Gene PKD1 (Mouse)

PKD1

Species: Mouse
Alias: PKD1, Prkcm
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CAMK
Family: PKD

Sequence

Name Sequence Type Origin Length Description Download
PKD1.NA RNA Sugen 3778 None Fasta, JSON
PKD1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 257 Kinase domain by global Sugen HMM Fasta, JSON
PKD1.AA Protein Sugen 918 None Fasta, JSON

Protein domain

Protein domains of PKD1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PKD_Nterm_DUF PKD1.AA PKD_Nterm_DUF 47-135 47 3.3e-44 145.24 In-house 1-87 (87) Show / Hide 
Range on Protein: 47-135
Range on HMM: 1-87/87
Sequence Identity: 47% (43 aa)

ISFHLQIGLSREPVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYG-LYDKILLFRHDPASDNILQLVKIASDIQEGDLIEVVLSASA
 .||.|.|..||.| .    ..  .|. ..| ||....||.|.||... |||||.|||||. |.||||... |||. ||.|||.||||..
CHFHFQCGFHREMVCV---EGHELTLTALKELACQFIEQKYPDCGCCNRLYDKIYLFRHDYNSPNILQMITSASDVTEGCLIEIVLSACP
C1_1 PKD1.AA C1_1 145-197 43 1.9e-16 64.03 Pfam 1-55 (55) Show / Hide 
Range on Protein: 145-197
Range on HMM: 1-55/55
Sequence Identity: 43% (24 aa)

HALFVH-SYRAPAFCDHCGEMLWG-LVRQGLKCEGCGLNYHKRCAFKIPNNCSGV
|   .| ... |.||.||||..|| | .||.||. |..|.|.||. | |..| . 
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 PKD1.AA C1 138-194 24 7.3e-15 56.63 SMART 1-61 (61) Show / Hide 
Range on Protein: 138-194
Range on HMM: 1-61/61
Sequence Identity: 24% (17 aa)

EDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQ-----GLKCEGCGLNYHKRCAFKIPN-------NC
........         |..|.||..|.||. .|     |..|. |....||.|. |.|.       .|
HHWHWWRF--------KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 PKD1.AA C1_3 156-187 25 0.000646 11.46 Pfam 1-30 (30) Show / Hide 
Range on Protein: 156-187
Range on HMM: 1-30/30
Sequence Identity: 25% (8 aa)

AFCDHCGEMLWGLVRQGLKCEGCGLNYHKRCA
 .|. ||. . .  . . .|  |  . |..||
FTCNCCGLPIYR--DPFYHCMQCDFMLHEDCA
C1 PKD1.AA C1 277-326 32 3e-20 74.49 SMART 1-61 (61) Show / Hide 
Range on Protein: 277-326
Range on HMM: 1-61/61
Sequence Identity: 32% (20 aa)

HTFVIHSYTRPTVCQFCKKLLKGLFRQ-----GLQCKDCRFNCHKRCAPKVPN-------NC
|....... .|| |. |.|...|.|.|     |..| .|...|||.|..|||.       .|
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_1 PKD1.AA C1_1 277-329 40 3.1e-18 70.61 Pfam 1-55 (55) Show / Hide 
Range on Protein: 277-329
Range on HMM: 1-55/55
Sequence Identity: 40% (22 aa)

HTFVIH-SYTRPTVCQFCKKLLKG-LFRQGLQCKDCRFNCHKRCAPKVPNNCLGE
| .| | .. .|| |  |.... | |..||..| .| .|||.||..|||..| . 
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1_3 PKD1.AA C1_3 288-319 25 9.5e-05 13.58 Pfam 1-30 (30) Show / Hide 
Range on Protein: 288-319
Range on HMM: 1-30/30
Sequence Identity: 25% (8 aa)

TVCQFCKKLLKGLFRQGLQCKDCRFNCHKRCA
  |. |.. ...  . .  |  | |. |..||
FTCNCCGLPIYR--DPFYHCMQCDFMLHEDCA
PH PKD1.AA PH 429-547 21 1.4e-12 47.96 Pfam 1-92 (92) Show / Hide 
Range on Protein: 429-547
Range on HMM: 1-92/92
Sequence Identity: 21% (26 aa)

VMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILCLEPAKPSALTPVGATPHCFEITTANVVYYVGENVVNPSSSPPNNSVLPS
|.||||.  .. |   .|...  | ..|. ....|. .|. . ||||..  .......        ||||.|.| .                  .... .
VIKEGWLHKKG-KRKSWKKRWFVLFNNCLYYYKDDK-YRPKGSIPLSDC-QVTKVPDN------KRPHCFQIRT-DR-----------------RTYYFQ

