Gene MNK1 (Mouse)

MNK1

Species: Mouse
Alias: Mknk1, MNK1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CAMK
Family: MAPKAPK
Subfamily: MNK

Sequence

Name Sequence Type Origin Length Description Download
MNK1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 286 Kinase domain by global Sugen HMM Fasta, JSON
MNK1.NA RNA Sugen 2493 None Fasta, JSON
MNK1.AA Protein Sugen 415 None Fasta, JSON

Protein domain

Protein domains of MNK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MNK1.AA MNK 37-321 76 8.8e-238 796.23 In-house 1-292 (292) Show / Hide 
Range on Protein: 37-321
Range on HMM: 1-292/292
Sequence Identity: 76% (223 aa)

QLTSELLGEGAYAKVQGAVNLQSGKEYAVKIIEKQ-AGHSRSRVFREVETLYQCQGNRNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKRKHFNEREA
.||.|.|||||||.||..||.|||||||||||.|| .||||.||||||||.|.|||.||||.|||.||||.||||||||..||..|.|||.||||.|.||
KLTDEHLGEGAYASVQTCVNIQSGKEYAVKIIDKQGPGHSRKRVFREVETFYHCQGHRNILQLIEWFEDDDRFYLVFEKMRGGPLLQHIQQRKHFTEHEA

SRVVRDVATALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSG---VKLNNSC-TPITTPELTTPCGSAEYMAPEVVEVFR-DEATFYDKRCD
|.|..|.|.||||.|.||||||||||||||||.|..|.||||||||||||   ..||..| .|||||||.|||||||.||||||..|. |||..||||||
SQVIKDIASALDFMHNKGIAHRDLKPENILCEHPNHVCPVKICDFDLGSGRPPIHLNHDCSQPITTPELLTPCGSAEFMAPEVVDAFVYDEAHYYDKRCD

LWSLGVVLYIMLSGYPPFVGHCG-ADCGWDRGEVCRMCQNKLFESIQEGKYEFPDKDWAHISNEAKDLISKLLVRDAKQRLSAAQVLQHPWV
||||||.|||||.|||||||||| .||||||||.||.|||.||..||||.||||.|.|.|||.|||||||.||||||||||||||||.||||
LWSLGVILYIMLCGYPPFVGHCGDEDCGWDRGEACRDCQNMLFHCIQEGHYEFPEKEWHHISEEAKDLISNLLVRDAKQRLSAAQVLNHPWV
Kinase MNK1.AA MAPKAPK 37-321 58 1.6e-220 690.15 In-house 1-292 (292) Show / Hide 
Range on Protein: 37-321
Range on HMM: 1-292/292
Sequence Identity: 58% (170 aa)

QLTSELLGEGAYAKVQGAVNLQSGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNRNILELIEFFED----DTRFYLVFEKLQGGSILAHIQK--RKHF
.|..|.||||.|.||| .|....|.||||||.|.|.||||....||||....|||..||...|..||.    |..||||.|...||....|||.  .|||
KLWKEVLGEGIYGKVQTCVHKRTGQEYAVKILEDQPGHSRQKARREVELHWHCQGHPNIVQIIDWFENMYQFDKCFYLVMECMEGGELFQHIQQRGHKHF

NEREASRVVRDVATALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGVKLNNSC-TPITTPELTTPCGSAEYMAPEVVEVFRDEATFYDKRC
.|||||....|...|.||||...|||||||||||||.......|||.|||.......||..| ||||||||.|||....|||||||..|. ||..|||.|
TEREASQIMKDICSAVDFLHSMNIAHRDLKPENILCTDTNHNCPVKLCDFGFAKEIHLNHDCTTPITTPELMTPCYTPYYMAPEVVGAFK-EAHTYDKSC

DLWSLGVVLYIMLSGYPPFVGHCG-ADCGWDRGEVCRMCQNKLFESIQEGKYEFPDKDWAHISNEAKDLISKLLVRDAKQRLSAAQVLQHPWV
|.|||||..||||.|||||...|| .||.|||||.||.|||..|..||||.|||||..|.|||.||||||.|||.||..|||...||..|||.
DMWSLGVIMYIMLCGYPPFYSNCGDEDCSWDRGEACRDCQNMMFHRIQEGQYEFPDEEWSHISEEAKDLIRKLLRRDPTQRLTIEQVMNHPWI
Kinase MNK1.AA CAMK 42-321 26 4.8e-117 378.87 In-house 1-425 (425) Show / Hide 
Range on Protein: 42-321
Range on HMM: 1-425/425
Sequence Identity: 26% (115 aa)

