Gene NEK1 (Mouse)

NEK1

Species: Mouse
Alias: Nek1, NEK1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK1

Sequence

Name Sequence Type Origin Length Description Download
NEK1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 255 Kinase domain by global Sugen HMM Fasta, JSON
NEK1.AA Protein Sugen 1275 None Fasta, JSON
NEK1.NA RNA Sugen 5590 None Fasta, JSON

Protein domain

Protein domains of NEK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase NEK1.AA NEK1 4-258 70 2.8e-209 701.53 In-house 1-276 (276) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-276/276
Sequence Identity: 70% (194 aa)

YVRLQKIGEGSFGKAVLVKSTEDGRHYVIKEINISRMSDKERQESRREVAVLANMKHPNIVQYKESFEENGS--LYIVMDYCEGGDLFKRINAQ--KGAL
|.....|||||||||.|||..|||.||||||||...|..|||.||..|||.||.|||||||.|||||||||.  |||||.||.||||...||.|  || |
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

FQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLT--KDG---------------TVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNN
|.||||..||.||||||.|.||||||||||||||||||  |.|               .|.||||||||.||.|.|.|.||||||||||||||.||||||
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KSDIWALGCVLYELCTLKHAFEAGNMKNLVLKIISGSFPPVSPHYSYDLRSLLSQLFKRNPRDRPSVNSILEKGFI
|||||.|||||||||||||.|||.|.|||||||..|..||..|||||.|.||.||.||||||.|||||.|||..||
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase NEK1.AA NEK 4-258 54 2.9e-176 591.85 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-286/286
Sequence Identity: 54% (155 aa)

YVRLQKIGEGSFGKAVLVKSTEDGRH-----YVIKEINISRMSDKERQESR-REVAVLANMKHPNIVQYKESFEENG--SLYIVMDYCE-GGDLFKR---
| ...|||.|||||. .|....||.|     ||.|.||...||.||.|..   || .|. .|||||| |..||.|..  .|.|||.||| ||||...   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

INAQK--GALFQEDQILDWFVQICLALKHVHDR-----KILHRDIKSQNIFLTKDGT----VQLGDFGIARVLNSTVELART-CIGTPYYLSPEICENKP
|. ||  | .|.|.||.|||.|.|||||..|||     ||||||||.|||||||...    | .|||||..|||.|...|.| ..|||||.|||.|.|||
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YNNKSDIWALGCVLYELCTL--KHAFEAG--NMKNLVLKIISG-SFPPVSPH--YSYDLRSLLSQLFKRNPRDRPSVNSILEKGFI
||||||||.|||||||.|||  ||.|||   ||..|..||. |  .||...|  || ||..|.||.....| .|||.|.|||. ||
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase NEK1.AA NEK8 4-258 42 5.3e-138 396.65 In-house 1-278 (278) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-278/278
Sequence Identity: 42% (118 aa)

YVRLQKIGEGSFGKAVLVKSTEDG--RHYVIKEINISRMSDKERQESRREVAVLANMKHPNIVQYKESFEENGSLYIVMDYCEGGDLFKRINAQKGALFQ
| |   .| |.|| ..|   .||.     ..|.|| .||| ||||    |. ||.   ||||. | ..|.|...| |.| |..|| |   |. |.. || 
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNKLFE

ED-----------------QILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKD-GTVQLGDFGIARVLNSTVELA--RTCIGTPYYLSPEICENKPYN
|                  .||. |.|.|.|. |.|.  |||||.| ||||.|.. . | .|||||. ..|.    .  .| .|||||.|||.|| ||||
EERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYN

NKSDIWALGCVLYELCTLKHAFEAGNMKNLVLKIISG-SFPPVSPHYSYDLRSLLSQLFKRNPRDRPSVNSILEKGFI
.|||.|||||||||.|.|| |||| |  .||.||...  . |.| ||| ..|.| ... .  |  |||.  |.    .
QKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase NEK1.AA NEK4 4-258 49 3.8e-132 445.33 In-house 1-257 (257) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-257/257
Sequence Identity: 49% (126 aa)

