Gene PKCh (Mouse)
PKCh
Sequence
Protein domains of PKCh.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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C2_PKD | PKCh.AA | C2_PKD | 9-167 | 28 | 1.3e-30 | 104.43 | In-house | 1-183 (183) | Show / Hide |
Range on Protein: 9-167 Range on HMM: 1-183/183 Sequence Identity: 28% (53 aa) NGYLRVRIGEAVGLQPTRWSLRHSLF---KKGHQLLDPYLTVSVDQVR----VGQTSTKQKTNKPTYNEEFCANVTDGGHLELAVFHETPLGYDHFVANC | .|||...| || |. .| | . .. |||. | || . .||| .| || | |..| ..|..| |......| .. . .||.| MGFCRVRLCRADGLKPKMFQHWHNLTFGKPADCEAIDPYCVVHVDEKHENQHIGQTTQKKKTFYPEWNKCFDHHVYEGRHIQIVCMHNAIMPPNKMVAEC TLQFQELLRTAGT-SDTFEGWVDLEPEGKVFVVITLTGSFTEATLQR---------------DRIFKHFTRKRQRAMR-RRVH | . .. ...| |.. . |..||| |||.| | . . |.. . | . |.|.| ||| ...| TMKLEDCIEMCKTNSGITHIWINLEPQGKVHVQIKWFNEDTDHKHHCDMIHPVPVLKMMKEFKRQRPGFNRRRGNAMRHAKIH |
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C2 | PKCh.AA | C2 | 12-102 | 26 | 1.8e-17 | 62.05 | Pfam | 1-90 (90) | Show / Hide |
Range on Protein: 12-102 Range on HMM: 1-90/90 Sequence Identity: 26% (26 aa) LRVRIGEAVGLQPTRWSLRHSLFKKGHQLLDPYLTVSVDQVRV----GQTSTKQKTNKPTYNEEFCAN--VTDGGH-LELAVFHETPLGYDHFVANCT |||.. || .| |. | .. . ||| .|....... .|.....| |..||.| . . |. | |.. |... .| |.|. |. LRVHVIEARNLPPMDW--------DKNGKSDPYVKVYLGGDPKDTQKYKTKVIKNTLNPVWNETFTFDVPPPDLQHTLRFTVWDWDRFGRDDFIGQCC |
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C2 | PKCh.AA | C2 | 11-117 | 17 | 5.3e-16 | 60.41 | SMART | 1-92 (92) | Show / Hide |
Range on Protein: 11-117 Range on HMM: 1-92/92 Sequence Identity: 17% (22 aa) YLRVRIGEAVGLQPTRWSLRHSLFKKGHQLLDPYLTVSVDQVRVGQTSTKQKTN---KPTYNE---EFCANVTDGGHLELAVFHETPLGYDHFVANCTLQ |.|.| || .| ||| .|. .|.....|. |..|| .| .|.. |.. |... |. |.. TLTVHIIEARNLP------------------DPYVKVY-------KTKVVKNTLSGFNPVWNEWMETFYFDVHP-Q-LRFEVWDH------DFIGHCCIP --------------FQELLRTAGTSDT ....| .. PNNPHWHQWDGCIHLSDIL-GYRH-WW |
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C1_1 | PKCh.AA | C1_1 | 172-225 | 41 | 2e-20 | 78.67 | Pfam | 1-55 (55) | Show / Hide |
Range on Protein: 172-225 Range on HMM: 1-55/55 Sequence Identity: 41% (23 aa) HKFMAT-YLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACTCQ |..... ..|||.|.||.||.|| .|.||..||.| ..|.|||.. .. | |. HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN |
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C1 | PKCh.AA | C1 | 172-222 | 35 | 4.4e-16 | 60.68 | SMART | 1-61 (61) | Show / Hide |
Range on Protein: 172-222 Range on HMM: 1-61/61 Sequence Identity: 35% (22 aa) HKFMATYLRQPTYCSHCREFIWGVFG----KQGYQCQVCTCVVHKRCHHLIVT-------AC |..... .||||.|||..|||.| .|||.|..| ..||.||. . .| HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC |
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C1_1 | PKCh.AA | C1_1 | 246-298 | 47 | 6.7e-22 | 83.87 | Pfam | 1-55 (55) | Show / Hide |
Range on Protein: 246-298 Range on HMM: 1-55/55 Sequence Identity: 47% (26 aa) HKFNVH-NYKVPTFCDHCGSLLWG-IMRQGLQCKICKMNVHIRCQANVAPNCGVN |.. .| |.| ||||.|||...|| . .||..| |..|.| ||. .|.|.|| | HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN |
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C1 | PKCh.AA | C1 | 246-295 | 27 | 1.3e-17 | 65.71 | SMART | 1-61 (61) | Show / Hide |
Range on Protein: 246-295 Range on HMM: 1-61/61 Sequence Identity: 27% (17 aa) HKFNVHNYKVPTFCDHCGSLLWGIMRQ-----GLQCKICKMNVHIRCQANVAP-------NC |.. ... ||.|.||....||. .| |..| ||...| .|...|.. .| HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC |
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Kinase | PKCh.AA | PKC | 355-614 | 71 | 7.6e-214 | 699.79 | In-house | 1-262 (262) | Show / Hide |
Range on Protein: 355-614 Range on HMM: 1-262/262 Sequence Identity: 71% (188 aa) FEFIRVLGKGSFGKVMLARIKETGELYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEA |.|..|||||||||||||. |.| |.||.||||||||.|||||||||||||.|.||..|||||.|.|||||.||||||||.|||||||||||..|||.|. FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE RARFYAAEIISALMFLHEKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPF .|||||||||.||.||||||||||||||||||||||||.|.||||||||...||.||.|||||||||||||||.. ||..|||||.|||.|||..|..|| HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF EAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQG--GEHEILRHPFF ..|.||.||..|..|...|| ||...|..|.|.||||||..|||. .|. ||..| .|||| HGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF |
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Kinase | PKCh.AA | Eta | 355-614 | 79 | 1.1e-210 | 706.2 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 355-614 Range on HMM: 1-261/261 Sequence Identity: 79% (208 aa) FEFIRVLGKGSFGKVMLARIKETGELYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEA |.||.|||||||||||||..|.|.|.||.||||||||.|||||||||||||||||||.|||||||.|||||.||||||||.||||||||.||..|.|||. FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLARKHPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFDEP RARFYAAEIISALMFLHEKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPF ||||||||...||||||..|.|||||||||.||||||||||||||||||||.||.||.||||||||||||||||| |||.|||||||||.|||.||..|| RARFYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMCGQPPF EAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLT-QGGEHEILRHPFF ||.|||||||.||.|.|.||.|||..|..|||.||||||..|||..| |||||.|..|||| EADNEDDLFESILHDDVLYPVWLHKEAVSILKAFMTKNPHKRLGCMTAQGGEHAIRQHPFF |
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Kinase | PKCh.AA | AGC | 355-614 | 35 | 9.90000000001e-197 | 514.52 | In-house | 1-395 (395) | Show / Hide |
Range on Protein: 355-614 Range on HMM: 1-395/395 Sequence Identity: 35% (141 aa) FEFIRVLGKGSFGKVMLARIK------ETGELYAVKVLKKDV-ILQDD--DVECTMTE------------KRILSLARN---------HPFLTQ-LFCCF |||..|.||||||||.|.| | ||..||.|||||.. |.... .||.|||| ..||..... |||... |...| FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF QTPDR--LFFVME----FVN-----GG-DLMFHIQ---KSRRFDEARARFYAAE-------IISALMFLHE-KGIIYRD-LKLDNVLLDHEGHCKLADFG |..|. |.|||| .|| || .|..|.| |..|||| |||||||| |..|| .||. .|||.|| ||..|.|||..||.||.||| QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG MCKEGICNG--------------------------------------------------VTTATFCG--TPDYIAPEILQEMLYGPAVDWWA--MGVLLY .||||. .| ..| |||| ||.|.||||| ||.|.|||. .|.|.| LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY EMLCGHAPFEAEN----------EDDLFEAIL------NDEVVYP----------TWLHEDATGILKSFMTKNPTMRLGSLTQG----GEHEILRHPFF |||.|. || ..| ....|. |. |..| .| |. ..| ..| ...|.|. |||.. .. | || .||.| EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF |
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Kinase | PKCh.AA | Alpha | 355-614 | 64 | 5.5e-163 | 547.75 | In-house | 1-259 (259) | Show / Hide |
Range on Protein: 355-614 Range on HMM: 1-259/259 Sequence Identity: 64% (167 aa) FEFIRVLGKGSFGKVMLARIKETGELYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEA | |. ||||||||||||| | | ||||.|.|||||| |||||||||.|||.| | |||.|. ||||.|||.||||.|||||||.|||. .| | FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPGKPPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFKEP RARFYAAEIISALMFLHEKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPF | |||||| .| |||||||||||||||||.|| ||| |.||||||||.. ...|| ||||||||||||| || .||||| |||||||. | .|| HAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQPPF EAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHEILRHPFF . | ||.||.|| . .|.|| . | | |.|.||.| |||. .. ||..| |||| DGEDEDELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGC-GPDGEQDIREHPFF |
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Kinase | PKCh.AA | Delta | 355-614 | 60 | 3.2e-146 | 492.05 | In-house | 1-259 (259) | Show / Hide |
Range on Protein: 355-614 Range on HMM: 1-259/259 Sequence Identity: 60% (157 aa) FEFIRVLGKGSFGKVMLARIKETGELYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEA | | .||||||||||||| .|.. . ||.| |||||.|.|||||||| |.|.|.|| .||||..||| ||| . ||||||..||||||.|||...||||. FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEK RARFYAAEIISALMFLHEKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPF ||||||.|||..| |||.||||||||||||||||..|| |.|||||||| . .. |||||||||||||.. .| .||||. |||.|||| | .|| RARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSPF EAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHEILRHPFF . |.||.||..|.||. || |. ..|...|| . ..|. |||. . . .| .|.|| HGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGV-QYCPKGDIRQHCFF |
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Kinase | PKCh.AA | Akt | 355-614 | 48 | 7.29999999999e-140 | 449.82 | In-house | 1-264 (264) | Show / Hide |
Range on Protein: 355-614 Range on HMM: 1-264/264 Sequence Identity: 48% (130 aa) FEFIRVLGKGSFGKVMLARIKETGELY-AVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDE |.|..||||||||||.|.. | |...| | ||||||.|.| . || |.||..|| . |||...| |||.|.|.|||...|||.| .|.|. |||.| FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCN-HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSE ARARFYAAEIISALMFLHEKGIIYRD-LKLDNVLLDHEGHCKLADFGMCKEG-ICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWA-MGVLLYEMLCG |||||.||||.|. .||.|.||||| ||. |.|.|..|| .|.|||.|||. | .. .| |||||| |.|||||. .. |||||. |...|||.|| DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCG HAPFEAENEDDLFEAILNDEVVYP--TWLHEDATGILKSFMTKNPTMRLGSLTQGGEHEILRHPFF || ... . .|. |.| .| .| |. .. .... .|.|..|||. . .. .|| |||.| RPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGG-GPNDAQEIKRHPWF |
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Kinase | PKCh.AA | SGK | 355-614 | 42 | 5.5e-132 | 410.07 | In-house | 1-283 (283) | Show / Hide |
Range on Protein: 355-614 Range on HMM: 1-283/283 Sequence Identity: 42% (122 aa) FEFIRVLGKGSFGKVMLARIKET------------------GELYAVKVLKKDVIL-------QDDDVECTMTEK-RILSLARNHPFLTQLFCCFQTPDR |.|. |.||||||||.... |.. . .||.|||.|. |. . . .|.|. ||.. .|||. .| |||.. FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNM-KHPFIVNLHYAFQTKWK LFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHEKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQE |.|||..||||.. .|.|. ..| | |||||||||..|| ||.. ||||||| .|.||||.|||.| ||| ||||| || |||||| | |||.|. LYFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRK MLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHEILRHPFF .. .|||| .| .||||. | ||. | ... |.| . |. || ... .|.|. ||| | . || .|||| QPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLG--TKRDFMEIKNHPFF |
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Kinase | PKCh.AA | Iota | 355-614 | 55 | 6.8e-124 | 414.72 | In-house | 1-271 (271) | Show / Hide |
Range on Protein: 355-614 Range on HMM: 1-271/271 Sequence Identity: 55% (150 aa) FEFIRVLGKGSFGKVMLARIKETGELYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEA || |||.|.||. ||.... |.| .||.||.||... .|.|.. ||| . | ||||| | ||||. |||||.|||||||||||.|. |. | FELIRVIGRGSYAKVLMVEHKKTRRIYAMKVIKKEMVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEFVNGGDLMFHMQRQRKLPEE RARFYAAEIISALMFLHEKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPF ||||.|||. || ||||.||||||||||||||||||| || |.||||||| .| ||.|||||| ||||||| || .|||||.|||..||. | .|| HARFYSAEICLALNFLHERGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPF ---------EAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQG--GEHEILRHPFF . || || || .. | | |...||.|. |.|. ||| | | ..| |||| DIVGNMDNPDQNTEDYLFQVILEKQIRIPRSLSVRAAHVLKGFLNKDPKERLGCHPQTNEGFMDIKEHPFF |
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Kinase | PKCh.AA | PKN | 355-614 | 52 | 2.7e-111 | 376.07 | In-house | 1-260 (260) | Show / Hide |
Range on Protein: 355-614 Range on HMM: 1-260/260 Sequence Identity: 52% (137 aa) FEFIRVLGKGSFGKVMLARIKETGELYAVKVLKKDVILQDDDVECTMTEKRILSLARN--HPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFD | .| |||.| ||||.|.. |.|||.||.|.||| |. |.|| |.||||. . |||| .|| |||| . .||||.. ||||| || . |. FRCIAVLGRGHFGKVLLSQYKHTGEYYAIKALKKQDIVARDEVESLMCEKRIFEVVNRMRHPFLVNLFACFQTEEHVCFVMEYAMGGDLMMHIHED-VFS EARARFYAAEIISALMFLHEKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHA |.||.|||| .. | .|||. ||||||||||.|||.||. |.||||.||||. | |.||||||...|||.| . | ||||| .|||.|||| | . EPRACFYAACVVLGLQYLHEHKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLIYEMLVGEC PFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHEILRHPFF || ..|...|..|.||.| || .| .| |.. . ||| |||. . | .| .||| PFPGDDEEEVFDCIVNDDVRYPRFLSVEAIAIMRRLLRKNPERRLGAGERDAE-DIKMQPFF |
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Kinase | PKCh.AA | AktR | 355-614 | 40 | 5e-104 | 351.9 | In-house | 1-268 (268) | Show / Hide |
Range on Protein: 355-614 Range on HMM: 1-268/268 Sequence Identity: 40% (109 aa) FEFIRVLGKGSFGKVMLARIK-ETGELYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDE |.....|||| ||||.|.. | .....|| |..|| | . . | ||. |. ||||. .|. |||| . |||.||.. ||.| .|..|...|.| FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE ARARFYAAEIISALMFLHEK-GIIYRDLKLDNVLLDHEGHCKLADFGMCK-EGIC-NGVTTATFCGTPDYIAPEILQE-MLYGPAVDWWAMGVLLYEMLC .||||.|.|. || .||.. ||||||| .| ||| .|| |..|||. | ... . .. .||||| |.|||.... .. .||||| |...|||. EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT GHAPFEAENEDDLFEAILNDE---VVYPTWLHEDATGILK-SFMTKNPTMRLGSLTQGGEHEILRHPFF |. ||...| ..|. |.. . . ||. . . . ... . |||..|||. . | | || .||.| GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWE-EIKSHPWF |
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Kinase | PKCh.AA | S_TKc | 355-614 | 37 | 3.5e-102 | 346.71 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 355-614 Range on HMM: 1-231/231 Sequence Identity: 37% (100 aa) FEFIRVLGKGSFGKVMLARIKETGELYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNG--GDLMFHIQKSRR-- .|..|..|||.||||...| |.||...|.|..| | .. | .||. .||.. .|. .||. |.|..|||...| |||. .|.| .| YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG ----FDEARARFYAAEIISALMFLHEKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGP-AVDWWAMGVLLY |.| .||||...|..|| ..|..|||.|||| .|.|||. | |..|||.... ||||||.|.|||.| ||. ..|||. |..|| LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY EMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGG-EHEILRHPFF ||||| ||. ... .|. |. ..| ... ..|.|. |.. | .| ||.| EMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | PKCh.AA | Pkinase | 355-614 | 31 | 5.4e-86 | 296.79 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 355-614 Range on HMM: 1-293/293 Sequence Identity: 31% (94 aa) FEFIRVLGKGSFGKVMLARIKETGELYAVKVLKKDVILQDDDVECTM-TEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGG----DLMFHIQ--K ....|..|.||||.| ... | ||...|||..||. . . |.. . .| .|. |||. .|...|...|.. .|||...|| ||. .|. . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR SRRF--DEARARFYAAEIISALMFLHEKGIIYRDLKLDNVLLDHEGHC----KLADFGMCKEG-ICNGVTTATFCGTPDYIAPEILQ-EMLYGPAVDWWA ...| .| ..||. .|...| ..|..|||.||||..|.|.|..||. |..||| .| . |.. . ||||||.|.|||... |||.||.|. HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS MGVLLYEMLCGHAPFEAE------NEDDLFEAILNDEVVYPTWLH---------------------EDATGILKSFMTKNPTMRLGSLTQGGEHEILRHP .|..|||||||. || . ... ... |. .. .. . |.. ..|. .|.|. |.. ..|| || CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT------AEQILQHP FF .| WF |
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Kinase | PKCh.AA | S_TK_X | 615-678 | 40 | 4.4e-27 | 97.21 | SMART | 1-79 (79) | Show / Hide |
Range on Protein: 615-678 Range on HMM: 1-79/79 Sequence Identity: 40% (32 aa) KEIDWAQLNH--RQLEPPFRPRIK----SREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDE---------FRNFSYVS ..||| .| . ...||||.|.|| | .|.|||||.| .|.|.|||.|.. .. ..|.| ||.|.|| RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF |
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Kinase | PKCh.AA | Pkinase_C | 634-680 | 44 | 1.1e-18 | 69.0 | Pfam | 1-46 (46) | Show / Hide |
Range on Protein: 634-680 Range on HMM: 1-46/46 Sequence Identity: 44% (21 aa) RIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPE ..||..|.|||||.| .| |..|| |. .. ..|..||.|.||.|. QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD |
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Kinase | PKCh.AA | TyrKc | 355-609 | 21 | 5.7e-16 | 35.52 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 355-609 Range on HMM: 1-280/280 Sequence Identity: 21% (62 aa) FEFIRVLGKGSFGKVMLARIKETGELYAVKVLKKDVILQDDDVECTMTEKRILSLA-RNHPFLTQLFCCFQTP-------DRLFFVMEFVNGGDLMFHIQ .....|| | ||.|.... | . |||.||.| .| | | ||.. .|| . .|. . .. . |. |||.. .||| ... ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR KSRR-FDEARARFYAAEIISALMFLHEKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICN-------GVTTATFCGTPD------YIAPEILQEMLYG |.|. . . .. | . .||.|..| ||| |.|.......| .|||..... . ... . . ||| ... . KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT PAVDWWAMGVLLYEML-CGHAPFEA-----ENEDDLFEAILNDEVVYPTWL----------HEDATGILKSFMTKNPTMRLGSLTQGGEHEIL .. | |. ||...|.. | | . . ....| . . . . | . | |. .| .| . ||.. TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI---HECF |
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Kinase | PKCh.AA | Pkinase_Tyr | 421-502 | 25 | 9.1e-08 | 26.93 | Pfam | 72-159 (270) | Show / Hide |
Range on Protein: 421-502 Range on HMM: 72-159/270 Sequence Identity: 25% (22 aa) CCF-QTPD-RLFFVMEFVNGGDLMFHIQK----SRRFDEARARFYAAEIISALMFLHEKGIIYRDLKLDNVLLDHEGHCKLADFGMCK .| | ... |||.. .||| . .| .... . ....| ... .|..|..| ||| |.|.......| .|||... VCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR |
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Kinase | PKCh.AA | Pkinase_Tyr | 355-389 | 35 | 1e-06 | 23.08 | Pfam | 1-39 (270) | Show / Hide |
Range on Protein: 355-389 Range on HMM: 1-39/270 Sequence Identity: 35% (14 aa) FEFIRVLGKGSFGKVMLARIK----ETGELYAVKVLKKD .|...||.|.||.|.... | .|. |||.|| . ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEG |
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Kinase | PKCh.AA | Pkinase_Tyr | 522-566 | 27 | 0.748433 | 3.51 | Pfam | 182-228 (270) | Show / Hide |
Range on Protein: 522-566 Range on HMM: 182-228/270 Sequence Identity: 27% (13 aa) APEILQEMLYGPAVDWWAMGVLLYEMLC-GHAP-FEAENEDDLFEAI ||| .... . . | |. |||..|.. | | .. ...|.| APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI |