Gene NRBP1 (Mouse)

NRBP1

Species: Mouse
Alias: Nrbp, NRBP1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Other
Family: NRBP

Sequence

Name Sequence Type Origin Length Description Download
NRBP1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 264 Kinase domain by global Sugen HMM Fasta, JSON
NRBP1.AA Protein Sugen 535 None Fasta, JSON
NRBP1.NA RNA Sugen 2146 None Fasta, JSON

Protein domain

Protein domains of NRBP1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase NRBP1.AA NRBP 73-328 81 2.1e-180 605.64 In-house 1-261 (261) Show / Hide 
Range on Protein: 73-328
Range on HMM: 1-261/261
Sequence Identity: 81% (214 aa)

QRNVPGIDSAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADVKENKARVIFITEYMSSGSLKQFLKKTKKNHKTM
||.|||||.|||||||||||||||||||||||||.|.||||.|.||||||||.|.|||||||||.|.||.|.|||||||||||||.||||||||||||.|
QRDVPGIDCAYLAMDTEEGVEVVWNEVQFSERKNFKAQEEKIRQVFDNLIQLDHQNIVKFHKYWTDTKEEKPRVIFITEYMSSGSMKQFLKKTKKNHKNM

NEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGSVAPDTINNHVKTCREEQKNLHFFAPEYG--EVTNVTTAVDIYSFGMCALEMA
|||||||||||||||||||||||||||||||||||||||||||||||.|.||.|..||.|||||..|.||||||||  |||..|||||||||||||||||
NEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGCVWPDAIHHHVRTCREEMRNMHFFAPEYGILEVTDLTTAVDIYSFGMCALEMA

VLEIQ---GNGESSYVPQEAISSAIQLLEDSLQREFIQKCLQSEPARRPTARELLFHPALF
|||||   .||||.||..|||..||..|||..||.||.||||..|||||.|||||||..||
VLEIQSGCQNGESEYVTEEAIQRAIHSLEDPMQRDFIRKCLQKDPARRPSARELLFHQILF
Kinase NRBP1.AA WNK 83-219 41 1.8e-33 105.41 In-house 16-148 (261) Show / Hide 
Range on Protein: 83-219
Range on HMM: 16-148/261
Sequence Identity: 41% (58 aa)

YLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADVKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCT
| ..||| .||| |.|.|  ..|  |      .   . | .|.| |||.| .||  |   |  .. .|| | || || .||      | |. |  ..|| 
YRGLDTETWVEVAWCELQ--DQKLSKNERQRFKEEAEMLKKLQHPNIVRFYDYWESVLCGKKCIVLVTELMTSGTLKTYLKR----FKKMKPKVLRSWCR

QILSALSYLHSCDP-PIIHGNLTCDTIFIQ-HNGLIKIG
|||. |..||.. | ||||  | || |||   .| .|||
QILKGLHFLHTRQPHPIIHRDLKCDNIFITGTTGSVKIG
Kinase NRBP1.AA STE 119-327 20 3.2e-24 82.49 In-house 80-359 (359) Show / Hide 
Range on Protein: 119-327
Range on HMM: 80-359/359
Sequence Identity: 20% (59 aa)

DNLIQLE--HLNIVKFHKYWADV---KENKARVIFITEYMSSGSLKQFLK---KTKKNHK-------TMNEKAWKRWCTQILSA-LSYLHSCDPPIIHGN
. . ..   | ||||.. .  .    ..|.  .  . |||. ||| ...|   ...|...       ...|.  .. | ||| . |.||||    |||  
KIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRD

LTCDTIFIQHNGLIKIG------SVAPD--------------TINNHVKTCREEQKNLHFFAPEYGEV------TNVTTAVDIYSFGMCALEMAVLEIQ-
. .. |..     .|.       .....              |.  . .|.   .    . |||  .          .| .||.|.| ...|||  .   
IKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP----WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPW

GNGESSYVPQEAISS---------------AIQLLED----------------------SLQREFIQKCLQSEPARRPTARELLF--HPAL
 ..   ..  ... .                .  |.|                      .  ..||.|||| .|  |||| .||   || .
HDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase NRBP1.AA Ciliate-E2-Unclassified 121-269 25 4.8e-14 45.14 In-house 75-263 (352) Show / Hide 
Range on Protein: 121-269
Range on HMM: 75-263/352
Sequence Identity: 25% (49 aa)

LIQLEHLNIVKFHKYWADVKENKARVIFITEYMSSGSLKQFLKKTKKN--------HKTMN-----EKAWK-----RWCTQILSALSYLHSCDPPIIHGN
|... |..|||..    .....|  .....||.  |.|.|..|| ||.        |....     |.. |     ... |||..|.|||.    ||| .
LLNHPHPFIVKMF----YCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRD

LTCDTIFIQHNG---LIKIGS--VAP--------DTINNHVKTCREEQKNLHFF-----------APEYGEVTNVT----TAVDIYSFGMCALEM
.... |... ||    |||     .         |  |. .|. .  |.... |           |||. .  |       ..||.|.|... ||
IKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEM
Kinase NRBP1.AA CAMK 123-218 19 2.5e-13 38.6 In-house 94-237 (425) Show / Hide 
Range on Protein: 123-218
Range on HMM: 94-237/425
Sequence Identity: 19% (28 aa)

QLEHLNIVKFHKYWAD-----------VKEN-----KARVIFIT---EYMSSG----SLKQFLKKTKKN-----------HKTMNEKAWKRWCTQILSAL
.| | ||.|.. .. |             ..     . ......   ||.| |     | ..... ...           .. ..|.  .|.  ||.||.
KLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAV

SYLHSCDPPIIHGNLTCDTIFIQHN-----------------GLIKI
 |.||..  |.|  | .. | ...|                 . |||
HYCHSHN--IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKI
Kinase NRBP1.AA S_TKc 81-327 21 3.2e-13 16.96 SMART 14-231 (231) Show / Hide 
Range on Protein: 81-327
Range on HMM: 14-231/231
Sequence Identity: 21% (58 aa)

SAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADVKENKARVIFITEYMSS--GSLKQFLKKTKK--NHKTMNEKA
. |.. ... | .|   ..            |..|   . | .  | ||||.. .. |      .. ...||..   |.|....|| ..  ... ..|  
KVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H

WKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIG-----SVAPDTINNHVKTCREEQKNLHFFAPEYGEVTNVTT-AVDIYSFGMCALEMA
 .... ||..|| |.||    |||  |  . |.. .   |||.      .            .     ... |||       .. ..|..|.| .  ||.
ARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

VLEI--QGNGESSYVPQEAISSAIQLLEDSLQREFIQKCLQSEPARRPTARELLF-------HPAL
. .   .         ....   |    ..  ..||.|||| .|..|||| |.|        || .
CGYPPFP--------QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase NRBP1.AA TKL 108-204 20 6.2e-12 39.27 In-house 45-167 (364) Show / Hide 
Range on Protein: 108-204
Range on HMM: 45-167/364
Sequence Identity: 20% (27 aa)

KLQE---------------------EKVRAVFDNLIQLEHLNIVKFHKYWADVKE---------NKARVIFITEYMSSGS-LKQFLKKTKKNHKTMNEKA
..||                     .. . .   ...| | |||.|  |  . .          ..    ...||.. || | ...              
NSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQ

WKRWCTQILSALSYLHSCD------PPIIHGNLT
  ||. .| ....||||..      ||||| .|.
RCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLK
Kinase NRBP1.AA Pkinase 124-200 28 1.1e-10 38.8 Pfam 57-131 (293) Show / Hide 
Range on Protein: 124-200
Range on HMM: 57-131/293
Sequence Identity: 28% (24 aa)

LEHLNIVKFHKYWADVKENKARVIFITEYMSSG----SLKQFLKKTKKNHKTM--NEKAWKRWCTQILSALSYLHSCDPPIIH
| | |||... .. |    | .. ...||.  |    .|. ...   ..|...   |.  |....|||..| |.||.   |||
LNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIH
Kinase NRBP1.AA Ciliate-E2 123-218 29 3.6e-10 31.08 In-house 88-197 (365) Show / Hide 
Range on Protein: 123-218
Range on HMM: 88-197/365
Sequence Identity: 29% (35 aa)

QLEHLNIVKFHKYWADVKENKARVIFITEYMSSGSLKQFLK--KTKKNHK-----TMNEKAWKRWCTQILS---------------ALSYLHSCDPPIIH
|| | ||.|.. .. . ..|.  . ...|| . |.|....|  |.|.||.      ..||  |.  .|||.               || ||||  . |||
QLNHPNIIKMYECFQEKDDNN--IYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIH

GNLTCDTIFIQHNGLIKI
 ..  . |..     |||
RDIKPENILF-----IKI
Kinase NRBP1.AA WNK 255-274 60 7.9e-10 27.84 In-house 183-202 (261) Show / Hide 
Range on Protein: 255-274
Range on HMM: 183-202/261
Sequence Identity: 60% (12 aa)

TAVDIYSFGMCALEMAVLEI
..||.|.|||| ||||..|.
ESVDVYAFGMCMLEMATSEY
Kinase NRBP1.AA STE11 301-327 44 8.6e-10 31.87 In-house 277-303 (303) Show / Hide 
Range on Protein: 301-327
Range on HMM: 277-303/303
Sequence Identity: 44% (12 aa)

REFIQKCLQSEPARRPTARELLFHPAL
|.|...|.. .|  ||||..|| || .
RDFLRHCFEHDPKKRPTANQLLQHPFI
Kinase NRBP1.AA TyrKc 99-327 18 4.2e-09 -75.48 SMART 1-280 (280) Show / Hide 
Range on Protein: 99-327
Range on HMM: 1-280/280
Sequence Identity: 18% (55 aa)

VQFSER-----------------------KNYKLQEEKVRAVFDNLIQL--EHLNIVKFHKYWADVKENK---ARVIFITEYMSSGSLKQFLKKTKKNHK
... .                        |...  .|  .     . .|  .| |||... .  . ..|      .  ..|||. |.||..|.|....  
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--

TMNEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIG------SVAPD------TINNHVKT--CREEQKNLHFFAPEYGEVTNV-TT
  . |    .|.|| .  .||||   ..||  | .  . . .|. .||.       .  |      .   ..|.  ..     .   |||    ... ||
-LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTT

AVDIYSFGMCALEMAVLEIQGNGE-----------SSYVPQEAISSAIQL--------LEDSLQREFIQKCLQSEPARRPTARELLFHPAL
. |..||| |  |.  .  |   .             || |       .           | . .  ...| . .|. ||| .|.  |  .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase NRBP1.AA STE-Unique 257-327 25 1.9e-08 25.48 In-house 534-616 (616) Show / Hide 
Range on Protein: 257-327
Range on HMM: 534-616/616
Sequence Identity: 25% (21 aa)

VDIYSFGMCALEMAVL----EIQGNGES--SYVPQEAISSA------IQLLEDSLQREFIQKCLQSEPARRPTARELLFHPAL
|||.|.|.  ..|...      ......  ..    .          |..    .|..||.|||  .|  ||.| .|| |..|
VDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMCIHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase NRBP1.AA Dicty3 149-213 24 9.6e-08 21.44 In-house 81-148 (351) Show / Hide 
Range on Protein: 149-213
Range on HMM: 81-148/351
Sequence Identity: 24% (17 aa)

ITEYMSSGSLKQF-----LKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHN
..||.. ... .|     ..|..||..  ||.  ..  .... .|.|.|     |||....|| | .. .
YMEYIEGEIPISFVKTNNMLKKHKNNR-FNEHEISKIICDLVKTLNYIHKNC-HIIHRDIKCDNIMLDND
Kinase NRBP1.AA Ciliate-E2 254-327 20 4.6e-07 20.26 In-house 274-365 (365) Show / Hide 
Range on Protein: 254-327
Range on HMM: 274-365/365
Sequence Identity: 20% (19 aa)

TTAVDIYSFGMCALEMAVL-----EIQGNGESSYVPQEAISSAIQ--------LLEDSLQ-REFIQK----CLQSEPARRPT-ARELLFHPAL
....||.|.|..  ||        ... ... .. ..| ..   |         .. |..   .|.|    .|| .|  |.| . ..| || .
DYKCDIWSLGVILYEMLFGKPPFQQQIKQCKIDFPCPEWQKD-TQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase NRBP1.AA Dicty3 302-322 42 9.9e-07 18.03 In-house 331-351 (351) Show / Hide 
Range on Protein: 302-322
Range on HMM: 331-351/351
Sequence Identity: 42% (9 aa)

EFIQKCLQSEPARRPTARELL
.|||.|.| .|  |. . ||.
NFIQHCWQIDPNHRWDMHELI
Kinase NRBP1.AA STE-Unique 151-219 32 1e-06 18.7 In-house 374-452 (616) Show / Hide 
Range on Protein: 151-219
Range on HMM: 374-452/616
Sequence Identity: 32% (26 aa)

EYMSSGSLKQFLKKTKK-----NHKTMNEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNG-----LIKIG
|| . |.|.| .| .       | . . |   ..  .||| .| ||||   ||||..|  . ||.   |      .||.
EYCEHGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKIC
Kinase NRBP1.AA TKL 254-325 16 3e-06 18.41 In-house 267-364 (364) Show / Hide 
Range on Protein: 254-325
Range on HMM: 267-364/364
Sequence Identity: 16% (16 aa)

TTAVDIYSFGMCALEMAV--LEIQGNGESSYVPQ----EAISSAIQ-LLEDSLQ-------------------REFIQKCLQSEPARRPTARELLFHP
....|.||||..  |..   .  ....... ..|    | .. ...  |   .                    .. .|.| ...|  ||.. |.| . 
SEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase NRBP1.AA Ciliate-E2-Unclassified 290-327 26 6.9e-05 12.92 In-house 320-352 (352) Show / Hide 
Range on Protein: 290-327
Range on HMM: 320-352/352
Sequence Identity: 26% (10 aa)

SAIQLLEDSLQREFIQKCLQSEPARRPTARELLFHPAL
.|. ...     ...||.|.  |  |.|. ..| || .
EAKDFIN-----DLLQKMLKKNPNKRITFEQILNHPWF
Kinase NRBP1.AA WNK 291-327 27 7.6e-05 11.48 In-house 225-261 (261) Show / Hide 
Range on Protein: 291-327
Range on HMM: 225-261/261
Sequence Identity: 27% (10 aa)

AIQLLEDSLQREFIQKCLQSEPARRPTARELLFHPAL
..|. ..   .|.| ||.. .   ||....|| |  .
SFQKIQNPEVKEIIEKCIRHNKEERPSIQQLLNHDFF
Kinase NRBP1.AA Pkinase_Tyr 121-219 28 0.000119 16.38 Pfam 57-153 (270) Show / Hide 
Range on Protein: 121-219
Range on HMM: 57-153/270
Sequence Identity: 28% (28 aa)

LIQL-EHLNIVKFHKYWADVKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIG
. ||  | |||...    | .| . ... ..|||  |.|. .|.| . . .  . |    .|.|| ....||.|    .||  | .  . . .|. .||.
MKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKIC
Kinase NRBP1.AA STE11 123-193 29 0.000139 12.82 In-house 66-134 (303) Show / Hide 
Range on Protein: 123-193
Range on HMM: 66-134/303
Sequence Identity: 29% (23 aa)

QLEHLNIVKFHKYWADVKE---NKARVIFITEYMSSGSLKQFLKKTKKNHK--T--MNEKAWKRWCTQILSALSYLHS
.| | |||...    ...     .  |  . ||.. |||.. |.     ||  .  ..|.  ..  .|||..|.||||
HLNHKNIVRYY----GCCLHDNQNDHVNIFMEYCPGGSLSSMLR-----HKWGPMKFDEMVIRKYTKQILEGLQYLHS
Kinase NRBP1.AA Pkinase 301-327 44 0.000399 15.67 Pfam 267-293 (293) Show / Hide 
Range on Protein: 301-327
Range on HMM: 267-293/293
Sequence Identity: 44% (12 aa)

REFIQKCLQSEPARRPTARELLFHPAL
..|| .||.  |..||||...| || .
KDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase NRBP1.AA CAMK 301-327 37 0.000413 8.35 In-house 399-425 (425) Show / Hide 
Range on Protein: 301-327
Range on HMM: 399-425/425
Sequence Identity: 37% (10 aa)

REFIQKCLQSEPARRPTARELLFHPAL
. .|.|.|| .| .|.|. . | || .
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase NRBP1.AA Pkinase_Tyr 302-327 30 0.769065 3.47 Pfam 247-270 (270) Show / Hide 
Range on Protein: 302-327
Range on HMM: 247-270/270
Sequence Identity: 30% (8 aa)

EFIQKCLQSEPARRPTARELLFHPAL
. ...| . .|..||| .|.  |  |
DLMKQCWHYDPEDRPTFSEI--HEQL