Gene MSK2 (Mouse)

MSK2

Species: Mouse
Alias: MSK2, Rps6ka4
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation: Secondary Group: CAMK, Secondary Family: RSKb, Secondary Subfamily: MSKb,

Classification

Group: AGC
Family: RSK
Subfamily: MSK

Sequence

Name Sequence Type Origin Length Description Download
MSK2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 269 Kinase domain by global Sugen HMM Fasta, JSON
MSK2.NA RNA Sugen 3142 None Fasta, JSON
MSK2.AA Protein Sugen 773 None Fasta, JSON
MSK2.kin_dom2 Protein Kinase Domain Sugen global kinase HMM prediction 258 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of MSK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MSK2.AA AGC 33-301 35 2.2e-188 492.46 In-house 1-395 (395) Show / Hide 
Range on Protein: 33-301
Range on HMM: 1-395/395
Sequence Identity: 35% (141 aa)

FALLKVLGTGAYGKVFLVRKTGGH---DAGKLYAMKVLRKAA-LVQRAK-TQEHTRTE------------RSVLELVRQ---------APFLVT-LHYAF
| .|||.|.|..|||.|||| .|.   | ||.||||||.|.   |.. | ..||| ||            | .||....          ||.|  |||.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTDAK--LHLILDYVS---------GG-EMFTHLY---QRQYFKEAEVRVYGGE-------IVLALEHLHK-LGIIYRD-LKLENVLLDSEGHIVLTDFG
|.. .  |.....|..         || |.|.||.   ....| | ..| |  |       ||||||.||. .|||.|| ||.||.|||..||| |||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKEFLTEE-------------------------------------------------KERTFSFCG--TIEYMAPEIIRSKAGHGKAVDWWS--LGILL
|.||. ...                                                 ..|| .|||  | |||||||.     .|||.||||  ||.|.
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-----YGKACDWWSFGLGCLM

FELLTGASPFTLEG------ERNTQAEVSRRIL------KCSPPFP----------LRIGPVAQDLLQRLLCKDPKKRLGAGPQ-----GAQEVKSHPFF
.|.||| .||. .       ......|.  .|.      .. ..||            . | |.||...||||||.||||.|..     ||.|.|.||.|
YEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase MSK2.AA RSK 36-301 53 1e-165 556.84 In-house 1-278 (278) Show / Hide 
Range on Protein: 36-301
Range on HMM: 1-278/278
Sequence Identity: 53% (148 aa)

LKVLGTGAYGKVFLVRKTGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQY---
|||||.|.||||||.||...||.|..||||||.|| .|||.|...||.|||..||...| ||.|||||||||. ||.||..|..|||.||||.....   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDS---EGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIR---SKAGHGKAVDWWSLGI
| | |...|  |||||.||||..|||.||||.||.|.|.   ||||.|||||..|.|  .....| .||.||||||||...    . ||.||.||||||.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LLFELLTGASPFTLEGERNTQAEVSRRILKCS--PPFP--LRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVKSHPFF
|..|.|||..||.  ...|...|...||.|.   ...|    . . |.||....|..||.||||.|||.|.|.|.||.|
LMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase MSK2.AA MSK 36-296 48 1.4e-163 549.7 In-house 1-277 (277) Show / Hide 
Range on Protein: 36-296
Range on HMM: 1-277/277
Sequence Identity: 48% (133 aa)

LKVLGTGAYGKVFLVRKTGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKE
|||||||.|||.|..|| ..||.|||||||.|.||..||..||.|||.|||..||...|.|..|.||||||......|...|..|||.|||...|..|.|
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

AEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSE---GHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIR----SKAGHGKAVDWWSLGILL
.|.|.. .|.|.|..|.|..|||.||||.||.|.|.|   ||..|.|||....|...|..|..|.|.|..|||||..|    .. |...|.||||||..|
SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVIL

FELLTGASPFT--LEGER---NTQAEVSRRILKCSPPFP----LRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVK
...|||..||.   ....   |...|...||.|....||     ...|.|.||.|.||.||||||||.....|.|.|
YTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase MSK2.AA p70 33-301 46 2.2e-132 446.1 In-house 1-299 (299) Show / Hide 
Range on Protein: 33-301
Range on HMM: 1-299/299
Sequence Identity: 46% (142 aa)

FALLKVLGTGAYGKVFLVRKTGGHDAGKLYAMKVLRKAALVQRAKTQEHTR-------------------------TERSVLELVRQAPFLVTLHYAFQT
| |||||| |.|||||.|||. |.|.||.|||||||||  |  .|  .|||                          ||..|| | . ||.. |||||||
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEV-KHPFICDLHYAFQT

DAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKE---------RTFSFC
. || |||.| .||| |.||     . |  .. |  ||..||||||..|||||||| ||..|.. ||.|||||||.|| . . .           |..||
NGKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFC

GTIEYMAPEIIRSKAGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCS--PPFPLRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVK
||||||||||.. . ||..||||||||.|..  |||. ||| |    . ..    |||.   .  |    . . ||...|| ..|..|.||||. |....
GTIEYMAPEILM-RCGHNHAVDWWSLGCLMYDMLTGGPPFTGE----NRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQ

SHPFF
.||||
EHPFF
Kinase MSK2.AA SGK 33-301 43 6.1e-132 409.95 In-house 1-283 (283) Show / Hide 
Range on Protein: 33-301
Range on HMM: 1-283/283
Sequence Identity: 43% (127 aa)

FALLKVLGTGAYGKVFLVRKTGG---------------HDAGKLYAMKVLRKAALV------QRAKTQEHTRTER-SVLELVRQAPFLVTLHYAFQTDAK
| .|||.| | .|||..|.. .                   .|.||||||.|.. .       . | | |. .||  .| ...  ||.| |||||||. |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMK-HPFIVNLHYAFQTKWK

LHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIR
| . .||| ||||| ||  ...|.| ..| |  |||.|||.||.. ||||||| ||.|||..||..||||||.||   .... ||.|||| ||.|||..|
LYFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGI-KTNDTTFTFCGTPEYLAPEVLR

SKAGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPLRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVKSHPFF
 |..|...||||.||..|.|...|. ||    . .  ..    |..    .|  . . | ||.| || ||||||||.  ... |.|.||||
-KQPHDRTVDWWCLGCVLYEMMYGLPPF----YSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTK-RDFMEIKNHPFF
Kinase MSK2.AA AktR 33-301 47 2e-118 399.76 In-house 1-268 (268) Show / Hide 
Range on Protein: 33-301
Range on HMM: 1-268/268
Sequence Identity: 47% (129 aa)

FALLKVLGTGAYGKVFLVRKTGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQY
| ..|.|| ||.|||.||.|    | .|.||||...|  ...| . ..||.||| ..|   . ||.| |||.|||. || .|..|. |||.|.|| ... 
FHVYKCLGKGAFGKVYLVQKKR--DNQKQYAMKMIKKKKIIER-NQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKK

FKEAEVRVYGGEIVLALEHLHKL-GIIYRDLKLENVLLDSEGHIVLTDFGLSK-EFLTEEKERTFSFCGTIEYMAPEIIRSKAGHGKAVDWWSLGILLFE
|.| ..| |  .|.||||.||.   ||||||| || |||..||. .||||||| .|  .. |.. ||||| ||||||.|. | ||.|.||||..||...|
FSEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYE

LLTGASPFTLEGERNTQAEVSRRILK-CSPPFPLRIGPVAQDLLQ-RLLCKDPKKRLGAGPQGAQEVKSHPFF
..||  ||  . . ..|   . .|    ..|.|  . . ..||.| .||||.|.|||| .  |..|.||||.|
MVTGCPPF--YHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase MSK2.AA RSK 33-301 38 2.4e-111 376.22 In-house 1-271 (271) Show / Hide 
Range on Protein: 33-301
Range on HMM: 1-271/271
Sequence Identity: 38% (107 aa)

FALLKVLGTGAYGKVFLVRKTGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQY
. |....|.|...||....|  . |....||||...||... . .    . .|| .|. . . || |.|||.||.  |. .|.|   ||..|..|    .
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR--VCWEEERIILRYG-HHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKM

FKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSE----GHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKAGHGKAVDWWSLGILL
| | ||. |  || ||.|.||..||..|||| ||.|.|.|    ||| ..|||..|. |  | . . .||.|..|||||... . ||..|.||||.|.|.
FSEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQ-LRDENGMLMTFCYTANYMAPEVLK-RQGHDQACDWWSFGVLM

FELLTGASPFTLEGERNTQAEVSRRILKC---SPPFPLRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVKSHPFF
.| |||. ||       . .   |  |     . . .  | . |.||| ..|  || .||||||.|....|.||.|
YEMLTGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase MSK2.AA Akt 33-238 52 5.70000000001e-111 355.99 In-house 1-203 (264) Show / Hide 
Range on Protein: 33-238
Range on HMM: 1-203/264
Sequence Identity: 52% (109 aa)

FALLKVLGTGAYGKVFLVRKTGGHDAGKLY-AMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQ
| .||||| |..||||||.|    | .|.| |||||.|  ..|.    ||| ||| .|. ..  ||.| |||.|||  || ...||..||| |.||....
FDFLKVLGKGSFGKVFLVKK---KDTQKWYYAMKVLKKDYIIQKN-QVEHTKTERNILQHCN-HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKR

YFKEAEVRVYGGEIVLALEHLHKLGIIYRD-LKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKAGHGKAVDWWS-LGILLF
.|.| . | |. ||.||.||||. .||||| ||.||.|.|..||| ||||||.|| .  . ..| .|||| ||.||||.    ||.||||||. ||....
RFSEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNG-NGHTKAVDWWGSLGCVMY

ELLTGASPF
|...|. ||
EMMCGRPPF
Kinase MSK2.AA S_TKc 33-301 32 1.2e-100 341.59 SMART 1-231 (231) Show / Hide 
Range on Protein: 33-301
Range on HMM: 1-231/231
Sequence Identity: 32% (92 aa)

FALLKVLGTGAYGKVFLVRKTGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSG--GEMFTHLYQR
. .|...| ||.|||...|...    |...|.|...           ||.| |...|.   . |..|.|...||.  .|.....|..|  |..|... .|
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK-----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR

QY------FKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKAGHGK-AVDWWS
..      | | ..| |  .|..|||..|..|||.|||| ||.|||.  || ..||||....         .|||| .|||||..    |.|| ..||||
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCDWWS

LGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPLRIGPVAQDLLQRLLCKDPKKRLGAGPQGA--QEVKSHPFF
.|..|.|.|.|  ||       ..... ..|.           | | |.....|.|||.||..|    .  ...|.||.|
CGCILYEMLCGYPPFP------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MSK2.AA Pkinase 33-301 29 1.9e-86 298.28 Pfam 1-293 (293) Show / Hide 
Range on Protein: 33-301
Range on HMM: 1-293/293
Sequence Identity: 29% (90 aa)

FALLKVLGTGAYGKVFLVRKTGGHDAGKLYAMKVLRKAALVQRAKTQEHTR-TERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGG----EMFTHL
. .....| |..|.|.. ..   .. ||..|.|...|       | |.|.| .| ...  . . |. |.|...|... .......|. ||    . |...
YHIGRKIGSGSFGCVYKCHH---KGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

Y--QRQYF--KEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHI----VLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKAGHGKAV
   ..  |   | |.. |  .|. .||..|. |||.||||.||.|.|..|||     ..||||.| | .  .. . .||||..|||||.||.  ..|..|
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DWWSLGILLFELLTGASPFTLEG----ERNTQAEVSRRILKCSPPFPLRIG---------------------PVAQDLLQRLLCKDPKKRLGAGPQGAQE
|.||.|..|.|.|.|  ||  .     . ..| .. .||... ..|.                         . ..|.. ..||||||||..     |..
DMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQ

VKSHPFF
.. ||.|
ILQHPWF
Kinase MSK2.AA Ciliate-E2 33-301 24 1.3e-82 280.73 In-house 1-365 (365) Show / Hide 
Range on Protein: 33-301
Range on HMM: 1-365/365
Sequence Identity: 24% (93 aa)

FALLKVLGTGAYGKVFLV--RKTGGH------------------DAGKLYAMKVLRKAALVQRAKTQEHTR---------TERSVLELVRQAPFLVTLHY
. ..|..|.|..|.|...  .|..                    ...|.||||...|  . |  . .   |          |...||.. . |... ...
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQL-NHPNIIKMYE

AFQ--TDAKLHLILDYVSGGEMFTHLYQR-----------QYFKEAEVR---------------VYGGEIVLALEHLHKLG-IIYRDLKLENVLLDSEGH
.||  .| .. |...|..||..| .....           .||.| |..                | ..|.||||.||. . ||.||.|.||.|.     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

IVLTDFGLSKEFLTE-----------------EKERTFS-------------FCGTIEYMAPEIIRSKA--------GHGKAVDWWSLGILLFELLTGAS
| ..||||||.. ..                 ...||..             .||| .||||||...|         |.....|.||||..|.|.|.|  
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFTLEGERNTQAEVSRRILKCSPPFP------------------LRIGPVAQDLLQR----LLCKDPKKRLGAGPQGAQEVKSHPFF
||             . |..|   ||                  . . . ..||...    .|.|||.||..    |..... ||.|
PF------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF
Kinase MSK2.AA CAMK 38-301 19 5.5e-79 253.99 In-house 1-425 (425) Show / Hide 
Range on Protein: 38-301
Range on HMM: 1-425/425
Sequence Identity: 19% (84 aa)

VLGTGAYGKVFLVRKT-GG---------HDAGKLYAMKVLRKAALVQ------------------------RAKTQEHTRTERSVLELVR------QAPF
.||.|..|||.|.. .  .          . |. .|.|.. |  |                          |.|...  | | ... ...      . | 
TLGRGSFGKVKLCIHKNTTGKERVHHIYTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN

LVTLHYAFQT-------------------DAKLHLIL---DYVSGGEM----FTHLYQR---------------QYFKEAEVRVYGGEIVLALEHLHKLG
.. |. ....                   | ......   .|.||||.    | .. ..                .|.|.|.| |   |. |....|...
IIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIYRDLKLENVLLDSE-----------------GHIVLTDFGLSKEFLTEEKER----------------------TFSFCGTIEYMA-PEIIRS-----
|. ||||.||.|||.                  . | ..|||....|   |...                         |||| |||| ||....     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------KAGHGKAVDWWSLGILLFELLTGASPFTLEGERN---------TQAEVSRRILKCSPPFPLRIGPV------------------------AQ
        | ..|...| ||.|..|. .|.| .||  . . .         .. |  ..|.|.   ||    .                         ..
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DLLQRLLCKDPKKRLGAGPQGAQEVKSHPFF
||....|..||.||.      ......||..
DLIRKMLQVDPEKRM-----TIEQCLNHPWM
Kinase MSK2.AA Akt 254-301 52 1.5e-21 65.56 In-house 215-264 (264) Show / Hide 
Range on Protein: 254-301
Range on HMM: 215-264/264
Sequence Identity: 52% (26 aa)

ILKCSPPFP--LRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVKSHPFF
|. .   ||   .| | ..||. .|| ||||||||.||..|||.|.||.|
IKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase MSK2.AA S_TK_X 302-363 27 2.9e-16 61.28 SMART 1-79 (79) Show / Hide 
Range on Protein: 302-363
Range on HMM: 1-79/79
Sequence Identity: 27% (22 aa)

QGLDWVALAA--RKIPAPFRPQIR----SELDVGNFAEEFTRLEPVYSPAGSPPPGDPRI-----------FQGYSFVA
 |.|| .| .  ..|..||.|.|.    |. |..|| .|||. .|...|. .|. .               | |...|.
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase MSK2.AA Pkinase_C 321-365 34 3e-13 49.9 Pfam 1-46 (46) Show / Hide 
Range on Protein: 321-365
Range on HMM: 1-46/46
Sequence Identity: 34% (16 aa)

QIRSELDVGNFAEEFTRLEPVYSP--AGSPPPGDPRIFQGYSFVAPS
|..|..|. || .|||.  |...|      ..|| . |.|...|.|.
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase MSK2.AA TyrKc 33-301 20 2e-12 -21.81 SMART 1-280 (280) Show / Hide 
Range on Protein: 33-301
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

FALLKVLGTGAYGKVFLVRKTGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVLELV-RQAPFLVTLHYAFQTD-------AKLHLILDYVSGGEMF
  |.|.|| ||.|.|.. . .         | |.|.. |       .|  . | ...  .  . | .| |. .  ..         | ... |...|   
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

THL-YQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTE----EKERTFSF----CGT----IEYMAPEIIRS
 .| . |  .. ..   .   |    |.||. ..| |||   |.|.......  .|||||..   .    | . . .     .|     |  |||| |  
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-N

KAGHGKAVDWWSLGILLFELLTGASPFTLEGER--NTQAEVSRRILKC-SPPFPLR--------IGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVKSHPF
.     . | || |....|..|   .   . .    . .|| ... .   .| |            .   .. ..    ||..|        .|.  | .
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP-----TFSEI--HEC

F
|
F
Kinase MSK2.AA Pkinase_Tyr 33-49 41 0.047357 7.57 Pfam 1-17 (270) Show / Hide 
Range on Protein: 33-49
Range on HMM: 1-17/270
Sequence Identity: 41% (7 aa)

FALLKVLGTGAYGKVFL
  ..|.|| ||.|.|..
ITFGKKLGEGAFGEVYK
Kinase MSK2.AA Pkinase_Tyr 166-184 31 0.109284 6.34 Pfam 141-159 (270) Show / Hide 
Range on Protein: 166-184
Range on HMM: 141-159/270
Sequence Identity: 31% (6 aa)

NVLLDSEGHIVLTDFGLSK
|.|.......  .||||..
NCLVTENNVVKICDFGLAR
Kinase MSK2.AA Pkinase_Tyr 222-238 42 0.157762 5.8 Pfam 198-216 (270) Show / Hide 
Range on Protein: 222-238
Range on HMM: 198-216/270
Sequence Identity: 42% (8 aa)

WSLGILLFELLT-GASP-F
|| |.|..|..| |..| .
WSFGVLMWEIFTYGEQPTY
Kinase MSK2.AA APH 149-183 20 0.497831 4.39 Pfam 164-202 (248) Show / Hide 
Range on Protein: 149-183
Range on HMM: 164-202/248
Sequence Identity: 20% (8 aa)

LEHLHKLGIIYRDLKLENVLLD--SEGHIV--LTDFGLS
..|.. .... .|... ||..|  ..|  |  . |.. .
EAHWPPPCWCHGDFHPGNVMWDPRPDGGRVTGVIDWDDA
Kinase MSK2.AA MSK 412-674 50 1.6e-168 566.18 In-house 1-277 (277) Show / Hide 
Range on Protein: 412-674
Range on HMM: 1-277/277
Sequence Identity: 50% (140 aa)

LREP-ALGQGSFSVCRRCRQRQSGQEFAVKILS-------RRLEENTQREVAALRLCQSHPNVVNLHEVLHDQLHTYLVLELLRGGELLEHIRKKRLFSE
|..   .|.|.|..||.|.....|...|.||||       |...|.||.|...|..||.|||.||||.. .||.|||||.|...||||..||||.. |.|
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

SEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPAEPMQTPCFTLQYAAPELLA----QQG-YDESCDLWSLGVI
||...|.|.||.||..||... ..||||||||||..|......||.||||||||.||.....|..|||||.|.|||.|.    |.| |||.||.||||||
SECRMIMRELVMAVDHMHQKG-IIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVI

LYMMLSGQVPFQ--GASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRSSSWL
||.||.||||||  ....|.......|||..|..|.||..|.|||..|..||.|...|||.||.|||....|| ..|.
LYTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase MSK2.AA RSK 412-674 37 1.3e-139 470.08 In-house 1-278 (278) Show / Hide 
Range on Protein: 412-674
Range on HMM: 1-278/278
Sequence Identity: 37% (107 aa)

LREP-ALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEENTQ-------REVAALRLCQSHPNVVNLHEVLHDQLHTYLVLELLRGGELLEHIRKKRL---
|..   .|.|....||.|.....||..|.|.|...   ..|       .|.  | .||.||..|.||.. ......||..|..|||||..|..|..    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPG-APVKIIDFGFARLRPQSPAEPMQTPCFTLQYAAPELLA----QQGYDESCDLWSL
|||.||..... .|.||...|.   ..|||||||||||.|.. . . .|..||||..... .  ....|.|.|..|.|||.|.    | |.|..||.|||
FSEDEACFYMAEIVLAVEHLHQQG-IIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSL

GVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLK-----LEGLRSSSWL
||..|.||.|..|||| ...   ....|||..|..|.|||....|| .|.|||.|.|..|..||.|||.     .| .....|.
GVLMYEMLTGCPPFQG-PND---NNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase MSK2.AA CAMK 416-674 23 1.5e-105 341.15 In-house 1-425 (425) Show / Hide 
Range on Protein: 416-674
Range on HMM: 1-425/425
Sequence Identity: 23% (102 aa)

ALGQGSFSVCRRCRQRQSG------------QEFAVKILSRR-------------------------------LEENTQREVAALRLCQ------SHPNV
 ||.|||.. ..|......            |..|.||....                                ..| .||.. ....|      .|||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNLHEVLHD-------------------QLHTYLVL---ELLRGGEL----LEHIRKK---------------RLFSESEASQILRSLVSAVSFMHEEAG
..|.||  |                   . | |.|.   |.  ||||    ...|...               . |.|.||... | ..||| ..|.   
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN-

VVHRDLKPENILYADDTPG--------------APVKIIDFGFARLRPQSP----------------------AEPMQTPCFTLQYAA-PELLAQ-----
.|||||||||||. |. ..              ...||||||||.  ...                        ..|.|.| |. |.| ||.| .     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------QGYDESCDLWSLGVILYMMLSGQVPFQGASGQ----GGQSQ----AAEIMCKIREGRFSLDGEA------------WQGVSEE--------
         ..|...|| ||.|||||.||.|  ||.| ...    . . .      |.. ||..|... . .             | ..|.|        
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICED-E-WIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQE

AKELVRGLLTVDPAKRLKLEGLRSSSWL
.| |.|..|.||| ||...|   .  |.
CKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MSK2.AA AGC 417-674 23 1.5e-103 268.03 In-house 7-395 (395) Show / Hide 
Range on Protein: 417-674
Range on HMM: 7-395/395
Sequence Identity: 23% (92 aa)

LGQGSFSVCRRCRQR------QSGQEFAVKILSRRL---------EENTQRE------------VAALRLCQS---------HPNVVN-LHEVLHDQLH-
.|.|||. .. .| .      ..|. .|.|.|. .          .|.|..|               | .|..         ||..|. ||   .|. | 
IGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDHT

-TYLVLELLR---------GG-ELLEHIRK--KRLFSESEASQILRS--------LVSAVSFMHEEAGVVHRD-LKPENILYADDTPGAPVKIIDFGFAR
  |.|.|..          || ||. |...  |.   . |....  .        .|.|. ..|.. |..||| |||||||  .|     .|. |||.. 
YLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED---GHIKLTDFGLCK

LRPQSP----------------------------------------------------AEPMQTPCFTLQYAAPELLAQQGYDESCDLWS--LGVILYMM
  ....                                                    .  .  || | .| ||| |    |. .|| ||  ||...| |
EGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPC-TPEYMAPEIL----YGKACDWWSFGLGCLMYEM

LSGQVPFQGASG----QGGQSQAAEIMCKIREGR-FSLDGEAW-----------QGVSEEAKELVRGLLTVDPAKRLK----------LEGLRSSSWL
|.|. ||.| .     . .. . .|.. ||..|| |. ... .           . .|.||| |...||..||.|||            | ...  | 
LTGYPPFYGDNPQENRH-PFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase MSK2.AA RSK 408-663 38 6.4e-91 308.37 In-house 1-255 (271) Show / Hide 
Range on Protein: 408-663
Range on HMM: 1-255/271
Sequence Identity: 38% (102 aa)

YELDLREPALGQGSFS---VCRRCRQRQSGQEFAVKILSRRLEENT-----QREVAALRLCQSHPNVVNLHEVLHDQLHTYLVLELLRGGELLEHIRKKR
|||      .||||||   ||..|. ....|..|.||.      ..       |   ||  . ||..| ||.|  |. . |......|||.|. .. |..
YEL---HECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGH-HPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQK

LFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADD--TPGAPVKIIDFGFARLRPQSPAEPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGV
 |||.|.. ... . .|. . |.  |.||||||||||||.|.  .||  .|| |||||     .  .   |.| | .| ||| | .||.|..|| ||.||
MFSEREVKFYMAEIALAMEYLHSQ-GIVHRDLKPENILYDDESGNPGH-IKICDFGFAKQ-LRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGV

ILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRL
..| ||.|  |||.    .      .|  .| .|.||. .  |. .|.|||.|.|..|..||..||
LMYEMLTGCTPFQN----KPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRL
Kinase MSK2.AA S_TKc 411-674 31 7.1e-90 305.81 SMART 1-231 (231) Show / Hide 
Range on Protein: 411-674
Range on HMM: 1-231/231
Sequence Identity: 31% (89 aa)

DLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEENTQREVAALRLCQSHPNVVNLHEVLHDQLHTYLVLELLRG--GELLEHIRKKRL------FS
      .|.|.|.....|| . .|...|.||..    |...||.. |.    |||.|.|..| .|  | |.|.|.. |  |.|...|.|..       |.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

ESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPAEPMQTPCFTLQYAAPELLAQQGYDE-SCDLWSLGVILYM
| .|  ... ...|. ..|.  |..||||||||||  .      .||.|||.||.          | | |. | |||.|   ||.  .|| ||.|.||| 
E-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE-----HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRS-------SSWL
||.|. ||.         | .... ||.              |.|||...|..|..||.||.    .           |.
MLCGYPPFP---------QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MSK2.AA Pkinase 417-674 29 9.9e-81 279.31 Pfam 7-293 (293) Show / Hide 
Range on Protein: 417-674
Range on HMM: 7-293/293
Sequence Identity: 29% (89 aa)

LGQGSFSVCRRCRQRQSGQEFAVKILSRRLEENTQR-------EVAALRLCQSHPNVVNLHEVLHDQLHTYLVLELLRGG----ELLEHIR--KKRLF--
.|.|||.....|. . .|...||||...| |.  ..       |.. .. . .|||.| |... .|  | |.|.|...||    .| ..|.  ... |  
IGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYF

SESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYA-DDTPGAPVKIIDFGFAR-LRPQSPAEPMQTPCFTLQYAAPELLA-QQGYDESCDLWSLGVI
|| |.  ... ..... ..|.  |..||||||||||.  .....|.|||.|||.|. ..   . . |.|.| |. |.|||..  .|.|. ..| ||.|.|
SEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCI

LYMMLSGQVPFQGA----SGQGGQSQAAEIMCKIREGRFSLDGEAWQGVS-----------------EEAKELVRGLLTVDPAKRLKLEGLRSSSWL
|| ||.|. ||.|.    .    .    ...|.|...... | . |  .|                 ||.|......|..||.||.  | .  . |.
LYEMLCGRPPFPGHCWHDN-HDQM----QMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MSK2.AA Ciliate-E2 417-674 21 1.5e-70 240.69 In-house 7-365 (365) Show / Hide 
Range on Protein: 417-674
Range on HMM: 7-365/365
Sequence Identity: 21% (84 aa)

LGQGSFSVCRRCRQRQSG-----------------------QEFAVKILSRRLEENTQREVAALR--------------LCQS-HPNVVNLHEVLH--DQ
.|||.|.. ..|.... .                       ...|.||.. .  |.. .|   .|              | |  |||.....|.    |.
IGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDD

LHTYLVLELLRGGELLEHIRKKRLFS-----------ESEASQILRSLVS---------------AVSFMHEEAGVVHRDLKPENILYADDTPGAPVKII
 . |||.|.. ||.|...|.......           | |...| . ...               |. ..|..  ..|||.||||||.        .|||
NNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------IKII

DFGFARLRPQS-------PAEPMQTPCF------------------------TLQYAAPELLA---------QQGYDESCDLWSLGVILYMMLSGQVPFQ
|||...   ..       .   . .  .                        |. | ||| |          |.|||..||.||||||||.||.|. || 
DFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-

GASGQGGQSQAAEIMCKIREGRFSLDGE--------------AWQGVSEEAKELVRG----LLTVDPAKRLK-LEGLRSSSWL
              . .| .. .... .               |. .|.|.| | .     .| .|| ||.   | .    |.
--------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase MSK2.AA p70 463-663 30 9.6e-25 86.58 In-house 87-283 (299) Show / Hide 
Range on Protein: 463-663
Range on HMM: 87-283/299
Sequence Identity: 30% (64 aa)

HPNVVNLHEVLHDQLHTYLVLELLRGGELLEHIRKKRLFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSP
||... ||   ..    ||.|| | ||||  |  ..  . |  |.  |   . |  . |.  |.. |||||||..   .  |  |.  |||      .  
HPFICDLHYAFQTNGKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQH-GIIYRDLKPENCML--NQQGH-VVLTDFGLCKESIHDG

AE---------PMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGR--FSLDGEAWQGVSEEAKELV
|             | | |  | |||.|   |..  .| ||||. .| || |. || |       .  .... ||  |.   .|        ..|.. |.
AVDEEDPENVNATHTFCGTIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTG-------ENRKKTIDKILKGKQGLKLPPY----LTHEMRDLI

RGLLTVDPAKRL
. ||  .|..|.
KKLLKRHPTQRW
Kinase MSK2.AA SGK 480-609 35 4.2e-23 67.79 In-house 101-225 (283) Show / Hide 
Range on Protein: 480-609
Range on HMM: 101-225/283
Sequence Identity: 35% (46 aa)

YLVLELLRGGELLEHIRKKRLFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPAEPMQTPCFTLQYAAPE
|.|.. . |||.  |... . |.|..|      .|.|    |.   ...|||||||||   |  |  ... ||| . .  . . .   | | |. | |||
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQD-IIYRDLKPENILL--DHQGH-CCLTDFGLCKEGIK-TNDTTFTFCGTPEYLAPE

LLAQQGYDESCDLWSLGVILYMMLSGQVPF
 |. |..| . | |.|| .|| |..|  ||
VLRKQPHDRTVDWWCLGCVLYEMMYGLPPF
Kinase MSK2.AA AktR 417-610 30 2.2e-21 77.36 In-house 7-206 (268) Show / Hide 
Range on Protein: 417-610
Range on HMM: 7-206/268
Sequence Identity: 30% (62 aa)

