Gene PDGFRb (Mouse)

PDGFRb

Species: Mouse
Alias: PDGFRb, Pdgfrb
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: PDGFR

Sequence

Name Sequence Type Origin Length Description Download
PDGFRb.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 354 Kinase domain by global Sugen HMM Fasta, JSON
PDGFRb.NA RNA Sugen 5410 None Fasta, JSON
PDGFRb.AA Protein Sugen 1098 None Fasta, JSON

Protein domain

Protein domains of PDGFRb.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IGc2 PDGFRb.AA IGc2 44-106 23 1.6e-05 25.61 SMART 1-56 (56) Show / Hide 
Range on Protein: 44-106
Range on HMM: 1-56/56
Sequence Identity: 23% (16 aa)

NISSTFVLTCS----GSAPVMWEQMSQVPWQEAAMNQDGTFSSVLTLTNVTGGDTGEYFCVYNNSLG
..  ...|||       . ..|   ...|            .. ||..||| .| |.| |.  |. |
HEGQSVTLTCPATGNPDPNIHWYKGQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG PDGFRb.AA IG 38-120 18 0.000143 22.43 SMART 1-58 (58) Show / Hide 
Range on Protein: 38-120
Range on HMM: 1-58/58
Sequence Identity: 18% (16 aa)

GPEFVLNISSTFVLTCSGSAPVMWEQMSQVPWQEAAMNQDGTFSSVLTLTNVTGGDT---GEYFCVYNNSLGPELSERK--RIYIFVP
 |  . .  .| .|||  |  . |                      ||. ||.  |.   |.|.|. .       .  .   ... | 
PP-VTVKEGETVTLTC-VS-QIWWY---------------------LTI-NVQPEDSQQHGTYYCQAT-----HGQYWSIQGTTLTVQ
V-set PDGFRb.AA V-set 84-119 27 0.388182 5.75 Pfam 95-128 (128) Show / Hide 
Range on Protein: 84-119
Range on HMM: 95-128/128
Sequence Identity: 27% (10 aa)

LTLTNVTGGDTGEYFCVYNNSLGPELSERKRIYIFV
||..|..  |.| |.|.  |.  .|..  . .   |
LTISNLQPSDSGTYYCAVWNC--NEDYFGHGTRLTV
IGc2 PDGFRb.AA IGc2 225-297 23 1.5e-14 55.61 SMART 1-56 (56) Show / Hide 
Range on Protein: 225-297
Range on HMM: 1-56/56
Sequence Identity: 23% (17 aa)

RQGESITIRCIVMGNDVVNFQWTYPRMKSGRLVEPVTDYLFGVPSRIGSILHIPTAELSDSGTYTCNVSVSVN
..|.|.|..|.. ||.. |..|..    . .|               .. |.|  ....|||.||| .. ...
HEGQSVTLTCPATGNPDPNIHWYK----GQPLP-------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG PDGFRb.AA IG 219-310 18 9.6e-11 42.94 SMART 1-58 (58) Show / Hide 
Range on Protein: 219-310
Range on HMM: 1-58/58
Sequence Identity: 18% (18 aa)

AVQTVVRQGESITIRCIVMGNDVVNFQWTYPRMKSGRLVEPVTDYLFGVPSRIGSILHIPTAELSDS---GTYTCNVSVSVNDHGDEKA---INISVI
   ..|. ||..|..| |      ...|.                           |.|  ....||   |||.| ..     ||. ..   ....| 
PP-VTVKEGETVTLTC-VS-----QIWWY---------------------------LTI-NVQPEDSQQHGTYYCQAT-----HGQYWSIQGTTLTVQ
V-set PDGFRb.AA V-set 212-309 16 7e-06 22.12 Pfam 1-128 (128) Show / Hide 
Range on Protein: 212-309
Range on HMM: 1-128/128
Sequence Identity: 16% (21 aa)

SINVSV-NAV----QTVVRQGESITIRCIVM-GN----DVVNFQWTY-PRM--------KSGRLVEPVTDYLFGVPSRIGSI------------LHIPTA
.. |.. .        .| .|.|.|..| .. .     ..  ..| .  .         ..   . .....    |.  |..            |.|  .
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

ELSDSGTYTCNVSVSVNDHGDEKAINISV
..||||||.| |. . | .. .. ..  |
QPSDSGTYYCAVWNC-NEDYFGHGTRLTV
IGc2 PDGFRb.AA IGc2 330-402 17 0.004866 4.04 SMART 1-56 (56) Show / Hide 
Range on Protein: 330-402
Range on HMM: 1-56/56
Sequence Identity: 17% (13 aa)

HRSRTLRVVFE--AYPMPSVLWLKDNRTLGDSGAGELVLSTRNMSETRYVSELILVRVKVSEAGYYTMRAFHEDD
|  ....   .  ..| |.. |.| .  |                   . ..| . .|... .|||| .| ..  
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG PDGFRb.AA IG 324-413 9 0.021636 11.71 SMART 1-58 (58) Show / Hide 
Range on Protein: 324-413
Range on HMM: 1-58/58
Sequence Identity: 9% (9 aa)

VEIAELHRSRTLRVVFEAYPMPSVLWLKDNRTLGDSGAGELVLSTRNMSETRYVSELILVRVKVSEA---GYYTMRAFHEDDEVQL--SFKLQVN
 .  .  .  |..    .    .. |.                             |.. .|... .   | |. .|     ...   ...|.| 
PP-VTVKEGETVTLTC-VS---QIWWY-----------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
Kinase PDGFRb.AA PDGFR 599-957 65 2.7e-292 949.61 In-house 1-358 (358) Show / Hide 
Range on Protein: 599-957
Range on HMM: 1-358/358
Sequence Identity: 65% (237 aa)

LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHT
|..|.||||||||.||||||.|||.|||.|||||||||.||.||||.|||||||||||||.|.|.||||||||.|||||||||||.||||..||||..|.
LQFGKTLGSGAFGKVVEATAYGLSKSQAVMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTHGGPIYIITEYCCYGDLLNYLHRKRHS

FLQRHSNKHCPPSAELYSNAL-PVGFSLPSHLNLTGESDGGYMDMSKDESIDYVPMLDMKGDIKYADIESPSYMAPYDNYVPSAPERTYRATLIND-SPV
|.|.|..|   |..|..||.. |..||.........|.||.|||||..|...|||||..||..||.|.....||.|..||..|..|......|..| |.|
FHQHHPEK---PKKETWSNQQDPHNFSFYKNVHHHKENDGDYMDMSSCEDSQYVPMLMHKGVDKYVDMQRNNYMSPHSNYEDSYIEQDVKNELMEDDSNV

LSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIF
|.|.||..||||||.||.||||||||||||||||||.|.||.|||||||||||||.||||..||...||.|||||||||...|||.|||||.||||||||
LTYWDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGILLWEIF

TLGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQLVLLL
.|||.|||..|....||..||.|||||||.||..||||||||||....|.||.|.||...|
SLGGNPYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase PDGFRb.AA Pkinase_Tyr 599-957 35 2e-153 520.27 Pfam 1-270 (270) Show / Hide 
Range on Protein: 599-957
Range on HMM: 1-270/270
Sequence Identity: 35% (132 aa)

LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSE--KQALMSELKIMSHLGPHLNVVNLLGACT-KGGP--IYIITEYCRYGDLVDYLH
...|..||.||||.|...|..| .... ...||||||| .| ...  ....|.|.|||..|| | |.|.|.|.|| .|.|  |||..||. .||| |||.
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

RNKHTFLQRHSNKHCPPSAELYSNALPVGFSLPSHLNLTGESDGGYMDMSKDESIDYVPMLDMKGDIKYADIESPSYMAPYDNYVPSAPERTYRATLIND
...                                                                                               .|
KHR-----------------------------------------------------------------------------------------------ED

SPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNY-ISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILL
 . |.  ||.....|.|.||..|.||||.||||||||.|. |.. ||||||||||||. |..|  ..|.. || ||||||.|... .|| |||||||.|.
KQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLM

WEIFTLGGTP-YPELPMNDQFYNAI-KRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQLVLLL
|||||.|..| ||..  | ..|..| ..||||..| ...||||..|..||... | || ||...  |
WEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase PDGFRb.AA TyrKc 599-957 32 3.4e-138 466.3 SMART 1-280 (280) Show / Hide 
Range on Protein: 599-957
Range on HMM: 1-280/280
Sequence Identity: 32% (125 aa)

LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLG-PHLNVVNLLGACTKG-------GPIYIITEYCRYGDLVD
..||..||.||||.|...|.         ..|||||||. |    ....|.|..||..||  | |.|.|.|.||..       .|..|..||. .||| |
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YLHRNKHTFLQRHSNKHCPPSAELYSNALPVGFSLPSHLNLTGESDGGYMDMSKDESIDYVPMLDMKGDIKYADIESPSYMAPYDNYVPSAPERTYRATL
||......                                                                                            
YLRKHRPK--------------------------------------------------------------------------------------------

INDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRD------SNYISK----GSTF-LPLKWMAPESIFNSLY
      |.  ||. |..|.|.||..|.||||.||||||||.|. |.. |||.||||.|||  |      . |..|    |. . ||..|||||.|. . .
------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TTLSDVWSFGILLWEIFTLGGTPYPEL----PMNDQFYNAIKRGYRMAQPAH--------ASDEIYEIMQKCWEEKFETRPPFSQLVLLL
|| |||||||...|||||.|..|||.       |.. .. .|.|||| ||..        ..||.|.||..||.|. | || ||... ..
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase PDGFRb.AA TK 599-957 26 1.7e-126 426.35 In-house 1-486 (486) Show / Hide 
Range on Protein: 599-957
Range on HMM: 1-486/486
Sequence Identity: 26% (139 aa)

LVLGRTLGSGAFG---QVVEATAHGLS--------------------HSQATMKVAVKMLKSTARSSEKQALM----------------SELKIMSH-LG
..||..||.|.||   .| .....|..                    .......|||||||... .|... ..                .|.|.|.| ||
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

PHLNVVNLLGACTKG------------GPIYIITEYCRYGD----LVDYLHRNKHTFLQRHSNKHCPPSAELYSNALPVGFSLPSHLNLTGESDGGYMDM
 | |.|.|.|.||.|            .|..|..||. .||    | |||......| .  ....  .. ...|. |        |  ..          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSK-L--------H--HC----------

SKDESIDYVPMLDMKGDIKYADIESPSYMAPYDNYVPSAPERTYRATLIND-SPVLSYTDLVG-------------------FSYQVANGMDFLASK---
          |   |||     |   .|  ...|..  ..|..|  .|| | .| |. .||.                    ...|.|.|| .|.||   
----------M---KGD-----I---TY-SHESNSPC-PEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCE

---NCVHRDLAARNVLICEGKL-----------VKICDFG--------LARDIMRDSNYISKG------------------------STFLPLKWMAPES
   |.|||||||||.|..|..            .||.|||        ||||| .|..| .|.                        .. ||..|||||.
FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPEC

IF---------NSLYTTLSDVWSFGILLWEIFTLG-GTPYPELPM--------NDQFYNAIKRG--------------YRMAQPAHAS------------
..         .  .|| |||||||.|.|||||.| ...|....         |..... ..||              .||.||.|..            
LNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHC

--DEIYEIMQKCWEEKFETRPPFSQLVLLL
  .|.|..||.||... | || ||||.  |
PPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase PDGFRb.AA TK-Unique 599-957 34 4.4e-112 378.65 In-house 1-294 (294) Show / Hide 
Range on Protein: 599-957
Range on HMM: 1-294/294
Sequence Identity: 34% (129 aa)

LVLGRTLGSGAFGQVVEATAHGLS-HSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGG-PIYIITEYCRYGDLVDYLHRNK
|..|...|.||||||  ... |.. |. .. .|||||||  |.  .||....|...|..||.| |.|..||.||| . | .|| |||..|.| .||....
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

