Gene PLK5 (Mouse)

PLK5

Species: Mouse
Alias: PLK5
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , iHOP
Annotation:

Classification

Group: Other
Family: PLK
Subfamily: PLK2

Sequence

Name Sequence Type Origin Length Description Download
PLK5.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 257 Kinase domain by global Sugen HMM Fasta, JSON
PLK5.AA Protein Sugen 599 None Fasta, JSON
PLK5.NA RNA Sugen 2105 None Fasta, JSON

Protein domain

Protein domains of PLK5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PLK5.AA PLK2 27-283 66 6.1e-227 738.29 In-house 1-257 (257) Show / Hide 
Range on Protein: 27-283
Range on HMM: 1-257/257
Sequence Identity: 66% (170 aa)

YRRGKLIGKGAFSRCYKLTDMSTSAVFALKVVPRGGAGRLRLRGKVEREIALHSRLRHRNIVAFHAHFADRDHVYMVLEYCSRQVPLQSLAHVLKVRRTL
|.||||.|||.|.|||..|||.|..|.|.|.||.........|.|.||||.||..||||.||.||.||.|||..|..||||||||||.|.||..|||..|
YCRGKLLGKGGFARCYEMTDMDTHYVYAVKIVPHSRVAKPHQREKMEREIELHRQLRHRHIVQFHHHFEDRDNIYILLEYCSRQVPLKSMAHMWKVRHHL

TEPEVRYYLRGLVSGLRYLHQQRIVHRDLKPSNFFLNKNMEVKIGDLGLAARVGPAGRCHRVLCGTPNFQAPEVVSRNGHSCKSDIWALGCIMYTVLTGT
||||||||.|..||||||||||.|.|||||..|||.|.||||||||.|||||..|...|||..|||||..||||..|.||||.||||||||||||.|.|.
TEPEVRYYMRQIVSGLRYLHQQCIIHRDLKLGNFFINDNMEVKIGDFGLAARLEPEEHCHRTMCGTPNYIAPEVLNRQGHSCESDIWALGCIMYTMLCGR

PPFAAAPLSEMYQNIRDGHYLEPTHLSPSARSLIARLLAPDPAERPSLDHLLQDDFF
|||..|.|.|.|..||..||..||||||.||.||||.|.|||..||||||....|||
PPFETANLKETYRCIRHNHYHMPTHLSPPARHLIARMLSPDPEDRPSLDHIIRHDFF
Kinase PLK5.AA PLK 27-283 49 1.4e-170 559.55 In-house 1-258 (258) Show / Hide 
Range on Protein: 27-283
Range on HMM: 1-258/258
Sequence Identity: 49% (130 aa)

YRRGKLIGKGAFSRCYKLTDMSTSAVFALKVVPRGGAGRLRLRGKVEREIALHSRLRHRNIVAFHAHFADRDHVYMVLEYCSRQVPLQSLAHVLKVR-RT
|.||...|||.|..||..||..|..|.| ||||.    . ..| |...||..|..|.|.|||.|| .| |...||.|||||..    .||.|..| | ..
YERGHFLGKGGFAKCYEMTDIHTKQVYAIKVVPKSLMQKPHQREKMKQEIEIHRQLHHPNIVKFHHFFEDHENVYIVLEYCHN----RSLMHYHKRRAKR

LTEPEVRYYLRGLVSGLRYLHQQRIVHRDLKPSNFFLNKNMEVKIGDLGLAARVGPAGRCHRVLCGTPNFQAPEVV--SRNGHSCKSDIWALGCIMYTVL
|||||||||.. .|.||.||||.||.|||||..|.|||.||.||||| |||.|. . |.... .|||||..||||.  ...|||...|.|.||||||| |
LTEPEVRYYMYQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFGLATRLEYDGERKKTMCGTPNYIAPEVLDGNKQGHSYEVDCWSLGCIMYTLL

