Gene p38b (Mouse)

p38b

Species: Mouse
Alias: p38b, Mapk11
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: p38

Sequence

Name Sequence Type Origin Length Description Download
p38b.AA Protein Sugen 364 None Fasta, JSON
p38b.NA RNA Sugen 1295 None Fasta, JSON
p38b.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 285 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of p38b.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase p38b.AA p38 24-308 74 5.9e-228 763.58 In-house 1-289 (289) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-289/289
Sequence Identity: 74% (214 aa)

LQGLRPVGSGAYGSVCSAYDARLRQK---VAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTP-ATSIEDFSEVYLVTTLMGADLNNIVKC
 | |.||||||||.||.|.|.| .||   ||.|||.||||| |||.|||||||||||..|||||.||||||| |.|..||..||.||..||||||||.||
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQG
|.|||.|.||||||.|||||||||||||||||||||.|||||||||||||||||..|.|||||||||||||||||||||||.|||||||||||||||..|
QRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARHCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAELITG

KALFPGNDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSVFHGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF
..||||.|.||||.|||.|.|||..|...||.||.||.||||.|.||..|...||.||||.||||| .||.||.|.|..|.||..|.||
RTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase p38b.AA MAPK 24-308 55 2.7e-198 665.05 In-house 1-328 (328) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-328/328
Sequence Identity: 55% (182 aa)

LQGLRPVGSGAYGSVCSAYDARLRQK------VAVKKLSRPFQSLIHARRTYRELRLLKHL-KHENVIGLLDVFTP-----ATSIEDFSEVYLVTTLMGA
 | |.|.|.|||| ||||.| |..||      ||.||.|||||...|..|||||..||.|. .|||.|.|||.|||     . |.|.| ..|.|. ||..
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLNNIVKCQA-LSDEHVQFLVYQLLRG--LKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE-----------------MTGYVATRWYRAP
||..| |.|  |||.|.|...||.|||  |||||||..|||||||||..|||.|.|.|.||||||..| |                 ||.||||||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EIMLN--WMHYNQTVDIWSVGCIMAELLQ-GKALFPGNDYIDQLKRIMEVVGTPSPEVLAKIS-SEHARTYIQSL---PPMPQKDLSSVFHG----ANPL
|||||  ||||...||.||||||.||.|. .| ||||.|||||...||||.||||.|.. .|. |||||.|||||   |..|.|.....| .    |||.
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

AIDLLGRMLVLDSDQRVSAAEALAHAYF
||||| .|||.| |.| ...|||.| ||
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase p38b.AA ERK 25-308 50 2.2e-148 499.26 In-house 2-307 (307) Show / Hide 
Range on Protein: 25-308
Range on HMM: 2-307/307
Sequence Identity: 50% (155 aa)

QGLRPVGSGAYGSVCSAYDAR-----LRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK-HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK
| . ..| |||| |||| |        .||||.|| ...|  .| . ||.||..||.|.| |||.|.|.|.. | .|.|.. ..|.|. ||  ||  | .
QIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMP-NSPEQYNDIYCVEELMETDLHQIIN

CQ-ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR----QADEE-------MTGYVATRWYRAPEIMLNWMHYNQTVDI
 | .|||.|.|...||.|.||||||||..|||||||||. ||..| | | ||||||     ..|        ||.||||||||||||||.|  |.. .||
SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDI

WSVGCIMAELLQGKALFPGNDYIDQLKRIMEVVGTP-SPEVLAKISSEHARTYIQSLPP--MPQKDLSSVFHGAN--PLAIDLLGRMLVLDSDQRVSAAE
||.|||.||.| .| ||||.||..|. || .. ||| | | | .| || |. || .||    | |.....|  ||  |.||||| .||| |.|.| ...|
WSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEE

ALAHAYF
.|.| ||
CLEHPYF
Kinase p38b.AA CMGC 24-308 27 3.4e-139 460.51 In-house 1-513 (513) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-513/513
Sequence Identity: 27% (142 aa)

LQGLRPVGSGAYGSVCSAYDARLRQK--------------VAVKKLSRPFQSLIHAR----------RTYRELRLLKHLK-----------------HEN
 . ....|.|.|| |....| |  ||              ||.||...||   ..|.          |..||...||||.                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VIGLLDVFTPATS------------IEDFSEVYLVTTLMGADLNNIVKCQA----------LSDEH------------VQFLV------YQLLRGLK--Y
...|.|.|..  |            . .| ..|||. .|. || .. | .           ||. |            .....      ||.|||||  |
IVKLYDIFYHKNSDGNEYEDKHIISQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

IHSAG--IIHRDLKPSNVAVNEDCEL--------------------RILDFGLARQADEE------------------------MTGYVATRWYRAPEIM
.||..  ||||||||.|. .|..|||                    .| ||||||. ...                        .| ||.|||||||||.
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

LNW---------MHYNQTVDIWSVGCIMAELLQG--------KALFP-----------GNDYIDQLKRIMEVVGTP----------------SPEVLAKI
|.|         |||....|.||||||.||...|        | |||           |...||||..|..| |||                . |   .|
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

S--------------------SEHARTYIQS---LPPMPQKDLSSVFHG-----------------------------------ANPLAIDLLGRMLVLD
.                    ||.||.||||   .|. | |.....| .                                   ..|.||||| .||..|
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

SDQRVSAAEALAHAYF
 |.| .|..||.| ||
PDKRITAEQALQHPYF
Kinase p38b.AA ERK5 25-308 43 1.5e-117 396.79 In-house 2-295 (295) Show / Hide 
Range on Protein: 25-308
Range on HMM: 2-295/295
Sequence Identity: 43% (129 aa)

QGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC-QALS
. .  .| |||| ||||   .  |.||.||.   |  .  |.||.|||..|.| .|.|.| . |.  |   . .. .|| |  || .||  |.   | ..
KIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPFT

DEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR-----QADEE---MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAE
 ||. . .||.||||||.||| .|||||||||. ||| |||.| |||.||      .|..   || |||||||||||.|.    | | .|.||||||. |
LEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFGE

LLQGKALFPGNDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQS-LPPMPQKDLSSVFHGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF
..  . .|||  ||.||. ||.|.|.|.| ..  .|..| . |.|. .|.   ||.. |. .| . |.|||.|||. .  .|.....|| | . 
MIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase p38b.AA JNK 25-263 45 1.7e-117 396.63 In-house 2-249 (309) Show / Hide 
Range on Protein: 25-263
Range on HMM: 2-249/309
Sequence Identity: 45% (113 aa)

QGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRP--FQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC--Q
| |...|.|| | ||.|.|. . |.||.||..||  ||   |..| |||. ..|...|.|.|... .|||....|.| .||.|  .| . | ...     
QNLKFIGQGAQGIVCMAFDQVTNQRVAIKKMMRPDNFQNWMHWKRAYREFICMKCINHKNIIKMYNCFTPQETLEEFQDVYIVMEYMDWNLCQVIHSTFM

ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE--MTGYVATRWYRAPEIMLNWM-HYNQTVDIWSVGCIMAELL
 |  | . .|.|| ..| |. ||.|||||||||||. ||.|| | |.|||.|| .|.   || || ||.|||||. .  |  |   ||||||||||||..
ELDHERMSYLFYQMCCGIKHLHSMGIIHRDLKPSNIVVNQDCTLKICDFGHARTEDPTFMMTPYVVTRYYRAPEVICGMMDNYKENVDIWSVGCIMAEMI

QGKALFPGNDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSL---P
... |||| |.|||  .|.|. |||.|. . .   .|.|.|. ..   |
RHHVLFPGKDHIDQWNKIIEFLGTPDPHFMMQM-QPHVRNYVENRNMDP
Kinase p38b.AA ERK1 25-308 50 5e-113 381.81 In-house 2-289 (289) Show / Hide 
Range on Protein: 25-308
Range on HMM: 2-289/289
Sequence Identity: 50% (145 aa)

QGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSD
  |. .| |||| |||||| . .|.||.||.| ||    .  || ||...|.  ||||.|.. |.   | .|| . .||.|  ||  ||  ..| | || 
TNLQYIGEGAYGMVCSAYDTVHKQRVAIKKIS-PFEHQTYCQRTLREIKILTRFKHENIINIQDIIR-ADTIEQMRDVYIVQCLMETDLYKLLKTQHLSN

EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE------MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ
.|. . .||.|||||||||| ..||||||||. .|  |.|.| |||||| || |      .| |||||||||||||||   | . .||||||||.||.| 
DHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS

GKALFPGNDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSVFHGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF
 . .|||  |.|||  |. |.| || . |  |  | || |.||||  |.  . ..| .| . |.|||..||    ..|.   ||||| | 
NRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase p38b.AA ERK7 18-308 39 1.4e-102 347.12 In-house 1-292 (292) Show / Hide 
Range on Protein: 18-308
Range on HMM: 1-292/292
Sequence Identity: 39% (120 aa)

WEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK-HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNI
.|. .||      | |||| |  ||| | .| ||.||    |.  . | ||.||  .|. .. |.|.| |..|. .|    |.   |||   | .||...
YEIRKRL------GKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVI-RADNDRDI---YLVFEFMETDLHAV

VK-CQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR---------QADEEMTGYVATRWYRAPEIMLNWMHYNQTVDI
..  . | | |.|. .||||| .||.||. .|||||||||. .. .| ... ||||||         ...  .| ||||||||||||.|   .| . || 
IRKGNILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDM

WSVGCIMAELLQGKALFPGNDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSVFHGANPLAIDLLGRMLVLDSDQRVSAAEALAHA
||.|||..|.|.||..|||.  ..|. .|.|... |. | .. | |. | . .....  ..| |. .. .. . ||||| |.||.  ..|..| .||.| 
WSIGCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHP

YF
| 
YV
Kinase p38b.AA nmo 24-308 46 8.70000000001e-102 313.84 In-house 1-292 (292) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-292/292
Sequence Identity: 46% (136 aa)

LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNN-IVKCQAL
 |  ||.| ||.| | |  | |  ..||.||.   ||.|. ..| .|||..|   ||.||. .||.  |.  .. | |.| || || .||   ||  |.|
IQPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPH-KDFFQEIYVVTELMQSDLHKIIVSPQHL

SDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE----MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ
| .||.  .||.||||||.|||.|.|||.|| |. || .| |.| ||||||  ...    ||  | | .||||||..   || . ||||||||| ||||.
SSDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLG

GKALFPGNDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQK-----DLSSVFHGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF
 . ||     |.||. |....|||| | . |   | |.. .   |. | .      |||  | |.  |..|| |||. | |.|.|. .|||| | 
RRILFQAQSPIQQLQMITDLLGTPSMEDM-KYACEGAKAHMLRMPHKPPCLQVLYTLSSPDH-ATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase p38b.AA S_TKc 24-308 28 1e-86 295.33 SMART 1-231 (231) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-231/231
Sequence Identity: 28% (85 aa)

LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGA---DLNNIVKCQ
 . ||..|.||.|.|. ... .  ..||.|...         ....||...||. .|.|.. |.|||         ...|.|. ...    ||  . | .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKR

A-------LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQ-TVDIWSVGCI
        ..  |..|..||....|.|.|| |||||||||.|. ..|  .. | |||||||     | .. |.||.|||..    .|.   .|.||.|||
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCI

MAELLQGKALFPGNDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSVFHGANPLAIDLLGRMLVLDSDQRVSAAEALA-------H
..|.| |. .||      |........|                                      | |.|.. ..|. | ..| .| |||.       |
LYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCH

AYF
 .|
PWF
Kinase p38b.AA Pkinase 24-308 28 3.9e-81 280.65 Pfam 1-293 (293) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-293/293
Sequence Identity: 28% (89 aa)

LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSL---IHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGA-----DLNN
.. .|..|||..|.|. ...   ...||||..... ..    ...||. .|....|.|.|.|.. |.|.|.        ...|.|. ...      ||  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFD

IVK---CQAL--SDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCEL----RILDFGLARQ---ADEEMTGYVATRWYRAPEIMLNWMHYNQT
...     ..  |.....| .||.||||.|.|| |||||||||.|. .......    .| |||||.|    .. ||... |.||.|||. .   .| . 
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQYYGPK

VDIWSVGCIMAELLQGKALFPGN----DYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSVFHGANPLAIDLLGRMLVLDSDQRVSA
||.||.|||..|.| |. .|||     . .||...| .. |.| ..   . .|.  .. ..  .    . .. . | ... ..|.. ..| .|  .| .|
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTA

AEALAHAYF
...| | .|
EQILQHPWF
Kinase p38b.AA MAPK-Unclassified 23-173 43 3.6e-64 219.51 In-house 2-157 (575) Show / Hide 
Range on Protein: 23-173
Range on HMM: 2-157/575
Sequence Identity: 43% (68 aa)

RLQGLRPVGSGAYGSVCSAYDARL-RQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIE-DFSEVYLVTTLMGA---DLNNIV
 .|..  .||||||.|| | | ..  |.|| ||. . |.  . ..|. ||.|.| .| |.|.| . |.|..      .|  .|.|. .|     ||  | 
EYQKN--IGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQII

KCQA--LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR
|     ....|.| . ||.||||||.|||.||||||||||. .|.|| .|| |||..|
KSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase p38b.AA MAPK-Unclassified 178-308 33 1.4e-43 151.09 In-house 404-575 (575) Show / Hide 
Range on Protein: 178-308
Range on HMM: 404-575/575
Sequence Identity: 33% (58 aa)

EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQG-----------KALFPGND--------------------YIDQLKRIMEVVGTPSPEV
.||.||.|||||||||||    |   |||||.||| ||..|            . |||| |                    ..||.| | .. |.|  |.
HMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEED

LAKISSEHARTYIQSLPPMPQKDLSSVFHGANP----------LAIDLLGRMLVLDSDQRVSAAEALAHAYF
.  | .  || ||||. . .. . .. .  ..|          ..||..  ||. .   | .| .|| | ||
CNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase p38b.AA TyrKc 24-308 21 1.1e-13 -1.34 SMART 1-280 (280) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-280/280
Sequence Identity: 21% (69 aa)

LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHL--KHENVIGLLDVFTPATSIEDF---SEVYLVTTLMGA-DLNNIV
.. ..  |.||.| |. .  ..  ..||||.|          .  .||.|....|  .|.|.. |. | |       |     ...|. .|   ||..  
ITLGKKLGEGAFGEVYKGT-WK--IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN--FMYIEPLMIVMEYMPHGDLKDYL

KCQA--LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE--------MT-------GY--VATRWYRAPEIMLNWM
.     |. ..     .|  .|  |.|| ..|||||   |. |.|.   .| ||||.|  ...        .        |   .  ||. ||| . |  
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYG

HYNQTVDIWSVGCIMAELL-QGKALFPG-----NDYIDQLKRIMEVVGTPSPEV-LAKISSEHARTYIQSLPPMPQKDLSSVFHGANPLAIDLLGRMLVL
 ..   |.|| |  | |..  |.   ||      . .. ......    | |.  .  .|                      | .. .   ..  .    
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MS----------------------FVCCPDEMYQIMKQCWHE

DSDQRVSAAEALAHAYF
| ..| . .|   | .|
DPEDRPTFSEI--HECF
Kinase p38b.AA JNK 283-308 53 2.4e-07 23.48 In-house 284-309 (309) Show / Hide 
Range on Protein: 283-308
Range on HMM: 284-309/309
Sequence Identity: 53% (14 aa)

DLLGRMLVLDSDQRVSAAEALAHAYF
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DLLFRMLVINPDDRISVDDALQHPYI
Kinase p38b.AA Pkinase_Tyr 24-87 23 2.2e-05 18.85 Pfam 1-70 (270) Show / Hide 
Range on Protein: 24-87
Range on HMM: 1-70/270
Sequence Identity: 23% (17 aa)

LQGLRPVGSGAYGSVCSAYDA----RLRQKVAVKKLSRPFQSLIH--ARRTYRELRLLKHL-KHENVIGLL
.. ..  |.||.|.|. ..        ...||||.| ..  .  .   .   ||....|.| .|.|.. |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase p38b.AA Pkinase_Tyr 136-208 32 0.014908 9.27 Pfam 122-199 (270) Show / Hide 
Range on Protein: 136-208
Range on HMM: 122-199/270
Sequence Identity: 32% (26 aa)

RGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA-DEEMTGYVAT-------RWYRAPEIMLNWMHYNQTVDIWS
.|. | .| ..|||||   |. |.|.   .| ||||||   ...   |...       .|. ||| . .   ..   |.||
KGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWM-APECINYGK-FTTKSDVWS