Gene PKN2 (Mouse)

PKN2

Species: Mouse
Alias: PKN2, 6030436C20Rik
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: AGC
Family: PKN

Sequence

Name Sequence Type Origin Length Description Download
PKN2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 260 Kinase domain by global Sugen HMM Fasta, JSON
PKN2.AA Protein Sugen 983 None Fasta, JSON
PKN2.NA RNA Sugen 6207 None Fasta, JSON

Protein domain

Protein domains of PKN2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
HR1 PKN2.AA HR1 47-114 32 9.2e-21 77.58 Pfam 1-74 (74) Show / Hide 
Range on Protein: 47-114
Range on HMM: 1-74/74
Sequence Identity: 32% (24 aa)

DIKDRIKREIRKELKIKEGAENLRKV---TTDKKN----LAYVDNILKKSNKKLEELHHKLQELNAHIVVSDPED
. .......|..|.||||||||.|..   |||.|     .. ... |. ||.|.|.|...|..|... .. .|..
QRLQQLRKKIEREMKIKEGAENMRRAYQMTTDNKKHRKVRQQCQQMLRESNQKIEYLRMQLEKLQQRHQD-HPPN
HR1 PKN2.AA HR1 136-208 36 1e-19 73.85 Pfam 1-74 (74) Show / Hide 
Range on Protein: 136-208
Range on HMM: 1-74/74
Sequence Identity: 36% (27 aa)

NRLMALQKQLDIELKVKQGAENMIQMY--SNGSSKDRKLHGTAQQLLQDSKTKIEVIRMQILQAVQTNELAFDNA
.|| .|.|....|.|.|.|||||...|  ... .|.||..  .|| |..|..||| .|||. .  | ..   . .
QRLQQLRKKIEREMKIKEGAENMRRAYQMTTDNKKHRKVRQQCQQMLRESNQKIEYLRMQLEKLQQRHQD-HPPN
HR1 PKN2.AA HR1 217-289 26 2.7e-19 72.34 Pfam 1-74 (74) Show / Hide 
Range on Protein: 217-289
Range on HMM: 1-74/74
Sequence Identity: 26% (20 aa)

LRMEELRHHFKIEFAVAEGAKNVMKLL--GSGKVTDRKALSEAQARFNESSQKLDLLKYSLEQRLNELPRNHPKS
.|...||... .| .. |||.|.....   ...  .||.....|.. .||.||...|. .||..  ...  || .
QRLQQLRKKIEREMKIKEGAENMRRAYQMTTDNKKHRKVRQQCQQMLRESNQKIEYLRMQLEKLQQRHQD-HPPN
C2 PKN2.AA C2 329-462 9 1.1e-10 42.68 SMART 1-92 (92) Show / Hide 
Range on Protein: 329-462
Range on HMM: 1-92/92
Sequence Identity: 9% (15 aa)

TLEVRLMGCQDILENVPGRSKATSVALPGWSPSDNRSSFMSRTSKSKSGSSRNLLKTDDLSNDVCAVLKLDNTVVGQTSWKPIS----NQSWDQ---KFT
||.|... ....                                                  |  ....       .|.... .    |  |..   .|.
TLTVHIIEARNLP-------------------------------------------------DPYVKVY-------KTKVVKNTLSGFNPVWNEWMETFY

LELDRSRELEISVYWRDWRSLCAVKFLR-------------LEDFLDNQRHGMC
..... . |...|. .  . .  . . .             |.| | ..|| ..
FDVHP-Q-LRFEVWDH--DFIGHCCIPPNNPHWHQWDGCIHLSDIL-GYRH-WW
C2_PKD PKN2.AA C2_PKD 386-488 19 6.7e-10 31.41 In-house 32-147 (183) Show / Hide 
Range on Protein: 386-488
Range on HMM: 32-147/183
Sequence Identity: 19% (23 aa)

DDLSNDVCAVLKLDNTV----VGQTSW-KPISNQSWDQKFTLELDRSRELEISVYWRDW---RSLCAVKFLRLEDFLD-----NQRHGMCLYLEPQGTLF
|. ..|.  |...|...    .|||   |..    |...|  .....|...| .. ..    .. .|    .|||        .   .. . ||||| ..
DCEAIDPYCVVHVDEKHENQHIGQTTQKKKTFYPEWNKCFDHHVYEGRHIQIVCMHNAIMPPNKMVAECTMKLEDCIEMCKTNSGITHIWINLEPQGKVH