LGQGSFSVCRRCRQR-QSGQEFAVKILSR------RLEENTQREVAALRLCQSHPNVVNLHEVLHDQLHTYLVLELLRGGELLEHIRKKRLFSESEASQI
||.| |.    .. . .... .| |...       .... |..|   .  |..||  |.||.   .. . ....|  .||||. |..||. |||..|  .
LGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSEEQARFY

LRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQS-PAEPMQTPCFTLQYAAPELLAQ-QGYDESCDLWSLGVILYMMLSGQV
    . |. . |..  .. |||||||||   |     |||.||| ..| ..    |. .. | | .| ||| . . .|.. |.|.|..|. .| |..|. 
FAQILLALEYLHQHMNIIYRDLKPENILLDED---GHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCP

PFQ
||.
PFY
Kinase MSK2.AA Akt 480-537 40 1.9e-12 36.01 In-house 76-133 (264) Show / Hide 
Range on Protein: 480-537
Range on HMM: 76-133/264
Sequence Identity: 40% (24 aa)

YLVLELLRGGELLEHIRKKRLFSESEASQILRSLVSAVSFMHEEAGVVHRD-LKPENIL
|.|..   ||||  |...|| |||..|      ...|  . |.  ... || |||||||
YFVMDYCNGGELFYHLQRKRRFSEDRARFYCAEIILAIEHLHS-KNIIYRDYLKPENIL
Kinase MSK2.AA Akt 575-609 41 2.1e-11 32.63 In-house 168-203 (264) Show / Hide 
Range on Protein: 575-609
Range on HMM: 168-203/264
Sequence Identity: 41% (15 aa)

YAAPELLAQQGYDESCDLWS-LGVILYMMLSGQVPF
| ||| | ..|.. ..| |. ||...| |. |. ||
YLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPF
Kinase MSK2.AA Akt 643-663 57 0.000411 8.95 In-house 228-248 (264) Show / Hide 
Range on Protein: 643-663
Range on HMM: 228-248/264
Sequence Identity: 57% (12 aa)

VSEEAKELVRGLLTVDPAKRL
.| |.| |..|||. || |||
ISPECKDLISGLLNKDPKKRL
Kinase MSK2.AA SGK 641-663 47 0.000465 7.91 In-house 246-268 (283) Show / Hide 
Range on Protein: 641-663
Range on HMM: 246-268/283
Sequence Identity: 47% (11 aa)

QGVSEEAKELVRGLLTVDPAKRL
...| .|..|  |||. || |||
PQMSNDAWDLIQGLLQKDPKKRL
Kinase MSK2.AA Pkinase_Tyr 410-499 24 0.001824 12.36 Pfam 1-102 (270) Show / Hide 
Range on Protein: 410-499
Range on HMM: 1-102/270
Sequence Identity: 24% (25 aa)

LDLREPALGQGSFSVCRRCRQR----QSGQEFAVKILSRRLEENT------QREVAALRLCQSHPNVVNLHEVLH-DQLH--TYLVLELLRGGELLEHIR
. . .  ||.|.| . .... .    . ... |||.|     .         ||.. ..   .|||.|.|. |   .. .   |.|.|.  .| ||.. |
ITFGKK-LGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

KKR
|.|
KHR
Kinase MSK2.AA APH 523-557 21 0.003086 11.92 Pfam 169-204 (248) Show / Hide 
Range on Protein: 523-557
Range on HMM: 169-204/248
Sequence Identity: 21% (8 aa)

EAGVVHRDLKPENILYADDTPGAPVK--IIDFGFARL
.....|.|..| |... .  |. .    .||...|..
PPCWCHGDFHPGNVMWDP-RPDGGRVTGVIDWDDACW
Kinase MSK2.AA AktR 643-664 39 0.006729 7.51 In-house 231-253 (268) Show / Hide 
Range on Protein: 643-664
Range on HMM: 231-253/268
Sequence Identity: 39% (9 aa)

VSEEAKELVR-GLLTVDPAKRLK
.|...|.|.  .||  .| |||.
FSSQCKDLIQRKLLCKNPNKRLG
Kinase MSK2.AA Pkinase_Tyr 577-615 29 2.561849 1.7 Pfam 182-222 (270) Show / Hide 
Range on Protein: 577-615
Range on HMM: 182-222/270
Sequence Identity: 29% (12 aa)

APELLAQQGYDESCDLWSLGVILYMMLS-GQVP-FQGASGQ
||| ..   . .  | || || .. ... |. | ..| | .
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNE