Gene PFTAIRE1 (Mouse)

PFTAIRE1

Species: Mouse
Alias: PFTAIRE1, Pftk1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: PFTAIRE

Sequence

Name Sequence Type Origin Length Description Download
PFTAIRE1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 285 Kinase domain by global Sugen HMM Fasta, JSON
PFTAIRE1.AA Protein Sugen 469 None Fasta, JSON
PFTAIRE1.NA RNA Sugen 4911 None Fasta, JSON

Protein domain

Protein domains of PFTAIRE1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PFTAIRE1.AA PFTAIRE 135-419 78 2.9e-240 804.46 In-house 1-287 (287) Show / Hide 
Range on Protein: 135-419
Range on HMM: 1-287/287
Sequence Identity: 78% (225 aa)

YEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVK
||||||||||||||||||.|..|...||||.||||.||||||||||||||||.|||||||.||||||||||||.|||||||||||||||||||.||.||.
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQQEEGTPFTAIREASLLKNLKHANIVCLHDIIHTKETLTFVFEYVHTDLCQYMDKHPGGMHPNNVR

LFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPG
||||||||||||.|||..|||||||||||||..||||||||||||||||||||||.|||||||||||||||||||||.|||||||||||||..|..||||
LFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMWGQPAFPG

MKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFT--VYSSKSLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYF
||||.||||.|| |||||.|||||||..||..||..|.  .|..|.|...|....|..|||||..|.|||.|..|.|||.|..|.||
MKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase PFTAIRE1.AA CDK 135-419 46 1.2e-170 550.3 In-house 1-284 (284) Show / Hide 
Range on Protein: 135-419
Range on HMM: 1-284/284
Sequence Identity: 46% (149 aa)

YEKLEKLGEGSYATVYKGKSKVNG-----KLVALKVIRLQ------EEEGTPFTAIREASLLKGLKHANIVLLHDIIHTK-----------ETLTLVFEY
||||||.|||.|..|||...| .|     ..|||| ||..      |.|| |.||||| |||| | |.||| |||..|||            .|..||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

VHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGE-----LKLADFGLARAKSV------PSHTYSNEVVTLWYRPPD
...|| .|||          .| ...||||||.|.|.. |.||||||||.||...||     ||.||||||||...      |. ||..||||||||.|.
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

VLLGSTEYS--TCLDMWGVGCIFVEMIQ---GVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTVYSSKSLRQAWNKLSYVNHAEDLA
.||||..||  |  |||.|||||.||..   . . |||  . .|||..|| ..|||.||.|||| .||..                           || 
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSE-IDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------DLL

SKLLQCSPKNRLSAQAALSHEYF
.|.|.. ||.|.||..||.|.||
NKMLCYDPKKRISAEQALQHPYF
Kinase PFTAIRE1.AA PCTAIRE 135-419 62 2.2e-170 572.33 In-house 1-291 (291) Show / Hide 
Range on Protein: 135-419
Range on HMM: 1-291/291
Sequence Identity: 62% (182 aa)

YEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVK
| ||.|||||.||||||..||  . ||||| |||. ||| |.|||||.||||.||||||| |||||||   |||||||   || ||||    ..   |||
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTHHQLTLVFEYMDMDLKQYMDDCGNIMNMHNVK

LFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPG
|||||||||| | |.| |||||||||||||   |||||||||||||||||. |||.|||||||||||||.|||.||| .||||||||| ||  | . |||
LFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMCTGRPLFPG

MK-----DIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTVYSSKSLRQAWNKLS-YVNHAEDLASKLLQCSPKNRLSAQAALSHEYF
 .      ..|||. || .|||| | ||||| |.. |... |  |  ..|     .|   .    || ..|||  .|||.|| .|..| ||
STDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTYNFPRYREQPLINHAPRLDKILKQCQDLLTMLLQYESKNRVSAEKAMKHPYF
Kinase PFTAIRE1.AA CDK5 135-419 54 8.70000000001e-156 496.07 In-house 1-287 (287) Show / Hide 
Range on Protein: 135-419
Range on HMM: 1-287/287
Sequence Identity: 54% (159 aa)

YEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNV
|||.||.||| |.||||.. |  . .|||| .|| .| ||.| ||||| .||| ||| ||| |||.||.   ||||||..  ||  |||.  |.. .. .
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

KLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMI-QGVAAF
| |..|||.||.. |.. .||||||||||||.  |||||||||||||  .|  .|| |||||||||||||.||  |||  ||| .|||| ||.  |   |
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

PGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFK--PERFTVYSSKS-LRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYF
||  | .||| ||| ..|||.||.||..  || .|   . . .|  .  . |   ||.   .  || .|.||| |. |.||.||| | ||
PGN-DVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLD--EKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase PFTAIRE1.AA CDC2 135-419 48 6.1e-141 436.17 In-house 1-301 (301) Show / Hide 
Range on Protein: 135-419
Range on HMM: 1-301/301
Sequence Identity: 48% (147 aa)

YEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQ-EEEG--TPFTAIREASLLKGLK-HANIVLLHDIIHTKETLTLVFEYVHTDLCQYMD-KHPG--G
|.|.||.|||.|  |||.| .  ...|||| |||  |.||   | ||||| |.|| || | ||| |||.||    | .||||.. || .||| . |    
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

LHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYS--NEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEM
. |..|| ...|.|.|... ||| |.||||||||.||...|..|.|||||||| ..|. ||    ||||||||.| .|||.  |||  ||| .|||| ||
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---IQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTVYSSKSLRQAWNK-------LSYVNHAEDLASKLLQCSPKNRLSAQAALS
   ..  . |.|   | ||| .|| .||||||.||||| .||..|.  |  .  . |..   .       .   . . || ...||  | .|.||..||.
FMDVTKKPLFHGDSEI-DQLFKIFRILGTPNEQTWPGVTQLPDYKNT-FPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQ

HEYF
| ||
HPYF
Kinase PFTAIRE1.AA CMGC 135-419 25 1.4e-128 424.98 In-house 1-513 (513) Show / Hide 
Range on Protein: 135-419
Range on HMM: 1-513/513
Sequence Identity: 25% (129 aa)

YEKLEKLGEGSYATVYKGKS--------------KVNGKLVALKVIRLQ----------EEEGTPFTAIREASLLKGLK-----------------HANI
||...|.|||.|..|||..               . ....||.| |...          |..| |..|.|| ..|| |.                 | ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VLLHDIIHTKE-----------------TLTLVFEYVHTDLCQYMDKHP------GGLHP-------------DNVKLFL------FQLLRGLS--YIHQ
| |.||...|.                  | |||||. .||.||.....      ....               |.| |.      .|.||||   |.|.
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHS

RY--ILHRDLKPQNLLISDTGEL--------------------KLADFGLARAKSVP---------------------SHTYSNEVVTLWYRPPDVLLGS
.   |.||||||.|.||....||                    |..||||||. ...                     ...|...|||.|||.| .|||.
HWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGW

TEYS---------TCLDMWGVGCIFVEMIQG--------VAAFPGMKDI----------QDQLERIFLVLGTPN---------------EDTWPGVHSLP
..|.         |  |||.||||| ||..|           |||  .           .|||..|| |||||.               |..||.. .||
KHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLP

HF---------------KPER----------FTVYSSKSLRQAWNKLS---------------------------------YVNHAEDLASKLLQCSPKN
..               ..|           |  .  |....   ...                                     | || .|.||. |..
WYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDK

RLSAQAALSHEYF
|..|. ||.|.||
RITAEQALQHPYF
Kinase PFTAIRE1.AA CDK7 135-419 40 1.8e-116 311.75 In-house 1-288 (288) Show / Hide 
Range on Protein: 135-419
Range on HMM: 1-288/288
Sequence Identity: 40% (117 aa)

YEKLEKLGEGSYATVYKGKSKVNGKLVALKVIR-----LQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLH
|||....||| .|||||.  .. |. || | |.      . . |  .|||||  .|. ..| |.. | ||.  |  . |||..  .||          | 
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

PDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGV
| ..| .  ..|.|| | |. .|||||||| |||..  |.||.|||||||.   |   |.  ||| ||| |  | |   | |  ||| ||||| | .  |
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRV

AAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHF-KPERFTVYSSKSLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYF
  .||  || |||.|||  ||||.| .||.. ... . |   |. ||   ||.     |  . . || ....   | .|...  .|...||
PYLPGDSDI-DQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAAS--DDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase PFTAIRE1.AA PITSLRE 135-419 40 6.5e-96 324.94 In-house 1-295 (295) Show / Hide 
Range on Protein: 135-419
Range on HMM: 1-295/295
Sequence Identity: 40% (121 aa)

YEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQ---EEEGTPFTAIREAS-LLKGLKHANIVLLHDII--HTKETLTLVFEYVHTDLCQYMDKHP---
...| . .|| |  ||..| |  .  |||| . .    | || | |..|| . .|..|.| ||| .  |.   ..    .|.|||  ||   |...    
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

GGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEM
    |  .| .. ||||| .. |   |.|||||  |||.|  | ||..||||||    |   |.  ||||||| | .|||. .||| .||| ||||| |.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

IQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPER-FTVYSSKSLRQAWN---KLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYF
|..   |.|  .| ||...||  .|||.|  |||. .|||.|    |. |    ||.      ..|    . ||  ..|   ||||..| .|| |..|
ITMKPLFQGKSEI-DQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHIS--DTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase PFTAIRE1.AA S_TKc 135-419 28 2.2e-87 297.54 SMART 1-231 (231) Show / Hide 
Range on Protein: 135-419
Range on HMM: 1-231/231
Sequence Identity: 28% (85 aa)

YEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHT---DLCQYMDKHPGG----
||.|.|.|.|....|||.. |  |..||.|.|.         ...|| ..||  .| ||| |.|.... . | .|.||. .   || .|..|....    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYST-CLDMWGVGCIFVEM
 ...  .. .. |....| |.|.. |.||||||.|.|...  ..|..||||||         .  ..|.||..| ||     |..   |.| .|||. ||
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEM

IQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTVYSSKSLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALS-------HEY
. |   ||       |....| ..|                                         | |. .|.||  |..|..|  ||        |..
LCGYPPFP-------QMQMMFKKIG--------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

F
|
F
Kinase PFTAIRE1.AA CDK4 135-419 41 1.3e-86 294.04 In-house 1-290 (290) Show / Hide 
Range on Protein: 135-419
Range on HMM: 1-290/290
Sequence Identity: 41% (125 aa)

YEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQ-EEE--GTPFTAIREASLLKGLK---HANIVLLHDIIHTKET------LTLVFEYVHTDLCQYMD
|...  .||| | |||.  .  .|. |||| .| . .||  | |   ||| |... |.   |.||| | |. |. .|      .|.||| .  || .|.|
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

KHPG-GLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNE------VVTLWYRPPDVLLGSTEYSTCLDM
| |  |. |  .|   .|||||. . |   | ||||||||.|..  |..|||||||||       .||..      ||||||| | ||| |. | |  ||
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLAR-------IYSFQMALTPVVVTLWYRAPEVLLQSY-YNTPVDM

WGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTVYSSKSLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALS
| ||||| ||    . |.|  .  |||..|| | |.| || ||   |||    . |  .. ....     ..  . . ||  | |   .. |.|| ..|.
WSVGCIFAEMYCRRPLFCGQSE-KDQLHKIFDVMGLPPEDDWPRDVSLPW---DHFPQRHPRPFKDFCPHMC--KQGDDLLQKMLCYNHHKRMSAYQCLQ

HEYF
| ||
HPYF
Kinase PFTAIRE1.AA CRK7 135-419 32 5.4e-85 288.68 In-house 1-343 (343) Show / Hide 
Range on Protein: 135-419
Range on HMM: 1-343/343
Sequence Identity: 32% (113 aa)

YEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE----EGTPFTAIREASLLKGLKHANIVLLHDIIHTK----------ETLTLVFEYVHTDLCQY
||...  ||| |  ||| | | .|..|||| .|.. |    || | |||||  .|. |.|.||| |..|.  |           .  .||||.  ||   
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

MDKH-PGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPS--HTYSNEVVTLWYRPPDVLLGSTEY--------
..        ....| |. ||| |. |.|.. .||||.|  |.|.   ||.|.|||||||     .    | | |.|||||||  ||| ..|        
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKE

------------------------------STCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTV-YSSKS
                               .  |||..|||..|   . . |.|   . .||| |. . |.|| . || |  || ..  .    | ...
LIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEM-AQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNRRL

LRQAW---NKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYF
. .     .       . ||. |.|   || | .|. .| |..|
REEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase PFTAIRE1.AA Pkinase 135-419 32 3.8e-80 277.35 Pfam 1-293 (293) Show / Hide 
Range on Protein: 135-419
Range on HMM: 1-293/293
Sequence Identity: 32% (99 aa)

YEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPF-TAIR--EASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHT-----DLCQYMD-KHP
|....|.|.||...|||.. | .||.||.|.|....|.     |..|  |....| |.| ||| |.|. ..|  . .|.||.       ||. |.  .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GGL--HPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGEL----KLADFGLARAK-SVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGV
|..   .. .| .. |.|||| |.|.. |.||||||.|.||...|..    |..|||||. .   ... ..  ..|.||..| |..|...|..  |||..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCIFVEMIQGVAAFPGM---KDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTVYSSKSLRQAWNKLSYVN-HAEDLASKLLQCSPKNRLSAQAAL
|||. ||. |   |||    ..  ||...|....|.|..  ||  .| . |.  |.   .    . .| .  ...  . |. ...|.  || |..|. .|
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H----F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQIL

SHEYF
 |..|
QHPWF
Kinase PFTAIRE1.AA Pkinase_Tyr 135-280 31 1.3e-18 63.71 Pfam 1-160 (270) Show / Hide 
Range on Protein: 135-280
Range on HMM: 1-160/270
Sequence Identity: 31% (51 aa)

YEKLEKLGEGSYATVYKGKSK----VNGKLVALKVIRLQEEEGTPFTA------IREASLLKGL-KHANIVLLHDIIH-TKET--LTLVFEYVHT-DLCQ
 ....|||||.. .||||. |     ..  || |...    ||.   .      .|||...| | .| ||| |. ..   .|   . .|.||.   ||  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

YMDKH---PGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARA
|  ||   .. | .     . .|  .|..| ... . ||||   | |.....  | .||||||.
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase PFTAIRE1.AA TyrKc 135-419 23 4.2e-12 -27.03 SMART 1-280 (280) Show / Hide 
Range on Protein: 135-419
Range on HMM: 1-280/280
Sequence Identity: 23% (75 aa)

YEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGL--KHANIVLLHDIIHTK-------ETLTLVFEYV-HTDLCQYMDKH
 ....||||| . .||||. |     || |...           .|||.... |  .| ||| |. .. ..       | | .|.||. | || .|  ||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

PGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVP------SHTYS-----NEV--VTLWYRPPDVLLGSTEYST
 . | ..    | .|  .| .|.|.. . ||||   | |... .  | .||||.|.          . .|.     ..   . .   .| ..    ...|
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTT

CLDMWGVGCIFVEMI-QGVAAFPGM----KDIQDQLERI--FLVLGTPNEDTWPGVHSLPHFKPERFTVYSSKSLRQAWNKLSYVNHAEDLASKLLQC--
  | |  |    |.   |    |||    .. |. .|..     .  | .|  | .                          . |   ... .  .||  
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MS-------------------------F-VCCPDEMYQIMKQCWH

-SPKNRLSAQAALSHEYF
  |..| . ..   ||.|
EDPEDRPTFSEI--HECF