AEVTFFNPVIERRPKL
. .  ||.. ......
VQIKWFNEDTDHKHHC
Kinase PKN2.AA PKN 656-915 89 1.1e-208 699.61 In-house 1-260 (260) Show / Hide 
Range on Protein: 656-915
Range on HMM: 1-260/260
Sequence Identity: 89% (232 aa)

FRCCAVLGRGHFGKVLLAEYKHTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSE
|||.|||||||||||||..||||.|..|||||||.||||||||.||||||||||.||..||||||||||||||.||||||||||.|||||||||.|||||
FRCIAVLGRGHFGKVLLSQYKHTGEYYAIKALKKQDIVARDEVESLMCEKRIFEVVNRMRHPFLVNLFACFQTEEHVCFVMEYAMGGDLMMHIHEDVFSE

PRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESP
|||.||||||||||||||||||.|||||||||||||||.|||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||.|
PRACFYAACVVLGLQYLHEHKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLIYEMLVGECP

FPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGAGEKDAEDVKKHPFF
|||||||||||.||||.||||||||.|||.|||||||.||||||||||.||||.|..|||
FPGDDEEEVFDCIVNDDVRYPRFLSVEAIAIMRRLLRKNPERRLGAGERDAEDIKMQPFF
Kinase PKN2.AA AGC 656-915 33 2.7e-185 484.27 In-house 1-395 (395) Show / Hide 
Range on Protein: 656-915
Range on HMM: 1-395/395
Sequence Identity: 33% (133 aa)

FRCCAVLGRGHFGKVLLAEYKH------TNEMFAIKALKKGD-IVARD--EVDSLMCE------------KRIFETVNSVR-------HPFLVN-LFACF
|.   |.|.|.|||| |.. |.      |....|.| ||| . || ..  .|.  | |            ..|.|..|. .       |||.|. |. .|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTKEH--VCFVMEYAA---------GG-DLMMHIHTD----VFSEPRAVFYAAC-------VVLGLQYLHE-HKIVYRD-LKLDNLLLDTEGFVKIADFG
|.|.|  ..|||||.          || .|..|.. .    .|.|.|| ||||.       .||.|.|||. ..|..|| ||..|.||| .| .|..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LCKEGMGYG--------------------------------------------------DRTSTFCG--TPEFLAPEVLTETSYTRAVDWWG--LGVLIY
||||||..|                                                  |||.||||  |||..|||.|    |..|.|||.  ||.|.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLVGESPFPGD----------DEEEVFDSIV------NDEVRYP----------RFLSTEAISIMRRLLRRNPERRLGAGEKD-----AEDVKKHPFF
|||.| .|| ||          ...|.|..|       |..|..|          |..| || .....|| ..||.|||.|..|     ||..|.||.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PKN2.AA PKC 656-915 53 7.29999999999e-153 498.95 In-house 1-262 (262) Show / Hide 
Range on Protein: 656-915
Range on HMM: 1-262/262
Sequence Identity: 53% (142 aa)

FRCCAVLGRGHFGKVLLAEYKHTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTD-VFS
|.   |||.| ||||.||| | |.|..|||.|||  |.  | |.. |.|||.... .   ||||..|. ||||...  |||||  ||||| ||     |.
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWK--HPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFK

EPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGES
|..|.|||| ....||.|||. |.|||||||| ||| || .||||||.|||.| .||.||||||||...|||.| .  |. .|||| .||| |||..| |
EEHARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQS

PFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGAGEKD---AEDVKKHPFF
|| |.||.|.|.|| .|...||| || || ||.  .. .|||.|||.....   ..|...||||
PFHGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase PKN2.AA Akt 656-915 43 1.8e-127 409.61 In-house 1-264 (264) Show / Hide 
Range on Protein: 656-915
Range on HMM: 1-264/264
Sequence Identity: 43% (117 aa)

FRCCAVLGRGHFGKVLLAEYKHTNEMF-AIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTD-VF
|.   |||.| ||||.|.. | |.... |.|.|||  |.....|   . |..| ...|   |||.|||   |||... .|||.|. ||.|  |.. . .|
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCN---HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRF

SEPRAVFYAACVVLGLQYLHEHKIVYRD-LKLDNLLLDTEGFVKIADFGLCKEG-MGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWG-LGVLIYEML
||.|| ||.| ..|....||.. |.||| ||. |.|.| .| ....|||||||. . ..|.| ||||||| ||||.|  . .|.|||||| ||...|||.
SEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMM

VGESPFPGDDEEEVFDSIVNDEVRYP--RFLSTEAISIMRRLLRRNPERRLGAGEKDAEDVKKHPFF
 |  ||  .| .. |. | | .|..|  ...| |. .. ..|| ..|..|||.|..||...| ||.|
CGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase PKN2.AA Eta 656-915 51 4.2e-120 405.3 In-house 1-261 (261) Show / Hide 
Range on Protein: 656-915
Range on HMM: 1-261/261
Sequence Identity: 51% (136 aa)

FRCCAVLGRGHFGKVLLAEYKHTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHI-HTDVFS
|    |||.| ||||.||| | |.|..||| |||  |.  |.|.  |.||||    .  .|||| .|..|||||. . |||||  ||||| .| ..  | 
FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLAR--KHPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFD

EPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGES
|||| |||| |.. |..||.| ..||||||||.||| ||  |.||||.||||.  |  |.||||||...|||.| |  |  .|||| .|||.|||. |..
EPRARFYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMCGQP

PFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGAGE--KDAEDVKKHPFF
||  | |...|.||..|.| || .|. ||.||..  . .||..|||. .   . .....||||
PFEADNEDDLFESILHDDVLYPVWLHKEAVSILKAFMTKNPHKRLGCMTAQGGEHAIRQHPFF
Kinase PKN2.AA Alpha 656-915 50 1.4e-119 403.58 In-house 1-259 (259) Show / Hide 
Range on Protein: 656-915
Range on HMM: 1-259/259
Sequence Identity: 50% (133 aa)

FRCCAVLGRGHFGKVLLAEYKHTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHI-HTDVFS
|    |||.| ||||.||| | |.|..||| |||  |.  | |.  | |||.    .  . |||| .  ||||     |||||  ||||| ||     | 
FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPG--KPPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFK

EPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGES
|| |||||| .  || .|||  |.|||||||| .|| || .||||||.|||.|  .. | ||||||...|||.     | ..||||  ||| |||..|  
EPHAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQP

PFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGAGEKDAEDVKKHPFF
|| |.||.|.| .| . .| ||. .| ||..| . .| ..| .|||.| .. .|...||||
PFDGEDEDELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGCGPDGEQDIREHPFF
Kinase PKN2.AA Delta 656-915 51 9.20000000001e-119 400.85 In-house 1-259 (259) Show / Hide 
Range on Protein: 656-915
Range on HMM: 1-259/259
Sequence Identity: 51% (135 aa)

FRCCAVLGRGHFGKVLLAEYKHTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHI-HTDVFS
|   .|||.| ||||.||| |..|. .|||.|||  ..  |.|.. | |.|.     ...||||  ||  ||||||. |||||  ||||| || ..  |.
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLAL--AWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFD

EPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGES
| || |||. ...|||.||.. |.||||||||.||| .| .||||||.||| |    ..|||||||...|||..    |...||||  |||.||||.| |
EKRARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQS

PFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGAGEKDAEDVKKHPFF
|| |.||.|.|.||.||.  |||... || .....|. |.||.|||  .  . |...|.||
PFHGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKGDIRQHCFF
Kinase PKN2.AA SGK 656-915 39 3.1e-112 347.97 In-house 1-283 (283) Show / Hide 
Range on Protein: 656-915
Range on HMM: 1-283/283
Sequence Identity: 39% (114 aa)

FRCCAVLGRGHFGKVLLAEYKHT------------------NEMFAIKALKKGDIV-------ARDEVDSLMCEK-RIFETVNSVRHPFLVNLFACFQTK
|.   |.| | ||||.... | .                    ..|.| |.|  |.       .. |.   | |.  |    . ..|||.|||   ||||
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVIL---KNMKHPFIVNLHYAFQTK

EHVCFVMEYAAGGDLMMHIH-TDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVL
.   |||.|. ||..  |.     |.|.|| |||| .|. | |||. .|.||||| .|.||| .| ... ||||||||.   | |.||||||| ||||||
WKLYFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVL

TETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGAGEK-DAEDVKKHPFF
    . |.|||| || . |||..|  ||   . .. .| | | . . |.. | .| ...  || ..|. |||.  | |....|.||||
RKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGT--KRDFMEIKNHPFF
Kinase PKN2.AA AktR 656-915 41 2.1e-102 346.53 In-house 1-268 (268) Show / Hide 
Range on Protein: 656-915
Range on HMM: 1-268/268
Sequence Identity: 41% (111 aa)

FRCCAVLGRGHFGKVLLAEYK-HTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIH-TDVF
|.  ..||.| |||| |.. |  .....|.| .|| .|. |   . .  |. | |  . ..|||.|.|. ||||||.  |.||| .||.|  |.     |
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIME--MCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKF

SEPRAVFYAACVVLGLQYLHEH-KIVYRDLKLDNLLLDTEGFVKIADFGLCK-EGMG-YGDRTSTFCGTPEFLAPEVLTE-TSYTRAVDWWGLGVLIYEM
|| .| ||.| ..|.|.|||.| .|.||||| .|.||| .| |||.|||| | ..|  | ... .|||||| .|||..|.   ....|||| .|..||||
SEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEM

LVGESPFPGDDEEEVFDSIVNDE---VRYPRFLSTEAISIMR-RLLRRNPERRLGAGEKDAEDVKKHPFF
..|  ||  .. .. |..| . .   . ||  .| .. ..   .|| .||. ||| . ...|..|.||.|
VTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase PKN2.AA S_TKc 656-915 34 4.8e-102 346.23 SMART 1-231 (231) Show / Hide 
Range on Protein: 656-915
Range on HMM: 1-231/231
Sequence Identity: 34% (95 aa)

FRCCAVLGRGHFGKVLLAEYKHTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAG--GDLMMHIHTDV-
..   ..|.| |||| ..  |.|.. .||| .|          .... | .| .     .||..|.|. .||. .|...||||. |  |||. .|.    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

------FSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTR-AVDWWGLGVL
      |.| .| ||.. ....|.|.|.|.|..|||| .|.|||.   .||.||||...        .||||||...|||||   .|.. ..||| .|..
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

IYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGAGEKDA--EDVKKHPFF
.||||.|. |||  .....|. |.          | ||....|..|...||.|..| |  .  .|.|.||.|
LYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PKN2.AA RSK 659-915 39 1.4e-96 327.17 In-house 1-278 (278) Show / Hide 
Range on Protein: 659-915
Range on HMM: 1-278/278
Sequence Identity: 39% (110 aa)

CAVLGRGHFGKVLLAEYK---HTNEMFAIKALKKGDIVARDE-VDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVF-
  |||.| .||| |   .    |.  .| | |||  ||.|.  .   | | .| |...  .|||.|.|.  |||....  .|||  ||.| .|. . .. 
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQ--QHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHF

---SEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDT---EGFVKIADFGLCKEG-MGYGDRTSTFCGTPEFLAPEVLT----ETSYTRAVDWWGL
   || .| ||.| .|| ...||...|..||||..| |.|    || .|. |||.||..   .. .| |||.| |..|||.|.    .  ...|.||| |
GCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSL

GVLIYEMLVGESPFPG---DDEEEVFDSIVNDE--VRYP--RFLSTEAISIMRRLLRRNPERRLGAGEKDAEDVKKHPFF
|||.||||.| .|| |   .. .|... | . .  .. |   .||.|| .. |..| |.|..|||.| .|||..|.||.|
GVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase PKN2.AA Pkinase 656-915 29 1.1e-84 292.5 Pfam 1-293 (293) Show / Hide 
Range on Protein: 656-915
Range on HMM: 1-293/293
Sequence Identity: 29% (90 aa)

FRCCAVLGRGHFGKVLLAEYKHTNEMFAIKALKKGDIVARDEVDSLM-CEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGG----DLMMHIH-
...  ..|.| ||.| ..  | |....|.| .|| ..    ..  .   | .|   .|   ||. | |. .|..| |...||||. ||    ||. .|. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN---HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

--TDVF--SEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFV----KIADFGLCKE--GMGYGDRTSTFCGTPEFLAPEVLT-ETSYTRAVD
    .|  ||  . ||.  .. ||.|.|...|..||||..|.|.| .| .    ||.||||.|      ..  ..||||||...||||.   . |...||
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVD

WWGLGVLIYEMLVGESPFPGD------DEEEVFDSIVNDEVRYPRFLS---------------------TEAISIMRRLLRRNPERRLGAGEKDAEDVKK
.|..|...|||| |. ||||.      |. .... |   ....... .                      |........|...|..|..     ||....
MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQ

HPFF
||.|
HPWF
Kinase PKN2.AA Pkinase_Tyr 656-858 26 3.3e-22 75.82 Pfam 1-218 (270) Show / Hide 
Range on Protein: 656-858
Range on HMM: 1-218/270
Sequence Identity: 26% (60 aa)

FRCCAVLGRGHFGKVLLAEYK----HTNEMFAIKALKKGDIVARDE--VDSLMCEKRIFETVNSV-RHPFLVNLFACFQ-TKEH--VCFVMEYAAGGDL-
 .   .||.|.||.| ....|     |.   |.| ||       ..   ...| | .|  .     .|| .|.| ..    .|.  .. ||||...||| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQ---LGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

-MMHIH---TDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMG---Y-GDRTSTFCGTPEFLAPEVLTETSYTRA
   . |    . .. .. . ... .  |..||...... |||   | |.. ...|||.||||..  .    |   |...       .|||.. .  .| .
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGKFTTK

VDWWGLGVLIYEMLV-GESP-FPG
 | |  |||..|..  ||.| .||
SDVWSFGVLMWEIFTYGEQPTYPG
Kinase PKN2.AA S_TK_X 916-980 35 3.6e-18 67.59 SMART 1-79 (79) Show / Hide 
Range on Protein: 916-980
Range on HMM: 1-79/79
Sequence Identity: 35% (28 aa)

RLTDWSALMD--KKVKPPFVPTIR----GREDVSNFDDEFTSEAPILTPPRE---PRILLEE-----EQEMFHDFDYVA
| .|| .|    |...|||.|.|.    . .|.||||.|||.|.| |||. .   ...  .|     . ..| .|.||.
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase PKN2.AA TyrKc 656-909 22 7.4e-18 66.04 SMART 1-280 (280) Show / Hide 
Range on Protein: 656-909
Range on HMM: 1-280/280
Sequence Identity: 22% (67 aa)

FRCCAVLGRGHFGKVLLAEYKHTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETV--NSVRHPFLVNLFACFQTK-------EHVCFVMEYAAGGDLMM
 .   .||.|.||.| ....|   .. |.| ||..       .  .| | ||   .  .   || .|.|...  ..       | .. ||||...|||  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGH---HPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

HIHTDV--FSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGY---GDRTSTFCG----TPEF------LAPEVLTET
...     .. .  . ..  .  | .|||..... |||   | |.. .. |||.||||....  .   | ....          .      .|||.. . 
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

SYTRAVDWWGLGVLIYEML-VGESPFPG-----DDEEEVFDSIVNDEVRYPRFL---------STEAISIMRRLLRRNPERRLGAGEKDAEDV
 .| . | |  ||...|..  |..| ||      . .||.  . . . . .            ..|  .||..  ...|| |    |   |. 
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase PKN2.AA Pkinase_C 935-982 39 1.8e-16 61.17 Pfam 1-46 (46) Show / Hide 
Range on Protein: 935-982
Range on HMM: 1-46/46
Sequence Identity: 39% (19 aa)

TIRGREDVSNFDDEFTSEAPILTPPREPRILLEEEQEMFHDFDYVADW
......|.||||.|||.|.| .||  ..| . ...|| |..| ||...
QVKSPTDTSNFDPEFTDEPPMDTP-PDWR-MSSGDQEPFRGFTYVNPD