GIGPDVARMWEVAIQHALM
   .. .. |  ||| |. 
AESEEEMNDWMQAIQSACR
PH PKD1.AA PH 429-549 18 1.5e-11 45.64 SMART 1-82 (82) Show / Hide 
Range on Protein: 429-549
Range on HMM: 1-82/82
Sequence Identity: 18% (22 aa)

VMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILCLEPAKPSALTPVGATPHCFEITTANVVYYVGENVVNPSSSPPNNSVLPS
| ||||. ...     .|... .|...|.......   .. ..||||.. . | .             ||||.. .                   . . .
VIKEGWLYKKS--K-RWKKRWFVLFNDCLYYYKDK---KPKGSIPLSDCTVRE-P-------------CFEIHH-DR------------------TYYFQ

GIGPDVARMWEVAIQHALMPV
   .. ...|  ||| |. . 
CESEEEMQEWMQAIQKAIHNN
Kinase PKD1.AA PKD 589-845 86 1.5e-233 782.18 In-house 1-260 (260) Show / Hide 
Range on Protein: 589-845
Range on HMM: 1-260/260
Sequence Identity: 86% (225 aa)

IFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQ--ESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPE
||||||||||||||||||.||.|||.||.|.||||||||||  |.|.||||||||...|||||.||||.|||.|.||||||.||||||||||||||||.|
IFPDEVLGSGQFGIVYGGIHRHTGRHVAVKVIDKLRFPTKQSGEEQMRNEVAILQQVCHPGVVCLECMCETPDRIFVVMEKMHGDMLEMILSSEKGRLNE

HITKFLITQILVALRHLHFKNIVHCDLKPENVLLASA-DPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSG
..|||||||||.||..||..||||||||||||||.|. ..||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
RVTKFLITQILCALKYLHHQNIVHCDLKPENVLLSSMGSDFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSG

TFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWL
||||||||||.|||||||||||||||||||..|||||||||||||||||.|||.||||||
TFPFNEDEDINDQIQNAAFMYPPNPWKEISENAIDLINNLLQVKMRKRYTVDKCLSHPWL
Kinase PKD1.AA CAMK 594-845 23 1.7e-107 347.52 In-house 1-425 (425) Show / Hide 
Range on Protein: 594-845
Range on HMM: 1-425/425
Sequence Identity: 23% (99 aa)

VLGSGQFGIVYGGKHRKTG------------RDVAIKIIDK----------------LRFP----------TKQESQLRNEVAILQN-------LHHPGV
.||.|.||.|. ..|..|.            . ||||||||                ...            | . ..|.|..|...       |.|| .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNLECMFE------------TPER--------VFVVM---EKLHG-----DMLEMILSSEK-------------GRLPEHITKFLITQILVALRHLHFKN
..|  ..|            | ..        .. ||   |   |     |....| . ..             ||..|. ..... ||. |....| .|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHCDLKPENVLLASADPFP--------------QVKLCDFGFARIIGE------------------------KSFRRSVVGTPAYLA-PEVLRN-----
|||.||||||.|| . ..                ..|..|||||... .                            . ..|||.| | ||||.      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------KGYNRSLDMWSVGVIIYVSLSGTFPFNED---------------EDIHDQIQNAAFMYPPNP------------WKEISHE--------AI
         ..|... ||||.||| |. |.|..||..|               .... .|... . .|| .            |..|| |        ..
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DLINNLLQVKMRKRYSVDKTLSHPWL
|||...|||   ||....  |.|||.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase PKD1.AA RAD53 592-845 34 4.4e-102 304.88 In-house 4-305 (305) Show / Hide 
Range on Protein: 592-845
Range on HMM: 4-305/305
Sequence Identity: 34% (105 aa)

DEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFP------TKQESQLRNEVAILQNLHHPGVVNLECMFETP-ERVFVVMEKLHG-DMLEMILSSEKGR
...|||| ||.|. .. .||.. |||||||| .|       .| ..|..||| ||..|.|| .....  |.|| . .. |.|.  | . .. | |. |..
SKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSN-KRC

---LPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFP---------------QVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNK-
   . | . |..  |.. |.. || ..|.| ||||||.|... |                  ..|. ||| ....||.|| .   |||.|.||||...| 
QMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFVGEGSFMKTMCGTPQYVAPEVITSKG

--------------GYNRSLDMWSVGVIIYVSLSGTFPFNED-------EDIHDQIQN-AAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSH
              ||... |.|| |.| |..|.|. || .|        .. .|| | . . .|.  |..|| || |||...|.|   |||..|. |.|
HNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEALNH

PWL
||.
PWM
Kinase PKD1.AA S_TKc 589-845 33 7.7e-95 322.29 SMART 1-231 (231) Show / Hide 
Range on Protein: 589-845
Range on HMM: 1-231/231
Sequence Identity: 33% (92 aa)

IFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHG---DMLEMILSSEKGR--
    ...|.| || || ..|.|||| ||||||.          ..|.|..||.. ||| .|.|  .|.. .....||| . |   |....| .  ...  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNR-SLDMWSVGVIIY
  .||  ..|.. ||. || ..| ..|.|.||||||.|| .     ..|.||||.||..      ....||| |.|||||   ||.. . |.||.|.|.|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

VSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLS-------HPWL
  |.|  ||    ...  ...             |.||.|.|...||.  .||... . |        |||.
EMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PKD1.AA AGC 589-845 21 3.5e-87 224.72 In-house 1-395 (395) Show / Hide 
Range on Protein: 589-845
Range on HMM: 1-395/395
Sequence Identity: 21% (86 aa)

IFPDEVLGSGQFGIVYGGKHR------KTGRDVAIKIIDKLR--FPTK--QESQLRNE------------VAILQNLH----------HPGVVN-LECMF
     |.| | || ||  ...       ||.  |.|...| .    .|  .. .  .|              ||....          || .|. | . |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETPER--VFVVME----KLH-----GD-MLEMILSS--EKGRLPEHITKFLITQ-------ILVALRHLHF-KNIVHCD-LKPENVLLASADPFPQVKLC
.....  .. |||     .      |. .| ..|     .||..|  ..| . .       |. || .||  ..|.| | |||||.|| .      .||.
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED---GHIKLT

DFGFARIIG---------------------------------------------------EKSFRRSVVG--TPAYLAPEVLRNKGYNRSLDMWS--VGV
|||.. ..                                                    ..    . .|  || |.|||.|    |... | ||  .|.
DFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGC

IIYVSLSGTFPFNEDE------------DIHDQIQ------NAAFMYPPN------PWKEISHEAIDLINNLLQVKMRKRYS----------VDKTLSHP
..|  |.|  ||. |.            .....|.      |    .|..      .....| || |||. ||..  .||            ..   .||
LMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHP

WL
| 
WF
Kinase PKD1.AA Pkinase 589-845 31 4.7e-79 273.75 Pfam 1-293 (293) Show / Hide 
Range on Protein: 589-845
Range on HMM: 1-293/293
Sequence Identity: 31% (93 aa)

IFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRN--EVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGD----MLEMILS-SEK
.   ...||| || || ..|..||. ||.|||.| .   ... ..|.  |..|...|.|| .| | ..||.. .. .||| . |.     |  ..| ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GRL--PEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFP--QVKLCDFGFARI--IGEKSFRRSVVGTPAYLAPEVLR-NKGYNRSLDMWS
|..  .|.  || ..||| .| ..| ..|.|.||||||.|.   .. .   ||.||||.|.   .  .|   ...||| |.||||.| ...| .. ||||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

VGVIIYVSLSGTFPFNED--------EDIHDQIQNAAFMYPPNPWKEIS-----------------HEAIDLINNLLQVKMRKRYSVDKTLSHPWL
.|.|.|  |.| .|| ..          ....|  . ....   | .||                  |..|.|...|.... ||.. .  | |||.
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase PKD1.AA CAMKL 587-845 30 7.5e-77 244.75 In-house 1-297 (297) Show / Hide 
Range on Protein: 587-845
Range on HMM: 1-297/297
Sequence Identity: 30% (94 aa)

YQIFPDEVLGSGQFGIVYGGKH-RKTGRDVAIKIID--KLRFPTKQESQ-----------LRNEVAILQNLH---HPGVVNLECMFETPER------VFV
|.|   ..|| | || |  ..| | ||. |||||||  |..  .. ..            .| |..|.. |.   || .. |  ..||||       .. 
YRI--GKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYL

VMEKLHGD---MLEMILSSEK--GRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASAD-PFPQVKLCDFGFARIIGE-----KSFRRSVVGT
|||   |    ....| . ..  ||.||| .... .||. |. ..| ..||| |.||||.|| . .    ..|..||||. .. .       . .   |.
VMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN--NIKIIDFGFSNMYRPCIFGPGQKLKTFCGS

PAYLAPEVLRN--KGYN-RSLDMWSVGVIIYVSLSGTFPFNEDEDI---------HDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTL
|.| |||..    | |. .  |.|| ||| |. . |..||..| .          . .|    ...|  .|...| ...|||  .|||.  ||....  .
PPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPP--IWYHVS-DCRDLIRKMLQVNPEKRPTIHQIM

SHPWL
.|||.
NHPWM
Kinase PKD1.AA Ciliate-E2 593-845 23 7.3e-70 238.42 In-house 5-365 (365) Show / Hide 
Range on Protein: 593-845
Range on HMM: 5-365/365
Sequence Identity: 23% (88 aa)

EVLGSGQFGIVYGGKHRKTGR------------------DVAIKIIDKLRFPTKQESQLRNEVAILQNLH----------------HPGVVNLECMFE--
...|.|.||.|| .|..|...                   |.|||. . ..  .|  |. .|  |.. ..                || ....   |.  
KKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEK

TPERVFVVMEKLHG-DMLEMILSS-----------------EKGRLPEHITK-------FLITQILVALRHLHFKN-IVHCDLKPENVLLASADPFPQVK
. . .. ||| . | |... | ..                 | ... ..|..       | |..|..||..|| || |.| |.||||.|.        .|
DDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------IK

LCDFGFARIIGEKSFRRS--------------------------------VVGTPAYLAPEVLRNKG---------YNRSLDMWSVGVIIYVSLSGTFPF
..|||..... ... .|.                                ..||| |.|||.|..|.         |. . |.||.|||.|  |.| .||
IIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF

NEDEDIHDQIQNAAFMYPPN--------------PWKEISHEAIDLINN----LLQVKMRKRYS-VDKTLSHPWL
       .||..  . .|..               ||..| |..|||..    .||..  ||..  .. | |||.
------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase PKD1.AA ULK 589-845 29 3e-65 223.09 In-house 1-324 (324) Show / Hide 
Range on Protein: 589-845
Range on HMM: 1-324/324
Sequence Identity: 29% (95 aa)

IFPDEVLGSGQFG-IVYGGKHRKT---GRDVAIKIIDKLRF-PTKQES-------QLRNEVAILQNLH---HPG--VVNLECMFETPER--VFVVMEKLH
.  ...||.|.||  || |.. ||   . .||.|.|||  .   |.|.       .|.||. |.. |.   ||   .| |  .|||.    .. .||   
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GDMLEMILSSEKG--------RLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPF---------PQVKLCDFGFARIIGE----KSFRRS
|  || ..   |.        ||.| ...  . ||. ....|| .||.|.|.||.| |.   .|          ...|..|||||... .    .  . .
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

VV------GTPAYLAPEVLR----NKGYNRS-LDMWSVGVIIYVSLSGTFP----FNEDE----DIHDQ-------IQNAAFMYPPN-PWKEISHEAIDL
 |      ||| | ||..|     .| |. .  |.||.|.|.|  | |  |    ||...    .  ..       |.|  . .|.. . . || | .||
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDL

INNLLQVKMRKRYSVDKTLSHPWL
|  .||.. ..| | .  ..|||.
IRRMLQYDEKDRISWEEIFNHPWF
Kinase PKD1.AA ULK 589-845 28 1.3e-64 221.02 In-house 1-329 (329) Show / Hide 
Range on Protein: 589-845
Range on HMM: 1-329/329
Sequence Identity: 28% (95 aa)

IFPDEVLGSGQFGIVYGGKHRKT----GRDVAIKIIDKLRF-PTKQESQ-------LRNEVAILQNLH--------HPGVVNLECMFETPER--VFVVME
.  ...||.|.|| || |.. ||    . .||.|.|||  .   ..|..       |.||. |.. |.        || .| |  .|||.    .. .||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

KLHGDMLEMILSSEKG---------RLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPF---------PQVKLCDFGFARIIG----EKS
   |  || ...  |.         ||.| ...  . ||| ....|| .||.|.|.||.|.|.   .|          ...|..|||||. .     |. 
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

FRRSVV------GTPAYLAPEVLR----NKGYNRS-LDMWSVGVIIYVSLSGTFP----FNEDE-----DIHDQ-------IQNAAFMYPPN-PWKEISH
   . |      ||| | ||..|     .| |. .  |.||.|.|.|  | |  |    ||..      .  ..       |..  . .|.. . . || 
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISP

EAIDLINNLLQVKMRKRYSVDKTLSHPWL
| .|||  .||.. ..| | .  ..|||.
ECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase PKD1.AA CAMK1 692-845 38 1e-63 184.04 In-house 113-276 (276) Show / Hide 
Range on Protein: 692-845
Range on HMM: 113-276/276
Sequence Identity: 38% (63 aa)

LITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVK--LCDFGFARIIGEKS-FRRSVVGTPAYLAPEVLRN---KGYNRSLDMWSVGVIIYVSLSG
.. ||| |. ..| |.|||.|||||| |... |.  ..|  ..||| ..|..... .   ..||| | ||||| .   |.|  . ||||.||| |. | |
IMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMWSIGVITYILLCG

TFPFNEDE-D--IHDQIQNAAFMYPPNPWKEISHE-AIDLINNLLQVKMRKRYSVDKTLSHPWL
  ||...  |  . ..| .. . .| . | .|| . | |.|...| |   |||.... | |||.
YPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase PKD1.AA Ciliate-E2-Unclassified 592-845 25 3.1e-63 216.4 In-house 4-352 (352) Show / Hide 
Range on Protein: 592-845
Range on HMM: 4-352/352
Sequence Identity: 25% (91 aa)

DEVLGSGQFGIVYGGKHRKTGRDV-------AIKIIDKLRFPTK----QESQLRNEVA-------------ILQNLHHPGVVNLECMFETPERVFVVMEK
 ...|.|.||.||  .|.|..  .        |.|....   .|    .| .  |.               ||.|. || .|... .|.. . .. |||.
IKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEY

L-HGDMLEMILSSEK---------------GRLPEHITK-----FLITQILVALRHLHFKN-IVHCDLKPENVLLASAD-PFPQVKLCDFGFARIIGE--
. .||....| ...|                ...|  .|     |.. |||..| .|| || |.| |.||||.|. .    . ..|..|||... ...  
CEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNY-YIKIIDFGISKKYQQNN

--------------KSFRRSVVGTPAYL----APEVLRNKGYNRS----LDMWSVGVIIYVSLSGTFPFN--EDED----------------IHDQIQNA
              .    ...||| |.    |||||....|. |     |.||.|||.|  | |..||.   .|.                ....|.. 
NCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQK

AFMYPPNPW----KEISHEAIDLIN----NLLQVKMRKRYSVDKTLSHPWL
 . .|. ||    | .| ||.|.||     .|.... ||.. .. | |||.
NIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase PKD1.AA CAMK1 587-666 28 2.8e-27 76.28 In-house 1-88 (276) Show / Hide 
Range on Protein: 587-666
Range on HMM: 1-88/276
Sequence Identity: 28% (26 aa)

YQIFPDEVLGSGQFGIVYGGKHRKT---GRDVAIKIID-KLRFPTKQE---SQLRNEVAILQN---LHHPGVVNLECMFETPERVFVVME
|...  ...|.| |..|| ..|..|   |...|||.|| |    .| .    .|.||..|...   ..|| ...... .|... .  |||
YEFG--KEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVME
Kinase PKD1.AA TyrKc 589-825 20 1.1e-14 15.04 SMART 1-280 (280) Show / Hide 
Range on Protein: 589-825
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

IFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNL--HHPGVVNLECMFETP-------ERVFVVMEKL-HGDMLEMILS
|  ...||.|.||.|| |. .   ..||.| . .       .  ...|  |. .|  ||| .|.|     ..       | ...|||   ||| .. . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

SEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEK--------SFRRSV-VGTP-----AYLAPEVLRNK
...  |.        .||    ..|| ||..| ||   |.|...     .|| .||| .| |...          | .   |.        .|||... .
HRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

GYNRSLDMWSVGVIIY--VSLSGTFPFN------EDEDIHDQIQNAAFMYPPNP--------------------WKEISHE---AIDLINNL
 ..   | || || ..   .. .. . .      ...... ....   | .|                      |.|  ..     ...  .
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase PKD1.AA Pkinase_Tyr 592-651 32 3.2e-09 31.85 Pfam 4-69 (270) Show / Hide 
Range on Protein: 592-651
Range on HMM: 4-69/270
Sequence Identity: 32% (22 aa)

DEVLGSGQFGIVYGGKHR----KTGRDVAIKIIDKLRFPTKQ--ESQLRNEVAILQNL-HHPGVVNL
...||.|.|| || |. .    .|. .||.|.. |     .|     . .|..|. .| ||| .|.|
GKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRL
Kinase PKD1.AA Pkinase_Tyr 699-767 27 0.011514 9.65 Pfam 123-192 (270) Show / Hide 
Range on Protein: 699-767
Range on HMM: 123-192/270
Sequence Identity: 27% (20 aa)

ALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGT-----PAYLAPEVLRNKGYN
.. .|. ||..| ||   |.|...     .|| |||| || | ...   .....        .|||..... ..
GMEYLESKNCIHRDLAARNCLVTE---NNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFT