Gene PLK4 (Mouse)

PLK4

Species: Mouse
Alias: Stk18, PLK4
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Other
Family: PLK
Subfamily: SAK

Sequence

Name Sequence Type Origin Length Description Download
PLK4.AA Protein Sugen 925 None Fasta, JSON
PLK4.NA RNA Sugen 3098 None Fasta, JSON
PLK4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 254 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of PLK4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PLK4.AA SAK 12-265 80 8.3e-201 673.4 In-house 1-254 (254) Show / Hide 
Range on Protein: 12-265
Range on HMM: 1-254/254
Sequence Identity: 80% (204 aa)

FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSVLELYNYFEDNNYVYLVLEMCHNGEMNRYLKNRMKPFSER
..|..|||||.||.||||..|||..||||||||||.|.|.||||||.|||.|||||||||.|||||||||||||||||||||||||.||.|.||.||.|.
YQVQHLLGKGGFACVYRAKCIHTHQEVAIKMIDKKLMQKTGMVQRVRNEVEIHCQLKHPSILELYNYFEDNNYVYLVLEMCHNGEMHRYMKHRMRPFTEE

EARHFMHQIITGMLYLHSHGILHRDLTLSNILLTRNMNIKIADFGLATQLNMPHEKHYTLCGTPNYISPEIATRSAHGLESDIWSLGCMFYTLLIGRPPF
|||||||||..||||||||||.|||||||||||||.|..|||||||||||.||||||||.||||||||||||||.||||.||.||||||.||||||||||
EARHFMHQIVIGMLYLHSHGIMHRDLTLSNILLTRDMHCKIADFGLATQLKMPHEKHYTMCGTPNYISPEIATRTAHGLQSDVWSLGCMLYTLLIGRPPF

DTDTVKNTLNKVVLADYEMPAFLSREAQDLIHQLLRRNPADRLSLSSVLDHPFM
|||.||||||||..|.|.|||.||.|||||||..||.||..|..||.||.||||
DTDAVKNTLNKVMMAEYIMPAHLSMEAQDLIHKMLRKNPHERITLSTVLCHPFM
Kinase PLK4.AA PLK 12-265 45 3.7e-177 581.33 In-house 1-258 (258) Show / Hide 
Range on Protein: 12-265
Range on HMM: 1-258/258
Sequence Identity: 45% (117 aa)

FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSVLELYNYFEDNNYVYLVLEMCHNGEMNRYLKNRMKPFSER
...|..|||| || .|....|||. ..|||...|. |.| .. .....|..||.||.||........|||...||.|||.|||.....|.|.|.|...| 
YERGHFLGKGGFAKCYEMTDIHTKQVYAIKVVPKSLMQKPHQREKMKQEIEIHRQLHHPNIVKFHHFFEDHENVYIVLEYCHNRSLMHYHKRRAKRLTEP

EARHFMHQIITGMLYLHSHGILHRDLTLSNILLTRNMNIKIADFGLATQLNMPHEKHYTLCGTPNYISPEIA--TRSAHGLESDIWSLGCMFYTLLIGRP
|.|..|.||..|..|||.|.|.||||.|.|..|..||..||.||||||.|....|...|.|||||||.||..  ... |..|.|.|||||..||||||.|
EVRYYMYQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFGLATRLEYDGERKKTMCGTPNYIAPEVLDGNKQGHSYEVDCWSLGCIMYTLLIGKP

PFDTDTVKNTLNKVVLADYEMPAF--LSREAQDLIHQLLRRNPADRLSLSSVLDHPFM
||.|..||.|..... ..|..|.   .| ||.|||...|..||..|.... .|.|||.
PFETKDVKETYKRIKHNHYSFPEHCPISDEAKDLIQKMLNWNPDERPTIDQILQHPFF
Kinase PLK4.AA Aur 12-265 36 9.40000000001e-111 293.4 In-house 1-257 (257) Show / Hide 
Range on Protein: 12-265
Range on HMM: 1-257/257
Sequence Identity: 36% (94 aa)

FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSVLELYNYFEDNNYVYLVLEMCHNGEMNRYLKNR-MKPFSE
|..| .||||.|  || |   .|.  .|.|...|. . | .|.. ...|.||. .|.|| .|..|.||.|....||.||   .||. ..|..  .| |.|
FEIGKPLGKGKFGNVYLARHKKTHFIFALKVMFKEQIKKYCMEHQLRREIKIQSHLNHPNILKMYGYFHDDQRIYLILEYAPGGELYKELQKQPNKRFDE

REARHFMHQIITGMLYLHSHGILHRDLTLSNILLTR-NMNIKIADFGLATQLNMPHEKHYTLCGTPNYISPEIATRSAHGLESDIWSLGCMFYTLLIGRP
 .|  .| ||. .  |.|| .| |||.   ||||   | ||||.||| ... .  ...  |.|||  |..||.  .  |. . |||.|| . | |. |.|
QRAAKYMYQICNALDYCHSKNIIHRDIKPENILLDQCNGNIKICDFGWSVHCPN-NNRRMTFCGTLDYMPPEMVEGQMHDHKVDIWCLGVLCYELCHGCP

PFDT-DTVKNTLNKVV-LADYEMPAFLSREAQDLIHQLLRRNPADRLSLSSVLDHPFM
||   .. . |. ..    |...| ..| ||.||| ..|...|  |..|  .. ||..
PFESNENHDETYDRIKNKVDIQFPSHISKEAKDLISKILQHDPKQRMTLDQIMNHPWI
Kinase PLK4.AA AGC 12-265 23 4.6e-108 279.94 In-house 1-395 (395) Show / Hide 
Range on Protein: 12-265
Range on HMM: 1-395/395
Sequence Identity: 23% (92 aa)

FKVGNLLGKGSFAGVYRAESIH------TGLEVAIKMIDKKA-MYKAG--MVQRVQNE------------VKIHCQLK----------HPSVLE-LYNYF
|..  ..|||||  || ..  .      ||   |.|...||  ...    ||.....|             .|  ...          || .   |.  |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

EDNNY--VYLVLEMCH---------NG-EMNRYLKN--RMKPFSEREARHFMHQ-------IITGMLYLHS-HGILHRD-LTLSNILLTRNMNIKIADFG
.|...  .|.|.| .           | |.  .|..  . . |.| .||... .       |. .. |||| .|| ||| | . ||||... .||..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LATQLNMPH--------------------------------------------------EKHYTLCG--TPNYISPEIATRSAHGLESDIWS--LGCMFY
|...... .                                                  .. .|.||  ||.|..|||     .| . |.||  |||..|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

TLLIGRPPFDTDT----------VKNTLNKVV------LADYEMP----------AFLSREAQDLIHQLLRRNPADRLS----------LSSVLDHPFM
 .|.|.|||  |.           . . .|.         . ..|           ..| ||.||| .|| ..|..||            . . .||. 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PLK4.AA PLK-Unclassified 12-265 42 9.90000000001e-107 360.88 In-house 1-264 (264) Show / Hide 
Range on Protein: 12-265
Range on HMM: 1-264/264
Sequence Identity: 42% (111 aa)

FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSVLELYNYFEDNNYVYLVLEMCHNGEMNRYLKNR------M
 ..| .|||| || .| . .| |  . |.| |.|  ..|    |.  .| ||| .|.|. .   .  |||. .||..||.| || .. |.| |       
YHRGHFLGKGGFAKCYQVKNIETKKIYAAKIIPKSSLTKNRARQKLISEIKIHKSLHHKNIVKFEHCFEDHENVYILLEYCPNGTLMEYIKRRNFQLFEK

KPFSEREARHFMHQIITGMLYLHSHGILHRDLTLSNILLTRNMNIKIADFGLATQLNMPHEKHYTLCGTPNYISPEIATRSA--HGLESDIWSLGCMFYT
|  .| |.. .  ||. .  |||...| |||| | ||.|. ||..||.|||||| |.   || .| |||||||.|||   .   |. |.|.||.||. ||
KRLTEYEVKCYTYQIVQALKYLHQNRIIHRDLKLGNIFLNDNMEVKICDFGLATKLENDGEKKKTICGTPNYIAPEILDGKHQGHSYEVDCWSFGCILYT

LLIGRPPFDTDTVKNTLNKVVLADY--EMPAFLSREAQDLIHQLLRRNPADRLSLSSVLDHPFM
||||.||| |  ||.|. |.   .|  . |. .| .| ||| . |  ||. |....  ..|||.
LLIGKPPFETKDVKQTYKKIKCNQYSFPEPCHISDNAKDLIQHILNWNPDQRPTIDQIMMHPFY
Kinase PLK4.AA S_TKc 12-265 34 2.1e-102 347.44 SMART 1-231 (231) Show / Hide 
Range on Protein: 12-265
Range on HMM: 1-231/231
Sequence Identity: 34% (92 aa)

FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSVLELYNYFEDNNYVYLVLEMCHN--GEMNRYLKNRMKP--
.......|||.|. ||..  ..|| .||||.|.          .....|..|. . .|| .  || .|.| ...|.|.|.| .  |.. .|.|.| ..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FSEREARHFMHQIITGMLYLHSHGILHRDLTLSNILLTRNMNIKIADFGLATQLNMPHEKHYTLCGTPNYISPEIATRSAHGL-ESDIWSLGCMFYT
   |.| .||..|.||. .. |.|||||.||||  .||||..  .|||.|||||.||       .|.||||.|..||.     .|  ..|.||.||..| 
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LLIGRPPFDTDTVKNTLNKVVLADYEMPAFLSREAQDLIHQLLRRNPADRLSLSSVLD-------HPFM
.| |.|||.  ... ...|..          |.|| |.| ..|...|..|..   .|        ||..
MLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PLK4.AA CAMK 17-265 23 5.1e-99 319.72 In-house 1-425 (425) Show / Hide 
Range on Protein: 17-265
Range on HMM: 1-425/425
Sequence Identity: 23% (98 aa)

LLGKGSFAGVYRAESIHTG------------LEVAIKMIDKKAMYK-------------------------AGMVQRVQNEVKIHCQ-------LKHPSV
 ||.|||. |.... ..|.             .||||.|||| . .                         . . ..|..|..|. .       |.|| .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LELYNYFED-------------------NNYVYLVL---EMCHNGEM----NRYLKNR--------------MKPFSEREARHFMHQIITGMLYLHSHGI
. || ..||                   ....|.|.   |.| .||.      |.. .               . |.|||||....||. .. |.|||.|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LHRDLTLSNILLTRNM-----------------NIKIADFGLATQLNM-----------------------PHEKHYTLCGTPNYIS-PEIATR------
 |||| . ||||. |.                 ||||.|||.|....                        . .| .| |||| |.. ||.  .      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------SAHGLESDIWSLGCMFYTLLIGRPPFDTD-------------TVKNTLNKVVLADYE-MPAFLSR-----------------------EAQD
          .| ..|.||.|.. |..| |.|||. |             . .... |.  ..|.  | ..|                        |..|
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIHQLLRRNPADRLSLSSVLDHPFM
|| ..|...| .|.... .|.||.|
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase PLK4.AA CAMKL 12-265 33 1.3e-92 295.89 In-house 1-297 (297) Show / Hide 
Range on Protein: 12-265
Range on HMM: 1-297/297
Sequence Identity: 33% (100 aa)

FKVGNLLGKGSFAGVYRAES-IHTGLEVAIKMIDKKAMYK-------------AGMVQRVQNEVKIHCQLK---HPSVLELYNYFEDNNY------VYLV
...|  ||||||. |  |.  ..|| .||||.|||| . .               .. |.. |..|. .|.   || .  ||  .|. ..      .|||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

LEMCHNGE--MNRYLKNRM---KPFSEREARHFMHQIITGMLYLHSHGILHRDLTLSNILLTRNM--NIKIADFGLATQ---L-NMPHEKHYTLCGTPNY
.| | .||  .  |....    ....|.|||..  ||. .. |.||||| |||. . ||||. |.  ||||.|||....     . | .|  | ||.|.|
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

ISPEIATR---SAHGLESDIWSLGCMFYTLLIGRPPFDTDTVK-------NTLNKVVLADYEMPAF--LSREAQDLIHQLLRRNPADRLSLSSVLDHPFM
 .|||  .   . .| . ||||.| . |... |. ||| ||..       . ..|.    |..| .  .| ...|||...| .|| .| ..  .. ||.|
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase PLK4.AA PLK1 12-265 38 3.8e-90 296.5 In-house 1-253 (253) Show / Hide 
Range on Protein: 12-265
Range on HMM: 1-253/253
Sequence Identity: 38% (99 aa)

FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSVLELYNYFEDNNYVYLVLEMCHNGEMNRYLKNRMKPFSER
.. |  |||| ||  |  .  .|   .| |.. |. . |    ...  |..|| ||.|. . .....|||...||.|||.|.   .   |. | |.  | 
YEKGRFLGKGGFAHCYEIRDKDTKEVFAGKVVPKSLLIKQHQRDKMTQEIQIHRQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLME-LHKRRKAITEP

EARHFMHQIITGMLYLHSHGILHRDLTLSNILLTRNMNIKIADFGLATQLNMPHEKHYTLCGTPNYISPEIATRSAHGLESDIWSLGCMFYTLLIGRPPF
|.|..|.||. |..|||   |.|||| | |. |  ....|| ||||||....  |.  ||||||||| ||. ..  |  | ||||.||..|.||.|.|||
ECRYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDGERKKTLCGTPNYIAPEVLNKKGHSFEVDIWSIGCIMYILLFGQPPF

DTDTVKNTLNKVVLADYEMPAFLSREAQDLIHQLLRRNPADRLSLSSVLDHPFM
.| ..|.|  ..  ..| .|  .|. |..||...|  .|  |   . ||   |.
ETKCLKETYSRIKKNEYRIPSHISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF
Kinase PLK4.AA PLK2 12-265 39 2.3e-88 284.61 In-house 1-257 (257) Show / Hide 
Range on Protein: 12-265
Range on HMM: 1-257/257
Sequence Identity: 39% (103 aa)

FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSVLELYNYFEDNNYVYLVLEMCHN----GEMNRYLKNRMKP
.  | ||||| ||  | .  . |.   |.| . .    |      . .|. .| ||.|. . . . .|||   .|..|| |        |   .| | . 
YCRGKLLGKGGFARCYEMTDMDTHYVYAVKIVPHSRVAKPHQREKMEREIELHRQLRHRHIVQFHHHFEDRDNIYILLEYCSRQVPLKSMAHMWKVR-HH

FSEREARHFMHQIITGMLYLHSHGILHRDLTLSNILLTRNMNIKIADFGLATQLNMPHEKHYTLCGTPNYISPEIATRSAHGLESDIWSLGCMFYTLLIG
  | | | .| ||. |. |||...|.|||| |.|  .. || .|| |||||  |  . . | |.|||||||.||.  |  |. |||||.|||  ||.|.|
LTEPEVRYYMRQIVSGLRYLHQQCIIHRDLKLGNFFINDNMEVKIGDFGLAARLEPEEHCHRTMCGTPNYIAPEVLNRQGHSCESDIWALGCIMYTMLCG

RPPFDTDTVKNTLNKVVLADYEMPAFLSREAQDLIHQLLRRNPADRLSLSSVLDHPFM
|||| |   | |   .  . | ||. ||  |  || ..|. .|.|| ||  ...| | 
RPPFETANLKETYRCIRHNHYHMPTHLSPPARHLIARMLSPDPEDRPSLDHIIRHDFF
Kinase PLK4.AA Pkinase 12-265 31 5.1e-87 300.2 Pfam 1-293 (293) Show / Hide 
Range on Protein: 12-265
Range on HMM: 1-293/293
Sequence Identity: 31% (93 aa)

FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQN--EVKIHCQLKHPSVLELYNYFEDNNYVYLVLEMCHNG----EMNRYLK-NR
...|  .|.|||. ||..  . || .||.| |.|.   | .. |.  .  |..|.  |.|| ...|| .|||....|.|.| | .|    .  .|..  |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

MKPF--SEREARHFMHQIITGMLYLHSHGILHRDLTLSNILLTRNMNI----KIADFGLATQL-NMPHEKHYTLCGTPNYISPEIAT-RSAHGLESDIWS
 ..|  ||.|....| ||. |. |.||.||.|||| ..|||. .|..|    ||.||||| |. . . .  .|.||||.|..||.   .. .| ..|.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGCMFYTLLIGRPPFDTD------TVKNTLNKVVLADYEMPAFLS---------------------REAQDLIHQLLRRNPADRLSLSSVLDHPFM
.||..| .| |||||. .      . .  ....  .... . . .                     .|..|.|  .|...|..|..   .| ||..
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase PLK4.AA Ciliate-E2 12-265 23 3.6e-78 265.99 In-house 1-365 (365) Show / Hide 
Range on Protein: 12-265
Range on HMM: 1-365/365
Sequence Identity: 23% (87 aa)

FKVGNLLGKGSFAGVYRAESIHTG-----------------------LEVAIKMIDKKAMYKAGMVQRVQ----------NEVKIHCQLKHPSVLELYNY
.|. ...|.|.|. ||... . ..                        ..|.|.. |.      .....           || .|  ||.|| ....| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--DNNYVYLVLEMCHNGEMNRYLKNR-MK---------PFSEREARHFMHQIIT---------------GMLYLHSHG-ILHRDLTLSNILLTRNMNI
|.  |.|..|||.| |  |..  |.||.  |         .|.|.|....| ||.                .. |||| . |.|||. ..|||.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIADFGLATQLNMPHE-------------------------------KHYTLCGTPNYISPEIATRSA---------HGLESDIWSLGCMFYTLLIGRPP
||.||||..... ...                                ..|.||||.| .|||  .           .. ..||||||...| .| |.||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FDTDTVKNTLNKVVLADYEMPAF------------------LSREAQDLIHQ----LLRRNPADRLS-LSSVLDHPFM
|        ...    ... | .                  .| |..||| .    .| ..|  |..  . .|.||..
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase PLK4.AA Pkinase_Tyr 12-158 32 1.5e-27 93.9 Pfam 1-158 (270) Show / Hide 
Range on Protein: 12-158
Range on HMM: 1-158/270
Sequence Identity: 32% (52 aa)

FKVGNLLGKGSFAGVYRAESI----HTGLEVAIKMIDKKAMYK-AGMVQRVQNEVKIHCQL-KHPSVLELYNYFE-DNNY--VYLVLEMCHNGEMNRYLK
 . |  ||.|.|  ||...       |...||.||.  .|| .   . .   .|.|| .|| .|| .. ||     .     .|.|.| . .| .  ||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN-CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

NR---MKPFSEREARHFMHQIITGMLYLHSHGILHRDLTLSNILLTRNMNIKIADFGLA
..    .|..  .  .. .||  || ||.|... ||||   |.|.|.|. .||.|||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase PLK4.AA TyrKc 12-265 22 3.8e-18 67.54 SMART 1-280 (280) Show / Hide 
Range on Protein: 12-265
Range on HMM: 1-280/280
Sequence Identity: 22% (67 aa)

FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQL--KHPSVLELYNYFEDN-------NYVYLVLEMCHNGEMNRYLK
 . |  || | |  ||... .   ..||.||. . |      ..   .| .| |.|  .|| .. || .  .          ...|.| . .|  . ||.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

NRMKPFSEREARHFMHQIITGMLYLHSHGILHRDLTLSNILLTRNMNIKIADFGLATQLNMP-----HEKHYTL----CGTP----NYISPEIATRSAHG
.. . .. ..  .|..||  || ||||... ||||   |.|...|  .||.||||.  .         .. |.     .|         .||    .   
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

LESDIWSLGCM---FYTLLIGRPPFDT-----DTVKNTLNKVVLADYEMPAFL---------SREAQDLIHQLLRRNPADRLSLSSVLDHPFM
 .||.|| | .    .|.  | .|         . .  ...|   .. ..            . |  ... |  ...|.|| . | .  | ..
TKSDVWSFGVCMWEIFTY--GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
POLO_box PLK4.AA POLO_box 847-911 25 6.7e-16 62.33 Pfam 1-74 (74) Show / Hide 
Range on Protein: 847-911
Range on HMM: 1-74/74
Sequence Identity: 25% (19 aa)

FVKNVGWATQLTSGAVWVQ-FNDGSQLVVQAGVS-SISYTS--PDGQTTRYGENEKL-----PEYIKQKLQCLS
.  . |.  ||. | |.|. |||.........   ...|..  |..|...|  .. |     || ...||..|.
YRTKYGIMYQLSNGTVQVNFFNDHTKIILCPNMKYAVTYIDHDPNWQRQTYPLSTILEHGCYPEDLQKKLTYLK