Gene MAST2 (Mouse)

MAST2

Species: Mouse
Alias: Mtssk, MAST2
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: AGC
Family: MAST
Subfamily: MAST

Sequence

Name Sequence Type Origin Length Description Download
MAST2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 274 Kinase domain by global Sugen HMM Fasta, JSON
MAST2.NA RNA Sugen 5729 None Fasta, JSON
MAST2.AA Protein Sugen 1794 None Fasta, JSON

Protein domain

Protein domains of MAST2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
DUF1908 MAST2.AA DUF1908 202-279 66 2.6e-47 168.28 Pfam 1-89 (369) Show / Hide 
Range on Protein: 202-279
Range on HMM: 1-89/369
Sequence Identity: 66% (59 aa)

PLDSPRNFSPNAPAHFSFVPAR-------RTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKL----HQLPFQPTADELHFLTKHFS
|.||||||| .....| |||.|       | ||||||.|||||||||||.|||.|||.|||||.|    ||||||||.|.|||| |||.
PIDSPRNFSTSSMMNFPFVPIRRITNCRDRADGRRWSVASLPSSGYGTNPPSSNVSSQCSSQERLNQLPHQLPFQPTQDDLHFLSKHFC
DUF1908 MAST2.AA DUF1908 283-477 68 3.4e-139 473.53 Pfam 168-369 (369) Show / Hide 
Range on Protein: 283-477
Range on HMM: 168-369/369
Sequence Identity: 68% (138 aa)

VPDEE----GRRSPAMRPRSRSL-SPGRSPVSFDSEIIMMNHVYKERFPKATAQMEERLADFISSNT--PDSVLPLADGALSFIHHQVIEMARDCLDKSR
. ||.    |.||| .||||||| ||.||...||.||.||||||||||||||.|||||| .||  .   |.. |.|||. . ||||||.|||||||.||.
CQDEDNNFCGCRSPHHRPRSRSLSSPSRSCITFDNEIVMMNHVYKERFPKATQQMEERLQHFIHHFKNIPCDSLRLADPVVRFIHHQVVEMARDCLHKSH

SGLITSHYFYELQENLEKLLQDAHERSESSDVAFVIQLVKKLMIIIARPARLLECLEFDPEEFYHLLEAAEGHAKEGHGIKCDIPRYIVSQLGLTRDPLE
 .|||| ||||.||.||.||..||||||| .|.|. ...|||.|||.|||||||||||||||||||||||||.||...||| ||||||..||||.|||.|
AKLITSRYFYEMQEKLERLLHEAHERSESEEVPFITHVIKKLLIIISRPARLLECLEFDPEEFYHLLEAAEGQAKVMQGIKTDIPRYIIHQLGLNRDPIE

EM
||
EM
Kinase MAST2.AA MAST 513-786 55 3.7e-233 720.68 In-house 1-337 (337) Show / Hide 
Range on Protein: 513-786
Range on HMM: 1-337/337
Sequence Identity: 55% (188 aa)

FETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFET--KRHLCMVMEYVEGGDCATLLKNIG-ALP
||.||.||.||||||.||.||.|..|||||.||.|..|..||..|.||||.|||...|||||.||.||.|  |..|||||||.||||||.||...| ..|
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

VDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEG---------------HIEKDAREFL------------
..|...|.|||||.|||||.||||||||||||.||.|.||||||||||||.|.|..|||.|||               ||.|....|             
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDKTTNHYEGYFNTNIFGKNHFNEYHIQKNYQQFQQDFGINGNTNKN

------------------------DKQVCGTPEYIAPEVILRQG-YGKPVDWWAMGIILYEFLVGCVPFFGDTPEE-LFGQVIS--DEIVWPEG-----D
                        .||.||||.||||||||.|| ||||||||.||||.|||||||.||.|||||| .|...|.  .|| |||.     |
QIQQQQEQPQCQQQNEMRPHNIHQNKQCCGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDD

DALPPDAQDLTSKLLHQNPLERLGTSSAYEVKQHPFF
|...|.|||| .|||..||..|||.  |.|.||||||
DCMSPEAQDLIKKLLQPNPKKRLGANGADEIKQHPFF
Kinase MAST2.AA MAST 513-786 51 7e-214 696.35 In-house 1-334 (334) Show / Hide 
Range on Protein: 513-786
Range on HMM: 1-334/334
Sequence Identity: 51% (173 aa)

FETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFETKRHLCMVMEYVEGGDCATLLKNIGALPVDM
||.||.||.||||.|.||.||.|..|||||.|.|...|..|...| .|||.||....|||||.||.||.||..|||||||.||||||.||...|.....|
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

VRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEG---------------HIEKDAREFL---------------
...|.|||||.|||||..|||||||||||.||.|.||||||||||||.|.|......|||               ....|...|                
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDLNMMYEGYTPPNIFNNSTDPMNKNQQDYSQFPGDFGINGNTNKNQIQ

--------------------DKQVCGTPEYIAPEVILRQG-YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDE---IVWPEG-----DDALP
                    .||.||||.||||||||.|| .|||||||.||||.|||||||.||..|||||.|.......   | ||||     |.|..
QQQEQPQCQQQNMRPHNIHQNKQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMS

PDAQDLTSKLLHQNPLERLGTS-SAYEVKQHPFF
|.||||..|||...|..|||..  |.||||||||
PEAQDLIEKLLQPDPRKRLGANNGADEVKQHPFF
Kinase MAST2.AA AGC 513-786 29 1e-170 445.73 In-house 1-395 (395) Show / Hide 
Range on Protein: 513-786
Range on HMM: 1-395/395
Sequence Identity: 29% (117 aa)

FETIKLISNGAYGAVFLVRHK------STRQRFAMKKINKQN-LILRN--QIQQAFVE------------RDILTFAE----------NPFVVS-MFCSF
|| .|.|. |..| |.|||.|      .| . .|||...|.   ....  ..... .|            |.||. .           .||.|. ...||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETKRH--LCMVMEYVE--------GGDCATLLKNIG-----ALPVDMVRLYFAE-------TVLALEYLHN-YGIVHRD-LKPDNLLITSMGHIKLTDFG
..|.|  |..||||..        ||.| ..| . |      .. ...| |.||       .||||||||.  ||.||| |||.|.|... |||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKIGLMS-----------LTTNLYEG---------------HIEKDA----------REFLDKQVCG--TPEYIAPEVILRQGYGKPVDWWA--MGIIL
|.|.| ..           .... ...               .. ...           ... .  ||  ||||.|||..    |||..|||.  .|...
LCKEGMNDGEKGQQSQSNMKFHW-HNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLM

YEFLVGCVPFFGDTPE----------ELFGQVI------SDEIVWP-------EGDDALPPDAQDLTSKLLHQNPLERLGTSS-------AYEVKQHPFF
||.|.|. ||.||.|.          |.| ...      .... .|       ..|. . |.|.|| .|||. .| .|||.         | |.|.||.|
YEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase MAST2.AA S_TKc 513-786 32 1.8e-101 344.35 SMART 1-231 (231) Show / Hide 
Range on Protein: 513-786
Range on HMM: 1-231/231
Sequence Identity: 32% (94 aa)

FETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFETKRHLCMVMEYVEG--GDCATLLKNIGA---
.| ...|  ||.| |...|||.| ...|.|.|.          ...  |..||     |..| .. .|..  ||.|||||..|  ||  ...|. |    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYG
   .|  ..| |......||||.|. ||.||||||.|.|...  |||..||||...                       . .||||.|.||||.   |||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------------------TTFCGTPWYMAPEVL---GYG

K-PVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDDALPPDAQDLTSKLLHQNPLERLGTSSAYE----VKQHPFF
| ..|||. |.||||.|.|. ||   .....| ..              .|.| |. .|.|. .| .|..   | .    .|.||.|
KCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MAST2.AA RSK-Unclassified 513-786 37 1.2e-92 291.36 In-house 1-283 (283) Show / Hide 
Range on Protein: 513-786
Range on HMM: 1-283/283
Sequence Identity: 37% (108 aa)

FETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFETKRHLCMVMEYVEGGDCATLLK--NIGALPV
|. ..||  |  | |.||| | | | .|||  .|. .| .| |. .  |..|.   . ||.| .. || |.  | ..|||  |||    |       .  
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

DMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIG------LMS--LTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQG
| || | .|...||||||  ... ||||||| .    ||..||||.||. .       |       . .  |  .   |  .  ||| ||.|||.| | |
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHG--FRTNSFCGTEEYLAPEMIRRCG

YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDDALPPDAQDLTSKLLHQNPLERLGTSSA--YEVKQHPFF
 .| |||| .||..|| |.|| |. |.  .|.|  .   ..  |. |  .  ...||  ||| .||  |||  .    ..|.||||
HTKAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPH-DSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase MAST2.AA AktR 513-786 37 2.3e-91 309.87 In-house 1-268 (268) Show / Hide 
Range on Protein: 513-786
Range on HMM: 1-268/268
Sequence Identity: 37% (105 aa)

FETIKLISNGAYGAVFLVRHK-STRQRFAMKKINKQNLILRNQIQQAFVERDILT-FAENPFVVSMFCSFETKRHLCMVMEYVEGGDCATLLKNIGALPV
|. .|.. .||.| |.||..|  . . .||| | |...| |||....  ||.|.   . .|| | .. .|.||..|  .|||..||.  . ||... .  
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

DMVRLYFAETVLALEYLHNY-GIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDA-REFLDKQVCGTPEYIAPEVILR-QGYGKPV
...| |||. .|||||||.   |. |||||.|.|. . ||.|.|||||||              ....  .. . . .||||||.|||.|.. .|..|.|
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK--------------LQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSV

DWWAMGIILYEFLVGCVPFFG-DTPEELFGQVISDEIVWPEGDDALPPDAQDLTS-KLLHQNPLERLG--TSSAYEVKQHPFF
|||| || .|| ..|| ||.  .. .... . |.. .. ..    . . ..||   ||| .|| .|||  .... |.| ||.|
DWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQ-QNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase MAST2.AA RSK 516-786 34 4.5e-84 285.63 In-house 1-278 (278) Show / Hide 
Range on Protein: 516-786
Range on HMM: 1-278/278
Sequence Identity: 34% (102 aa)

IKLISNGAYGAVFLVRHK---STRQRFAMKKINKQNLILRNQ-IQQAFVERDILTFAE-NPFVVSMFCSFETKRHLCMVMEYVEGGDCATLLKNIGA---
.|.   |.||.|||.| .    |.| .||| ..|  .. |.  .  .. ||.||   .  ||.|. . .|.|. .| ..|||..||.  | |.. .    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITS---MGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAR-EFLDKQVCGTPEYIAPEVIL----
.  | .. |.|| |||.|.||  ||.||||||.| | ..    |||||||||..|..               ... ... .  |.| ||.|||..     
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF---------------RCDHNQWTMTFCYTIEYMAPEMLKRANQ

RQGYGKPVDWWAMGIILYEFLVGCVPFFG---DTPEELFGQVISDEIVWPEGD--DALPPDAQDLTSKLLHQNPLERLG--TSSAYEVKQHPFF
. |..| .|||  |...|| |.||.|| |   ....|.. .. . .   ....  . | ..|.|| .|.|| .|  |||   . | |.||||.|
QGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGK-FSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase MAST2.AA Pkinase 513-786 29 5e-81 280.3 Pfam 1-293 (293) Show / Hide 
Range on Protein: 513-786
Range on HMM: 1-293/293
Sequence Identity: 29% (92 aa)

FETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFV--ERDILTFAENPFVVSMFCSFETKRHLCMVMEYVEGG----DCATLLK--N
..... |  |..| |.. .||.|....|.|.|.|.  .  .. |...   |  |.     |..| ....||.|.|..|||||.|||    | .....  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

IGAL--PVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHI----KLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVI
 |..  . . .. |. ... .|||.|. ||.||||||.|.|| . |||    |..||||.|               .   . .  . .||||.|.|||||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------------Y-NNS-M--TTFCGTPWYMAPEVI

L-RQGYGKPVDWWAMGIILYEFLVGCVPFFGD------TPEELFGQVIS--DEIVWPEGDD----------------ALPPDAQDLTSKLLHQNPLERLG
. .|.||..||.|..|.||||.| |  || |.      .. ... .. .   .  ||. ..                .......|. ...|...| .|..
RGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT

TSSAYEVKQHPFF
   | ...|||.|
---AEQILQHPWF
Kinase MAST2.AA NDR 513-659 47 1.3e-77 238.8 In-house 1-152 (350) Show / Hide 
Range on Protein: 513-659
Range on HMM: 1-152/350
Sequence Identity: 47% (72 aa)

FETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAE--NPFVVSMFCSFETKRHLCMVMEYVEGGDCAT---LLKNIGA
|| ||.|. ||.| |.|||.|.|.. .|||...|.  . .||. .   ||||.. |   ||.||....||  | .|. ||||. |||  |   ||.. . 
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

LPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSK
.. |. | | ||.|.|.|..|..|..|||.||||.|| . ||||||||||..
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFGLCT
Kinase MAST2.AA Akt 513-664 40 1.1e-54 173.17 In-house 1-154 (264) Show / Hide 
Range on Protein: 513-664
Range on HMM: 1-154/264
Sequence Identity: 40% (62 aa)

FETIKLISNGAYGAVFLVRHKSTRQRF-AMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFETKRHLCMVMEYVEGGDCATLLKNIGALPVD
|. .|..  |..| ||||. |.| . . ||| . |. .| .||..... || ||    .||.|..  || |. .|..||.|. ||.  ..|.  .  . |
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

MVRLYFAETVLALEYLHNYGIVHRD-LKPDNLLITSMGHIKLTDFGLSKIGLMS
  | | || .||.|.||. .|. || ||| |.|. . |||.||||||.| ....
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIK
Kinase MAST2.AA SGK 513-659 36 1.2e-52 160.69 In-house 1-173 (283) Show / Hide 
Range on Protein: 513-659
Range on HMM: 1-173/283
Sequence Identity: 36% (63 aa)

FETIKLISNGAYGAVFLVRHKST------------------RQRFAMKKINKQNLI-------LRNQIQQAFVER-DILTFAENPFVVSMFCSFETKRHL
|. .|.|  | .| |..|.||..                   . .||| ..||  |        ...      || .||     || |.   .| ||  |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

CMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSK
 .||.||.||.    |.  . .| | .| | || |.||||||   |..|||||.|.|  ..||..||||||.|
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCK
Kinase MAST2.AA PKA 513-659 42 5.4e-52 179.05 In-house 1-149 (263) Show / Hide 
Range on Protein: 513-659
Range on HMM: 1-149/263
Sequence Identity: 42% (64 aa)

FETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVV-SMFCSFETKRHLCMVMEYVEGGDCATLLKNIGALPVD
||.|... .| .| | |.|||.. . .||| ..||  . ..|..    |. ||.  ..||.| .|  .| . |.| ||||||.||.  . | . | .. .
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

MVRLYFA-ETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSK
. ..| | . ||||||||.  |..||||| |.|| . ||||.|||| .|
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAK
Kinase MAST2.AA Akt 686-786 38 3.6e-42 132.55 In-house 162-264 (264) Show / Hide 
Range on Protein: 686-786
Range on HMM: 162-264/264
Sequence Identity: 38% (40 aa)

VCGTPEYIAPEVILRQGYGKPVDWWA-MGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDDALPPDAQDLTSKLLHQNPLERLG-TSS-AYEVKQ
.||||||.|||... .|..|.||||.  |...||.. |  ||. .  ...| .  . ..  |.  |.. |...|| |.||. .| .||| ... | |.|.
FCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPVKFPDK-DWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKR

HPFF
||.|
HPWF
Kinase MAST2.AA NDR 688-786 40 7.5e-41 123.29 In-house 243-350 (350) Show / Hide 
Range on Protein: 688-786
Range on HMM: 243-350/350
Sequence Identity: 40% (44 aa)

GTPEYIAPEVILR-QGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVW-----PEGDDA-LPPDAQDLTSKLLHQNPLERLGTSS--AY
|||.|.||||... .||.. .|||  | |.||.|||  ||..|||.| .  ... .. |       . .| | |.|.||  .|.. .| .|||     . 
GTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKGVD

EVKQHPFF
|.|.||||
EIKSHPFF
Kinase MAST2.AA SGK 687-786 40 9.4e-40 120.13 In-house 186-283 (283) Show / Hide 
Range on Protein: 687-786
Range on HMM: 186-283/283
Sequence Identity: 40% (41 aa)

CGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDDALPPDAQDLTSKLLHQNPLERLGTS-SAYEVKQHPF
|||||| ||||.. |.... |||| .|..|||...|  ||.    .... . |. ..  | .     .|| ||   ||. .| .||||   . |.|.|||
CGTPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQ---MSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPF

F
|
F
Kinase MAST2.AA PKA 686-786 38 2.3e-36 127.15 In-house 158-263 (263) Show / Hide 
Range on Protein: 686-786
Range on HMM: 158-263/263
Sequence Identity: 38% (42 aa)

VCGTPEYIAPEVILRQ-GYGKPVDWWAMGIILYEFLVGCVPFFGD--TPEELFGQVISDEIVWPEGDDALPPDA---QDLTSKLLHQNPLERLGTSSA--
.||||||.|||.|..  |.||.||||| ||. ||.|.|  ||. .  .| ...   .. .| .|. .|   .||    || .|||  .. .|.|. ..  
LCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPFYDHNRDPMQIYEKICNGKIKFPRHFD---SDANYFKDLIKKLLQVDLTKRYGNMKNGV

YEVKQHPFF
  .| |..|
NDIKNHKWF
Kinase MAST2.AA TyrKc 513-786 19 4.8e-12 -27.86 SMART 1-280 (280) Show / Hide 
Range on Protein: 513-786
Range on HMM: 1-280/280
Sequence Identity: 19% (58 aa)

FETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFA--ENPFVVSMFCSFETK-------RHLCMVMEYVEGGDCATLLK
 . .| . .||.| |.. . |   .  | |....        ..    |  |..    ..| .| ..    ..         |..||||...||.   |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

NIGA-LPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMS----LTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVI
. .  |...    .        ||||  ...||||   | |... ...| .|||||. .         .  |    .|...  |           |||.|
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTML------PIRWMAPECI

LRQGYGKPVDWWAMGIILYEFLVGCVPFFGD------TPEELFGQVISDEIVWPEGDDA------LPPDAQDLTSKLLHQNPLERLGTSSAYEVKQHPFF
    .    | |. |. ..| .  . .   .      ...|.. .| . .   .  .|        |..  .. ..  | .| .|   |       | .|
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-----HECF
Kinase MAST2.AA Pkinase_C 804-849 27 3.7e-08 32.0 Pfam 1-46 (46) Show / Hide 
Range on Protein: 804-849
Range on HMM: 1-46/46
Sequence Identity: 27% (13 aa)

QLESEDDTSYFDTRSERYHHVDS-EDEEEVSEDGCLEIRQFSSCSPR
|..|..|||.||.  .. ...|.  |..  |.   .. |.|. ..| 
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase MAST2.AA Pkinase_Tyr 585-659 29 1.7e-07 26.0 Pfam 81-159 (270) Show / Hide 
Range on Protein: 585-659
Range on HMM: 81-159/270
Sequence Identity: 29% (23 aa)

HLCMVMEYVEGGDCATLLKN----IGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSK
....||||...||  . |..     ..|.. .   . ..   ..|||.. ...||||   | |.|. ...| .||||..
QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase MAST2.AA S_TK_X 787-847 20 0.000394 11.4 SMART 1-79 (79) Show / Hide 
Range on Protein: 787-847
Range on HMM: 1-79/79
Sequence Identity: 20% (17 aa)

MGLDWTGLLR----QKAEFIPQLE----SEDDTSYFD---TRSERYHHVDSEDEEEVSEDGCLE----------IRQFSSCS
 |.|| .|..     .. |.|..     |. |||.||   |. .     .. |.. .|.    .           |.|.   
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM---LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
PDZ MAST2.AA PDZ 1110-1190 25 1.2e-14 55.88 SMART 1-80 (80) Show / Hide 
Range on Protein: 1110-1190
Range on HMM: 1-80/80
Sequence Identity: 25% (24 aa)

KKYGFTLRAIRVYMGDTDVYTVHHMVWHVEDGGPASEAG------LRQGDLITHVNG-EPVHGLVHTEVVELVLKSGN-----KVSISTTPLE
. .||...              .. . .|..||||. ||      || || |. ||| .|| .. | ..|..  ..|.     ||..   . .
GGLGFSIVG-------------GIFISSVVPGGPAEKAGRNTRGHLRPGDRILEVNGQQPVENMTHEQAVDMLKQCGGGGIGDKVTLTVQRPG
PDZ MAST2.AA PDZ 1137-1187 25 2e-06 24.97 Pfam 33-86 (86) Show / Hide 
Range on Protein: 1137-1187
Range on HMM: 33-86/86
Sequence Identity: 25% (14 aa)

HVEDG-GPASEAG-LRQGDLITHVNGEPVHGLVHTEVVELVLKSGN-KVSISTT
.|  | |.|  .| .. || |. .||... .. | ..|..  .|.. .|..   
EVMPGSGAAERGGRIHEGDQIISINGQDIRNMTHDRAVQAIKGSKGGEVHLTIQ