LLGEGAYAKVQGAVNLQSG------------KEYAVKIIEKQ----------------------------AGHSRSRVFREVETLYQCQG------NRNI
 ||.|...||  ... ...            ...|.|||.|.                             ...| .|.||.| . ..||       .||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LELIEFFED-------------------DTRFYLVF---EKLQGG----SILAHIQKRKH---------------FNEREASRVVRDVATALDFLHTKGI
. |.|..||                   |...|.|.   |  .||     .. .|.....               |.||||.|..| .. |....| ..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

AHRDLKPENILCESPE--------------KVSPVKICDFDLGSGVKLNNSCT----------------PITTPELTTPCGSAEYMA-PEVVEVFR----
.||||||||||. . .              .. ..||.|| .   .. .....                |.... ..|.||. |||| |||..  .    
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-----DEATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCG-ADCGWDRGEVCR--MCQNKLFESIQEGKYEFPDKD------------WAHISNE------
     .| . |.. || ||.||.|||||.||||| | |.  .|. |  |  .  |....||| |..|||.||..             | .||.|      
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICE-D--E--WIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVS

--AKDLISKLLVRDAKQRLSAAQVLQHPWV
  .||||.|.|..| ..|....|.|.|||.
QECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MNK1.AA S_TKc 37-321 30 1.2e-89 305.06 SMART 1-231 (231) Show / Hide 
Range on Protein: 37-321
Range on HMM: 1-231/231
Sequence Identity: 30% (93 aa)

QLTSELLGEGAYAKVQGAVNLQSGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNRNILELIEFFEDDTRFYLVFEKLQG--GSILAHIQKRKH-----
    ...|.||..||  ...  .|...|.|||         .. ||.. | .  .  ||  |...|.| ...|.|.| . |  |. . .|.||..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-FNEREASRVVRDVATALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGVKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFRDEATFYDK-
 |.| .| .... .. ||...| .|| ||||||||||. .      .||||| |   .              || ||. .||||||.         |.| 
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL--------GYGKC

RCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRMCQNKLFESIQEGKYEFPDKDWAHISNEAKDLISKLLVRDAKQRLSAAQVLQ-------HPW
.|| ||.|..||.||.|||||             .. .| .. .                   | ||||.|.|.|..| ..|..| ..||       |||
KCDWWSCGCILYEMLCGYPPFP------------QMQMMFKKIG-------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

V
.
F
Kinase MNK1.AA RSK 39-321 32 4e-84 285.77 In-house 1-278 (278) Show / Hide 
Range on Protein: 39-321
Range on HMM: 1-278/278
Sequence Identity: 32% (97 aa)

TSEL--LGEGAYAKVQGAVNLQSGKEYAVKIIEKQAGHSRSR----VFREVETLYQCQGNRNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKRKH---
 ..|  .| |..  ..  .. ..|..||.|...|     | .    ...|.. |  ||.  .| .| . |.... .||. | . ||  . |.||.||   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FNEREASRVVRDVATALDFLHTKGIAHRDLKPENILCESPEKV-SPVKICDFDLGSGVKLNNSCT-PIT-TPELTTPCGSAEYMAPEVVEVFRDEATFYD
| |.||. . . .. |...||..|| |||||||||| .. .     .|..||..        ..  ..  .  . |.|...||||||.. .       .|
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGF--------CKQFRCDHNQWTMTFCYTIEYMAPEMLKRAN-QQGGHD

KRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRMCQNKLFESIQEGKYEFPDKDWAHISNEAKDLISKLLVRDAKQRLS-----AAQVLQHPWV
| ||.|||||..| ||.|.||| |  ..|            ...... ||.||. .. . |. .|.||||||.|.| || ..||.     |....|||| 
KACDWWSLGVLMYEMLTGCPPFQG--PND----------NNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase MNK1.AA CAMK1 36-248 33 1.1e-81 237.25 In-house 1-216 (276) Show / Hide 
Range on Protein: 36-248
Range on HMM: 1-216/276
Sequence Identity: 33% (77 aa)

YQLTSELLGEGAYAKVQGAVNLQS---GKEYAVKIIE-KQ--AGHSR---SRVFREVETLYQCQ--GNRNILELIEFFEDDTRFYLVFEKLQGGSILAHI
|....| .|.|| ..|  ... ..   ||.||.|.|. |.  .....    .. .|.| . ..      ||  ..|..|.|. |||| | ..|| ..  |
YEFGKE-IGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRI

QKRKHFNEREASRVVRDVATALDFLHTKGIAHRDLKPENILCESPEKVSPVK--ICDFDLGSGVKLN-NSCTPITTPELTTPCGSAEYMAPEVVEVFRDE
 ......|..|..... .. |. ..| |||.||||||||.|.....  |..|  |.|| |   .. . |         ..|.||. .|.||||.|     
VEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDEN--------LMKTACGTPGYVAPEVLECKK--

ATFYDKRCDLWSLGVVLYIMLSGYPPF
...||| ||.|| ||..||.| |||||
DKPYDKACDMWSIGVITYILLCGYPPF
Kinase MNK1.AA Pkinase 37-321 30 9.4e-77 266.09 Pfam 1-293 (293) Show / Hide 
Range on Protein: 37-321
Range on HMM: 1-293/293
Sequence Identity: 30% (97 aa)

QLTSELLGEGAYAKVQGAVNLQSGKEYAVKIIEKQAGHS--RSRVFR--EVETLYQCQGNRNILELIEFFEDDTRFYLVFEKLQGG----SILAHIQ--K
  . . .|.|....|  ...  .||..|||||.|.  .|  . . .|  |.. .  . .  ||..|...|||... |.|.| ..||    .  ..|.  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

RKHF--NEREASRVVRDVATALDFLHTKGIAHRDLKPENILCESPEKV-SPVKICDFDLGSGVKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFRDEAT
.. |   |.|. .... .. .|...| .|| ||||||||||. .   . ..|||||| |   ..          . .||.||. .||||||.     ...
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIR----GGQ

FYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRMCQNKLFESIQEGKYEFPDKDWAHIS-----------------NEAKDLISKLLVRDA
 |....| ||.|..||.||.|.||| |||  . . .       .|..... | .....|.   |  ||                  |.||.|...| .| 
YYGPKVDMWSCGCILYEMLCGRPPFPGHC-WHDN-H-------DQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDP

KQRLSAAQVLQHPWV
|.|..|.|.|||||.
KKRPTAEQILQHPWF
Kinase MNK1.AA CAMK-Unique 39-321 24 2.3e-71 234.81 In-house 3-363 (363) Show / Hide 
Range on Protein: 39-321
Range on HMM: 3-363/363
Sequence Identity: 24% (93 aa)

TSELLGEGAYAKVQGAVNLQSGKEYAVKIIEK-QAGHSRSRV------------------FREVETLYQCQGNRNILELIEF----FEDDT---------
. ...|.|.. .|  . .   ||..|.|...|  .| ..  .                  ... . . . ..  ||..| ..    |.|..         
MHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLIIK

------RFYLVFEKLQGGSILAHIQK--------------------RKHFNE--REASRVVRDVATALDFLHTKGIAHRDLKPENILCESPEK-------
      ..|.| | .|||  .. |||                    . ||.|  ........ .. |. ..| ..| |||||.|||.  ...|       
TPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRD

------VSPVKICDFDLGSGVKLNNSCTP-ITTPELTTPCGSAEYMAPEVV-----------EVFRDEATFYDKRC----DLWSLGVVLYIMLSGYPPFV
       . .|.|||.|   ...|..  . .    . | ||. .|||||.|           ||   ..  ||  |    |.|||||..|.||.|.||| 
FPYDWSNWHIKLCDFGL--CCHYNHNKMCHM----MQTMCGTPCYMAPEIVFCKNYQEMTRDEVI--NMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFD

GHCGADCGWDRGEVCRMCQNKLFESIQEGKY-EFPDKDWAH---ISNEAKDLISKLLVRDAKQRLSAAQVLQHPWV
. | ..              ..||.|  |.| .|. | |     ||.||||.. .....| ..|.||.. |.|.|.
CECEDR-------DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase MNK1.AA Ciliate-E2 37-321 25 3.8e-71 242.68 In-house 1-365 (365) Show / Hide 
Range on Protein: 37-321
Range on HMM: 1-365/365
Sequence Identity: 25% (100 aa)

QLTSELLGEGAYAKVQGA-VNLQ----------------------SGKEYAVKIIEKQAGHSRSR---VFREVE----------TLYQCQGNRNILELIE
    ...|.|....|  . | ..                       .|.||.||..|.   . ..   ..||..           | | . . ||....|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLN-HPNIIKMYE

FFE--DDTRFYLVFEKLQGGSILAHIQKRKH-----------FNEREASRVVRDVAT---------------ALDFLHTKG-IAHRDLKPENILCESPEK
.|.  ||. .|||.| .|||. . .|...|.           |.|.|.... . ..                || .|| |. | |||.||||||      
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

VSPVKICDFDL---------------GSGVKLNNSCTPITTPE----------LTTPCGSAEYMAPEVVE-VFRD---EATFYDKRCDLWSLGVVLYIML
   .||.|| |               ... ... .    .||             | ||...|||||...    |   . . ||. ||.|||||.||.||
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

SGYPPFVGHCGADCGWDRGEVCRMCQNKLFESIQEGKYEFPDK--------------DWAHISNEAKDLISK----LLVRDAKQRLS-AAQVLQHPWV
.|.|||                       .. |...|..|| .              .| ..|.|.||||.|    .|..| ..|.. . |.|.||| 
FGKPPF-----------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase MNK1.AA MSK 38-248 36 2e-62 209.86 In-house 1-210 (277) Show / Hide 
Range on Protein: 38-248
Range on HMM: 1-210/277
Sequence Identity: 36% (79 aa)

LTSE-LLGEGAYAKVQGAVNLQSGKEYAVKIIE----KQAGHSRSRVFREVETLYQCQGNRNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKRKHFNE
| .   .|.|..  .   |. ..||.||.||.      |     . . .|. .|  ||.. || .| . | |.. .||| | ..||  ..|| ||.|| |
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

REASRVVRDVATALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGVKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFRDEATFYDKRCDLW
 |.. ..| .  |.|..| ||| |||||||||| .. |   .||. || . .  ....   .  .     ||.. .|||||....   . . ||. ||.|
SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGF-ARLFPQDEEWRMKS-----PCFTLHYMAPEMLRRGYAQDGGYDEACDWW

SLGVVLYIMLSGYPPF
||||.|| ||.|  ||
SLGVILYTMLTGQVPF
Kinase MNK1.AA RSK 36-250 32 2.8e-52 179.98 In-house 1-207 (271) Show / Hide 
Range on Protein: 36-250
Range on HMM: 1-207/271
Sequence Identity: 32% (72 aa)

YQLTSELLGEGAYA---KVQGAVNLQSGKEYAVKIIEKQAGHSRSRVF-REVETLYQCQGNRNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKRKHFN
| |  | .|.|..     ..  .  .....||.|||.| .   ..||   |.. .       .|  | . |.| .  |.. . ..|| .. ...| | | 
YELH-ECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS

EREASRVVRDVATALDFLHTKGIAHRDLKPENILCESP-EKVSPVKICDFDLGSGVKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFRDEATFYDKRCD
|||.. . . .| |...||..||.||||||||||  .   . . .||||| .   ..  |         | |.|..|.||||||.         .|. ||
EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGM-------LMTFCYTANYMAPEVL-----KRQGHDQACD

LWSLGVVLYIMLSGYPPFVG
 ||.||..|.||.|..||..
WWSFGVLMYEMLTGCTPFQN
Kinase MNK1.AA CDPK 94-250 36 4.4e-45 136.35 In-house 62-215 (271) Show / Hide 
Range on Protein: 94-250
Range on HMM: 62-215/271
Sequence Identity: 36% (59 aa)

NILELIEFFEDDTRFYLVFE--KLQGGSILAHIQKRKHFNEREASRVVRDVATALDFLHTKGIAHRDLKPENILCESPEKVS----PVKICDFDLGSGVK
||. . ||..|.  .|.|.|   . ||  .  |. ..||.|.||. ..| .  |.   | ..| |||||||||| .| .. |    ..|. |...    .
NIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGHFTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFD

LNNSCTPITTPELTTPCGSAEYMAPEVVEVFRDEATFYDKRCDLWSLGVVLYIMLSGYPPFVG
 | .        ... ||   |.|||| .        |.. ||.||.||.|||.|.||||| |
QNQKI---EDKKMSQRCGTPYYIAPEVLQ------KKYNEKCDIWSCGVILYILLCGYPPFYG
Kinase MNK1.AA CDPK 272-321 56 2.5e-32 96.6 In-house 222-271 (271) Show / Hide 
Range on Protein: 272-321
Range on HMM: 222-271/271
Sequence Identity: 56% (28 aa)

FESIQEGKYEFPDKDWAHISNEAKDLISKLLVRDAKQRLSAAQVLQHPWV
.|....|||.| ...|.|||.||||||.|.|..| |.|.||.|.|||||.
MEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase MNK1.AA CAMK1 268-321 45 3.5e-30 84.89 In-house 222-276 (276) Show / Hide 
Range on Protein: 268-321
Range on HMM: 222-276/276
Sequence Identity: 45% (25 aa)

QNKLFESIQEGKYEFPDKDWAHISNE-AKDLISKLLVRDAKQRLSAAQVLQHPWV
.|.||| | ...|||| . | .||.. |||.|...|. | |.|....|.|.|||.
DNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase MNK1.AA RSK 275-321 40 6.3e-16 53.5 In-house 220-271 (271) Show / Hide 
Range on Protein: 275-321
Range on HMM: 220-271/271
Sequence Identity: 40% (21 aa)

IQEGKYEFPDKDWAHISNEAKDLISKLLVRDAKQRLSA-----AQVLQHPWV
|..|.. .    |. || |||||....| ||  .||.|     .|..||||.
IKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase MNK1.AA MSK 275-321 40 3.2e-12 37.61 In-house 231-277 (277) Show / Hide 
Range on Protein: 275-321
Range on HMM: 231-277/277
Sequence Identity: 40% (19 aa)

IQEGKYEFPDKDWAHISNEAKDLISKLLVRDAKQRLSAAQVLQHPWV
|..|.  ||   |  .| .|||||..|| .| | ||..   ..| | 
ICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase MNK1.AA TyrKc 37-319 17 2.7e-10 -56.11 SMART 1-280 (280) Show / Hide 
Range on Protein: 37-319
Range on HMM: 1-280/280
Sequence Identity: 17% (55 aa)

QLTSELLGEGAYAKVQGAVNLQSGKEYAVKIIEKQAGHSRSRVFREVETLYQC-QGNRNILELIEFFEDD-------TRFYLVFEKLQGGSILAHIQKRK
    . |||||. .|  ..      . ||| . . |   |    || . . .    . ||. |.    ..          ..|.|   .|. . ...|..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

H-FNEREASRVVRDVATALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDF----DLGSG-VKLNNSCTPITTPELTTPCG--SAE------YMAPEV
. .. ..      ..|   ..|| |.. ||||   |.|  ..     |||.||    |....  .           .  .. .  ..        ||||.
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQG-------ESKDYYRKKEHKGGKTMLPIRWMAPEC

VEVFRDEATFYDKRCDLWSLGVVLY-IMLSGYPPFVG---HCGADCGWDRGEVCRMCQNKLFESIQEGKYEFPDKD-----WAHISNEAKDLISKLLVRD
          .    | || ||... |.  | .|  |   .              |    ..| ...|..  . ..       . . |  .....   .|
I-----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-------------MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHED

AKQRLSAAQVLQHP
...| . ... .  
PEDRPTFSEIHECF
Kinase MNK1.AA CDPK 37-84 24 0.000364 8.91 In-house 1-53 (271) Show / Hide 
Range on Protein: 37-84
Range on HMM: 1-53/271
Sequence Identity: 24% (13 aa)

QLTSELLGEGAYAKVQGAVNL-QSGKEY-AVKIIEKQ-AGHSR--SRVFREVE
.  .. ||.|..  |  ...  ... |  |.|||.|    ..    ..|.|.|
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIE
Kinase MNK1.AA Pkinase_Tyr 36-159 22 0.000382 14.66 Pfam 1-137 (270) Show / Hide 
Range on Protein: 36-159
Range on HMM: 1-137/270
Sequence Identity: 22% (31 aa)

YQLTSELLGEGAYAKVQGAVNL----QSGKEYAVKIIEKQAGHS---RSRVFREVETLYQCQGNRNILELIEFFE-DDTR--FYLVFEKLQGGSILAHIQ
 ..  . |||||. .|  ..      . . . |||..  .| |.   |   .||.... |   . ||. |.     ..     |.|.|  ..|. | . .
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

K----RKHFNEREASRVVRDVATALDFLHTKGIAHRDL
|    .....  .     ...| ....|. |.. ||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL