Gene PKCb (Mouse)
PKCb
Sequence
Protein domains of PKCb.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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C1_1 | PKCb.AA | C1_1 | 37-89 | 45 | 2.8e-20 | 78.1 | Pfam | 1-55 (55) | Show / Hide |
Range on Protein: 37-89 Range on HMM: 1-55/55 Sequence Identity: 45% (25 aa) HKFTAR-FFKQPTFCSHCTDFIWG-FGKQGFQCQVCCFVVHKRCHEFVTFSCPGA |.. .. .|||||||.|| .|.|| .|.||..||.| ...|.|||..|. |.. HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN |
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C1 | PKCb.AA | C1 | 37-86 | 33 | 3.6e-18 | 67.59 | SMART | 1-61 (61) | Show / Hide |
Range on Protein: 37-86 Range on HMM: 1-61/61 Sequence Identity: 33% (21 aa) HKFTARFFKQPTFCSHCTDFIWGFGKQ-----GFQCQVCCFVVHKRCHEFVTF-------SC |.. .. | .||.|.|| ..|||. || |..|..|....||.||..|. .| HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC |
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C1_3 | PKCb.AA | C1_3 | 67-79 | 38 | 4.532068 | 1.68 | Pfam | 18-30 (30) | Show / Hide |
Range on Protein: 67-79 Range on HMM: 18-30/30 Sequence Identity: 38% (5 aa) CQVCCFVVHKRCH | | |..|..| CMQCDFMLHEDCA |
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C1_1 | PKCb.AA | C1_1 | 102-154 | 47 | 2.4e-25 | 95.32 | Pfam | 1-55 (55) | Show / Hide |
Range on Protein: 102-154 Range on HMM: 1-55/55 Sequence Identity: 47% (26 aa) HKFKIH-TYSSPTFCDHCGSLLYG-LIHQGMKCDTCMMNVHKRCVMNVPSLCGTD |... | .. .||||.|||....| |.|||.||..| .|.|.||.|.||..|| . HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN |
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C1 | PKCb.AA | C1 | 102-151 | 27 | 7.5e-18 | 66.54 | SMART | 1-61 (61) | Show / Hide |
Range on Protein: 102-151 Range on HMM: 1-61/61 Sequence Identity: 27% (17 aa) HKFKIHTYSSPTFCDHCGSLLYGLIHQ-----GMKCDTCMMNVHKRCVMNVPS-------LC |....... .||.|.||.....|. .| |..| | ...||.|. .||. | HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC |
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C1_3 | PKCb.AA | C1_3 | 113-144 | 25 | 0.000165 | 12.97 | Pfam | 1-30 (30) | Show / Hide |
Range on Protein: 113-144 Range on HMM: 1-30/30 Sequence Identity: 25% (8 aa) TFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCV .|. || .|. . . .| .| ..|..|. FTCNCCGLPIYR--DPFYHCMQCDFMLHEDCA |
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C2 | PKCb.AA | C2 | 173-260 | 49 | 2.4e-36 | 126.46 | Pfam | 1-90 (90) | Show / Hide |
Range on Protein: 173-260 Range on HMM: 1-90/90 Sequence Identity: 49% (45 aa) LIVVVRDAKNLVPMD--PNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQ-LKESDKDRRLSVEIWDWDLTSRNDFMGSLS | | | |.|| ||| .||.||||||..| .||| ..|.|||.|| .|||.||||| |. .. . .| ...|||| .|.||.| . LRVHVIEARNLPPMDWDKNGKSDPYVKVYLGGDPKDTQKYKTKVIKNTLNPVWNETFTFDVPPPDLQH-TLRFTVWDWDRFGRDDFIGQCC |
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C2 | PKCb.AA | C2 | 172-275 | 25 | 4.5e-26 | 93.87 | SMART | 1-92 (92) | Show / Hide |
Range on Protein: 172-275 Range on HMM: 1-92/92 Sequence Identity: 25% (32 aa) VLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSL---NPEWNE---TFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFG--- .| | . |.|| |||||.. |||..|..| ||.||| || | . . . | .|.||. ||.| .... TLTVHIIEARNLP--------DPYVKVY-----------KTKVVKNTLSGFNPVWNEWMETFYFDVHP----Q-LRFEVWDH------DFIGHCCIPPNN -----------ISELQKAGVDGWF .|... . . | PHWHQWDGCIHLSDIL-GYRH-WW |
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Kinase | PKCb.AA | Alpha | 342-600 | 89 | 2.6e-239 | 801.29 | In-house | 1-259 (259) | Show / Hide |
Range on Protein: 342-600 Range on HMM: 1-259/259 Sequence Identity: 89% (232 aa) FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEP |||||||||||||||||.||||||||||.|||||||.|||||||||||||||||||||||||.|.||||||||||||||||||||||||||||||.|||| FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPGKPPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFKEP HAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPF ||||||||||||||||..||||||||||||||||.|||||||||||||||.|...||.|||||||||||||||||||||||||||||||||||.|||.|| HAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQPPF EGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF .|||||||||.||||||.||||||||||.||||..||||.|||||||.||.||.||.|| DGEDEDELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGCGPDGEQDIREHPFF |
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Kinase | PKCb.AA | PKC | 342-600 | 78 | 8e-224 | 732.65 | In-house | 1-262 (262) | Show / Hide |
Range on Protein: 342-600 Range on HMM: 1-262/262 Sequence Identity: 78% (205 aa) FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEP ||||.||||||||||||.|||||||.||.|.|||||.||||||||||.|||||||..|.||||.||.||||||||.||||||||||||.||||..||||. FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE HAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPF ||.||||||...|.|| .|||||||||||||.||.|||||||||||||||.|.|.||.|||||||||||||..||.|||||||||||||.|||.|||.|| HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF EGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEG---ERDIKEHAFF .||||||||||||..|. ||...|||||.||||.|||.|.|||||.|.. |.||.||.|| HGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF |
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Kinase | PKCb.AA | AGC | 342-600 | 34 | 2.2e-192 | 503.04 | In-house | 1-395 (395) | Show / Hide |
Range on Protein: 342-600 Range on HMM: 1-395/395 Sequence Identity: 34% (137 aa) FNFLMVLGKGSFGKVMLSERK------GTDELYAVKILKKDV-VIQDD--DVECTMVE------------KRVLALPGK---------PPFLTQ-LHSCF |.|| |.||||||||.| ..| .|...||.|.|||.. ..... .||.||.| ...|.. . ||... ||..| FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF QTMDR--LYFVME----YVN-----GG-DLMYHIQ---QVGRFKEPHAVFYAAE-------IAIGLFFLQS-KGIIYRD-LKLDNVMLDSEGHIKIADFG |. |. |||||| ||| || .|..|.| . ||| |..| ||||| |. .| .| | .|||.|| ||..|..||..||||..||| QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG MCKENIWDG--------------------------------------------------VTTKTFCG--TPDYIAPEIIAYQPYGKSVDWWA--FGVLLY .|||.. || ..|.|||| ||.|.||||. |||..|||. .|.|.| LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY EMLAGQAPFEGE----------DEDELFQSIM------EHNVAYP----------KSMSKEAVAICKGLMTKHPGKRLGCGPE-----GERDIKEHAFF |||.|. || |. ...|.||.|| ...| .| ...|.||. ..|.|..|.| ||||||.. | .||.| .| EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF |
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Kinase | PKCb.AA | Eta | 342-600 | 67 | 2.8e-164 | 552.05 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 342-600 Range on HMM: 1-261/261 Sequence Identity: 67% (176 aa) FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEP |||. |||||||||||| |||||||.||.|.|||||.|||||||||| |||.|.| | |||||||.|||| |||.||||||||||||..||. .| || FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLARKHPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFDEP HAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPF | |||||. . | || .|.|||||||||..|| ||| |.|||||||| | .|.|| |||||||||||||. . || ||||||.|||.|||..||.|| RARFYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMCGQPPF EGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGP--EGERDIKEHAFF | . ||.||.||.. .| || ..||||.| |. ||| | ||||| ||..|..|.|| EADNEDDLFESILHDDVLYPVWLHKEAVSILKAFMTKNPHKRLGCMTAQGGEHAIRQHPFF |
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Kinase | PKCb.AA | Delta | 342-600 | 64 | 6.9e-146 | 490.95 | In-house | 1-259 (259) | Show / Hide |
Range on Protein: 342-600 Range on HMM: 1-259/259 Sequence Identity: 64% (169 aa) FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEP |.|. ||||||||||||.| ||... ||.| ||||||..||||||||||.||||| . |||..| ||| . |.|||||.|||||||||||..||.| FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEK HAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPF | |||.|| .|| || .|||||||||||||.|| .||||||||||||||. ...|||||||||||||| | | .|||||.||||.|||| ||.|| RARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSPF EGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGC--GPEGERDIKEHAFF .||||||||.||.. . ||. ..||| . |.|. ..| |||| |.| ||..| || HGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKG--DIRQHCFF |
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Kinase | PKCb.AA | SGK | 342-600 | 41 | 1.6e-126 | 392.89 | In-house | 1-283 (283) | Show / Hide |
Range on Protein: 342-600 Range on HMM: 1-283/283 Sequence Identity: 41% (119 aa) FNFLMVLGKGSFGKVMLSERKGT------------------DELYAVKILKKDVVI-------QDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRL | || |.||||||||.. ..|.. | .||.|.|.|. .| . . .| |. |. | ||. .|| ||| . | FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL YFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ ||||.|||||.. ||.| ..|.|. | ||||||. | | |. ||||||| .|..||..||... ||| |||.| . ||.|||||| | |||... | YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF |....|||| | .||||. | ||. . .... |. |..|| .| . .|| .| | |||| .. ..||.| || PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTK-RDFMEIKNHPFF |
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Kinase | PKCb.AA | Akt | 342-600 | 49 | 5.9e-125 | 401.4 | In-house | 1-264 (264) | Show / Hide |
Range on Protein: 342-600 Range on HMM: 1-264/264 Sequence Identity: 49% (130 aa) FNFLMVLGKGSFGKVMLSERKGTDELY-AVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKE |.|| ||||||||||.| . | |...| | |.||||. || . || |. |...| ||...|| ||| |.|||||.|.|||.| ||.|. .||.| FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCN-HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSE PHAVFYAAEIAIGLFFLQSKGIIYRD-LKLDNVMLDSEGHIKIADFGMCKEN-IWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWA-FGVLLYEMLAG . | ||.||| .. .| ||.||||| ||. |...|..|||...|||.|||| | |. .|||||||| |.||||. . ..|.||||. .|...|||. | DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCG QAPFEGEDEDELFQSIMEHNVAYP--KSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF . || .| ...|. |.. .| .| . |.|. . .|| .| | |||| ||.. ..||.| .| RPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF |
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Kinase | PKCb.AA | Iota | 342-600 | 52 | 3.2e-121 | 405.69 | In-house | 1-271 (271) | Show / Hide |
Range on Protein: 342-600 Range on HMM: 1-271/271 Sequence Identity: 52% (142 aa) FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEP |. . |.|.||. ||.. | | |. .||.|..||..| .|.|.. || | ||| ||||||| ||.||.|.|||||||.|.|. . | FELIRVIGRGSYAKVLMVEHKKTRRIYAMKVIKKEMVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEFVNGGDLMFHMQRQRKLPEE HAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPF || ||.|||.. | || ..||||||||||||.||.|||||. |.|||||.| .| || |||||| ||||||. . || |||||| |||..||.|| .|| HARFYSAEICLALNFLHERGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPF E--G-------EDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEG---ERDIKEHAFF . | || ||| |.|... |.|.| | . || . | | |||| |. .|||||.|| DIVGNMDNPDQNTEDYLFQVILEKQIRIPRSLSVRAAHVLKGFLNKDPKERLGCHPQTNEGFMDIKEHPFF |
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Kinase | PKCb.AA | PKN | 342-600 | 50 | 7.4e-112 | 377.92 | In-house | 1-260 (260) | Show / Hide |
Range on Protein: 342-600 Range on HMM: 1-260/260 Sequence Identity: 50% (133 aa) FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG--KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFK | .. |||.| ||||.||. |.|.|.||.|.||| .. |.|| |.|||... . . ||| .|..|||| . .|||||. ||||| || . |. FRCIAVLGRGHFGKVLLSQYKHTGEYYAIKALKKQDIVARDEVESLMCEKRIFEVVNRMRHPFLVNLFACFQTEEHVCFVMEYAMGGDLMMHIHE-DVFS EPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQA ||.|.|||| . .|| .| . ||||||||||..|| ||..||||||.|||.. | | ||||||...|||... . | . |||| |||.|||| | . EPRACFYAACVVLGLQYLHEHKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLIYEMLVGEC PFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF || |.||.|.|..|....| ||. .| ||.|| . |. | | .||| | ||| ..|| PFPGDDEEEVFDCIVNDDVRYPRFLSVEAIAIMRRLLRKNPERRLGAGERDAEDIKMQPFF |
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Kinase | PKCb.AA | AktR | 342-600 | 39 | 1e-107 | 364.17 | In-house | 1-268 (268) | Show / Hide |
Range on Protein: 342-600 Range on HMM: 1-268/268 Sequence Identity: 39% (106 aa) FNFLMVLGKGSFGKVMLSERK-GTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKE | .. .|||| ||||.| ..| ....|| |..|| |. . | |. ... . ||. .|| |||| . |.|.|||. ||.| .|... ..|.| FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE PHAVFYAAEIAIGLFFLQSK-GIIYRDLKLDNVMLDSEGHIKIADFGMCK-ENIW-DGVTTKTFCGTPDYIAPEIIAY-QPYGKSVDWWAFGVLLYEMLA | ||.|.| ..| .| .. ||||||| .| .||..||.||.|||. | ... . ....||||| |.|||.| ....|||||||||...|||.. EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT GQAPFEGEDEDELFQSIMEHN---VAYPKSMSKEAVAICK-GLMTKHPGKRLGCGPEGERDIKEHAFF |. ||. .. ..||.| ... . ||. |... ... .|. |.| |||| . .| .||.| .| GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF |
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Kinase | PKCb.AA | S_TKc | 342-600 | 37 | 2.7e-99 | 337.08 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 342-600 Range on HMM: 1-231/231 Sequence Identity: 37% (100 aa) FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNG--GDLMYHIQQVGR-- . .| ..|||.||||.. |.|....|.||.| | .. | ..| . |.. .|. .||. |.||.||||..| |||. .|.. || YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG ----FKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGK-SVDWWAFGVLLY | | || ||...|. .| .. |.|||.|||| .|..||. ||||.|||.... .||||||.|.|||.. .||| ..|||..|..|| LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY EMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGE--RDIKEHAFF |||.|. ||. .....|. |. |.|| . .....| | ||... . .||| | .| EMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | PKCb.AA | Pkinase | 342-600 | 32 | 1.2e-74 | 259.14 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 342-600 Range on HMM: 1-293/293 Sequence Identity: 32% (99 aa) FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTM-VEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGG----DLMYHIQ--Q . .. ..|.||||.| . .||| ...||||.||. . |.. . | .... . |. .|. .|.. |..|.||||..|| ||. .|. . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR VGRF--KEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI----KIADFGMCKEN-IWDGVTTKTFCGTPDYIAPEIIA-YQPYGKSVDWWA |.| | .. ||. .|. || .. |.|||.||||..|...|..||| ||.||| .| . .. ..||||||.|.|||.| .|.||..||.|. HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS FGVLLYEMLAGQAPFEGE------DEDELFQSIME----HNVAYPKSMS-----------------KEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAF .|..||||| |. || |. |...... ||. . .. |.| .|. ..|.. .| | ||.. ..|..| . CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHPW F | F |
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Kinase | PKCb.AA | S_TK_X | 601-663 | 37 | 3.3e-22 | 81.03 | SMART | 1-79 (79) | Show / Hide |
Range on Protein: 601-663 Range on HMM: 1-79/79 Sequence Identity: 37% (30 aa) RYIDWEKLER--KEIQPPYKPKAC----G-RNAENFDRFFTRHPPVLTPPDQEVIRNIDQSE---------FEGFSFVN | |||.||.. |||.||.||| . . . ..||| ||. .|.|||.|. ......|.| |.||..|. RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF |
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Kinase | PKCb.AA | TyrKc | 342-576 | 21 | 7.8e-14 | 0.95 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 342-576 Range on HMM: 1-280/280 Sequence Identity: 21% (62 aa) FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG-KPPFLTQLHSCFQTM-------DRLYFVMEYVNGGDLMYHIQ .. .|| | ||.|.. . | . ||| ||.| .| | | |.. | . | . .|. . . . |. ||||. .||| ... ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR QVGR-FKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWD-------GVTTKTFCGTPD------YIAPEIIAYQPYG .. .. .. . .. || | .| ||..| ||| |.........||.|||.... | . .|. . . ||| | | . KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT KSVDWWAFGVLLYEMLA-GQAPFEG-----EDEDELFQSIMEHNVAYPKSM--------SKEAV------------------AICKGLM | |.|||...|.. || | .| . .|... ... . . ... . .. .. TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | PKCb.AA | Pkinase_C | 626-665 | 45 | 9.9e-14 | 51.57 | Pfam | 8-46 (46) | Show / Hide |
Range on Protein: 626-665 Range on HMM: 8-46/46 Sequence Identity: 45% (18 aa) AENFDRFFTRHPPVLTPPDQEVIRNIDQSEFEGFSFVNSE ..||| .||. ||..||||.. ....||..|.||..||.. TSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD |
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Kinase | PKCb.AA | Pkinase_Tyr | 415-489 | 30 | 3.1e-10 | 35.31 | Pfam | 81-159 (270) | Show / Hide |
Range on Protein: 415-489 Range on HMM: 81-159/270 Sequence Identity: 30% (24 aa) RLYFVMEYVNGGDLMYHIQQ----VGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK ..| ||||. .||| . .. .... .. . ....|| |. .| ||..| ||| |.........||.|||... QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR |
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Kinase | PKCb.AA | Pkinase_Tyr | 525-555 | 32 | 0.006244 | 10.55 | Pfam | 198-231 (270) | Show / Hide |
Range on Protein: 525-555 Range on HMM: 198-231/270 Sequence Identity: 32% (11 aa) WAFGVLLYEMLA-GQAP-FEGEDEDELFQSI-ME |.||||..|.. |. | ..| . |... | . WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYED |
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Kinase | PKCb.AA | Pkinase_Tyr | 342-376 | 35 | 0.016509 | 9.12 | Pfam | 1-39 (270) | Show / Hide |
Range on Protein: 342-376 Range on HMM: 1-39/270 Sequence Identity: 35% (14 aa) FNFLMVLGKGSFGKVMLSERK----GTDELYAVKILKKD |. .||.|.||.|.. . | .|. |||.|| . ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEG |