Gene PAK6 (Mouse)

PAK6

Species: Mouse
Alias: PAK6
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: STE
Family: STE20
Subfamily: PAKB

Sequence

Name Sequence Type Origin Length Description Download
PAK6.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 252 Kinase domain by global Sugen HMM Fasta, JSON
PAK6.AA Protein Sugen 682 None Fasta, JSON
PAK6.NA RNA Sugen 4137 None Fasta, JSON

Protein domain

Protein domains of PAK6.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PBD PAK6.AA PBD 11-67 31 1e-19 71.4 Pfam 1-60 (60) Show / Hide 
Range on Protein: 11-67
Range on HMM: 1-60/60
Sequence Identity: 31% (19 aa)

EISAP-QNFQHRVHTSFDPKEGKFVGLPPQWQNILDTL--RRPKPVVDPSRITRVQLQPM
.||.|  ||.|..|  .|...|.|.|.||.||..|..   ..|.. ..|.... |.  ..
MISTPLTNFKHTMHVGWDGQTGFFTGMPPEWQKLLQSSGISKPEQKHNPQAVFDVVQFYQ
PBD PAK6.AA PBD 12-47 47 1.8e-13 51.99 SMART 1-38 (38) Show / Hide 
Range on Protein: 12-47
Range on HMM: 1-38/38
Sequence Identity: 47% (18 aa)

ISAPQ-NFQHRVHTS-FDPKEGKFVGLPPQWQNILDTL
||.|  ||.|.||   .|...|.|.|||.|||..| . 
ISTPTGNFKHIVHVGPWDGQTGEFTGLPHQWQHLLKHC
Kinase PAK6.AA PAKB 408-659 83 8e-222 743.21 In-house 1-252 (252) Show / Hide 
Range on Protein: 408-659
Range on HMM: 1-252/252
Sequence Identity: 83% (210 aa)

LDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHLNVVEMYKSYLVGEELWVLMEFLQGGALTDIISQVRLNEEQIATV
||.|||||||||||||.|.|||.|||||||.|||||||||||||||||||||||| |.||||.|||||.||||.|||..|||||||....|.||||||||
LDNYVKIGEGSTGIVCIATEKHTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYQHPNIVEMYSSYLVGDELWVVMEFMEGGALTDIVTHTRMNEEQIATV

CEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSP
|..|||||||||||||||||||||||||| ||||||||||||||.||.|||||||||||||||||||||..|.|||||||||||||||||||||||...|
CRQVLQALAYLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMVDGEPPYFNEPP

VQAMKRLRDSAPPKLKNSYKVSPVLRDFLDRMLVREPQERATAQELLDHPFL
.|||||.||..||.|||..||||.||.||||||||.|..|.||||||.||||
LQAMKRIRDMHPPRLKNHHKVSPRLREFLDRMLVRDPNQRWTAQELLRHPFL
Kinase PAK6.AA STE20 408-659 44 6.4e-145 487.75 In-house 1-288 (288) Show / Hide 
Range on Protein: 408-659
Range on HMM: 1-288/288
Sequence Identity: 44% (129 aa)

LDSYVKIGEGSTGIVCLAREKHSGRQ----VAVKMMDLRKQ----QRRELLFNEVVIMRDYQHLNVVEMYKSYLVG----EELWVLMEFLQGGALTDIIS
 . . |||.||.| |..|..|..|..    ||.|.|.|.|.    ...|....|..||....| |.|..| |||..    .|||..||...|| ||||..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

QV----------RLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISK-----DVPKRKSLVGTPYWMAPEVISR----
..          ..||||||..|  |||.|.|||....||||||.| |||| ||.|||.|||.|||..|     . .||...||||||||||||..    
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-SLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLR--DSAPPKLKN--SYKVSPVLRDFLDRMLVREPQERATAQELLDHPFL
 . | . .|||||||. |||..||||||  .|..|| .    .  ||.||.  . | || ..||.|..|...|..|.||..|| |||.
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase PAK6.AA PAKA 409-659 48 8.9e-128 430.8 In-house 2-260 (260) Show / Hide 
Range on Protein: 409-659
Range on HMM: 2-260/260
Sequence Identity: 48% (125 aa)

DSYVKIGEGSTGIVCLAREKHSGRQ--VAVKMMDLRKQQRRELLFNEVVIMRDYQHLNVVEMYKSYLVGEELWVLMEFLQGGALTDIISQVR------LN
. . |||.|..| | .| ... . .  ||.| |.. .| . ||. ||  .|....| |.|  ..|||| .|||| ||...|| |||.|.|..      ..
KFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYMD

EEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEP
|.||| ||. .||.| ..|....|||||||| |||  ||.||. |||||||...   ||.. ||||||||||||.|  |   |||||||||.|||..|||
EGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIEGEP

PYFSDSPVQAMKRLRDSAPPKLKNSYKVSPVLRDFLDRMLVREPQERATAQELLDHPFL
|| .. |. ||  .     |..|.  |.|. ..||||. |  ....||.||||| ||||
PYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase PAK6.AA STE 408-659 29 9.5e-114 384.19 In-house 1-359 (359) Show / Hide 
Range on Protein: 408-659
Range on HMM: 1-359/359
Sequence Identity: 29% (107 aa)

LDSYVKIGEGSTGIVCLAREK------HSGRQ---------VAVKMMDLRKQ-----------------QRRELLFNEVVIMRDYQ--HLNVVEMYKSYL
..   |||.|..| |..|. .      ..|..         .|.| |.|...                 . .. . .|. ||....  | |.|. | .|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VG-------EELWVLMEFLQGGALTDIISQV---------------RLNEEQIATVCEAVLQA-LAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCA
..       .|||. ||.. || |.||| ..               |..|.|||..| ..|.. |.||| ...||||||.. |||     |||.|||.|.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QISKDVP----------------KRKSLVGTPYWMAPEVISR------SLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDS-----------
|......                ||...|||| |||||||..      . | | .||||||...|||..|.||..  .| .|| .  ..           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----APPKLKN-----------------SYKVSPVLRDFLDRMLVREPQERATAQELLD--HPFL
     ||.|..                 . |.|| ..||... |...|..|.||..||   |||.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase PAK6.AA S_TKc 408-659 29 1.4e-91 311.49 SMART 1-231 (231) Show / Hide 
Range on Protein: 408-659
Range on HMM: 1-231/231
Sequence Identity: 29% (79 aa)

LDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHLNVVEMYKSYLVGEELWVLMEFLQG--GALTDIISQVR-------
 .   |||.|. | |...|.|..||.||.|...       | . .|. |..  .| |.| .| ..   ..|.. ||.. |  | | |.| . .       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYAT-EVDIWSLGIMVIEMVD
..| ... ..  ...||.|.| .|.||||.| . |||.   ..|..|||...|.       ....|||..|||||.    | . ..|.||.|....||. 
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GEPPYFSDSPVQAMKRLRDSAPPKLKNSYKVSPVLRDFLDRMLVREPQERATAQELLD-------HPFL
|.||.    . . .|...             || ..||....|...|..| || |.|        ||..
GYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PAK6.AA Pkinase 408-659 27 1.7e-81 281.86 Pfam 1-293 (293) Show / Hide 
Range on Protein: 408-659
Range on HMM: 1-293/293
Sequence Identity: 27% (81 aa)

LDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRREL--LFN--EVVIMRDYQHLNVVEMYKSYLVGEELWVLMEFLQGG----ALTDIIS---Q
.    |||.|| | |.....| .|..|||| ...|..   ..  ...  |. ||.  .| |.|..| ..  . .... ||...||     | |.||   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

VRL--NEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRV----KLSDFGFCAQI-SKDVPKRKSLVGTPYWMAPEVIS-RSLYATEVDIWSL
 ..   |...  ..  .|..|.|.|..|.||||.|.. ||.  .| .    |..|||...|.     .  ....|||..||||||  .. | ..||.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GIMVIEMVDGEPPYFSD----SPVQAMKRLRDSAPPKLKNSYKVS---------------------PVLRDFLDRMLVREPQERATAQELLDHPFL
|....||. |.||. ..    . .  |....   .|.|. ..  .                     . ..||....| . |..| ||...| ||..
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase PAK6.AA YSK 411-659 38 2.1e-80 241.71 In-house 1-257 (257) Show / Hide 
Range on Protein: 411-659
Range on HMM: 1-257/257
Sequence Identity: 38% (100 aa)

YVK---IGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRR-ELLFNEVVIMRDYQHLNVVEMYKSYLVGEELWVLMEFLQGGALTDIISQ---VRLNEEQ
..|   || || | |  . ... .| ||.|  || .     |..  |. .  .    ..   | ||| .  ||. ||.. || . | . .     . |..
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKY

IATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISR--SLYATEVDIWSLGIMVIEMVDGEPP
||..   .|..| ||| . .||||||.  .||. .| ||| |||  .||   . ||   ||||||||||||    | | . .|||||||  .||  ||||
IAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEPP

YFSDSPVQAMKRLRDSAPPKLKN-SYKVSPVLRDFLDRMLVREPQERATAQELLDHPFL
|    |  .| ..  . ||||.  ||  |  . .| .  |. .|..| .|.||| | | 
YCDYHPMRVMFLIPKNNPPKLEGRSY--SKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase PAK6.AA KHS 409-659 41 1.5e-76 257.01 In-house 2-258 (258) Show / Hide 
Range on Protein: 409-659
Range on HMM: 2-258/258
Sequence Identity: 41% (107 aa)

DSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHLNVVEMYKSYLVGEELWVLMEFLQGGALTDIISQV-RLNEEQIATV
.   ..| |  | |  ||...|.  .|||.. .  ..  ...  |...|.| .| |.|  . |||  . ||. ||.  ||.| ||      |.| ||| |
ELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGPLSELQIAYV

CEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVIS---RSLYATEVDIWSLGIMVIEMVDGEPPYFS
|  .||.|.|||..| .|||||   |||| .| ||| |||  |||.  . |||| .|||||||||| .   .  |    |||..||  ||. .  || | 
CRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPMFD

DSPVQAMKRLRDSA--PPKLKNSYKVSPVLRDFLDRMLVREPQERATAQELLDHPFL
  |..|.  .  |.  |||||.  | |.   .|.   |...|. | ||. || |||.
LHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase PAK6.AA MST 413-659 41 7.7e-76 240.52 In-house 6-254 (254) Show / Hide 
Range on Protein: 413-659
Range on HMM: 6-254/254
Sequence Identity: 41% (103 aa)

KIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHLNVVEMYKSYL--VGEELWVLMEFLQGGALTDI--ISQVRLNEEQIATVC
|.|.|| | |  |  | .|  ||.||.        . . .|  || . .  ..|  | ||.    ...|  ||.  .| . ||  | |  |||.|||...
KLGQGSYGSVYKAIHKQTGKIVAIKMVPV--NEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQIACIL

EAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPV
  .|| |.|||    ||||||.  |||  .|  ||.|||  .| .    || ...|||||||||||  . | . .|||||||  |||  |.|||.   |.
YDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMPPYSDIHPM

QAMKRLRDSAPPKLKNSYKVSPVLRDFLDRMLVREPQERATAQELLDHPFL
 ||.    . ||..|.  . |. . ||. . |...|..|.|| .|| ||| 
RAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase PAK6.AA SLK 409-659 36 1.9e-72 243.71 In-house 2-259 (259) Show / Hide 
Range on Protein: 409-659
Range on HMM: 2-259/259
Sequence Identity: 36% (95 aa)

DSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHLNVVEMYKSYLVGEELWVLMEFLQGGALTDIISQVR--LNEEQIAT
.    .|.|  | |  |..|  ..  | ||......   |  . |. |. . .| |.|..|..| . ..||...|| .|||.  |.  .   | |.||. 
EIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQY

VCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVI-----SRSLYATEVDIWSLGIMVIEMVDGEPP
||. ...|| .|| . |||||.|   ||.|.|| |.| |||  |.  ... || . .||||||||||.         |   .||||||| .||| ..|||
VCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEPP

YFSDSPVQAMKRLRDSAPPKLKNSYKVSPVLRDFLDRMLVREPQERATAQELLDHPFL
.   .|.  . ... | ||.|..  . |   .||| . ||..|| | |...|..|...
HHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase PAK6.AA CAMK 413-659 18 4.2e-70 224.85 In-house 1-425 (425) Show / Hide 
Range on Protein: 413-659
Range on HMM: 1-425/425
Sequence Identity: 18% (77 aa)

KIGEGSTGIVCLAREKHSG------------RQVAVKMMDLRKQQR----------------------------RELLFNEVVIMRD-------YQHLNV
..|.|| |.| |...|...            ..||.|..| .| .                             |. ...|. ||.         .| |.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VEMYKSYL------------VGEE--------LWVLM---EFLQGGAL----TDIISQV----------------RLNEEQIATVCEAVLQALAYLHAQG
. .|  |               .         ..  |   |. .|| |     | | .                 |..|.. ...   ...|..|.| ..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

VIHRDIKSDSILLTLD-----------------GRVKLSDFGFCAQISKDV-----------------------PKRKSLVGTPYWMA-PEVISRSL---
..|||.| . |||. .                 . .|..|||| ... ..                        .| |  .|||. || |||....    
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----------YATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMK----------------RLRDS-APPKLKN------------------SYKVSPVL
           |  ..|.||.|..   |. |.||. .|.  . ..                . . .  ||....                  . .||.  
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH-FVSQEC

RDFLDRMLVREPQERATAQELLDHPFL
.|.. .||...|..|.|... |.||..
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase PAK6.AA MSN 408-659 35 5.1e-64 210.2 In-house 1-265 (265) Show / Hide 
Range on Protein: 408-659
Range on HMM: 1-265/265
Sequence Identity: 35% (95 aa)

LDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDY-QHLNVVEMYKSYL------VGEELWVLMEFLQGGALTDIISQVR--
 .    .| |  | | . | .  |. .|.|.||.|.    |.   |. ... |  | |..  |  ..        . ||. |||   |..||.. . .  
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVREDEEEEIKQ-EINMLKKYSHHRNIATYYGAFIKKSPPGHDHQLWMVMEFCGAGSVTDLVKMTKGQ

-LNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVIS-----RSLYATEVDIWSLGIMV
 | |. || .|  .|. ||.||.. |||||||   .||| .  ||| |||  ||... | .| . .|||||||||||      .  |    |.||.||  
SLKEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSVGITA

IEMVDGEPPYFSDSPVQAMKRLRDSAPPKLKNSYKVSPVLRDFLDRMLVREPQERATAQELLDHPFL
||| .|.||     |..|.  .   .||||| | | |    .|....|... ..| .....| |||.
IEMAEGQPPLCDMHPMRALFLIPRNPPPKLK-SKKWSKKFHNFMEKCLIKNYHQRPYTEQMLKHPFI
Kinase PAK6.AA Pkinase_Tyr 408-616 28 6.1e-25 85.1 Pfam 1-231 (270) Show / Hide 
Range on Protein: 408-616
Range on HMM: 1-231/270
Sequence Identity: 28% (65 aa)

LDSYVKIGEGSTGIVCLAREK----HSGRQVAVKMM--DLRKQQ--RRELLFNEVVIMRDY-QHLNVVEMYKSYL-VGEE--LWVLMEFLQGGALTDIIS
.    |.|||. | |.... |      . .|||||.  .  ..|  |....  |. ||. . .| |.| .|   .  ||   ... ||. ..| | |   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

QV-----RLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQI-SKDVP--KRKSLVGTPYWMAPEVISRSLYATEVDIWS
.      .|. ...   |  . ....||.... ||||.    .|.| .. || .||| .  | ..|    ||..      |||||.|. . . |. |.||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

LGIMVIEMVD-GEPP-YFSDSPVQAMKRL-RD
 |.   |..  || | |   |. . .... .|
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYED
Kinase PAK6.AA TyrKc 408-659 26 2e-23 85.07 SMART 1-280 (280) Show / Hide 
Range on Protein: 408-659
Range on HMM: 1-280/280
Sequence Identity: 26% (75 aa)

LDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDY--QHLNVVEMYKSYLVG-------EELWVLMEFLQGGALTDIISQVR
.    |.|||  |.|.... |   .||||||.   .   || . .|  ||. .  .| |.| .|   . .       | |...||.  .|.| | .   |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--LNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKD-------VPKRKSL-VGTP-----YWMAPEVISRSLYATEV
  |. ..    |  . .  .||| ...||||.    .|.. ...|| |||| .  |  |         .||.   |.       |||||.|  . . |. 
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DIWSLGIMVIEMV-DGEPPYFS-----DSPVQAMKRLRDS-APPKLKNSY-----KVSPVLRDFLDRMLVREPQERATAQELLDHPFL
|.|| |..  |.  .|..||        |. ........   .|. .| |       .. . .   .   ..| .| | .|.  | ..
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF