSQALQHPWF
Kinase PRP4.AA CMGC 687-1003 21 2.6e-103 340.44 In-house 1-513 (513) Show / Hide 
Range on Protein: 687-1003
Range on HMM: 1-513/513
Sequence Identity: 21% (111 aa)

YNVYGYTGQGVFSNVVRARD-------------NARANQEVAVKIIRNNELMQKTGL-------------KELEFLKKLN----------DADPDDKFH-
| . .. |.| ...|...||             . . |..||.|.|.|.. .. ...              |...||.||          | |||.| | 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRD-DPDNKHHN

-CLRLFRHFYHKQ-----------------HLCLVFEPLSMNLREVLKKYGK-DVG------------------------LHIKAVRSYSQQLFLALK--
 ...|. .||||.                 ||.|||| . ..| ...|.. . . |                        . | ..| |..|.. .||  
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

LLKRCN--ILHADIKPDNILVNESKTI-------------------LKLCDFGSASHVADN-----------------------DITPYLVSRFYRAPEI
 . . .  |.| |.|| |||.|. ..                    ||.||||.| .. ..                        .|.| |.|.||||||
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI

IIG----------KSYDYGIDMWSVGCTLYELYTG--------KILFPGKTN-----------NHMLKLAMDLKGKMPNKMIRKGVFKD-QHFDQNLNFM
..|          . |...|||||||| ..|.|||        |.||||...            ..|.. ... |. . .||.||  .. . |... . .
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGK-RHFN-FCKHEEEW

YIEVDKVTEREKVTVM--------STI-------------NPTKDLLADLIGC-------------------QRLPEDQR--------KKVHQLKDLLDQ
.  ... .   . ...         ..             .. .  . .|. .                    . ... .        .  .|. |||..
PNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSH-KFNHQFKRKCCDPQAIDLLKK

ILMLDPAKRISINQALQHAFI
.| .||.|||.. ||||| ..
MLQYDPDKRITAEQALQHPYF
Kinase PRP4.AA S_TKc 687-1003 22 3e-76 260.53 SMART 1-231 (231) Show / Hide 
Range on Protein: 687-1003
Range on HMM: 1-231/231
Sequence Identity: 22% (75 aa)

YNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSM---NLREVLKKYGK
| .    |.| |. | ..|..   ...||.|||.      .. ..|.. |||       .  .  .|. .|.. .||..|.| ..    .|....||.|.
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

---DVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDY-GIDMWSVGCTL
   .....   .|.| .|...||. . . .|.| |.||.|||..|    .|.||||.| ..     | . ....|.|||..   .|..  .|.||.||.|
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

YELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLKDL
||...|. .||  . . |.|. .                                                                       ...||.
YEMLCGYPPFP--QMQMMFKKIG----------------------------------------------------------------------SPEAKDF

LDQILMLDPAKRISINQALQ-------HAFI
....|  ||.||... .|||       | ..
IRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PRP4.AA DYRK2 687-891 39 7e-60 193.28 In-house 1-204 (318) Show / Hide 
Range on Protein: 687-891
Range on HMM: 1-204/318
Sequence Identity: 39% (81 aa)

YNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVG
| .    |.| |  ||.. |    .| ||.|.|||     .. . |.. |...   |.|  . | ...  ||   |.|..|| ||||| | .||  .  |
YEILEVIGKGSFGQVVKCYD-HKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQ-G

LHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNES-KTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTG
.  . ||   ...  .|..|.. || |.| || ||| ..  .  .|. ||||   .    |  |  ||||||||.|.|  |.  ||||| ||.. |||||
FSLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTG

KILFPG
..||||
YPLFPG
Kinase PRP4.AA HIPK 687-1003 31 2.3e-56 175.78 In-house 1-329 (329) Show / Hide 
Range on Protein: 687-1003
Range on HMM: 1-329/329
Sequence Identity: 31% (104 aa)

YNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVG
|.|  . |.| |  ||..   .  |  ||.||..|.    . |  |.. |..| . ..|. .| .| .  | ||.| ||||| |  || . .|.  |   
YEVLEFLGRGTFGQVVKCWKRG-TNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADE-YHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQN-KFMP

LHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNI-LVNESKT--ILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELY
| .|..|   ||   ||. ||   ..|||.||.|| || ...     |  |||||||| .    .|| ||.|||||||.|  .   .|||| || . ||.
LPLKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELF

TGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHF--DQNLNFMYIEVDKVTEREKVTVMSTINPTKDLL--ADLIGCQRLPEDQRKKVHQLK--
 |  |.||  .           ..    .. ... | . |  |....| .    .. | |. | .   .  |  .  .|..    .  |  .. .  .  
LGWPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRDKQSKFRPWRLKHIEEHEQQTSVKSKEARKYIFNCLDDMPEVNMLVDPERQDYRVEKI

------DLLDQILMLDPAKRISINQALQHAFI
      ..| ... .|. |||.  .||.| |.
DRREFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase PRP4.AA DYRK1 687-1003 31 1.1e-54 188.03 In-house 1-321 (321) Show / Hide 
Range on Protein: 687-1003
Range on HMM: 1-321/321
Sequence Identity: 31% (104 aa)

YNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVG
|..    |.| |  ||.| |     ..||.|||.|        . |.  |  .| .|...|.. ..| ||| .. ||||||| || || ..|.   .  |
YEIDSLIGKGSFGQVVKAYD-HQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRN-THFRG

LHIKAVRSYSQQLFLALKLLK--RCNILHADIKPDNI-LVNESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELY
  .  .| . ||.  ||  .     .|.| |.||.|| |.|  .  .|. ||||. .. .  |  |. |||||.||...| .||  |||||.|| | |. 
VSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQR-IYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMH

TGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKK---------VH
||  || |.     ..  ..  |  |..|| ..    ..|... . ..     .  ...       .|..  | ...| .    . |.|          .
TGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDPDNTW-----YCKKTRDKKKHYKEPCTRKLHEILGVETGGPGGRRKGEPGHSVEDYL

QLKDLLDQILMLDPAKRISINQALQHAFI
. |||. ..|  ||..||.  .||||.|.
KFKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase PRP4.AA GSK 687-900 31 3.6e-47 141.77 In-house 170-399 (328) Show / Hide 
Range on Protein: 687-900
Range on HMM: 170-399/328
Sequence Identity: 31% (76 aa)

YNVYGYTGQGVFSNVVRARDNAR--ANQEV-----AVKIIRNNELMQKTGLK---ELEFLKKL---NDADPDDKFHCLRLFRHFYHKQHL---------C
|  .   |.|.|..|..| .|     ..|.     |.| .      |..  |   ||...|.|   .. .      . ||  .||...           |
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKV-----WQDKRYKCNRELQIMKMLGKLDHPN------IVRLKYFFYMHYEKKDENHVYCNC

LVFEPLSMNLREVLKKY-GKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADND---ITPYLVSRFYRAPEI
||.| . ..| .|...|   .  . |. .. |. |.| .|. |   .| | ||||.||||.... .||.||||||  . .|     ..| .||.||||| 
LVMEYMPQTLYQVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPEL

IIG-KSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKL
|.| . |.  ||.||.|| . |. .|..||||.. ...|..
IFGCTNYTCQIDVWSCGCVMAEMLKGQPLFPGDSSVDQLVE
Kinase PRP4.AA YAK 687-923 37 1.2e-45 152.88 In-house 1-239 (347) Show / Hide 
Range on Protein: 687-923
Range on HMM: 1-239/347
Sequence Identity: 37% (91 aa)

YNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLND-ADPDDKF---HCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYG
| |    ||| |  ||  . |   |  .|||.| |       .  |   |. ||.  ||..|    | ||.   | || |.||||| ||.|| | ||   
YIVLDMLGQGTFGQVVKCQ-NCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQ-N

KDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNE-SKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYE
|  |. .  .| .  |   ..  |.  .| | | || ||.     |  .|. ||||.   .   .. |  .|.||.||||..  |   ||||| || . |
KFCGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKM-VYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAE

LYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHF
|. |  .|||      .|   |  |. |. || .| || . |
LFLGLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYF
Kinase PRP4.AA CDK 687-893 28 1.6e-37 117.5 In-house 255-483 (284) Show / Hide 
Range on Protein: 687-893
Range on HMM: 255-483/284
Sequence Identity: 28% (70 aa)

YNVYGYTGQGVFSNVVRARDNARA----NQEVAVKIIR---N-----NELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHK-----------QHL
|      |.| .  | .|||  .     .| || | ||   .      | .  | . |   ||.|    |    .  .|.  ...|             |
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL---HP----NIVKLHDVCHTKNMDRNNKDKHENKL

CLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKT----ILKLCDFGSASHVA--------DNDITPYLV
 .||| . . | ....            ...| .||  .|  . . .|.| |.|| |||.|.  .     ||. ||| |             .  |.  |
YMVFEYMDHDLKKYMD------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVV

SRFYRAPEIII-GKSYD--YGIDMWSVGCTLYELYT---GKILFPGKT
 . |||||.    | |.   .|||||||| ..|..|   .| ||||..
TLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDS
Kinase PRP4.AA Pkinase 687-907 26 2.1e-37 133.34 Pfam 1-234 (293) Show / Hide 
Range on Protein: 687-907
Range on HMM: 1-234/293
Sequence Identity: 26% (66 aa)

YNVYGYTGQGVFSNVVRARDNARANQEVAVKIIR---NNELMQKTGLK--ELEFLKKLNDADPDDKFHC--LRLFRHFYHKQHLCLVFEPLSM-----NL
| . .  |.| |. | ... .   ...||||||.   ... ...| ..  |.. .|.||        |.  .||.. |. |.|...|.| . .      |
YHIGRKIGSGSFGCVYKCH-HKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN--------HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDL

REVLK--KYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTI---LKLCDFGSAS---HVADNDITPYLVSRFYRAPEIII-GKS
 ....  ..|.   .  . ...|  |.. .|. . ...|.| |.||.|||...  .|   .|.||||.|    .  .   | . ....|.|||.|  |. 
FDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQY

YDYGIDMWSVGCTLYELYTGKILFPGK----TNNHMLKLAMDLKGK
|.. .||||.||.|||...|. .|||.    ....| .........
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPP
Kinase PRP4.AA CLK 687-822 30 7.2e-31 89.21 In-house 162-307 (350) Show / Hide 
Range on Protein: 687-822
Range on HMM: 162-307/350
Sequence Identity: 30% (44 aa)

YNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELE-FLKKLNDA-DPDDKFH--CLRLFRHFYH-KQHLCLVFEPLSMNLREVLKKY
| ..   |.|.|. ||. .|. . .. ||.||||| |        |..  .||.| . ||. |.   |....  | . . | |.||| .  .. ...|. 
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

G-----KDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNIL
.     |  .. | ..|. . ||  |.| |    . | | || ||.
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENIC
Kinase PRP4.AA CLK 831-926 37 5.5e-19 52.9 In-house 187-288 (350) Show / Hide 
Range on Protein: 831-926
Range on HMM: 187-288/350
Sequence Identity: 37% (38 aa)

KLCDFGSAS-HVADNDITPYLVS-RFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKG-KMPNKMIRKGV---FKDQHFD
.. |||||     |.   . .|| | |||||.| |  . .  | ||.|| |.|||||  ||..  |   | .   . |   |. ||.. .    |. .| 
CVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYFY

QN
.|
HN
Kinase PRP4.AA CLK 974-1003 50 5.3e-11 28.48 In-house 321-350 (350) Show / Hide 
Range on Protein: 974-1003
Range on HMM: 321-350/350
Sequence Identity: 50% (15 aa)

HQLKDLLDQILMLDPAKRISINQALQHAFI
.|| ||. ..|. ||.|||.  .|||| | 
RQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase PRP4.AA CDK 961-1003 41 1.1e-10 30.26 In-house 251-284 (284) Show / Hide 
Range on Protein: 961-1003
Range on HMM: 251-284/284
Sequence Identity: 41% (18 aa)

GCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFI
|.  ||.          |||.. |..||.||||  ||||| . 
GVTKLPDY---------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase PRP4.AA TyrKc 687-1001 16 2.6e-10 -55.95 SMART 1-280 (280) Show / Hide 
Range on Protein: 687-1001
Range on HMM: 1-280/280
Sequence Identity: 16% (56 aa)

YNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKL--NDADPDDKFHCLRLFRHFYHK-------QHLCLVFEPLSM-NLRE
       | | |  |.... .    ..|||| ....   ..  ..|.. ..||  .        . .||.    ..       . |..|.|  .  .|..
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA--REDFMREARIMCKLGGHHP------NIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

VLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDIT----PYLV------SR-----FYRAPEII
 |.|....  |  |   |.. |       | . |. | |.   |.||.| . . | .||| .  . | | .     | .      ..        ||| |
YLRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

IGKSYDYGIDMWSVGCTLYELYT-GKILFPG-----KTNNHMLKLAMDLKGKMPNKM---IRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPT
  . .    | || | ...|..| |.   ||     ..| ..... .. .  .. .    .                                       
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------------------

KDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHA
                       . ..  |  . ||..| . ..  .  
----------------FVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase PRP4.AA YAK 978-1003 46 2.3e-07 20.69 In-house 322-347 (347) Show / Hide 
Range on Protein: 978-1003
Range on HMM: 322-347/347
Sequence Identity: 46% (12 aa)

DLLDQILMLDPAKRISINQALQHAFI
|.. |.| |.| .| .  || || ||
DFINQLLQLNPRERWKPMQAMQHPFI
Kinase PRP4.AA Pkinase 976-1003 39 9.4e-07 24.96 Pfam 266-293 (293) Show / Hide 
Range on Protein: 976-1003
Range on HMM: 266-293/293
Sequence Identity: 39% (11 aa)

LKDLLDQILMLDPAKRISINQALQHAFI
.||... .| .||.||... |.||| ..
CKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase PRP4.AA GSK 978-1003 42 2e-06 14.95 In-house 303-328 (328) Show / Hide 
Range on Protein: 978-1003
Range on HMM: 303-328/328
Sequence Identity: 42% (11 aa)

DLLDQILMLDPAKRISINQALQHAFI
||. ..|  || ||.|  .|..| | 
DLISKCLVYDPKKRLSPLEACAHPFF
Kinase PRP4.AA DYRK2 987-1003 47 3.5e-05 12.43 In-house 302-318 (318) Show / Hide 
Range on Protein: 987-1003
Range on HMM: 302-318/318
Sequence Identity: 47% (8 aa)

DPAKRISINQALQHAFI
||..|..  |||.|..|
DPSERMTPSQALKHPWI