Gene MELK (Mouse)

MELK

Species: Mouse
Alias: MELK, Melk
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: MELK

Sequence

Name Sequence Type Origin Length Description Download
MELK.AA Protein Sugen 643 None Fasta, JSON
MELK.NA RNA Sugen 2914 None Fasta, JSON
MELK.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 253 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of MELK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MELK.AA MELK 11-263 83 1.2e-191 642.99 In-house 1-254 (254) Show / Hide 
Range on Protein: 11-263
Range on HMM: 1-254/254
Sequence Identity: 83% (211 aa)

YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSLRHQHICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETR
||....||||||||||||||.||..||||||||||.||.||||||||.||||.|||||||||||..||..|||||.|||||||.|||||.||||.|||||
YEVHDEIGTGGFAKVKLACHILTNQMVAIKIMDKNQLGHDLPRVKTEMDALKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEEEETR

VVFRQILSAVAYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYH-LQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPF
..||||.||.||||||||||||||||||||||.|.|||||||||||.||.|||| |||||||.|||||||||||.|.|||||||||||||||||||||||
HFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKTKGRKDYHNLQTCCGSPAYAAPELIQGKQYIGSEADVWSMGILLYVLMCGFLPF

DDDNVMALYKKIMRGKYEVPKWLSPSSILLLQQMLQVDPKKRISMRNLLNHPWV
||||.|..|||||.|.||.||||||.|..||..||||||||||||.||||||||
DDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISMKNLLNHPWV
Kinase MELK.AA CAMKL 11-263 43 2.9e-146 469.85 In-house 1-297 (297) Show / Hide 
Range on Protein: 11-263
Range on HMM: 1-297/297
Sequence Identity: 43% (130 aa)

YELYETIGTGGFAKVKLACH-VLTGEMVAIKIMDKNALG---------------SDLPRVKTEIDALKSLR---HQHICQLYHVLETKNK------IFMV
|.. .|.|.|.|.|||||.|  .|||.|||||.||. .                ||. |.. ||  .|.|.   |..|..||.|.||...      |..|
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

LEYCPGGE--LFDYIISQ----DRLSEEETRVVFRQILSAVAYVHSQGYAHRDLKPENLLFDENH--KLKLIDFGLCAKPK-G-NKDYH-LQTCCGSLAY
.|||.|||  |||||...    .|..|.|.|  ||||.|||.| ||.| .|||.||||.|.|||.  ..|.||||.... . . ... . | |.|||..|
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

AAPELIQG--KSYLGSEADVWSMGILLYVLMCGFLPFDDD--------NVMALYKKIMRGKYEVPKW--LSPSSILLLQQMLQVDPKKRISMRNLLNHPW
.|||..||  |.| | ..|.||.|..||...|| ||||||        |.  ||.|||.| |. |.|  .| . . |...||||.|.||... ...||||
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPW

V
.
M
Kinase MELK.AA AMPK 11-263 52 1.5e-144 432.04 In-house 1-254 (254) Show / Hide 
Range on Protein: 11-263
Range on HMM: 1-254/254
Sequence Identity: 52% (134 aa)

YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNAL--GSDLPRVKTEIDALKSLRHQHICQLYHVL-ETKNKIFMVLEYCPGGELFDYIISQDRLSEE
| . .|||.| | |||.. | |||| |||||..|  .   ..  |.. ||. ||..||.|| ||| |. ||.  ||||.|| .||||||||.. .||.|.
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQER

ETRVVFRQILSAVAYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFL
|.. .| ||.|.| |.|  . .||||||||||.|.|...|. ||||    | .    | |.|||  |||||.|.|| | | | |.|| |. ||...|| |
EACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDG--EFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYL

PFDDDNVMALYKKIMRGKYEVPKWLSPSSILLLQQMLQVDPKKRISMRNLLNHPWV
||||.|. .|||||. |.|..||.|||..  |...|||||| |||.   . |||| 
PFDDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase MELK.AA CAMK 16-263 28 1.1e-130 423.64 In-house 1-425 (425) Show / Hide 
Range on Protein: 16-263
Range on HMM: 1-425/425
Sequence Identity: 28% (123 aa)

TIGTGGFAKVKLACHVLTG------------EMVAIKIMDKNALGS---------------------------DLPRVKTEIDALKS-------LRHQHI
|.|.|.|.||||..| .|.            . |||||.||. | .                           |. .|. ||. .|.       |.| .|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

CQLYHVLE------------TKNK--------IFMVL---EYCPGGEL----FDYIISQ---------------DRLSEEETRVVFRQILSAVAYVHSQG
..||.| |            | .|        ..||.   |||.||||    ||||...                |..|.|.| .||||.|||.| ||..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

YAHRDLKPENLLFDENH-----------------KLKLIDFGLCAKPKGNKDYH----------------------LQTCCGSLAYAA-PELIQG-----
 .||||||||.|.|.|.                 ..|.||||. .| .......                      ..|.||...|.| ||...|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------KSYLGSEADVWSMGILLYVLMCGFLPFDDD-------------NVMALYKKIMRGKYE-VPKWLSP-----------------------SSI
        | | | ..|.||.|..||.. ||..||..|             |   |..|||.|||.  |...||                       . .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

LLLQQMLQVDPKKRISMRNLLNHPWV
 |...||||||.||..    |||||.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MELK.AA MARK 11-263 46 6.8e-122 400.14 In-house 1-262 (262) Show / Hide 
Range on Protein: 11-263
Range on HMM: 1-262/262
Sequence Identity: 46% (122 aa)

YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALG--SDLPRVKTEIDALKSLRHQHICQLYHVLE--TKNK-IFMVLEYCPGGELFDYIISQ--DR
|..  |||.|..||||||||..||. |||||..|. |     .  |. ||. .|.| | .| .|.|| |  |... |....||..||||.|||...   |
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

LSEEETRVVFRQILSAVAYVHSQGYAHRDLKPENLLFDENH--KLKLIDFGLCAK-PKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLY
|.|||.|. ||||.||| | ||.. .|||.||||.| |||   . |.||||.... | |.|   | |.||...|.|||....| | | ..|.||.|..||
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQK---LNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLY

VLMCGFLPFDDDN--VMALYKKIMRGKYEVPKWLSPSSILLLQQMLQVDPKKRISMRNLLNHPWV
.. || .|||.|.     ||||| ||||..|  .|..   |.|..|.|.|..|... ....|||.
FMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase MELK.AA NuaK 11-263 42 6.6e-108 284.81 In-house 1-252 (252) Show / Hide 
Range on Protein: 11-263
Range on HMM: 1-252/252
Sequence Identity: 42% (109 aa)

YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGS--DLPRVKTEIDALKSLRHQHICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEE
||. .| | | . |||||    ||  ||||   |..  .  |. ..  ||  . || | || . | | | |.|| .|.||  ||||.||| .  .|.|.|
YEFQKTLGKGTYGKVKLATEHSTGREVAIKSIKKCKIEDEQDMVHIRREIEIMSSLNHPHIIHIYEVFENKDKIVIVMEYASGGELYDYISECKSLPERE

TRVVFRQILSAVAYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLP
.| .|||| |||.| |  . .||||| || | |.|   |  ||||    .  ..  |.| |||  || || . |. | | | | ||.|.|||..  | .|
ARHFFRQIVSAVHYCHKHRICHRDLKLENILLDQNCNAKIADFGLSNYYH--DQKFLHTFCGSPLYASPEIVNGQPYHGPEVDCWSLGVLLYTMVYGTMP

FDDDNVMALYKKIMRGKYEVPKWLSPSSILLLQQMLQVDPKKRISMRNLLNHPWV
|| ..   | | | .|.|  |.  |  .  |  .||.|.|..| .. .  .|.||
FDGHDFKHLVKQISQGAYYEPCKPSDACM-LIRWMLMVNPRRRATIYDICHHWWV
Kinase MELK.AA S_TKc 11-263 35 1.7e-107 364.36 SMART 1-231 (231) Show / Hide 
Range on Protein: 11-263
Range on HMM: 1-231/231
Sequence Identity: 35% (96 aa)

YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSLRHQHICQLYHVLETKNKIFMVLEYCPG--GELFDYIISQDR-----
||. ..|| |.|.||... |. ||. |||||..         ... ||. ||. .| .|..|| | .. ....||.|||.|  |.||||| .. |     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LSEEETRVVFRQILSAVAYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVL
 ..| ..| ...||..|..| ||.|  ||||||||.|.||   .|..||||...          |.||.. | |||..   .| . ..|.|| |..|| .
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

MCGFLPFDDDNVMALYKKIMRGKYEVPKWLSPSSILLLQQMLQVDPKKRISMRNLLN-------HPWV
.||  ||.  ......|||.          ||. . .....||.||.||..   .|.       |||.
LCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MELK.AA QIK 11-263 40 1.4e-106 360.38 In-house 1-272 (272) Show / Hide 
Range on Protein: 11-263
Range on HMM: 1-272/272
Sequence Identity: 40% (112 aa)

YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNAL-GSDLPRVKTEIDALKSLRHQHICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDR------
|..  ||| | || |||| |  | . |||||.|| .|  ..| ... |.  .|.|.| ||  || |.||.. ...| |||..||.|||.... |      
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEENLQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKMV

--------------LSEEETRVVFRQILSAVAYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSE
              ..|.|.| .| ||.|||.| |... .||||| ||.|.|.|   |..|||.    |  ..  |.|.||| .|||||. .||.| | .
NSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFK--QGQLLMTWCGSPPYAAPEMFEGKEYDGPK

ADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYEVPKWLSPSSILLLQQMLQVDPKKRISMRNLLNHPWV
.|.||||..|||| || |||| ...  | .... ||. .| ..|     |  .|| |||..|... . ..|.| 
VDIWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
Kinase MELK.AA CAMK1 11-263 37 7.7e-99 287.95 In-house 1-276 (276) Show / Hide 
Range on Protein: 11-263
Range on HMM: 1-276/276
Sequence Identity: 37% (106 aa)

YELYETIGTGGFAKVKLACHVLT---GEMVAIKIMD-KNALGSD----LPRVKTEIDALKS---LRHQHICQLYHVLETKNKIFMVLEYCPGGELFDYII
||. ..||.| |..|.|..|  |   |. .|||..| | ..  .    . ....||. .|.   . |..| ..| . |..|.. .|.|.. |||||| |.
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV

SQDRLSEEETRVVFRQILSAVAYVHSQGYAHRDLKPENLLF---DENHKLK--LIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQG---KSYLGSEAD
  .  .|.. | . .|||||| | ||.| .||||||||||.   ||..|.|  ..|||| .|  ....  ..|.||.. | ||| . .   | | . . |
EKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGL-SKIFDHDENLMKTACGTPGYVAPEVLECKKDKPY-DKACD

VWSMGILLYVLMCGFLPFDDDN-VMALYKKIMRGKYEVPKWLSP---S-SIL----LLQQMLQVDPKKRISMRNLLNHPWV
.|| |. .|.| ||. || |.|  . |..||....||   . ||   . |      .. .|| ||||||..    |||||.
MWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYE---FPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase MELK.AA Pkinase 11-263 33 2.9e-97 334.24 Pfam 1-293 (293) Show / Hide 
Range on Protein: 11-263
Range on HMM: 1-293/293
Sequence Identity: 33% (98 aa)

YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKT---EIDALKSLRHQHICQLYHVLETKNKIFMVLEYCPGG----ELFDYII--SQ
|.. ..|| |.|..|....|. ||..||.||..|    |. .. ..   ||  .|.|.| .|..||.. |.|..| ||.|||.||    .|||||   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

DRL--SEEETRVVFRQILSAVAYVHSQGYAHRDLKPENLLFDENHKL----KLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSM
 ..  ||.| . ...|||....| ||.|  ||||||||.|.|.|  .    |..||||... .  ..  ..| ||.. |.|||.|.| .| |...|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GILLYVLMCGFLPFDDD------NVMALYKKIMRGKYEVPKWLS---------------------PSSILLLQQMLQVDPKKRISMRNLLNHPWV
|..|| ..|| .||...      . |.....||..... . . .                     .. . ..  .|..|||||.. . .|.|||.
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MELK.AA Ciliate-E2 11-263 24 2.3e-87 296.55 In-house 1-365 (365) Show / Hide 
Range on Protein: 11-263
Range on HMM: 1-365/365
Sequence Identity: 24% (94 aa)

YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNA--------------------LGSDLPRVKTEIDALK----------------SLRHQHICQLYH
|.. . ||.|.|..|..... ......|||| | .                       ...  .| ||. ..                .| | .|...| 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

VLE--TKNKIFMVLEYCPGGELFDYIISQD-----------RLSEEETRVVFRQILS---------------AVAYVHSQG-YAHRDLKPENLLFDENHK
. .  ..|.|..|.||| ||.|||||....           ...|.| . ...|||.               |. | ||..   |||.||||.||     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

LKLIDFGLCAKPKGNKDYHL------------------------------QTCCGSLAYAAPELIQGKSYLG--------SEADVWSMGILLYVLMCGFL
.|.|||||. | . . ....                              .|.||.. | ||| ..||.| .         ..|.||.|..|| ...| .
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFDDDNVMALYKKIMRGKYEVP----------------KW--LSPSSILLLQQ----MLQVDPKKRIS-MRNLLNHPWV
||        ...|. .|.. |                .|  .|.. . |...    |||.||.|||. .  .||||| 
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase MELK.AA BRSK 11-263 46 1.2e-83 284.26 In-house 1-254 (254) Show / Hide 
Range on Protein: 11-263
Range on HMM: 1-254/254
Sequence Identity: 46% (118 aa)

YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALG---SDLPRVKTEIDALKSLRHQHICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEE
| |  | | |   .|||  |  ||. |||||  |  |    | | .|  ||  .|   | |. ..| | |.|   ...||.  ||||||| .   ||   
YRLEKTLGKGQTGLVKLGVHCVTGKKVAIKIINKEKLSNKESMLMKVEREIAIMKLIDHPHVMKMYDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPK

ETRVVFRQILSAVAYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFL
| |  |||| ||. . ||    |||||||||| ||  . |  |||.       ||  | | |||  || || |.|  | |  ||||| |. || |. | |
EARKFFRQIISALDFCHSHNICHRDLKPENLLLDEKNNIKIADFGMASLQV--KDMMLHTSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYALLVGAL

PFDDDNVMALYKKIMRGKYEVPKWLSPSSILLLQQMLQVDPKKRISMRNLLNHPWV
||||||.  |  |. || . .| .  |    ||  |. |||.||||. .   |||.
PFDDDNLRQLLEKVKRGVFHMPHFIHPDCQDLLRGMIEVDPDKRISLKEIQKHPWY
Kinase MELK.AA TyrKc 11-263 21 4.9e-17 52.78 SMART 1-280 (280) Show / Hide 
Range on Protein: 11-263
Range on HMM: 1-280/280
Sequence Identity: 21% (62 aa)

YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSL--RHQHICQLYHVLETK-------NKIFMVLEYCPGGELFDYIISQ
 .| ...| | | .| ..      ..||.| . ..|    .     |.  ...|  .|..| .|| |  ..         ...|.||.|.| | ||. . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

DR-LSEEETRVVFRQILSAVAYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGN-------KDYHLQT--CC---GSLAYAAPELIQGKSYLGS
 . |. ..      || .  .| ||... ||||   | | .|||  |  ||||. . .         . |. ..  ..     .   ||| |. . .  .
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF-TT

EADVWSMGILLY-VLMCGFLPFDD-----DNVMALYKKIMRGKYEVPKWL---------SPSSILLLQQMLQVDPKKRISMRNLLNHPWV
. |||| |.... ..  |  |  .      .   .......|..  .            ..    . .|  . ||..| .....  |   
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase MELK.AA Pkinase_Tyr 11-224 27 1e-15 53.85 Pfam 1-232 (270) Show / Hide 
Range on Protein: 11-224
Range on HMM: 1-232/270
Sequence Identity: 27% (64 aa)

YELYETIGTGGFAKVKLACHV----LTGEMVAIKIMDKNALGSD---LPRVKTEIDALKSL-RHQHICQLYHVLE-TKNK--IFMVLEYCPGGELFDYII
 .. ...| | | .|...        |.  ||.|.. |.   ..   .     |.  .|.| .|..| .|| |    .    |..|.||.|.| | ||  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

S----QDRLSEEETRVVFRQILSAVAYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYH-LQTCCGSLAYA--APELIQGKSYLGSEADV
.    ...|. ..     .|| .. .| .|... ||||   | | .||.. |  ||||.     |.||   ..  | |     ||| |. .    .. ||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGK-FTTKSDV

WSMGILLYVLMC-GFLP-FDDDNVMALYKKI-MRG
|| |.|.. ..  |  | . .     .|..|  .|
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDG
UBA_CAMKL MELK.AA UBA_CAMKL 283-321 34 1.2e-09 32.81 In-house 1-41 (41) Show / Hide 
Range on Protein: 283-321
Range on HMM: 1-41/41
Sequence Identity: 34% (14 aa)

DEDCVTELSVH-HRSSRQTMEDLISSWQY-DHLTATYLLLL
||... |.  . |  .|. ... .... | .|.||||.|||
DEEIIQEMCKMWHGFDREEIIESLRNNKYHNHITATYYLLL
KA1 MELK.AA KA1 597-643 29 1.9e-19 68.43 Pfam 1-48 (48) Show / Hide 
Range on Protein: 597-643
Range on HMM: 1-48/48
Sequence Identity: 29% (14 aa)

GKVTMQFELEVCQLQ-RPDVVGIRRQRLKGDAWVYKRLVEDILSGCKM
.. ...||..||... |....|....|..|..|.|| |...||. .. 
EPEVVKFEIQVCKVPGRLGLYGVDFKRVSGNQWQYKDLCTKILKEMRL