Gene MET (Mouse)

MET

Species: Mouse
Alias: MET, Met
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Met

Sequence

Name Sequence Type Origin Length Description Download
MET.NA RNA Sugen 4641 None Fasta, JSON
MET.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 262 Kinase domain by global Sugen HMM Fasta, JSON
MET.AA Protein Sugen 1379 None Fasta, JSON

Protein domain

Protein domains of MET.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Sema MET.AA Sema 55-499 25 3.9e-158 536.44 Pfam 1-484 (484) Show / Hide 
Range on Protein: 55-499
Range on HMM: 1-484/484
Sequence Identity: 25% (125 aa)

VVLHGHH-----IYLGATNYIYVLNDKDLQKVSEFKTGPVLEHPDCLPCRDCSSKANSSGGVWKDNINMALLVDTYYDDQLISCGSVN-RGTCQRHVLPP
.... |.     .| ||.|..||||  .|..... |...  .| .| .|..| .|..... ||... |.......|.|..|..||... ...|..|.|..
FHTLLHDEDRDRLYVGARNHVYVLNLNNLSERCYQKIHWPSSH-GCEHCEECYMKGKDPP-VWTECQNYIRVLHPYNDTHLYVCGTNAFHPVCWYHNLGH

DNSADIQSEVHCMFSP--EEESGQCPDCVVSALGAKVLLSEKDRFINFFVGNTINSSYPPGYSLHSISVRRLKETQDGFKFLTDQSYIDVLPEFQDSYPI
...||.|.|.||.||.  ..|  .|..|......... . ..||| ....|..|.|.. . .........|.|.....|......|.....| | |||||
HHTADHQAEEHCLFSYDHDKEEDGCGRCPYDPKHNTTSVMVQDRFGELYSGTYIDSKVAYSFMGRDPWIYRSKGSHHPFRTEQHDSKWLNEPNFVDSYPI

KYIHAFESNHFIYFLTVQKETLDA----QTFHTRIIRFCSVDSGLHSYMEMPLECILTEKRRKRSTRE-----EVFNILQAAYVSKPGANLAKQIGASPS
.| |.| ...|.||....... ..    .|.|.|..|.|. |.|.|.|.||...|. ...|...|        ..||.||...| .....|| ..|.| .
HYVHDF-DDDFVYFFFRETAVEYSMNCGKTIHSRVARVCKNDMGGHRYLEMNKWCTFLKARLNCSVPGPDGYPFYFNELQDVFVLPTDNWLAHELGISWR

DDILFGVFAQSKPDSAEPVNRSAVCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNH-EHCFNR-TLLRNSSG--------------CEARSDEYRTEFTT
.....|||.........| ..||||||.....|..||....|.. .| ..... .. ... .|    .|...              . .|......|...
NPVIYGVFTTPWNIFRGPMHNSAVCAFHMNDINQVFNNGPFKHQEGCNHQWLPYRGLRVPYPRPGQCPNDPNHGNMSTKDLPDNTCNFIRCHPLMYEVVY

ALQRVDLFMGRLNQVLLTSISTF---IKGD---LTIANLGTSEGRFM--QVVLSRTAHLTPHVNFLLDSHPVSPE-VIVEHPSNQNG
......|||... ....|.|  .    .||   .|....||..||..  |||.||    ..|...|...|..... .|...   |  
PVHNRPLFMRQSVNYRFTQIAVDPRVRAGDGQWYTVMFIGTDDGRVHKKQVVVSRDSWPHYHEVVLEEIHVFPDPEPIQNMEISQKQ
Sema MET.AA Sema 52-495 23 1.7e-136 460.64 SMART 1-532 (532) Show / Hide 
Range on Protein: 52-495
Range on HMM: 1-532/532
Sequence Identity: 23% (129 aa)

IQNVVLHGH----HIYLGATNYIYVLNDKDLQKVSEFKTGPVLEHPDCLP-------CRDCSSKAN---SSGGVWKDNINMALLVDT--YYDDQLISCGS
 ....|. .    ..|.||.|.||.|.  .|.|..| .||||...|.| .       |. |..| .   .... |.|| ...|....  |||..|..||.
YNHMLLDEDRGNWRLYVGARNHIYQLSLPNLSKEWEHVTGPVIDWPSCPEPNEKCIKCQECQMKGKHFCPHNETWCDNYIRVLQPYNDHYYDTHLYVCGT

VNRGT---CQRHVLPPDNSAD-----IQSEVHCMFSPEEE-SGQ-CPDCVVSALGAKVLLSEKDRF---INFFVGNT-INSSYPPG-YSLHSISVRRLKE
. .|    |..|.|. . ..|     .|. .||..|.. . |.  |..|....|.... . .....   .....|..  .|....  .. ..|..|||..
NAFGPDVMCWYHNLGNHEPWDEMEQEDQIFTHCPHSKQHNRSESGCGKCPYDPLHNSTSVFVDGYNPDGGELYSGTVADFSGVAQSYHRSDPIIYRRLGM

TQDGFKFLTDQSYIDVLPEFQ--DSYPIKYIHAFES-----NHFIYFLTVQKETLD-----A--QTFHTRIIRFCSVD--------SGLHSYMEMPLECI
.||||.|....|..|... ..  |.|.....||||.     ..|.||.... .. .     .  ...|.|. |.|  |        .  .||....|.|.
FQDGFHFWFHPSRTDQYDSKWGYDLYEPHFVHAFEIPESNDGDFVYFFFRERAHEHMNRDCGYEKHYHSRVARVCKNDMGGQRLLQKKWTSYLKARLNCS

LTEKRRKRSTREE-VFNILQAAYVSKPGANLAKQIGASPSDDILFGVFAQSKPDSA----EPVNRSAVCAFPIKYVNDFFNKIVNKNNVRC--LQHFYGP
 ..|.|..    | .||.||...|..||| ||.. |  ..||.|.|||.|... |     .| . ||||||..| .|..||. ..| . ..   .|.|. 
VPDKGRRP----EFYFNELQDVFVLPPGA-LAQDWGW-EQDDVLYGVFTQGQQWSSRDAANPWPGSAVCAFSMKDINRVFNEGPFKCYEGPNHQWHPYNG

NHEHCFN--------------RTLLRN--SSGC-EARSDEYRTEFTTALQRVDLFMGRLNQVLLTSISTFIKGD-------LTIANLGTSEGRFMQVVLS
|   ...               .. ..   . .  ...  ...| ........||....  ...|.|     ..        |.. |||. ||...||..
NKVPWPRPGTCPSNHFREQRNCCHTKDLPDDVLCFIKHHPLMDEAVQPIHGRPLFVKTNTDYRFTHIAVDRVHNLDGHHNWYTVMFLGTDDGRIHKVVVW

RTAH--------LTPHVNFLLDSHP--VSPEVIVEHPS
|. |          .. .| ...|.  ..... . | .
RSRHNQSWHGWESHVYEEFQVFPHGSEPIRDMQFSHKQ
IPT MET.AA IPT 655-738 26 1.4e-27 98.88 SMART 1-111 (111) Show / Hide 
Range on Protein: 655-738
Range on HMM: 1-111/111
Sequence Identity: 26% (29 aa)

DPVITSISPRYGPQAGGT-LLTLTGKYLNS-GNSRHISIG------GKTCTLKSV------SDSILECYTPAQT----TSDEFPV----KLKIDLANRET
|||||.|.|..|| .||| ..|..||...| ...| ....      .  ||. ..      |.. ..|.||...    .  . ||    .......|..|
DPVITRIHPNCGPCSGGTERITICGKNFDSDIQVRFVRVNVGGRVWEVPCTFQPWDYHGKDSQTQIVCCTPPYHNQSPIPGQVPVRVTQEVQFCNDNVRT

-----SSFSYR
     ..|.|.
QLSWPQPFTYV
TIG MET.AA TIG 656-737 32 8.2e-19 66.03 Pfam 1-82 (82) Show / Hide 
Range on Protein: 656-737
Range on HMM: 1-82/82
Sequence Identity: 32% (28 aa)

PVITSISP-RYGPQAGGTLLTLTGKYL-NSGNSRHISIGGKTCTLKSVSDSILECYTPAQTTSDEFPVKLKIDL-ANRETSSFSY
|.||||||  .|| .|||..|.||... |.  .  . .||  ||  ..|.. ..|.||. |..  ..|.. ..   .  ...|.|
PTITSISPNTTGPPSGGTTITITGQNFGNDS-DTKCYFGGTPCTVIWWSSTQIVCTTPPHTPG-THNVSV-VNGQWSSNPTTFTY
TIG MET.AA TIG 562-653 27 1.6e-17 61.69 Pfam 1-82 (82) Show / Hide 
Range on Protein: 562-653
Range on HMM: 1-82/82
Sequence Identity: 27% (26 aa)

PAVYKVFP-TSAPLEGGTVLTICGWDFGFRKNNKFDLRKTKVLLGNESCTLTLSESTTNTLKCTVGPAMSEHFNVSVIISNSRETTQYSAFSY
| .....| |..| .|||..|| | .|        |  .||...|.. || .   .. ....||. |. ....|||| ...   ..... |.|
PTITSISPNTTGPPSGGTTITITGQNF------GNDS-DTKCYFGGTPCTVI--WWSSTQIVCTTPPHTPGTHNVSV-VNG-QWSSNPTTFTY
PSI MET.AA PSI 518-561 33 1.8e-17 55.61 Pfam 1-57 (57) Show / Hide 
Range on Protein: 518-561
Range on HMM: 1-57/57
Sequence Identity: 33% (19 aa)

GCGHFQSCSQCLSAPYFIQCGWCHN--QCVRFD-----ECPSGT------WTQEICL
.|....|||.||||... .||||..  .|.| .     .||...      |.|. | 
NCSQHTSCSSCLSARDPFYCGWCSSQHRCTRGHAYTYGQCPRWWQWMWWSWSQSQCP
IPT MET.AA IPT 561-654 20 3.2e-17 64.46 SMART 1-111 (111) Show / Hide 
Range on Protein: 561-654
Range on HMM: 1-111/111
Sequence Identity: 20% (23 aa)

LPAVYKVFPTSAPLEGGT-VLTICGWDFGFRKNNKFDLRKTKVLLG----NESCTLTLSES----TTNTLKCTVG-------PAMSEHF----NVSVIIS
.| .....|...|..||| ..||||..|.     ... |.  | .|    ...||.. ...      ... |...       .. . ..    .|.....
DPVITRIHPNCGPCSGGTERITICGKNFDS----DIQVRFVRVNVGGRVWEVPCTFQPWDYHGKDSQTQIVCCTPPYHNQSPIPGQVPVRVTQEVQFCND

NSRET-TQYSAFSYV
| |   .... |.||
NVRTQLSWPQPFTYV
PSI MET.AA PSI 518-561 30 5.2e-12 47.14 SMART 1-56 (56) Show / Hide 
Range on Protein: 518-561
Range on HMM: 1-56/56
Sequence Identity: 30% (17 aa)

GCGHF--QSCSQCLSAPYFIQCGWC--HNQCVRFDECPS-----GTWTQ---EICL
.| |.  .|||.||||. . .||||  ...|..  .|..       |..   . | 
NCSHYGVTSCSECLSARDPYRCGWCSWQHRCTHRHRCDERRFWRQNWEHGPHKQCP
IPT MET.AA IPT 740-835 28 1.2e-18 69.2 SMART 1-111 (111) Show / Hide 
Range on Protein: 740-835
Range on HMM: 1-111/111
Sequence Identity: 28% (32 aa)

DPVVYEIHPTKSFISGGS-TITGIGKTLNSVSLPKLVIDVHEVGVNY-TVACQHR--------SNSEIICCTTPSLKQ--LGLQLPLKT--KAFFLLDGI
|||...|||.....|||  .||  || ..| .    .. |.. |  . .|.|..         | ..|.||| |...|  .  | |...  ...| .|..
DPVITRIHPNCGPCSGGTERITICGKNFDS-DIQVRFVRVNVGGR-VWEVPCTFQPWDYHGKDSQTQIVCCTPPYHNQSPIPGQVPVRVTQEVQFCNDNV

LSK---HFDLTYV
 ..    ...|||
RTQLSWPQPFTYV
TIG MET.AA TIG 741-834 21 2.5e-07 27.18 Pfam 1-82 (82) Show / Hide 
Range on Protein: 741-834
Range on HMM: 1-82/82
Sequence Identity: 21% (20 aa)

PVVYEIHP-TKSFISGGSTITGIGKTLNSVSLPKLVIDVHEVGVNYTVACQHRSNSEIICCTTPSLKQLGLQLPLKTKAFFLLDGILSKHFDLTY
|... |.| | ...|||.||| .|. . . .  .. . .  . .. .      ..|  |.||||....  ... . .       .. |   ..||
PTITSISPNTTGPPSGGTTITITGQNF-GNDS-DTKCYFGGTPCTVI-----WWSSTQIVCTTPPHTPGTHNVSV-VNG-----QWSSNPTTFTY
IPT MET.AA IPT 837-933 17 1.5e-12 48.96 SMART 1-111 (111) Show / Hide 
Range on Protein: 837-933
Range on HMM: 1-111/111
Sequence Identity: 17% (20 aa)

NPVFEPFEKPVMISIGNENVVEIKGNNIDP-EAVKGEVLKVG----NQSCESLHW------HSGAVLCTVPSDLLK--LNSELNIEWKQAVSSTVLGKVI
.||.. ....  .  |..... |.|.| |.   |    ..||    ...|. ..|      .. . .|..|. . .  .... .....| |.   ...| 
DPVITRIHPNCGPCSGGTERITICGKNFDSDIQVRFVRVNVGGRVWEVPCTFQPWDYHGKDSQTQIVCCTPPYHNQSPIPGQVPVRVTQEVQF-CNDNVR

VQ--PDQNFAGL
.|  ..|.|  .
TQLSWPQPFTYV
TIG MET.AA TIG 838-897 19 0.031816 9.89 Pfam 1-58 (82) Show / Hide 
Range on Protein: 838-897
Range on HMM: 1-58/82
Sequence Identity: 19% (12 aa)

PVFEPFEKP-VMISIGNENVVEIKGNNIDPEAVKGEVLKVGNQSCESLHWHSGAVLCTVPS
|.   .. | .. ...  ... |.|.|    .  .   ..|.. |    | |  . ||.|.
PTITSIS-PNTTGPPSGGTTITITGQNF-GNDS-DTKCYFGGTPCTVIWWSSTQIVCTTPP
Kinase MET.AA Met 1077-1329 69 9.80000000001e-215 710.92 In-house 1-271 (271) Show / Hide 
Range on Protein: 1077-1329
Range on HMM: 1-271/271
Sequence Identity: 69% (187 aa)

HFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLN--RITDIEEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEG-SPLVVLPYMKHGDLRNFIRNETHN
||..|||.|||||||||...||||...|||.|||.  |||||...||||.|||.||.|.|||||||.||||..|| .|.|||||||||||..||||...|
HFDDVIGQGHFGCVYHGMYHDNDGNEHHCACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKTFIRNPQNN

PTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDM-YDKEYYSVHNKTG-AKLPVKWMALESLQ--------TQK-FTTKS
|.|.|||.|..||||||.|.||.||||||||.|||||||.||||||||||.||| |||||||....|. |.|||||||.|.||        |.. |||||
PCVRDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQMHHTHPARLPVKWMAPECLQQGVCLGCPTYRQFTTKS

DVWSFGVLLWELMTRGAPPYPDVNT-FDITIYLLQG--RRLLQPEYCPDALY-EVMLKCWHPKAEMRPSFS
|||||||..||||||||||||.|.. ||||..| ||  |||.|||||||.|| .|||.|||...|.||.||
DVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQPEYCPDHLYTDVMLCCWHANPEDRPQFS
Pkinase_Tyr MET.AA Pkinase_Tyr 1076-1335 44 4.5e-147 498.71 Pfam 1-270 (270) Show / Hide 
Range on Protein: 1076-1335
Range on HMM: 1-270/270
Sequence Identity: 44% (121 aa)

VHFNEVIGRGHFGCVYHGTLL-DNDGKKIHCAVKSLNRITDIEE--VSQFLTEGIIMKDF-SHPNVLSLLGICLRSEGS--PLVVLPYMKHGDLRNFIRN
..|....|.|.|| ||.||.  | |..||..|||.|.  .. |.     |. |  ||| . .|||...|.|.|.. ...  ...|..||.||||... |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

E---THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWS
     ...|.|||... .|.|||| ||.||...|||||||||...|...||..|||||||.|...|| .. ..|.|||.||||.|.... ||||||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

FGVLLWELMTRGAPP-YPDVNTFDITIYL-LQGRRLLQPEYCPDALYEVMLKCWHPKAEMRPSFSELVSRI
||||.||..|.|. | ||..  ...  |.  .|.|. .||.||| .|..|..|||...|.||.|||.....
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
TyrKc MET.AA TyrKc 1076-1335 39 2.4e-136 460.15 SMART 1-280 (280) Show / Hide 
Range on Protein: 1076-1335
Range on HMM: 1-280/280
Sequence Identity: 39% (114 aa)

VHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIEEVSQFLTEGIIMKDF--SHPNVLSLLGICLRSE------GSPLVVLPYMKHGDLRNFI
.......|.|.|| ||.||.       | .|||.|.  .    .  |. |  ||. .  .|||.. |.|.|. ..      . ...|. ||.||||....
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

RNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDK-------EYYSVHNKTGAK--LPVKWMALESLQTQKF
|.  .. ..|||. | .|.|.|| ||.||...|||||||||...|..|||..||||.|| ||.       .||..  . |.|  ||..|||.|.... ||
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TTKSDVWSFGVLLWELMTRGAPPYPD-----VNTFDITIYLLQGRRLLQPEY--------CPDALYEVMLKCWHPKAEMRPSFSELVSRI
|||||||||||..||..|.|..|||.     .. ...  |. ||.|. ||..        |||..|..|..||| ..|.||.|||.....
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MET.AA TK 1076-1335 24 2.6e-120 405.24 In-house 1-486 (486) Show / Hide 
Range on Protein: 1076-1335
Range on HMM: 1-486/486
Sequence Identity: 24% (120 aa)

VHFNEVIGRGHFG---CVYHGTLLDND----------------------GKKIHCAVKSLNR--ITDIEEVSQ-----------FLTEGIIMKDFS----
... ...|.|.||    || |.. . .                      |.|. .||| |     .. ||  .           || |  .|| ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNVLSLLGICLRSEGS-----------PLVVLPYMKHGD----LRNFIRNE-----------------------------------------------
 |||...|.|.|...|..           ...|. ||.|||    ||.. |.                                                
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------------------------THNPTVKDLIGFGLQVAKGMKYLASK------KFVHRDLAARNCMLDEKFT-----------VKVADFG---
                            .|..|...|. . .|.|.|| ||.||      .|||||||||||...|. .           .|.||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARDMY-DKEYYSVHNKT---------------------GAKLPVKWMALESLQ---------TQKFTTKSDVWSFGVLLWELMTRG-APPYPDV
     ||||.| |..||......                     |.|||..||| |.|.         . ||||||||||||||.||..|.| .|.|...
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

NT---------FDITIYLLQG--------------RRLLQPEYCP--------------DALYEVMLKCWHPKAEMRPSFSELVSRI
.           ..  || .|               |. ||..||              ...|..|..|||...| ||.||.|....
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MET.AA UTK 1076-1335 32 2.4e-98 333.04 In-house 1-296 (296) Show / Hide 
Range on Protein: 1076-1335
Range on HMM: 1-296/296
Sequence Identity: 32% (98 aa)

VHFNEVIGRGHFGCVYHGTLLDND--GKKIHCAVKSLN-RITDIEEVS---QFLTEGI---IMKDFS-HPNVLSLLGICLRSEGSPLVVLPYMKHGDLRN
|.. . .|.|.|| |..... . .  ... ..||| .. . ..  |     .|. |     .|| |. ||||| |.|.|...|. ...|. ||. ||||.
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLRS

FIRNETHNPT-------VKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEK-------FTVKVADFG---LARDMY-------DKEYYSVHNKTGA
. |. ...|          ..... ...| || ||.|..||||||||||| ...         ..|.||||   ..|...       ..|.| .      
YLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQD

KLPVKWMALESLQTQ-KFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITIYLLQG--RRLLQPEYCPDALYEVMLKCWHPKAEMRPSFSELVSRI
..|..||| |.|  . .||||||||||||..||..|.|. |||. .. ...  .. |  .|. .|. ||...|..|..|||.  ..||.| .||...
RWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase MET.AA TK-Unique 1076-1335 35 4.4e-97 328.83 In-house 1-294 (294) Show / Hide 
Range on Protein: 1076-1335
Range on HMM: 1-294/294
Sequence Identity: 35% (106 aa)

VHFNEVIGRGHFGCVYHGTLLDND---GKKIHCAVKSLNRITDIEEVSQFLTEGIIMKDFS-HPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIR---
. ...|||.| ||.|..|..  ..   .|... ||| |..  . .....|| |  .||    |||....||.| .|..... ...|.  |.|....|   
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

-------------------NETHNPT-VK--DLIGFGLQVAKGMKYLAS--KKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTG--AK
                   ... ... ..  ||. |. |.|.||.||||  ||.|||||.|||..| |....|..|||.||| |.     |.....   .
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT---NGVYSMMCSQGR

LPVKWMALESLQ--TQKF-TTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITIYLLQGRRLLQPEYC-PDALYEVMLKCWHPKAEMRPSFSELVSRI
.|..|||.|||.  .. . ||||||||||||.||..| ||.|||..   ||   . .| |..|||.| ....|..|  ||. ..|.||||.....|.
IPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase MET.AA Axl 1076-1333 44 8.2e-95 321.3 In-house 1-267 (267) Show / Hide 
Range on Protein: 1076-1333
Range on HMM: 1-267/267
Sequence Identity: 44% (119 aa)

VHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLN-RITDIEEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEG-----SPLVVLPYMKHGDLRNF---
.    ..|.| || |  | |  .||  .  ||| .   |    |. .|| | . ||.|.||||. |.|.|...        |.|.||.||||||  |   
FVLGKMLGEGEFGSVMEGQLKQEDGSFVKVAVKMMKIDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFLLY

--IRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDV
  . ..  .  .. |. | . .| || ||....|.||||||||||| |  || ||||||.. .|. .||       ||.||||.|.|||  . .| ||||
SRLGDQPFYLPLQMLVKFMVDIACGMEYLSNRNFIHRDLAARNCMLREDMTVCVADFGLSKKIYSGDYY--RQGCIAKMPVKWIAIESLADRVYTSKSDV

WSFGVLLWELMTRGAPPYPDVNTFDITIYLLQGRRLLQPEYCPDALYEVMLKCWHPKAEMRPSFSELVS
|.||| .||.||||  ||| |.  ..  ||..| || ||| | | ||..| .||.   . |||||.|  
WAFGVTMWEIMTRGQTPYPGVENHEMYDYLIHGHRLKQPEDCMDELYDLMYQCWEADPKDRPSFSVLRE
Kinase MET.AA Src 1076-1335 40 3.1e-88 299.42 In-house 1-255 (255) Show / Hide 
Range on Protein: 1076-1335
Range on HMM: 1-255/255
Sequence Identity: 40% (107 aa)

VHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIEEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSP-LVVLPYMKHGDLRNFIR--NETH
... . .|.|.|| |. |.  .|    .. |||.| . |   .. .|| |  ||| ..|.....|. .| . |  | . |  ||.|| |  . .   |..
IKLCRKLGQGQFGEVWMGYWNGN----TKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEE--PIYIVTEYMSHGSLLDYLKKDGEGR

NPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMY--DKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVL
.  ...|| .. |||.||.|| |....||||||||   .|.  .||||||||| .   | || . |   |||.|.||.| | .. ..||.||||||||.|
HLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARH---GAKFPIKWTAPEAINYGRFTIKSDVWSFGIL

LWELMTRGAPPYPDVNTFDITIYLLQGRRLLQPEYCPDALYE-VMLKCWHPKAEMRPSFSELVSRI
|.|..|.|  |||  .  .    . .| |. .|. ||| ||| .||.||| ..| || |  | .  
LTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase MET.AA InsR 1076-1337 37 3.2e-85 286.18 In-house 1-278 (278) Show / Hide 
Range on Protein: 1076-1337
Range on HMM: 1-278/278
Sequence Identity: 37% (107 aa)

VHFNEVIGRGHFGCVYHG--TLLDNDGKKI--HCAVKSLNRITDIEEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSP-LVVLPYMKHGDLRNFIR--
.  .   | | || || |    .  |.. .   ||.|..|     .|   || |  .|| | . .|  |||.|  | | | .||   |..|||... |  
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVC--SRGQPMYVVMEMMTYGDLKSYLRSR

------NETHNP------TVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQ
      |..  .      .  ...    ... || |||.|||||||||.|||| .. ||||..|||..|| |.  ||     .. .||| ||| |||   
RPEEEFNNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYY--RKGGKGMLPVRWMAPESLKDG

KFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITIYL-LQGRRLLQPEYCPDALYEVMLKCWHPKAEMRPSFSELVSRISS
.|||.||||||||.|||  | |. ||       .  |    |  | .|| ||....|.|  ||. .  |||.| .... .  
VFTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase MET.AA EGFR 1076-1336 38 2.8e-83 276.36 In-house 1-258 (258) Show / Hide 
Range on Protein: 1076-1336
Range on HMM: 1-258/258
Sequence Identity: 38% (102 aa)

VHFNEVIGRGHFGCVYHGTLLDNDGK--KIHCAVKSLNRITDIEEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHN
.    | | | || || |    . |.  ||  |.| |.  |. .    .| |  .|    ||... |||.|. |.    .|  || .| | ...|.   |
LKKVKVLGSGAFGTVYKGIWIPE-GENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQ--MQLVTQYMPYGCLLDYVRQHKDN

PTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWE
   ..|. ...|.||||.||  .. ||||||||| ..     ||..|||||. . ...  ..| . |.|.|.||||||... ...| .|||||.|| .||
IGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAK-LLEHDEKEYHAQ-GGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWE

LMTRGAPPYPDVNTFDITIYLLQGRRLLQPEYCPDALYEVMLKCWHPKAEMRPSFSELVSRIS
||| |. ||  . . .|   | .| || ||. |   .| ||.|||.  ..||| | ||... .
LMTFGQKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase MET.AA FGFR 1175-1335 46 6.7e-72 244.34 In-house 134-293 (293) Show / Hide 
Range on Protein: 1175-1335
Range on HMM: 134-293/293
Sequence Identity: 46% (76 aa)

TVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWEL
| |||. .  |||.|| ||||.| .||||||||    . .  |..|||||||  . .||    .|   ||.||||.|.|. ...|..|||||.|||||| 
TQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYY--RKTTNGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEI

MTRGAPPYPDVN-TFDITIYLLQGRRLLQPEYCPDALYEVMLKCWHPKAEMRPSFSELVSRI
|| |  ||| .    ..  ||  |.|.  |. |.  .| .|  ||| |.. ||.| .||  .
MTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase MET.AA S_TKc 1076-1339 22 2.7e-49 171.01 SMART 1-231 (231) Show / Hide 
Range on Protein: 1076-1339
Range on HMM: 1-231/231
Sequence Identity: 22% (63 aa)

VHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIEEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKH--GDLRNFIRNETHN
 .. ..||.| ||.|| ..  .    . ..|.| ..         ... |  |.|   |||.  |....    ..  .|. |. .  |||. .|..  ..
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRH

P-----TVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTT-KSDVWSF
.     .  .   .  |......|. |....||||   | .|||  ..|..|||||| .           |       .|| | |   .... |.|.||.
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GVLLWELMTRGAPPYPDVNTFDITIYLLQGRRLLQPEYCPDALYEVMLKCWHPKAEMRPSFSELVS-----RISSIF
|..|.|... | ||.|   . . .. ..           .. . . . ||..   | ||.  |.       ..   |
GCILYEMLC-GYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MET.AA Ryk 1244-1335 53 7.1e-47 146.12 In-house 201-292 (292) Show / Hide 
Range on Protein: 1244-1335
Range on HMM: 201-292/292
Sequence Identity: 53% (49 aa)

PVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITIYLLQGRRLLQPEYCPDALYEVMLKCWHPKAEMRPSFSELVSRI
|||||.||||| ... . ||||||||..||||| |  || ..  |  . ||. | || ||  ||| |..||. |||  .| ||.|. ||.  
PVKWMSLESLQHKHYSHASDVWSFGVTMWELMTLGQMPYMEIDPFEMYHYLKDGYRLQQPFNCPDELFTVMACCWHCMPEERPTFQQLVQCL
Kinase MET.AA Pkinase 1076-1335 20 7.4e-39 138.47 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1076-1335
Range on HMM: 1-293/293
Sequence Identity: 20% (61 aa)

VHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIE--EVSQFL-TEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHG----DLRNFIR
 |. ..||.| |||||...  ..       ||| ... .. .  ... .. .|  ||| ..|||.. |.... . .... .|..|. .|    ||  .|.
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIS

--NETHN-PTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTV----KVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQ-TQKFTT
  ...    . .... . .|...|..|. |....||||   |...|.. ..    |..|||||. ..   | . .  |.      .|| | ..  |. ..
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

KSDVWSFGVLLWELMTRGAPPYPD-----VNTFDITIYLLQGRRLLQ-PEYCP-------------------DALYEVMLKCWHPKAEMRPSFSELVSR-
|.|.||.|..|.|....  | . .     ..   .    ....   . |. |.                   ... ... .|.... . ||.. ...   
KVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

-I
 .
WF
Kinase MET.AA Ryk 1076-1226 24 1.7e-35 109.51 In-house 1-185 (292) Show / Hide 
Range on Protein: 1076-1226
Range on HMM: 1-185/292
Sequence Identity: 24% (45 aa)

VHFNEVIGRGHFGCVYHGTLLDNDG--------------KKIHCAVKSLNRITDIEEVSQFLTEGIIMKDFS-HPNVLSLLGIC--------LRSEGSPL
.   ...  | || .|||.. . |.              ..    || .      . |  .|.|.  .   | |.|.|..|..|            . |.
IQYSCLVQEGTFGRIYHGIWNQVDDVNNGDVDDEEDTFCDCQDVFVKTVKDHASQMQVHCMLQESCLLYGISPHQNILPVLHVCSFGRFDRPIEDHDPPF

VVLPYMK-HGDLRNFIRN----ETHNP---TVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEK---FTVKVADFGLARD
|..|.|.  | |  | ..    .. ..   . ..|  ...|...|| .|...  ||.|.|.||| .||      ||  |  | ||
VCYPHMNNWGNLKQFLQDCRHDKPKCHQAISTHQLVHMAIQITMGMMHLHKHRIVHKDIATRNCVIDEQNGRLQVKICDSALSRD
Kinase MET.AA FGFR 1076-1168 33 3.4e-05 13.6 In-house 1-97 (293) Show / Hide 
Range on Protein: 1076-1168
Range on HMM: 1-97/293
Sequence Identity: 33% (33 aa)

VHFNEVIGRGHFGCVYHGTLL--DND--GKKIHCAVKSLNRITDIEEVSQFLTEGIIMKDF-SHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIR
    ...| | || |  ..    |.|   |.|  ||| |      .. |    |  .||    |.|.. ||| |   || . |.  | .|| || | |
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQ-EGPLYVIVEYCHHGNLRDFLR