HT--------FLQRHSNKHCPPSAELYSNALPVGFSLPSHLNLTGESDGGYMDMSKDESIDYVPMLDMKGDIKYADIESPSYMAPYDNYVPSAPERTYRA
 .         |.                                                                                 . . ..
PAMRQHQTYGNLK---------------------------------------------------------------------------------FDFHHM

TLINDSPVLSYTDLVGFSYQVANGMDFLAS--KNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGS-TFLPLKWMAPESIF--NSLY-TTL
. ..    .|. ||. | .|.|.|| .|||  |..|||||.|||||. |.| .||||||.|||.. .  |....|   .|..||||||.      | || 
PDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTK

SDVWSFGILLWEIFTLGGTPYPELPMNDQFYNAIKRGYRMAQPAHA-SDEIYEIMQKCWEEKFETRPPFSQLVLLL
|||||||.|.|||||||..|||..|  | . ..|..|||| ||.|  |.|.|..|. || .. | || |.|..  |
SDVWSFGVLMWEIFTLGACPYPGMPWKD-IMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase PDGFRb.AA VEGFR 801-957 58 5.6e-95 321.83 In-house 174-332 (332) Show / Hide 
Range on Protein: 801-957
Range on HMM: 174-332/332
Sequence Identity: 58% (93 aa)

DLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARD-IMRDSNYISKGS-TFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTL
||. .|.|||.||.||||..|.||||||||.|.|| . ||||||||||. | .| .|  ||. . ||.|||||||||   ||| |||||.|..|||||.|
DLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEIFSL

GGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQLVLLL
|| |||   ... |.| .| ||||  |  .  |||.||. || .  | || || ||  |
GGSPYPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase PDGFRb.AA FGFR 774-957 51 3.5e-84 285.97 In-house 113-293 (293) Show / Hide 
Range on Protein: 774-957
Range on HMM: 113-293/293
Sequence Identity: 51% (94 aa)

YDNYVPSAPERTYRATLINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPES
| .| |. || .    ||   | |.  ||| . |||| ||..|||. |.||||||||||. ..   |||||||||||     |  ..   || ||||||.
YTDYKPRKPEQQDDIELI---PNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRLPIKWMAPEA

IFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQLVLLL
 |   ||. |||||.|.|||||.|.||.|||  |   . |   | |.||  |.. | ||| .|  || .| . ||.| |||  |
LFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase PDGFRb.AA Src 797-957 46 3.4e-70 237.68 In-house 94-255 (255) Show / Hide 
Range on Protein: 797-957
Range on HMM: 94-255/255
Sequence Identity: 46% (76 aa)

LSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMR--DSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWE
|. ..|. .. |||.||..| |.| .||||||||||. |. ..|..|||||| ..   | .| ..    .| ||.||| |    .|. ||||||||||.|
LHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTE

IFTLGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYE-IMQKCWEEKFETRPPFSQLVLLL
|.| | .|||   .| .   ...||||| .|..  ||.|| ||..||... | || |  |   |
IVTYGRVPYPGM-TNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase PDGFRb.AA Tie 791-957 47 1.7e-66 201.16 In-house 105-267 (267) Show / Hide 
Range on Protein: 791-957
Range on HMM: 105-267/267
Sequence Identity: 47% (79 aa)

INDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGI
.| .  ||   ...|   ||.||..|. |.|.||||||||.|.||  . || ||||.|    |  |. |    || .||| ||.  | ||| |||||.|.
VNVASTLSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSRG---DEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSYGV

LLWEIFTLGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQLVLLL
||||| .||||||  .   . .|. . .|||| ||    ||.|..|..|| ..   ||||.|... |
LLWEIVSLGGTPYCGMTCAE-LYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase PDGFRb.AA UTK 784-957 33 6.2e-66 224.53 In-house 102-296 (296) Show / Hide 
Range on Protein: 784-957
Range on HMM: 102-296/296
Sequence Identity: 33% (66 aa)

RTYRATLINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEG-------KLVKICDFG---LARDIMR--------DS-NYISKGSTFL
|. | |.  .   |. ..........|.|| .|.|...|||||||||.|...         ..||.|||   ..|.. .        .|  | . . . .
RRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRW

PLKWMAPESIFNS-LYTTLSDVWSFGILLWEIFTLGGTPYPELPMNDQFYNAIKRG--YRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQLVLLL
|..|||||.. .   .||.|||||||...|||.| | .|||..  |.|   .. .|  |||..|.. ....|..|..||.   . || | .||  .
PIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGM-SNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase PDGFRb.AA RTKB 797-957 45 5e-62 207.88 In-house 106-264 (264) Show / Hide 
Range on Protein: 797-957
Range on HMM: 106-264/264
Sequence Identity: 45% (74 aa)

LSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLS-DVWSFGILLWEI
|.   || |. |.|.|| || ..| .||||.|||||.  .   ||||||.|| |  |     .. | || |||||||.  . ||| | ||||||.  |||
LKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREI--DHECYETTCTRLPIKWMAPESWAHRIYTTKSGDVWSFGVTMWEI

FTLGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQLVLLL
|.||||||.... | .  .    |.|. .|  .. ....|||.|| .  . || |. || ..
FSLGGTPYQQYR-NGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase PDGFRb.AA Ret 801-959 45 8.5e-62 209.84 In-house 136-293 (293) Show / Hide 
Range on Protein: 801-959
Range on HMM: 136-293/293
Sequence Identity: 45% (72 aa)

DLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGG
... |  |.  || .|..   |||||||||||. ||.. || |||| ||.  |  |. .    .| ||||.|| .   ||| |||||||.|.||| |.|.
MIISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKDRIPVKWMAIESLYDHVYTTKSDVWSFGVLCWEIVTMGA

TPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQLVLLLER
 |||  |  .  ..  | ||||  |   | |.| || .|| .  . || |  .   .|.
NPYPGIPP-ERLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase PDGFRb.AA VEGFR 599-699 53 7.1e-53 181.97 In-house 1-104 (332) Show / Hide 
Range on Protein: 599-699
Range on HMM: 1-104/332
Sequence Identity: 53% (56 aa)

LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTK---GGPIYIITEYCRYGDLVDYLHRN
| ||. || ||||||.||.| |.  .. .  |||||||..| .||. |||||||.. |.| ||||||.||.|||   .||  .| |||..| | .||   
LKLGKMLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTK

KHTF
  .|
RMYF
Kinase PDGFRb.AA FGFR 599-695 44 1.1e-37 125.99 In-house 1-99 (293) Show / Hide 
Range on Protein: 599-695
Range on HMM: 1-99/293
Sequence Identity: 44% (44 aa)

LVLGRTLGSGAFGQVVEATAHGLSHS--QATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRN
|.|| .|| |.||||. |.| |.  .  .....|||||||. .   .   | ||. .|   | | |..||||.|| .|| |.| |||  | | |.|  .
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRAR
Kinase PDGFRb.AA Tie 608-692 40 5.1e-27 78.72 In-house 2-83 (267) Show / Hide 
Range on Protein: 608-692
Range on HMM: 2-83/267
Sequence Identity: 40% (34 aa)

GAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYL
| ||||. |.   .      |.||.||.|  |   ...  | || .|  .| | |..||.||| . | .|. .|| .|| |.|.|
GNFGQVMKAM---IKKDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYLYVAIEYAPYGNLLDFL
Kinase PDGFRb.AA Ret 599-692 43 7.6e-27 88.68 In-house 1-96 (293) Show / Hide 
Range on Protein: 599-692
Range on HMM: 1-96/293
Sequence Identity: 43% (42 aa)

LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKST-ARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGG--PIYIITEYCRYGDLVDYL
|.|. ||| | ||||| |.|  .        |||||||   | |||  .| ||. .   .  | .|. |.|||.  .  |  .| |||.|| |  .|
LQLDDTLGEGHFGQVVKAQAFHIRGHPGYTTVAVKMLKRNTANSSEYHDLLSEFQLLKQVN-HPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFL
Kinase PDGFRb.AA UTK 599-704 35 8.8e-24 78.23 In-house 1-114 (296) Show / Hide 
Range on Protein: 599-704
Range on HMM: 1-114/296
Sequence Identity: 35% (41 aa)

LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQA----LMSELK---IMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDY
. |||.||.||||.| .|..   |    .|.|||| ....| .  ...    .| | .   .|...  | ||..|.| ||...|..|.|||.. |||..|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LHRNKHTFL-QRHS
| |...|.  ..|.
LRRHRPTPPACPHW
Kinase PDGFRb.AA S_TKc 599-961 18 1.1e-23 85.98 SMART 1-231 (231) Show / Hide 
Range on Protein: 599-961
Range on HMM: 1-231/231
Sequence Identity: 18% (68 aa)

LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRY--GDLVDYLHRNK
  ..|..|.||||.|  .. ..        .||.|..|        . ...|..|...   | |.|.|....   . .|...|||    ||| ||.....
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

HTFLQRHSNKHCPPSAELYSNALPVGFSLPSHLNLTGESDGGYMDMSKDESIDYVPMLDMKGDIKYADIESPSYMAPYDNYVPSAPERTYRATLINDSPV
.  |..                                                                                             .
RHGLRF---------------------------------------------------------------------------------------------P

LSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTT-LSDVWSFGILLWEI
..  .   . ||........ |.. .||||   |.|..|   .||||||||| .          .    . .|||| .    |..  .|.||.|..|.| 
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

FTLGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQLVL-----LLERLL
.. | .|.|     .. .. |.           |.|  ....||..   | ||   ..        .   .
LC-GYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PDGFRb.AA Pkinase 789-957 23 8.8e-22 78.1 Pfam 93-293 (293) Show / Hide 
Range on Protein: 789-957
Range on HMM: 93-293/293
Sequence Identity: 23% (48 aa)

TLIN--DSPVL--SYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLIC-EGKL---VKICDFGLARD--IMRDSNYISKGSTFLPLKWMAPESIF-NS
..|   .. ..  |. ..  . ||.. |.... |....||||   |.||  .| .   |||||||||.   . ..| . .   |   . .|||| |  ..
DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGT---PWYMAPEVIRGGQ

LYTTLSDVWSFGILLWEIFTLGGTPYPEL----PMNDQFYNAIKRGYRMAQPAHA----------------------SDEIYEIMQKCWEEKFETRPPFS
 |.. .|.||.|..|.| .. | .|.|.     . .|| .   .....                             |.|  ... .|.. . . || . 
YYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE

QLVLL--L
|..    .
QILQHPWF
Kinase PDGFRb.AA Src 599-696 37 1.2e-20 66.84 In-house 1-90 (255) Show / Hide 
Range on Protein: 599-696
Range on HMM: 1-90/255
Sequence Identity: 37% (37 aa)

LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLH-RNK
. | | ||.| || | ...  |      ..||||| ||.     . .|.  | .||  |  | ..|.|.  |... ||||.||| . | | |||. . .
IKLCRKLGQGQFGEVWMGYWNG------NTKVAVKTLKPGT--MSPEAFLQEAQIMKKLR-HEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGE
Kinase PDGFRb.AA RTKB 599-693 37 1.8e-20 65.76 In-house 1-94 (264) Show / Hide 
Range on Protein: 599-693
Range on HMM: 1-94/264
Sequence Identity: 37% (36 aa)

LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLH
. ||. ||.||||.|  |    ..|.  .  .|.| ||  | . |.|.  ||. .|  ||.| ||. ..| | .  |  .  |.| .| | |||.
VWLGEKLGNGAFGEVFQAWVR-NRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLR
Kinase PDGFRb.AA Pkinase 599-696 33 1.5e-18 66.66 Pfam 1-101 (293) Show / Hide 
Range on Protein: 599-696
Range on HMM: 1-101/293
Sequence Identity: 33% (36 aa)

LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQ--ALM-SELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYG----DLVDY
...||..|||.||.| ... .| ..     .|||| .|   ..|.|.  ..  ||..|| .|  | |.| |..... .. ||...|||. |    || ||
YHIGRKIGSGSFGCVYKCHHKGTGK-----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

LH--RNK
..  |..
ISTWRHG