Gene PAK1 (Mouse)

PAK1

Species: Mouse
Alias: PAK1, Pak1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: STE
Family: STE20
Subfamily: PAKA

Sequence

Name Sequence Type Origin Length Description Download
PAK1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 248 Kinase domain by global Sugen HMM Fasta, JSON
PAK1.NA RNA Sugen 1968 None Fasta, JSON
PAK1.AA Protein Sugen 544 None Fasta, JSON

Protein domain

Protein domains of PAK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PBD PAK1.AA PBD 74-132 60 2e-31 111.92 Pfam 1-60 (60) Show / Hide 
Range on Protein: 74-132
Range on HMM: 1-60/60
Sequence Identity: 60% (36 aa)

EISLP-SDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYN
.|| | ..|.||.|||.|. ||.|||||..|..|||.|.|.|.|||.|||||.||. ||.
MISTPLTNFKHTMHVGWDGQTGFFTGMPPEWQKLLQSSGISKPEQKHNPQAVFDVVQFYQ
PBD PAK1.AA PBD 75-110 52 1.6e-18 68.8 SMART 1-38 (38) Show / Hide 
Range on Protein: 75-110
Range on HMM: 1-38/38
Sequence Identity: 52% (20 aa)

ISLPS-DFEHTIHVG-FDAVTGEFTGMPEQWARLLQTS
||.|. .|.|..||| .|. ||||||.|.||..||...
ISTPTGNFKHIVHVGPWDGQTGEFTGLPHQWQHLLKHC
Kinase PAK1.AA PAKA 269-520 72 1.4e-201 675.96 In-house 1-260 (260) Show / Hide 
Range on Protein: 269-520
Range on HMM: 1-260/260
Sequence Identity: 72% (189 aa)

YTRFEKIGQGASGTVYTAMDVATGQE--VAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC------M
|...|||||||||.||.| ...|.||  |||||||...||||||||||||||.|.|..|||||.||||| |||||||||..||.||||.|..|      |
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYM

DEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGE
||||||.|||||||.|||.||...|||||||||||||||||||.||||||||.|.||.||.|||||||||||||..|| |..||||||||||||||||||
DEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIEGE

PPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFL
||||||.||||.|||||||.|....|.|.|  |.|||..||..||..| ||.|||.| ||
PPYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase PAK1.AA STE20 269-520 50 1.7e-169 569.38 In-house 1-288 (288) Show / Hide 
Range on Protein: 269-520
Range on HMM: 1-288/288
Sequence Identity: 50% (145 aa)

YTRFEKIGQGASGTVYTAMDVATGQE----VAIKQMNLQQQ----PKKELIINEILVMRENKNPNIVNYLDSYLVG----DELWVVMEYLAGGSLTDVVT
|. .||||||..|.||.| .. ||..    ||||.||| ..    ...|.|..||..|.. |.||||.|..|||..    ||||.||||..||||||...
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

ETC----------MDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITP-----EQSKRSTMVGTPYWMAPEVVTR----
...          |.| |||..|||.||.|..||||..||||||.|||||..||.|||.|||.|||.|.     .|.|| |.|||||||||||. .    
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-KAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIA--TNGTPELQN--PEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFL
 | |. |.|||||||.||||.||||||....|.||...|.  .|..|.|..  |.| |  |.||...||..|.||| .|..||.|.|.
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase PAK1.AA PAKB 270-520 56 7.29999999999e-138 464.3 In-house 2-252 (252) Show / Hide 
Range on Protein: 270-520
Range on HMM: 2-252/252
Sequence Identity: 56% (143 aa)

TRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVC
. . ||| |  |.|  | .  ||. ||.|.|.|  |   ||  ||. .||. . ||||.  .|||||||||||||.. ||.|||.||.| |.| |||.||
DNYVKIGEGSTGIVCIATEKHTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYQHPNIVEMYSSYLVGDELWVVMEFMEGGALTDIVTHTRMNEEQIATVC

RECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPL
| .||||..||.  ||||||||| |||  || |||.|||||||.  |  ||  .|||||||||||. |  ||..||||||||| |||..||||| || ||
RQVLQALAYLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMVDGEPPYFNEPPL

RALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFL
.|.  |  .  | |.|  | |   |.||.|.|  |...| .|.|||.| ||
QAMKRIRDMHPPRLKNHHKVSPRLREFLDRMLVRDPNQRWTAQELLRHPFL
Kinase PAK1.AA STE 269-520 34 2.3e-135 456.01 In-house 1-359 (359) Show / Hide 
Range on Protein: 269-520
Range on HMM: 1-359/359
Sequence Identity: 34% (126 aa)

YTRFEKIGQGASGTVYTAMDV------ATGQE---------VAIKQMNLQQQ-----------------PKKELIINEILVMRENK--NPNIVNYLDSYL
... ||||.||.||||.||..       ||..         .|||||||...                  ... |..|| .|.. .   ||||.|...|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VG-------DELWVVMEYLAGGSLTDVVTETCMD---------------EGQIAAVCRECLQA-LEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCA
..       ||||..|||..||||.|.. ....                | |||..||..|.. |..|||...||||||..||||     |||.|||.|.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QITPE----------------QSKRSTMVGTPYWMAPEVVTR------KAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATN-----------
|.|..                |.|| |.|||| ||||||...      | |. |.||||||...|||..|.||. ...|.||...|..|           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----GTPELQN-----------------PEKLSAIFRDFLNRCLEMDVEKRGSAKELLQ--HQFL
    . | |..                 |.|.|  |.||.|.||..| .|| .|..||.  | |.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase PAK1.AA YSK 269-520 46 1e-116 353.07 In-house 1-257 (257) Show / Hide 
Range on Protein: 269-520
Range on HMM: 1-257/257
Sequence Identity: 46% (119 aa)

YTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKK-ELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTE---TCMDEGQ
.|. |.|| |  | || . |. |.. ||||  .| .     |.|  || .  . . |.| .|. ||| .  ||..|||..|||. |         .|| .
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKY

IAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR--KAYGPKVDIWSLGIMAIEMIEGEPP
|| . || |..|..|||...||||||. |.||  .| ||| |||  .|||  | || |.|||||||||||.     .|  |.||||||| |.||  ||||
IAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEPP

YLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFL
|    |.|.. ||  |  |.|.  .. |  | .| . ||. | |.| |||||| |.| 
YCDYHPMRVMFLIPKNNPPKLEG-RSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase PAK1.AA S_TKc 269-520 33 4.2e-100 339.78 SMART 1-231 (231) Show / Hide 
Range on Protein: 269-520
Range on HMM: 1-231/231
Sequence Identity: 33% (90 aa)

YTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAG--GSLTDVVTETC-------
|.  .|||.|| |.|| . .. ||..||||...       | |..|| .... . ||||...|..   |.|..||||. |  |.| |.  .         
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

MDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGP-KVDIWSLGIMAIEMIE
..| ... .... ..|||..||...||||.| .||||     .|..|||...|.       .|..|||..|||||.    ||. |.|.||.|.. .||. 
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQ-------HQFL
|.||.   .. . . .|              |  ..||...||..| ||| .| |.||       |...
GYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PAK1.AA MST 269-520 44 4.8e-100 318.69 In-house 1-254 (254) Show / Hide 
Range on Protein: 269-520
Range on HMM: 1-254/254
Sequence Identity: 44% (115 aa)

YTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL--VGDELWVVMEYLAGGSLTDVV--TETCMDEGQ
..  ||.|||. | || | .  ||..||||...       . ||.||  | . |...|| | .||.     ..| |||| ..||. |..  |     | |
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPV--NEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQ

IAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYL
||....  || |. ||.|  ||||||. ||||  .|  || |||  .| |  . || | .|||||||||| .   |  |.||||||| |||| ||.||| 
IACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMPPYS

NENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFL
.  | ||. .| ..  | ...||. |  | ||. .||  . |.| .|..|||| | 
DIHPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase PAK1.AA Pkinase 269-520 30 9.1e-98 335.91 Pfam 1-293 (293) Show / Hide 
Range on Protein: 269-520
Range on HMM: 1-293/293
Sequence Identity: 30% (90 aa)

YTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIIN----EILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGG----SLTDVVT---E
|.. .|||.|..|.|| .... ||..||.|..... . .......    || .|.. . |||| ..|..  .|....||||. ||    .| |...   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TCM--DEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSV----KLTDFGFCAQI-TPEQSKRSTMVGTPYWMAPEVVT-RKAYGPKVDIWSL
.|.  .| ..  .... |..||..||. .||||.|..|||.  .| .    |..|||...|. .  .|  .| .|||..|||||.  .. ||||||.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GIMAIEMIEGEPPYLNE----NPLRALYLIATNGTPELQNPEKLS---------------------AIFRDFLNRCLEMDVEKRGSAKELLQHQFL
|.. .||. |.||. ..    | .. ...|. .. |.|  ..  .                       ..||...||..| .|| .|...||| ..
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase PAK1.AA FRAY 269-520 37 1.5e-83 259.31 In-house 1-277 (277) Show / Hide 
Range on Protein: 269-520
Range on HMM: 1-277/277
Sequence Identity: 37% (104 aa)

YTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQP--KKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDV----VTETC---
|   | ||.||...|..|. .    ..|||  ||        . .| || .|  .. ||.| |  |..| .|||.|| || .||. |.    . .     
YELQEVIGEGATAVVHKAYCIPRQENCAIKRINLEKCQNTSMDELIKEIQAMCQCHHPNVVHYHTSFVVNEELWLVMRYLECGSCLDIMKFKMPQGEPHK

---MDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITP-----EQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLG
   .||  || . .| |..|...|.|. ||||||..|||.| ||.. . |||  | .        .  | |.|||| ||||||.     |  |.||||.|
QGVFDEHVIATILKEVLKGLCYFHKNGQIHRDIKAGNILIGEDGTIQIADFGVSAWLATGGDLSRCCVRHTFVGTPCWMAPEVMEQVHGYDFKADIWSFG

IMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPE--K-----LSAIFRDFLNRCLEMDVEKRGSAKELLQHQFL
| |||.. | .||    |   | |.  |  | |.  |  |      .  |.. .  ||  | .||  | |||.|.| 
ITAIELATGKAPYHKYPPMKVLMLTLQNDPPSLETDEDDKDMYKKYGHSFKKMIEKCLQKDPSKRPTASELLKHKFF
Kinase PAK1.AA KHS 269-520 44 1.9e-83 280.56 In-house 1-258 (258) Show / Hide 
Range on Protein: 269-520
Range on HMM: 1-258/258
Sequence Identity: 44% (115 aa)

YTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTET-CMDEGQIAA
|    ..| |  | || | |..... .|.| . .. .   ..|  ||..|.. . |||| |  |||  | ||..|||  |||| |.   |  . | ||| 
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGPLSELQIAY

VCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEV--VTRK-AYGPKVDIWSLGIMAIEMIEGEPPYL
|||| ||.|..|||.. .|||||  ||||  .| ||| |||  ||||   .||   .||||||||||  | ||  |.   |||..|| |||. |  ||  
VCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPMF

NENPLRALYLIATNG--TPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFL
.  |.|||.|..  .   |.|.. .| |..| .|.  .|  .  || .|. ||||.|.
DLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase PAK1.AA MKC 269-520 37 6e-81 275.23 In-house 1-260 (260) Show / Hide 
Range on Protein: 269-520
Range on HMM: 1-260/260
Sequence Identity: 37% (99 aa)

YTRFEKIGQGASGTVYTAMDVA-----TGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGD-ELWVVMEYLAGGSLTDVVTE-TCMD
|.  ...| |. |||| |  .        ..|||| |.     ..    ||| . .  . |||| |. |....| |.| |||.. || |..         
YKFLHQVGKGGFGTVYCAKYNNPHSTYDKCRVAIKKMPHVTKKHQRNNLNEIGFLNYCNHPNIVKYHCSHMKHDDEIWMVMEFMQGGTLEEASQNSHKFC

EGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEP
| .|| ||.| ||.|. ||... .|||.|| ||    || .|| |||.|.  . | ...  |.| |.||.||    |...  .||||.|| . ||  |.|
ESCIAYVCKEMLQGLMYLHEHNIVHRDLKSANIMMNTDGEIKLIDFGLCIDVSHE-KEEIHMCGSPFWMSPEMIQQKQHSYPCDIWSFGICLLEMANGRP

PYLNENPLRALYLIATNGTPE---LQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFL
|.  .... |  . ||||      .  |.. |  |.|||. ||.|| .|| .| .||.| |.
PH-HKSRMKAMFMVATNGCKFPKEFDDPCHWSDCFHDFLWQCLQMDPHKRPTAEQLLKHPFI
Kinase PAK1.AA STE11 269-520 35 8.3e-80 271.45 In-house 1-303 (303) Show / Hide 
Range on Protein: 269-520
Range on HMM: 1-303/303
Sequence Identity: 35% (108 aa)

YTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPK----------K----ELIINEILVMRENKNPNIVNYLDSYLV---GDELWVVMEYLAGGSL
... |.||.|| ||||..|.| ||...|.||. .| . .          .    ..|  || .|.  . .||| |... |     |.. . ||| .||||
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

TDVVTET--C--MDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGS-VKLTDFGFCAQITPEQSKRST----------MVGTPY--------
 ..      .  .||  |    .  |..| .|||...|||||| .||||  ||  .||.||| . ..  . .. ..          | ||||        
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPM

WMAPEVVTRKA---YGPKVDIWSLGIMAIEMIEGEPPYLNE--NPLRALYLIATNGTPELQNPEKLS------AIFRDFLNRCLEMDVEKRGSAKELLQH
||||||...     || |.||||||   |||. | ||. |   |.  |.. |... .|  . ||..|      .  ||||..|.| | .|| .| .||||
WMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQH

QFL
 |.
PFI
Kinase PAK1.AA TyrKc 269-520 23 2e-26 95.05 SMART 1-280 (280) Show / Hide 
Range on Protein: 269-520
Range on HMM: 1-280/280
Sequence Identity: 23% (67 aa)

YTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMREN--KNPNIVNYLDSYLVG-------DELWVVMEYLAGGSLTDVVTETC
 |  .|.| || |.|| ..     ..||.| ..      .| ...|. .|..   ..||||. .   . .       . |..|||| ..|.| |   .. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--MDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPE----QSKRSTMV----GTP-----YWMAPEVVTRKAYGPKV
      .    |    .  |.|||...||||.   |.|.| .. || .||| .  |. .     ||   ..    |.       |||||.   . . .| 
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DIWSLGIMAIEMIE-GEPPYLN-----ENPLRALYLIATNGTPELQNP-------EKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFL
|.|| |..  |.   |..|| .      .. ... .. . . ..           .  .....    .| . | |.| . .|.  |...
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase PAK1.AA Pkinase_Tyr 269-463 27 1.6e-22 76.93 Pfam 1-216 (270) Show / Hide 
Range on Protein: 269-463
Range on HMM: 1-216/270
Sequence Identity: 27% (60 aa)

YTRFEKIGQGASGTVYTAMDV----ATGQEVAIKQMNLQQQPK---KELIINEILVMREN-KNPNIVNYLDSYL-VGDE--LWVVMEYLAGGSLTDVVTE
 |  .|.|.|| |.|| .        |...||.| .. .  ..   .|  ..|. .|..  ..||||...   .  |.   ...|||| ..|.| |   .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

T-----CMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQI--TPEQ-SKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSL
        .  ..   |..  ...|.|.|.. ||||.   |.|.. .. || .||| .  |  . .   ||.       |||||.   . .  | |.|| 
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GIMAIEMIE-GEPP-Y
|.   |..  || | |
GVLMWEIFTYGEQPTY