TGTPPFAAAPLSEMYQNIRDGHYLEPTH--LSPSARSLIARLLAPDPAERPSLDHLLQDDFF
.|.||| .. . |.|..|.. ||  |.|  .|..|..||...| ..|.|||..|..||..||
IGKPPFETKDVKETYKRIKHNHYSFPEHCPISDEAKDLIQKMLNWNPDERPTIDQILQHPFF
Kinase PLK5.AA PLK1 27-283 46 2e-103 340.86 In-house 1-253 (253) Show / Hide 
Range on Protein: 27-283
Range on HMM: 1-253/253
Sequence Identity: 46% (120 aa)

YRRGKLIGKGAFSRCYKLTDMSTSAVFALKVVPRGGAGRLRLRGKVEREIALHSRLRHRNIVAFHAHFADRDHVYMVLEYCSRQVPLQSLAHVLKVRRTL
|..|. .||| | .|| ..| .|  ||| ||||.    .   | |. .|| .|  |.||.|| || .| |.. ||.||| |.|    .||  . | |...
YEKGRFLGKGGFAHCYEIRDKDTKEVFAGKVVPKSLLIKQHQRDKMTQEIQIHRQLHHRHIVKFHHFFEDKQNVYIVLELCRR----RSLMELHKRRKAI

TEPEVRYYLRGLVSGLRYLHQQRIVHRDLKPSNFFLNKNMEVKIGDLGLAARVGPAGRCHRVLCGTPNFQAPEVVSRNGHSCKSDIWALGCIMYTVLTGT
|||| |||.. .| | .|||...|.|||||  | ||| ...||||| ||| ..   |   . ||||||. ||||... |||   |||..|||||..| | 
TEPECRYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDGERKKTLCGTPNYIAPEVLNKKGHSFEVDIWSIGCIMYILLFGQ

PPFAAAPLSEMYQNIRDGHYLEPTHLSPSARSLIARLLAPDPAERPSLDHLLQDDFF
||| .  | | |. |.   |  |.|.|. |..|| ..| ||| .||  ...|.|.||
PPFETKCLKETYSRIKKNEYRIPSHISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF
Kinase PLK5.AA PLK-Unclassified 27-283 41 1.4e-100 340.44 In-house 1-264 (264) Show / Hide 
Range on Protein: 27-283
Range on HMM: 1-264/264
Sequence Identity: 41% (110 aa)

YRRGKLIGKGAFSRCYKLTDMSTSAVFALKVVPRGGAGRLRLRGKVEREIALHSRLRHRNIVAFHAHFADRDHVYMVLEYCSRQVPLQSLAHVLKVR---
|.||...|||.|..||. .. .| ...| |..|       | | |   || .|. | |.||| |   | | . ||..||||    | ..| . .| |   
YHRGHFLGKGGFAKCYQVKNIETKKIYAAKIIPKSSLTKNRARQKLISEIKIHKSLHHKNIVKFEHCFEDHENVYILLEYC----PNGTLMEYIKRRNFQ

----RTLTEPEVRYYLRGLVSGLRYLHQQRIVHRDLKPSNFFLNKNMEVKIGDLGLAARVGPAGRCHRVLCGTPNFQAPEV-VSRN-GHSCKSDIWALGC
      |||.||..|.  .| .| |||| || |||||. | ||| ||||||.| |||...   |   .  |||||  |||.   .. ||| ..|.|..||
LFEKKRLTEYEVKCYTYQIVQALKYLHQNRIIHRDLKLGNIFLNDNMEVKICDFGLATKLENDGEKKKTICGTPNYIAPEILDGKHQGHSYEVDCWSFGC

IMYTVLTGTPPFAAAPLSEMYQNIRDGHYL--EPTHLSPSARSLIARLLAPDPAERPSLDHLLQDDFF
| || |.| ||| .      |..|.   |   || |.| .|..|| . | ..|..||..| .....|.
ILYTLLIGKPPFETKDVKQTYKKIKCNQYSFPEPCHISDNAKDLIQHILNWNPDQRPTIDQIMMHPFY
Kinase PLK5.AA S_TKc 27-283 32 1.5e-92 314.7 SMART 1-231 (231) Show / Hide 
Range on Protein: 27-283
Range on HMM: 1-231/231
Sequence Identity: 32% (89 aa)

YRRGKLIGKGAFSRCYKLTDMSTSAVFALKVVPRGGAGRLRLRGKVEREIALHSRLRHRNIVAFHAHFADRDHVYMVLEYCSRQVPLQSLAHVLKVRRT-
|. ...||||||...|| .. .|  ..|.|...           ...|||..... .| ||| .. .| | ||.|||.|||.    | .| ...| |.. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGD--LGDLFDYIKKRGRH

-----LTEPEVRYYLRGLVSGLRYLHQQRIVHRDLKPSNFFLNKNMEVKIGDLGLAARVGPAGRCHRVLCGTPNFQAPEVVSRNGHSC-KSDIWALGCIM
     ..| ..|.|.. ....| |.|...|.||||||.| .|..  ..||.| |||...       . .||||.. ||||.   |... |.|.|..|||.
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

YTVLTGTPPFAAAPLSEMYQNIRDGHYLEPTHLSPSARSLIARLLAPDPAERPSLDHLLQ-------DDFF
|  |.| |||    . .|...|.          ||.|...| ..|  ||..||.   .||       . .|
YEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PLK5.AA CAMK 32-283 20 1.7e-85 275.35 In-house 1-425 (425) Show / Hide 
Range on Protein: 32-283
Range on HMM: 1-425/425
Sequence Identity: 20% (86 aa)

LIGKGAFSRCYKLTDMSTS------------AVFALKVVPRGGAG-------------------------RLRLRGKVEREIALHSR-------LRHRNI
 .|.|.|.  .. .. .|               .| |....  .                          | . | .|.|||.....       |.|.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VAFHAHFAD-------------------RDHVYMVL---EYCSRQVPLQSLAHVLKVR---------------RTLTEPEVRYYLRGLVSGLRYLHQQRI
. .. .. |                   ..|.|||.   ||||    .. |   .. .               . .|| |.|.| | ..|...|.|.. |
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKPSNFFLNKNM-----------------EVKIGDLGLAARVGPA-----------------------GRCHRVLCGTPNFQA-PEVVSR------
||||||| |  |..|.                  .|| | |.|... |                        |   .  |||| . | |||...      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------NGHSCKSDIWALGCIMYTVLTGTPPFAAAP-------------LSEMYQNIRDGHYL-EPTHLSP-----------------------SARS
         ... |.|.|..|.|.|. |.|.||| .               ..|....|. | |  .| ..||                       ....
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIARLLAPDPAERPSLDHLLQDDFF
|| ..| .|| .|....  |.. ..
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase PLK5.AA Pkinase 27-283 28 1.1e-84 292.45 Pfam 1-293 (293) Show / Hide 
Range on Protein: 27-283
Range on HMM: 1-293/293
Sequence Identity: 28% (83 aa)

YRRGKLIGKGAFSRCYKLTDMSTSAVFALKVVPRGGAGRLRLRGKVE-REIALHSRLRHRNIVAFHAHFADRDHVYMVLEYCSRQVPLQSLAHVLK--VR
|..|. ||.|.|...|| .. .|. ..|.|.... ..    .. ..  .||... ||.| ||| ..  | |.||.|||.|||   . ...|.....   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RTL--TEPEVRYYLRGLVSGLRYLHQQRIVHRDLKPSNFFLNKNMEV----KIGDLGLAARV-GPAGRCHRVLCGTPNFQAPEVVS-RNGHSCKSDIWAL
...  .| |.. |.. ...|| |.|...|.||||||.|.....|...    ||.| |||. .    ..   ..||||.. ||||.  ..... |.|.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCIMYTVLTGTPPFAAA------PLSEMYQNIRDGHYLEPTHLS---------------------PSARSLIARLLAPDPAERPSLDHLLQDDFF
|||.| .|.| |||  .         .|...|... . ..   .                     ......| ..|..||..||. ...||...|
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase PLK5.AA CAMKL 27-283 26 1.2e-74 237.62 In-house 1-297 (297) Show / Hide 
Range on Protein: 27-283
Range on HMM: 1-297/297
Sequence Identity: 26% (80 aa)

YRRGKLIGKGAFSRCYKLTD-MSTSAVFALKVVPRGGAGR-------------LRLRGKVEREIALHSRLR---HRNIVAFHAHFADRDH------VYMV
|| || .|||.|.     |. . |    | |.. . ..               ..   ...|||.....|.   | ||. .. .. ...|      .|.|
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

LEYCSRQVPLQS--LAHVL--KVRRT--LTEPEVRYYLRGLVSGLRYLHQQRIVHRDLKPSNFFLNKNM--EVKIGDLGLAARVGP----AGRCHRVLCG
.||||      .  | . .  . .|   ..|.| | | | .||.. |.|...|||||.|| |  | .|.   .|| | |...   |     |.  .  ||
MEYCSGG----EMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCG

TPNFQAPEVVSR-NGHSC--KSDIWALGCIMYTVLTGTPPFAAAPL--------SEMYQNIRDGHYL-EPTHLSPSARSLIARLLAPDPAERPSLDHLLQ
.|...|||.... | . .  | |||..| |.|. ..|. || ....         .. ..... .|   . |.| ..|.|| ..| ..| .||... ...
SPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMN

DDFF
. ..
HPWM
Kinase PLK5.AA SAK 27-283 33 3.3e-66 224.41 In-house 1-254 (254) Show / Hide 
Range on Protein: 27-283
Range on HMM: 1-254/254
Sequence Identity: 33% (87 aa)

YRRGKLIGKGAFSRCYKLTDMSTSAVFALKVVPRGGAGRLRLRGKVEREIALHSRLRHRNIVAFHAHFADRDHVYMVLEYCSRQVPLQSLAHVLKVRRTL
|. ..|.|||.|   |.   ..|    |.|.. .    .  .  .| .|. .|..|.|  |.   ..| |   ||.||| |     .  . | ...    
YQVQHLLGKGGFACVYRAKCIHTHQEVAIKMIDKKLMQKTGMVQRVRNEVEIHCQLKHPSILELYNYFEDNNYVYLVLEMCHNGEMHRYMKHRMRP---F

TEPEVRYYLRGLVSGLRYLHQQRIVHRDLKPSNFFLNKNMEVKIGDLGLAARVGPAGRCHRVLCGTPNFQAPEVVSRNGHSCKSDIWALGCIMYTVLTGT
|| | | ... .| |. |||   |.||||  ||  | ..|..|| | |||. .      |  .|||||. .||...|  |  .||.|.|||..||.|.|.
TEEEARHFMHQIVIGMLYLHSHGIMHRDLTLSNILLTRDMHCKIADFGLATQLKMPHEKHYTMCGTPNYISPEIATRTAHGLQSDVWSLGCMLYTLLIGR

PPFAAAPLSEMYQNIRDGHYLEPTHLSPSARSLIARLLAPDPAERPSLDHLLQDDFF
|||      .    .    |  |.|||  |. || ..|  .|.|| .|.  |   | 
PPFDTDAVKNTLNKVMMAEYIMPAHLSMEAQDLIHKMLRKNPHERITLSTVLCHPFM
Kinase PLK5.AA MARK 27-283 30 4.6e-66 214.99 In-house 1-262 (262) Show / Hide 
Range on Protein: 27-283
Range on HMM: 1-262/262
Sequence Identity: 30% (82 aa)

YRRGKLIGKGAFSRCYKLTDMSTSAVFALKVVPRGGAGRLRLRGKVEREIALHSRLRHRNIVAFHAHFA--DRDH-VYMVLEYCSRQVPLQSLAHVLKVR
|. .| ||.|...  .. ..  |   .|.|....    .   . .|.|||.....| | ||. ..  .   .. | .|...||.|..    .| . .| .
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGG----ELYDYIKAH

--RTLTEPEVRYYLRGLVSGLRYLHQQRIVHRDLKPSNFFLNKNM--EVKIGDLGLAARVGPAGRCHRVLCGTPNFQAPEVVSRNGHS-CKSDIWALGCI
  . |.|.| | . | .||.. |.|...|||||.|| |  . .|.   .|| | |..... | |.     |||| . |||....      | |||.|| .
PNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPP-GQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVV

MYTVLTGTPPFAAAP--LSEMYQNIRDGHYLEPTHLSPSARSLIARLLAPDPAERPSLDHLLQDDFF
.|. ..|. || ..   . |.|..|. |.|  |.|.|...|.|| ||| ..| |||... .... ..
LYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase PLK5.AA STE 27-283 21 4.1e-62 212.67 In-house 1-359 (359) Show / Hide 
Range on Protein: 27-283
Range on HMM: 1-359/359
Sequence Identity: 21% (78 aa)

YRRGKLIGKGAFSRCYKLTDM------STSAV---------FALKVVPRGGAGR--------------LRLRGKVEREIALHSRLR--HRNIVAFHAHFA
... . ||||||   ||  ..      .|  |         .| |...                       . ....|| ......  | ||| .. .. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

D-------RDHVYMVLEYCSRQVPLQSLAHVLKVRRTLT----------EPEVRYYLRGLVSG-LRYLHQQRIVHRDLKPSNFFLNKNMEVKIGDLGLAA
.       .|......||..     . . |. .. ..|.          |....|..| .. | | |||...|.|||.||.| .|     ||. | |...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

RVGP---------------AGRCHR-VLCGTPNFQAPEVVSR------NGHSCKSDIWALGCIMYTVLTGTPPFAA-APLSEMYQNIRD-----------
.. .                .  .|  ..||| . ||||...      .|...|.||| ||| .   .|| ||..   |.. |.. ..            
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---GHY---LE-----------------PTHLSPSARSLIARLLAPDPAERPSLDHLLQ--DDFF
   |.     .                 |...||. .  |.. |  || .||. . ||.    |.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase PLK5.AA RSK 116-283 28 1.9e-47 163.93 In-house 89-278 (278) Show / Hide 
Range on Protein: 116-283
Range on HMM: 89-278/278
Sequence Identity: 28% (55 aa)

LAHVLKVRRT--LTEPEVRYYLRGLVSGLRYLHQQRIVHRDLKPSNFFLNK---NMEVKIGDLGLAAR-VGPAGRCHRVLCGTPNFQAPEVVS----RNG
. | .| ..   ..| |...|.. .|. ...|||| |.||||||.|  ..    . ..|. | |..   .   .      |.| .. |||..     ..|
FTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGG

HSCKSDIWALGCIMYTVLTGTPPFAA---APLSEMYQNIRDGH--YLEP--THLSPSARSLIARLLAPDPAERPS-----LDHLLQDDFF
|.   |.| ||..||. ||| |||..   .  .|  ..|. |.     |    ||. |..|| ..|  ||. |..     .. ..|. .|
HDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase PLK5.AA TyrKc 27-282 20 1.7e-15 27.87 SMART 1-280 (280) Show / Hide 
Range on Protein: 27-282
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

YRRGKLIGKGAFSRCYK--LTDMSTSAVFALKVVPRGGAGRLRLRGKVEREIALHSRL--RHRNIVAFHAHFADR-------DHVYMVLEYCSRQVPLQS
 . || .| ||| . ||  ..        | |..  .       |    ||. . ..|  .| |||....   .        . ...|.||..    |..
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKD

LAHVLKVRRTLTEPEVRYYLRGLVSGLRYLHQQRIVHRDLKPSNFFLNKNMEVKIGDLGLAARVGPA---GRCHRVLC-----GTP-----NFQAPEVVS
  .  . .  |. ..  ..     .| .|||.....||||   |  ...|  |||.| ||.  ..     |  . .       |.         |||.  
YLRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

RNGHSCKSDIWALGCIMYTVLT-GTPPFAA-----APLSEMYQNIRDGHYLEPTHL---------SPSARSLIARLLAPDPAERPSLDHLLQDDF
 .  . |||.|. |  |. ..| | .|         . .|.......|..... .          ..   ... .  . ||..||.   .  ..|
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase PLK5.AA RSK 29-108 27 3.3e-10 33.89 In-house 1-84 (278) Show / Hide 
Range on Protein: 29-108
Range on HMM: 1-84/278
Sequence Identity: 27% (23 aa)

RGKL--IGKGAFSRCYKLTDMSTSAVFALKVVPRGGAGRLR--LRGKV-EREIALHSRLRHRNIVAFHAHFADRDHVYMVLEYCS
   |  .|.|... | | |.  |  ..| ||. .  . .    .| .  ||.| .... .| .||  |  | . ...|...|||.
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQ-QHPFIVTLHYAFQTEGKLYLIMEYCR
Kinase PLK5.AA Pkinase_Tyr 74-176 27 1.4e-07 26.3 Pfam 52-158 (270) Show / Hide 
Range on Protein: 74-176
Range on HMM: 52-158/270
Sequence Identity: 27% (31 aa)

REIALHSRL-RHRNIVAFHAHFA-DRDH--VYMVLEYCSRQVPLQSLAHVLKV----RRTLTEPEVRYYLRGLVSGLRYLHQQRIVHRDLKPSNFFLNKN
||... . | .| ||| ...    ....  .|.|.||.       .| . |.     .. || ..   . .   .|. ||......||||   |  ...|
REAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHG----DLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTEN

MEVKIGDLGLA
. |||.| |||
NVVKICDFGLA
Kinase PLK5.AA Pkinase_Tyr 197-249 30 0.011593 9.64 Pfam 182-237 (270) Show / Hide 
Range on Protein: 197-249
Range on HMM: 182-237/270
Sequence Identity: 30% (17 aa)

APEVVSRNGHSCKSDIWALGCIMYTVLT-GTPP-FAAAPLSEMYQNI-RDGHYLEP
|||. . .  . |||.|. |  |. ..| |  | ..  . .|.|. | .||. ...
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPC
POLO_box PLK5.AA POLO_box 424-487 31 8.9e-21 80.14 Pfam 1-74 (74) Show / Hide 
Range on Protein: 424-487
Range on HMM: 1-74/74
Sequence Identity: 31% (23 aa)

YSLKYGFGYQLSDGGSGVL-FRDGSHMALRPQGG-HVSYQP--DQGTLWTFTLRD------VPSPLRAKLAVLR
|. |||..||||.|  .|. | |.....| |... .|.|     ... .|..| .      .|. |. || .|.
YRTKYGIMYQLSNGTVQVNFFNDHTKIILCPNMKYAVTYIDHDPNWQRQTYPLSTILEHGCYPEDLQKKLTYLK
POLO_box PLK5.AA POLO_box 520-537 38 0.17954 9.04 Pfam 1-18 (74) Show / Hide 
Range on Protein: 520-537
Range on HMM: 1-18/74
Sequence Identity: 38% (7 aa)

IADSQAMVMLFSNGTVQV
  . .......|||||||
YRTKYGIMYQLSNGTVQV