YVRLQKIGEGSFGKAVLVKSTEDGRHYVIKEINISRMSDKERQESRREVAVLANMKHPNIVQYKESFE-ENG-SLYIVMDYCEGGDLFKRINAQKGALFQ
|  .. .| ||.|   ||... |.. ||.| ..  . | .||..  .|. .|  .||||||.||||.| |||  ||||| .||||||...   ||... .
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFLE

EDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKH
| |...||||| .||   |...||||| | |||||||   . .|||||.||||   ..|.| ||||||.|||.  |.||. |||||.||| .||. ||||
EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLKH

AFEAGNMKNLVLKIISGSFPPVSPHYSYDLRSLLSQLFKRNPRDRPSVNSILEKGFI
||.| .|  |. .|| |  ||..| || ||  |. |. .. | .|||. .|. . .|
AFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase NEK1.AA S_TKc 4-258 30 2.6e-97 330.53 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-231/231
Sequence Identity: 30% (82 aa)

YVRLQKIGEGSFGKAVLVKSTEDGRHYVIKEINISRMSDKERQESRREVAVLANMKHPNIVQYKESFEENGSLYIVMDYCEG--GDLFKRINAQKGAL--
|  |.|||.|.|||  ... ...||.. ||.|.         .  |||...| . .|||||.....|.. ..||.||.||.|  ||||..|  ...    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--FQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNN-KSDIWALGCVLYEL
  | | ..  .. |||.||.. |...|.|||.| .||.|..  .. ..|||.||.|       .|..|||.|..||..   .|.  |.|.|..||.|||.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

CTLKHAFEAGNMKNLVLKIISGSFPPVSPHYSYDLRSLLSQLFKRNPRDRPSVNSILE-------KGFI
.. .  |.     ....|.|           | .............|..||..  .|.         ..
LCGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase NEK1.AA NEK-Unclassified 4-258 40 1.5e-89 296.64 In-house 1-258 (258) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-258/258
Sequence Identity: 40% (108 aa)

YVRLQKIGEGSFGKAVLVKSTEDGRHYVIKEINIS-RMSDKERQESRREVAVLANMKHPNIVQYKESFEENGSLYIVMDYCEGGDLFKRINAQKGA--LF
| ..  .| |  |   ||.     || | .   || |   | ||     . .|. ..|| || | .|| ||  |.   |||.||.| .||  . .    |
YDKITTLGQGGGGAVYLVRHQISKRHLVQQ---ISKRKKKKKRQN---KIIILSQLRHPHIVTYHDSFFENAKLFYTQDYCDGGNLDRRIQKHRKKNEPF

QEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLK
 |  |  |..|.  |.  .| |||.||| | ||||||.| || .|||||.|... |.. ||||.||. ..|||.|. .||||.||.|.|||..||.||  
DEGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCE

HAFEAGNMKNLVLKIISGSF------PPVSPHYSYDLRSLLSQLFKRNPRDRPSVNSILEKGFI
 .| . ||  .  ||  .         |||  || ||  ..  . .||.  |||   |.|  .|
PFFDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI
Kinase NEK1.AA Pkinase 4-258 26 1.2e-88 305.63 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-293/293
Sequence Identity: 26% (77 aa)

YVRLQKIGEGSFGKAVLVKSTEDGRHYVIKEINISRMSDKERQESRR--EVAVLANMKHPNIVQYKESFEENGSLYIVMDYCEGG----DLFKRIN-AQK
|....|||.||||.  . .   .|. ...|.|. .. .....|. ||  |........|||||.....||.....|.||.|||||    ||| .|   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GAL-FQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTV----QLGDFGIARVL-NSTVELARTCIGTPYYLSPEICE-NKPYNNKSDIWAL
|.. |.|... ... ||. .|.. |...|.|||.|..||.. ..|..     ..|||.|... .   . . |  |||.|..||..  ...|  |.|.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCVLYELCTLKHAFEAG------NMKNLVLKIISGSFPPVSPHYS--------------------YDLRSLLSQLFKRNPRDRPSVNSILEKGFI
||.|||... .  |         ... .. .| .. ..  .|  .                     ....... .....| .||.   ||.  ..
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase NEK1.AA NEK2 4-258 34 6.7e-77 258.48 In-house 1-319 (319) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-319/319
Sequence Identity: 34% (111 aa)

YVRLQKIGEGSFGKAVLVKSTEDGRHYVIKEINISRMSDKERQESRREVAVLANMKHPNIVQYKESF--EENGSLYIVMDYCEGGDLFKRINAQKG--AL
|  |. ||.||||.   |.  .||.  | |||.   |  ||.|    |. .|   ||||||.|      ..| .||||| |||||||   |   .     
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

FQEDQILDWFVQICLALKHVHD---------------------RKILHRDIKSQNIFLTKDGT-------------------------------------
. |  |.  . |.|.||. .|                      . |||||||  ||||  |.                                      
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

--VQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGNMKNLVLKIISGSFPPVSPHYSYDLRSLLSQLF
  | ||||| ||.||     | | .||||| |||  .  .|| |||||..||..||.|.|.  |.| | . |  ||  | | ..   || .|  . .   
VVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMI

KRNPRDRPSVNSILEKGFI
. ... |||.. ||.  .|
NVDHYHRPSIEEILQHPQI
Kinase NEK1.AA CAMK 9-258 18 7e-75 240.53 In-house 1-425 (425) Show / Hide 
Range on Protein: 9-258
Range on HMM: 1-425/425
Sequence Identity: 18% (79 aa)

KIGEGSFGKAVLVKSTEDG------------RHYVIKEINISRMS--------------------------DKERQESRREVAVLAN-------MKHPNI
..|.|||||  |.. ....            ... || |. ....                          .| |.. |||.... .       ..||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQYKESFEE-----------NGS---------LYIVM---DYCEGG----DLFKRINAQKG-------------ALFQEDQILDWFVQICLALKHVHDRK
..  | .|            . |         .|.||   .||.||    ||| .| ....               |.|..   .| ||| |... |...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

ILHRDIKSQNIFLTKD-----------------GTVQLGDFGIARVLNSTV-----------------------ELARTCIGTPYYLS-PEICEN-----
| |||.|  || |...                 ... . ||| |.....                         .. .|. |||.| . ||. .      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------KPYNNKSDIWALGCVLYELCTLKHAFEAG-------------NMKNLVLKIISGSFPPVSPHYSY-----------------------DLR
         ..|. |.|.|..|..|| . . .  |..              |...|  ||..| .   .|. |                        . .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

SLLSQLFKRNPRDRPSVNSILEKGFI
.|.... ...| .|...  .|.  ..
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase NEK1.AA NEK11 4-258 40 9.8e-71 241.31 In-house 1-259 (259) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-259/259
Sequence Identity: 40% (106 aa)

YVRLQKIGEGSFGKAVLV--KSTEDGRHY-VIKEINISRMSDKERQESRREVAVLANMKHPNIVQYKESFEENGSLYIVMDYCEGGDLFKRINAQK--GA
||  ||.| ||||   ||  |    |    |.||| .  .   |      |  .|. ..|| ||..  || |     |. .|||| ||  ||   |  | 
YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANVEAQLLSRLHHPAIVRFHASFMEQDNFCIITEYCEGRDLDYRIQEYKQAGK

LFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCT
.| | ||..||.|. |    .|.|.|||||.||.|||| |   ...||||..|.|    .|| |  ||| |.|||    . |  |||||.| |.|||.| 
IFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNIFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCC

LKHAFEAGNMKNLVLKIISGSFPPVSPHYSYDLRSLLSQLFKRNPRDRPSVNSILEKGFI
. |||   |   .||.|. |  | .   |  .| ... ..  .||  |||   ||   ..
MDHAFAGSNFLSIVLNIVEGDTPSLPDRYPRELNTIMERMLNKNPSLRPSAIDILKIPYM
Kinase NEK1.AA STE 4-258 21 3.8e-70 239.36 In-house 1-359 (359) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-359/359
Sequence Identity: 21% (80 aa)

YVRLQKIGEGSFGKAVLVKST------EDGRH---------YVIKEINISRMS---------------DKERQESRREVAVLANMK--HPNIVQYKESFE
. ...|||.|.||. .. .        . |.          . ||..|... .               ..|.|.  .|. .. ...  |||||.|  ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

ENG-------SLYIVMDYCEGGDLFKRINAQKGALFQ------------EDQILDWFVQICLA-LKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIAR
 .|       .|.|.| |..|| | . |.  .| ...            |.||    .||. . |.. |. .| |||||..||.|     | | |||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

VLNS----------------TVELARTCIGTPYYLSPEICEN------KPYNNKSDIWALGCVLYELCTLKHAFEA-GNMKNLVLKIIS-----------
 |..                ...   |..||| . .||. ..      |.|. |.||| |||.. |..| |. .    .|... .....           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---GSFPPVSP-------------------HYSYDLRSLLSQLFKRNPRDRPSVNSILE--KGFI
   |  ||  .                   ..| ...  ... ....|..||...  |.    ||
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase NEK1.AA Ciliate-E2 4-258 20 1.9e-67 230.38 In-house 1-365 (365) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-365/365
Sequence Identity: 20% (77 aa)

YVRLQKIGEGSFGKAVLVKSTEDGRHY------------------VIKEINISRMSDKERQESRREVAVL----------------ANMKHPNIVQYKES
|  ..|||.|.||.  ..|  .... .                   ||.... .|. .. ..  .|  ..                 ...||||....|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--ENGSLYIVMDYCEGGDLFKRINAQKGALFQE---------DQILDWFVQICL---------------ALKHVHDRK-ILHRDIKSQNIFLTKDGTV
|.   . ..|.||.||.|||||..|. .|   ..|          .|.. . ||.                ||.. | .. |.||||| .||..     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

QLGDFGIARVLNS-------------------------------TVELARTCIGTPYYLSPEICENKP---------YNNKSDIWALGCVLYELCTLKHA
 . |||... ..                                  ....|..|||.|..||| ..|.         |. |.|||.||..|||... |. 
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FEAGNMKNLVLKIISGSFPP-------------VSPHYSYDLRSLLSQ----LFKRNPRDRPS-VNSILEKGFI
|    ...   . |. ..|                 . | .   |...    .....|  |..  . ||.  ..
F----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase NEK1.AA Pkinase_Tyr 4-199 23 5.8e-23 78.4 Pfam 1-210 (270) Show / Hide 
Range on Protein: 4-199
Range on HMM: 1-210/270
Sequence Identity: 23% (49 aa)

YVRLQKIGEGSFG---KAVLV-KSTEDGRHYVIKEINISRMSDKE--RQESRREVAVLANM-KHPNIVQYKESFE-ENGS--LYIVMDYCEGGDLFKRIN
 . ..|.|||.||   |...  .  ... .  .| ..    ....  |..  ||.... .. .|||||..      . ..  .|||| |...||| .   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

AQ--KGALFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVL----NSTVELARTCIGTPYYLSPE-ICENKPYNNKSDI
..   .  .   ..|.. .||. .. . ..... |||.   |. .|....|  .||| || .    .  .  .  .      ..|| | ..| .. |||.
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGK-FTTKSDV

WALGCVLYELCTL
|. | ...|..|.
WSFGVLMWEIFTY
Kinase NEK1.AA TyrKc 4-257 19 5e-21 77.1 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-280/280
Sequence Identity: 19% (58 aa)

YVRLQKIGEGSFG---KAVLVKSTEDGRHYVIKEINISRMSDKERQESRREVAVLANM--KHPNIVQYKESFEEN-------GSLYIVMDYCEGGDLFKR
 . ..|.||| ||   |...       .   .| .. .      |.. .||  .. .   .|||||.      .        . |.||| |...||| ..
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

INAQKGALFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNST-------VELAR----TCI--GTPYYLSPEICENK
. . ..  .. .. |.. .||.    . |.... |||.   |. .....||  .||| .| . .                  .        ..||    .
LRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

PYNNKSDIWALGCVLYELCTLKHAFEAG------NMKNLVLKIISGSFPPVSPH--------YSYDLRSLLSQLFKRNPRDRPSVNSILEKGF
 .. |||.|. | ...|..|.      |      . . .. .. .|  .|  |.         . .. .. .|  ...| |||. . |  . |
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF