Gene MUSK (Mouse)

MUSK

Species: Mouse
Alias: MUSK, Musk
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Musk

Sequence

Name Sequence Type Origin Length Description Download
MUSK.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 281 Kinase domain by global Sugen HMM Fasta, JSON
MUSK.AA Protein Sugen 878 None Fasta, JSON
MUSK.NA RNA Sugen 3384 None Fasta, JSON

Protein domain

Protein domains of MUSK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
I-set MUSK.AA I-set 28-117 30 1.3e-16 58.84 Pfam 1-92 (92) Show / Hide 
Range on Protein: 28-117
Range on HMM: 1-92/92
Sequence Identity: 30% (28 aa)

PVITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENG---QLLTILSVEDSDDGIYCCIANNGVGGAVESCGALQV
|..|...  | . . | |.| | |. .|.|..||...   ..  . |......|   . |||. |. .| |.| |.| |  .| .|.   |.|
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNS-FGEAECTAELTV
IGc2 MUSK.AA IGc2 40-106 25 5.9e-11 43.65 SMART 1-56 (56) Show / Hide 
Range on Protein: 40-106
Range on HMM: 1-56/56
Sequence Identity: 25% (17 aa)

LVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCIANNGVG
.  . .|. | .. .| |.|.|..    .           ... ||| .|. .|.|.| |.| | .|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP----------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG MUSK.AA IG 34-118 22 1.1e-08 36.11 SMART 1-58 (58) Show / Hide 
Range on Protein: 34-118
Range on HMM: 1-58/58
Sequence Identity: 22% (20 aa)

LETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDD---GIYCCIANNGVGGAVES--CGALQVK
 . | . . | .|. | |.     .|.|.                     ||| .|. .|    |.| | |.   .| ..|     |.|.
PP-VTVKEGETVTLTC-VS-----QIWWY---------------------LTI-NVQPEDSQQHGTYYCQAT---HGQYWSIQGTTLTVQ
V-set MUSK.AA V-set 27-99 19 8.887749 1.06 Pfam 1-110 (128) Show / Hide 
Range on Protein: 27-99
Range on HMM: 1-110/128
Sequence Identity: 19% (21 aa)

APVITT-PLE----TVDALVEEVATFMCAVE-SY----PQPEISWTR-NKI-----LIK-----------------LFDTRYSIRENGQ----LLTILSV
. ..|. | .     | . . . .|. | .  .|    .   |.| |  .      .|                   |  |...  |..     ||| ..
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

EDSDDGIYCC
. || |.| |
QPSDSGTYYC
I-set MUSK.AA I-set 121-208 39 3.5e-32 111.71 Pfam 1-92 (92) Show / Hide 
Range on Protein: 121-208
Range on HMM: 1-92/92
Sequence Identity: 39% (37 aa)

PKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDNALRE-NSRIAVLESG----SLRIHNVQKEDAGQYRCVAKNSLGTAYSKLVKLEV
||.|..| .|.. ||  | . |.  |.|.|.||| |..  ||. ..|. . ..|    .|.| |||..|.|.|.|||.||.|.| .. ..|.|
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECT-AELTV
IGc2 MUSK.AA IGc2 133-197 35 9.1e-17 62.94 SMART 1-56 (56) Show / Hide 
Range on Protein: 133-197
Range on HMM: 1-56/56
Sequence Identity: 35% (23 aa)

IEGLKAVLPCTTMGNPKPSVSWIKGDNALRENSRIAVLESGSLRIHNVQKEDAGQYRCVAKNSLG
.||  ..|.|   ||| |...|.| .  |          ...|.| ||..||.| |.|.| |. |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP--------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG MUSK.AA IG 127-209 25 2e-14 55.17 SMART 1-58 (58) Show / Hide 
Range on Protein: 127-209
Range on HMM: 1-58/58
Sequence Identity: 25% (22 aa)

PINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDNALRENSRIAVLESGSLRIHNVQKEDA---GQYRCVAKNSLGTAYS-KLVKLEVE
|  |   ||  ..|.|        ...|                    |.| |||.||.   | |.|.|.   |...| . ..|.|.
PP-VTVKEGETVTLTC-VS-----QIWWY-------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
V-set MUSK.AA V-set 134-208 18 8e-06 21.89 Pfam 20-128 (128) Show / Hide 
Range on Protein: 134-208
Range on HMM: 20-128/128
Sequence Identity: 18% (20 aa)

EGLKAVLPCTTMGNP----KP-SVSWIK-GDN-----------------------ALRENSRIAVLESGS-----LRIHNVQKEDAGQYRCVAKNSLGTA
|| .. |||. . ..     . ...|.. ..                          | . |. .  ..|     |.|.|.| .| | | |...|.    
EGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNLQPSDSGTYYCAVWNCNEDY

YSKLVKLEV
. . ..| |
FGHGTRLTV
IGv MUSK.AA IGv 137-192 16 0.000629 10.29 SMART 1-76 (76) Show / Hide 
Range on Protein: 137-192
Range on HMM: 1-76/76
Sequence Identity: 16% (13 aa)

KAVLPCTTMGNPKPSVSWIKG-------DNALR-----ENSRIAVLESG---------SLRIHNVQKEDAGQYRCVA
 . |.|.. |.    ..|..        ...|        .|. .  .          .|...|.. || | | |  
SVTLSCKFSGFTF-YMHWYRQPPDSTPKGKGLEWMGYSYKGRFTWSKDNITRWSKNQFYLTMSNLRPEDTGTYYCAR
IGc2 MUSK.AA IGc2 234-299 30 2e-06 28.42 SMART 1-56 (56) Show / Hide 
Range on Protein: 234-299
Range on HMM: 1-56/56
Sequence Identity: 30% (21 aa)

TFGSFVTLRCTAIGIPVPTISWIENGNAVSSGSIQESVKDRVIDSRLQLFITKP---GLYTCIATNKHG
  |  |||.| | | |.|.|.|.  |  ..             ...|..   .|   |.|||.|.|..|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set MUSK.AA I-set 222-266 21 3e-05 20.34 Pfam 1-46 (92) Show / Hide 
Range on Protein: 222-266
Range on HMM: 1-46/92
Sequence Identity: 21% (10 aa)

ARILRAPESHNVTFGSFVTLRCTAIGIPVPTISWIENGNAVSS-GS
 .... | .  |. |. ... |...| | |..||  .|  ... ..
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSD
IG MUSK.AA IG 228-310 20 0.000159 22.28 SMART 1-58 (58) Show / Hide 
Range on Protein: 228-310
Range on HMM: 1-58/58
Sequence Identity: 20% (19 aa)

PESHNVTFGSFVTLRCTAIGIPVPTISWIENGNAVSSGSIQESVKDRVIDSRLQLFITKP--------GLYTCIATNKHGEKFS--TAKAAAT
|. . |  |. |||.| .      .|.|                          | | .         | |.| ||  ||...|  ...   .
PP-VTVKEGETVTLTC-VS-----QIWWY-------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
I-set MUSK.AA I-set 288-306 57 0.005633 12.61 Pfam 71-89 (92) Show / Hide 
Range on Protein: 288-306
Range on HMM: 71-89/92
Sequence Identity: 57% (11 aa)

GLYTCIATNKHGEKFSTAK
| |||.|||. ||  .||.
GKYTCVATNSFGEAECTAE
Fz MUSK.AA Fz 327-458 28 5.3e-56 172.72 Pfam 1-143 (143) Show / Hide 
Range on Protein: 327-458
Range on HMM: 1-143/143
Sequence Identity: 28% (41 aa)

CAQYR--GEVCDAVLAKDALVFFNTS-----YRDPEDAQELLIHTAWNELKAV----SPLCRPAAEALLCNHLFQECSPGVVPTP-MPICREYCLAVKEL
|...|  ...|  .. . ...... .     . . |...|.. ...|..|...    ||.|.|... .||...|..| .|....| .| ||..|.||||.
CQPIRNDIPMCHGMPYNMTWMPNLLHHETGTQKEAELQWEMM-IHQWWPLVHTSTHLSPKCHPHIQFFLCSMYFPMCTDGFHHPPPIPPCRSMCEAVKEQ

FCAKEWQAMEGKAHRGLYRSGMHLLPVPECSKLPSMHRDPTACT
.|....|.||.|.||..|. |.| . ...|.|.|..|.|...|.
GCEPVMQMMEDKKHRRMYPFGFHWPEMLNCNKFPHHHDDRHMCM
Kinase MUSK.AA Musk 584-865 75 4.5e-241 804.81 In-house 1-282 (282) Show / Hide 
Range on Protein: 584-865
Range on HMM: 1-282/282
Sequence Identity: 75% (214 aa)

IEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHT
|.|||||||||||||||||||||.|||..|||||||||..||..||.||||||..|||||.||||||||||.||.||||||||||||||||||.|.|||.
IIYVRDIGEGAFGRVFQARAPGLVPYEEETMVAVKMLKDDASKQMQMDFQREACMMAEFDHPNIVKLLGVCFVGRPMCLLFEYMAYGDLNEFLHSCSPHR

VCSLSHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGETMVVKIADFGLSRNIYSADYYKADGNDAIPIRWMPPESI
.||..|.|...||.|||||||.|.|..|||.|.|.|.|||||||..||||||||||||..|.|.||||||||||.||..||||...||.|||||||||||
TCSRTHQDRGMRAQVSSPGPPQLKCYHQLCMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYKGHENDHIPIRWMPPESI

FYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSIHRIL
.||..|.|||||||||.|||||||.|||||||.|||||||.|.||||.||||||...|.|||.||.|.|||||.||.||...
WYNQFTYESDVWAYGVCLWEIFSYALQPYYGMTHEEVIYYIRQGNILSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI
Kinase MUSK.AA Pkinase_Tyr 584-865 45 5.9e-150 508.49 Pfam 1-270 (270) Show / Hide 
Range on Protein: 584-865
Range on HMM: 1-270/270
Sequence Identity: 45% (131 aa)

IEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADM--QADFQREAALMAEF-DNPNIVKLLGVCA-VGKP--MCLLFEYMAYGDLNEFLR
|.  . .||||||.|..... | .| .. . |||||||| |. .   ..|| |||..| .. ..||||.|.|||   |.|  ... .|||..||| ..||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

SMSPHTVCSLSHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGETMVVKIADFGLSRNIYSADYY-KADGNDAIPIR
. .                    ....||.  . |....|.|.||.||......|||||.|||||.|..||||.||||.| ||. ||| .. |.  .||.
KHR--------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIK

WMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQP-YYGMAHEEVIYYV-RDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSIHRIL
||.||.|.|...||.||||..||..||||.|| || |.||  |||. |. .||. ..|||||| |.|.||..|| . |.|||.|  ||..|
WMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MUSK.AA TyrKc 584-865 40 9.1e-143 481.51 SMART 1-280 (280) Show / Hide 
Range on Protein: 584-865
Range on HMM: 1-280/280
Sequence Identity: 40% (126 aa)

IEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEF--DNPNIVKLLGVCAVG-------KPMCLLFEYMAYGDLNE
|.  . .||||||.|.....         ..||||||||.|    ..|| ||| .| ..  ..||||.|.|||  .       .|.....|||..|||..
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FLRSMSPHTVCSLSHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGETMVVKIADFGLSRNIYSA-------DYYKA
.||.  |.                       |. .. | .. |.|.||.||......|||||.|||||||  .|||.||||||.||.        |||..
YLRKHRPK-----------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRK

----DGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYG-----MAHEEVIYYVRDGNILACPEN--------CPLELYNLMRLCWSK
    .|.. .|||||.||.|.|...||.||||..||..||||.|| |||.|     |  .||| ||..|. . .|.|        || |.|..|. ||  
KEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHE

LPADRPSFCSIHRIL
 |.|||.|  ||...
DPEDRPTFSEIHECF
Kinase MUSK.AA TK 584-865 26 5.9e-125 421.11 In-house 1-486 (486) Show / Hide 
Range on Protein: 584-865
Range on HMM: 1-486/486
Sequence Identity: 26% (131 aa)

IEYVRDIGEGAFG---RVFQARAPGLLPYEPF--------------------TMVAVKMLKEEASADMQADFQ-------------REAALMAEFD----
|.... .|||.||   .|..... |. |...                     | ||||||||........ |.             .||. |. ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-NPNIVKLLGVCAVG------------KPMCLLFEYMAYGD----LNEFLRSMSPHTVCSLSHSDLSTRARVSS--------------------------
  ||||.|.|||  |            .|.... |||..||    | ..||. .|.. ......| . . ...|                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------PGPPPLSCAEQLC-------------------IARQVAAGMAYLSER------KFVHRDLATRNCLVGETMV-----------VKIADFG----
      . ||||. ...|.                   ...|.|.||.||...      .|||||||.||||||| .|           .||||||    
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----LSRNIYS------------------------ADYYKADGNDAIPIRWMPPESIF---------YNRYTTESDVWAYGVVLWEIFSYGLQPYYG-MA
    |.| |||                         |||... .. .|||||.||...         |...||.||||..||..||||.|| .|||| | 
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

H---------EEVIYYVRDG--------------NILACPENCP--------------LELYNLMRLCWSKLPADRPSFCSIHRIL
.         .||. |.|.|              . ...|..||               |.| ||. ||.. |.|||.|  .|. |
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MUSK.AA Trk 584-865 45 1.1e-124 420.56 In-house 1-275 (275) Show / Hide 
Range on Protein: 584-865
Range on HMM: 1-275/275
Sequence Identity: 45% (129 aa)

IEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHT
|   ...||||||.|| |    |.| .  .||||| || .|| .   |||||| |. . . ..|||. |||  ..|. . ||||  ||||..||.  |  
IVLKWELGEGAFGKVFLAECYNLCPEQDKMMVAVKTLK-DASENARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQHGPDA

VCSLSHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGETMVVKIADFGLSRNIYS-ADYYKADGNDAIPIRWMPPES
.| .   .   .         ||   . | ||.|.|.|| |. .  |||||.||||||||.  .|||.|||.|| .||  |||. ..  . |||||||||
MCYAQYQPRQAPG--------PLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMPPES

IFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNI-LACPENCPLELYNLMRLCWSKLPADRPSFCSIHRIL
| | ..|.||||| .|||.||.|.|| ||.|..   ||| ..  |   | .|. || |.|..|. || . |  | .  .|| |.
IMYRKFTYESDVWSFGVVMWECFTYGKQPWYQLSNHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase MUSK.AA Ror 584-862 48 1.4e-123 416.84 In-house 1-272 (308) Show / Hide 
Range on Protein: 584-862
Range on HMM: 1-272/308
Sequence Identity: 48% (136 aa)

IEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHT
..    .||..|| |.     |... .. . ||.| .|..||   ..||..|. |||... ||||.|||||   .|.| |||||. ||| ||| . ||| 
VRFMEELGECQFGKVYKGHLMGPNFMYHCMAVAIKTCKHDASPAQWQDFRQEIMLMATLHHPNIVCLLGVCTMDQPYCMLFEYMNHGDLHEFLIMRSPHS

VCSLSHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGETMVVKIADFGLSRNIYSADYYKADGNDAIPIRWMPPESI
    |  |   |   ||     |. .. | || |.|||| ||| . |||||||.|||||||. .|||.||||.| |||.|||.  ..   |||||.||.|
DHGCSSDD--DRMVKSS-----LDHPDFLHIAIQIAAGMEYLSSHHFVHRDLAARNCLVGEHHHVKISDFGLMRDIYSSDYYRMQHKSWMPIRWMSPEAI

FYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSIH
 | . ...||.| .|||||||.|||.|||||    |||  .|   .| ||.|||   | ||  ||.  |. || |  ||
MYGKFSEDSDIWSFGVVLWEIWSYGMQPYYGYSNQEVIEMIRNRHLLPCPHNCPTWIYSLMIECWHEIPSRRPRFKDIH
Kinase MUSK.AA UTK 584-868 36 2.7e-104 352.77 In-house 1-296 (296) Show / Hide 
Range on Protein: 584-868
Range on HMM: 1-296/296
Sequence Identity: 36% (115 aa)

IEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQAD----FQREAA---LMAEFD-NPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEF
..  |..|.|||| |. ||.    . ..   |||| ....|.|  . .    | .||.   .|. |.  ||...|.|||  ..|.... |||. |||  .
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRSMSPHTVCSLSHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGET-------MVVKIADFG---LSRNIY-----
||. .| .                 . |  |.  ..|| |...|.||.||....||||||| |||||..        ||.||||||   .||...     
LRRHRPTPP----------------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFS

----SADYYKADGNDAIPIRWMPPESIFYN-RYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDG--NILACPENCPLELYNLMRLCWSKLPA
    ...||.|...|..||||| ||.. .. |.|| ||||..|||.|||...| .|| ||....|.  |..|    ..||. ||...|.||. || . |.
NRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQ

DRPSFCSIHRILQRM
.||.|   ....|.|
ERPDF---EDLVQQM
Kinase MUSK.AA InsR 584-867 41 3.2e-100 337.35 In-house 1-278 (278) Show / Hide 
Range on Protein: 584-867
Range on HMM: 1-278/278
Sequence Identity: 41% (120 aa)

IEYVRDIGEGAFGRVFQARAPGLLPYEPFT--MVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSP
|.  |  |.|.|| |    | |..| |. .   .|.| ..|.||.    .|  ||  | ||.  ..|.|||||  | ||    | |.||||  .|||  |
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRRP

HTVCSLSHSDLSTRARVSSPGPP----PLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGETMVVKIADFGLSRNIYSADYYKADGNDAIPIRW
  .                || .    . .  . .  | ... |||||  .|||||||| |||.| .   |||.|||. | ||  |||.  |    |.||
EEEF-------------NNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRW

MPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYV-RDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSIHRILQR
|.|||.    .|| |||| .||||||. . | ||| |   |.|  |. .|||.|  |||||  .. ||. ||   | .||.|  |  .|. 
MAPESLKDGVFTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase MUSK.AA DDR 584-865 38 4.4e-92 312.22 In-house 1-306 (306) Show / Hide 
Range on Protein: 584-865
Range on HMM: 1-306/306
Sequence Identity: 38% (120 aa)

IEYVRDIGEGAFGRVFQARAPGLL-------PYE----PFTMVAVKMLKEEASADMQADFQREAALMAEFD-NPNIVKLLGVCAVGKPMCLLFEYMAY-G
   |  |||| || |    . |..       . .      |.||||||...|.    .|| .|.. |.     ||||.|.||| . .|.|.. ||| . |
LIFVEKIGEGQFGEVHLCEVEGMQDYIEFDFHCDVHKGHPTLVAVKMLRPDACKHARNDFHKEIKCMSQCKRHPNIVRLVGVCTQDEPYCMIMEYMENLG

DLNEFLRSMSPHTVCSLSHS-DLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGETMVVKIADFG--LSRNIYSADYYKA
||| |.    . ....   . |..   . .      .| .  . |. |.|.||.||.   ||||||||||||||.   .||.|||  .||| || |||. 
DLNQFWMEHEAENSGLMNCKADTQNCQKPT------ISYECCVYICTQIASGMKYLESMNFVHRDLATRNCLVGKEYHIKICDFGTVMSRNLYSQDYYRV

DG-----NDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYG-LQPYYGMAHEEVI-----YYVRDGN--ILACPENCPLELY-NLMRLCWSKLPA
.|         ||||| .|||  .  || ||||| || .||.|.    |||  .  | ||      .  .|.  .|. | .|| |.| .||  ||.  . 
EGFTGRQRHHMPIRWMAWESILLGKFTTKSDVWAFGVTMWEMFMFCREQPYEQLTDEQVIENACEFFRHQGMQVYLPMPPMCPYEIYNQLMCRCWRRDQS

DRPSFCSIHRIL
 ||||  ||. |
QRPSFEEIHKFL
Kinase MUSK.AA TK-Unique 584-865 36 6.8e-89 301.63 In-house 1-294 (294) Show / Hide 
Range on Protein: 584-865
Range on HMM: 1-294/294
Sequence Identity: 36% (114 aa)

IEYVRDIGEGAFGRVFQARAPGLL-PYEPFTMVAVKMLKEEASADMQADFQREAALMAEFD-NPNIVKLLGVCAVGK-PMCLLFEYMAYGDLNEFLRSMS
.|  . ||||||| |. . . |.  . . .. |||||||..|.   ..|| .|...| | .  ||||..||.|     |.....||...|.|  .||.. 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

PHTVCS---------------------LSHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSE--RKFVHRDLATRNCLVGETMVVKIADFGLSR
| .. .                     .|  || .                   .| |.| ||.||..  .|.|||||..||.|..|  |.||.|||..|
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYH-------------------FAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMAR

NIY-SADYYKADGNDAIPIRWMPPESIF--YNRY-TTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILACPENC-PLELYNLMRLCWSKLP
 .|   .| . ..   ||||||.|||.   .. | ||.||||..||..||||..| .||.||  ....  .||| ..  ||.| . |.||||. ||.. |
DVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEP

ADRPSFCSIHRIL
 .|||| .|  .|
EERPSFRQIKHRL
Kinase MUSK.AA Src 584-865 37 3.8e-87 295.84 In-house 1-255 (255) Show / Hide 
Range on Protein: 584-865
Range on HMM: 1-255/255
Sequence Identity: 37% (106 aa)

IEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHT
|  .| .|.| || |...       .   | |||| ||.      ...|..|| .| ... ...|.|. ||  ..|     |||. | | ..|.      
IKLCRKLGQGQFGEVWMGY------WNGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK-----

VCSLSHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGETMVVKIADFGLSRNIYSA-DYYKADGNDAIPIRWMPPES
                ..    |.  ... .| |||.|||||......||||| || ||||. |.|.||||| | |    | | |     .||.|. || 
----------------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEA

IFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILACPENCPLELYN-LMRLCWSKLPADRPSFCSIHRIL
| |.|.|. |||| .|. |.||..||  || ||  .||.  |  |  . ||.||| |||. .|. || | | .|| |  ..  |
INYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase MUSK.AA CTKA 584-865 39 1.1e-86 291.28 In-house 1-290 (290) Show / Hide 
Range on Protein: 584-865
Range on HMM: 1-290/290
Sequence Identity: 39% (119 aa)

IEYVRDIGEGAFGRVFQARAPGLLPYEPF---------TMVAVKMLKEEASADMQADFQREAALMA--EFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDL
      |||| .| ||.|    .|  .|          . |||||||..|       |  || . .   |. ||.. |||||   ||.    |.| ||||
HCIMFKIGEGHYGQVFRA----WLMPDPDDFKAQRKKGKDVAVKMLKDHATEEDRRAFLHEAFVLSSEHFHHPNVLRLLGVCTQHKPWHMIMEHMQYGDL

NEFLRSMSPHT--VCSLSHSDLSTRARVSSP---GPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGETMVVKIADFGLSRNIYSA-DYYK
  .||   |    ||         ||| | |    |  ..  ||   |.|.|||| ||.|. ||||||| ||||.|   ..||||||..|   .   || 
HCYLRACRPADGQVC-------PARARRSIPRSFHPIEVHAHEQVYMAMQIAAGMNYLAEMGFVHRDLACRNCLLGQYCHIKIADFGHGRTLRTESQYYY

ADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDG--NILACPENCPLELYNLMRLCWSKLPADRPSFCSIHRI
      .|.||| || .  ..... |||||.||.||||.| |  |. .|   ||   .  .    |  | |||  || .| .||   |. ||.|  . | 
VSSQRVMPVRWMAPEALCFGKFSCASDVWAFGVLLWEIMSMGEKPWRHMSDQEVCQAYTSHGMRRLPVPRNCPQVLYHCMQECWKFEPNQRPTFETLQRM

L
|
L
Kinase MUSK.AA S_TKc 584-868 21 7e-42 146.38 SMART 1-231 (231) Show / Hide 
Range on Protein: 584-868
Range on HMM: 1-231/231
Sequence Identity: 21% (64 aa)

IEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAY--GDLNEFLRSMSP
 | .| ||.||||.|...|  .         ||.|..|         ...|| ... . . ||||||..|.   . ... .||.    ||| ...... .
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

HTVCSLSHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGETMVVKIADFGLSRNIYSADYYKADGNDAIPIRWMPPE
|  ..                  |..  .  ....|.. ...|. .....||||   | |. |  ..||.||||.| .                 .|.||
HGLRF------------------PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPE

SIFYNRYTT-ESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSIHR------ILQRM
 .    |.. ..|.|. |..|.| .. |  |..   ...... .            . |. ...| |. | |..||.   . .      . . .
VL---GYGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MUSK.AA Pkinase 584-868 21 2.8e-39 139.95 Pfam 1-293 (293) Show / Hide 
Range on Protein: 584-868
Range on HMM: 1-293/293
Sequence Identity: 21% (70 aa)

IEYVRDIGEGAFGRVFQARAPGL-LPYEPFTMVAVKMLKEEASADMQAD--FQR--EAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYG----DLNE
.. .| ||.|.||.|....  |         .|||| .| . ..... |    |  |...|.... ||||.|....  .. ... .||.  |    || .
YHIGRKIGSGSFGCVYKCHHKGTGK------IVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFD

FLRSMSPHTVCSLSHSDLSTRARVSSPGPPPL--SCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGETMVV----KIADFGLSRNIYSADYYKAD
...                           ..  |  |  ....|.. |..|. .....||||   |.|. .....    ||.||||.. ..   | .  
YIST----------------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS

GNDAIP--IRWMPPESIF-YNRYTTESDVWAYGVVLWEIFSYGLQPYYGM------AHEEVIYYVRD-GNILACPENCP-------------------LE
 .. .   ...|.|| |  .. |....|.|..|..|.| .. |  |..|        . ..|. ...  .   .|. |.                    |
-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEE

LYNLMRLCWSKLPADRPSFCSIHRILQR--M
.  ... |. | |..||.   .. |||   .
CKDFIKWCLCKDPKKRPT---AEQILQHPWF