Gene MarkmE2 (Mouse)

MarkmE2

Species: Mouse
Alias: MarkmE2
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: MARK

Sequence

Name Sequence Type Origin Length Description Download
MarkmE2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 247 Kinase domain by global Sugen HMM Fasta, JSON
MarkmE2.AA Protein Sugen 617 None Fasta, JSON
MarkmE2.NA RNA Sugen 1854 None Fasta, JSON

Protein domain

Protein domains of MarkmE2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MarkmE2.AA MARK 55-302 47 3.2e-153 504.05 In-house 1-262 (262) Show / Hide 
Range on Protein: 55-302
Range on HMM: 1-262/262
Sequence Identity: 47% (125 aa)

YKILTTLGQGSFGEVKLASHLLTNIKVAIKILP---QSR-RN-PLVQSEIEIMKSLDHPHIIKVLHIID--TTRN-IFIILEHAVGGELLSRIEKF--GY
||.|.|.|.||...|||| |..|..||||||..    ..  .   |..||||||.||||.||| .|.|.  |... |..|.|.| ||||...|...  |.
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

IGEKDCHRLFSQIVYALKYCHEKGIVHRDLKPENILLAHRG--DVKLADFGLGTKIIMGQKLVEFCGTLPYCAPEMLEGRGYDGRATDVWSLGVVLYFMA
. |....|.|.|||.|..|||.|.|||||.||||||. ..|  ..|..|||....|..|||| .||||.||.|||..... |||...|.|||||||||| 
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV

TGRLPFEGYS--YEATKQKIFAGRYPRSFSLSPELWDVIDNLLTVNPGDRPTVHEITRFKWT
.|..||.|..  |.  ..|| .|.|.. . .|.|... |  |||||| .|||..|| . .| 
CGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase MarkmE2.AA CAMKL 55-302 38 9.69999999999e-137 438.97 In-house 1-297 (297) Show / Hide 
Range on Protein: 55-302
Range on HMM: 1-297/297
Sequence Identity: 38% (116 aa)

YKILTTLGQGSFGEVKLASH-LLTNIKVAIKILP--------QSRRNPL---------VQSEIEIMKSLD---HPHIIKVLHIIDTTRN------IFIIL
|.|. |||.||||.|||| | ..|..||||||.         ....|..         .. ||.|||.|.   ||.||| ...|.| ..      |....
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EHAVGGE--LLSRIEKFGY----IGEKDCHRLFSQIVYALKYCHEKGIVHRDLKPENILLAHRGD--VKLADFGLGTKIIM-----GQKLVEFCGTLPYC
|.. |||  |. .|.| |.    . |....|.| ||| |..|||..||||||.||||||| ..|.  .|..|||......      |||| .|||..||.
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEMLEG--RGYDGRATDVWSLGVVLYFMATGRLPFEGYS---------YEATKQKIFAGRYPRSFSLSPELWDVIDNLLTVNPGDRPTVHEITRFKWT
|||...|  . |||...|.||.||.||.| .|.|||.. .         |.  |...  ...|  ...| .. | |  .|.||| .|||.|.| . .| 
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase MarkmE2.AA CAMK 60-302 25 1.1e-113 367.81 In-house 1-425 (425) Show / Hide 
Range on Protein: 60-302
Range on HMM: 1-425/425
Sequence Identity: 25% (109 aa)

TLGQGSFGEVKLASHLLTN------------IKVAIKILPQSRRN------------------------------PLVQSEIEIMKS-------LDHPHI
|||.||||.|||. | .|.             ||||||.. ..                                  |..||||||.       ||||.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKVLHIID------------TTRN--------IFIIL---EHAVGGEL----LSRIEKF---------------GYIGEKDCHRLFSQIVYALKYCHEKG
|| .....            | ..        .....   |.. ||||    ...| .                |.. |....|.| ||. |..|||...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDLKPENILLAHR-----------------GDVKLADFGLGTKIIM------------------------GQKLVEFCGTLPYCA-PEMLEG-----
||||||||||||| ..                 ...|..|||. .|..                         |||. .||||..|.| ||.|.|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------RGYDGRATDVWSLGVVLYFMATGRLPFEGY-------------SYEATKQKIFAGRYP-RSFSLSP-----------------------ELW
        . |.|...|.||.||.||.| .|..||.|              ... ...|| .|.|   .. .||                       |  
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DVIDNLLTVNPGDRPTVHEITRFKWT
| | ..|.|.| .|.|.... . .| 
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MarkmE2.AA S_TKc 55-302 34 1e-95 325.23 SMART 1-231 (231) Show / Hide 
Range on Protein: 55-302
Range on HMM: 1-231/231
Sequence Identity: 34% (91 aa)

YKILTTLGQGSFGEVKLASHLLTNIKVAIKILPQSRRNPLVQSEIEIMKSLDHPHIIKVLHIIDTTRNIFIILEHAVG--GELLSRIEKFGY------IG
|.|| ..|.|.||.|... |  |. .|||||..       ...||.|.|. .||.|.| . ....  ......|.. |  |.|...|.| |.      . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

EKDCHRLFSQIVYALKYCHEKGIVHRDLKPENILLAHRGDVKLADFGLGTKIIMGQKLVEFCGTLPYCAPEMLEGRGYDGRATDVWSLGVVLYFMATGRL
| .. ... ||. ||.|||..||.||||||||||| .   .|..|||| ...        ||||. |.|||.|   ||.... |.||.|..|| |..|. 
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYP

PFEGYSYEATKQKIFAGRYPRSFSLSPELWDVIDNLLTVNPGDRPTVHEITR-------FKWT
||.   .... .||           |||..| |...|...| .|||. |. .         | 
PFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MarkmE2.AA AMPK 55-302 42 9.3e-93 275.7 In-house 1-254 (254) Show / Hide 
Range on Protein: 55-302
Range on HMM: 1-254/254
Sequence Identity: 42% (109 aa)

YKILTTLGQGSFGEVKLASHLLTNIKVAIKILPQSRRNPL-----VQSEIEIMKSLDHPHIIKVLHII-DTTRNIFIILEHAVGGELLSRIEKFGYIGEK
| |  |.| |.|| ||.. | ||. |||||||   .   .     .|.||.|.|.. |||||.   .| .|.. ||...|.. |||| . | | | . |.
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQER

DCHRLFSQIVYALKYCHEKGIVHRDLKPENILLAHRGDVKLADFGLGTKIIMGQKLVEFCGTLPYCAPEMLEGRGYDGRATDVWSLGVVLYFMATGRLPF
.  |.| ||. .. |||. .||||||||||.|| |   .|..||||      |..|   ||   | |||| .|. | |. .|.|| ||.|| |  |.|||
EACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYLPF

EGYSYEATKQKIFAGRYPRSFSLSPELWDVIDNLLTVNPGDRPTVHEITRFKWT
.  .  .  .|| .|.|.    ||||  | | ..|.|.|  | |.|.|   .| 
DDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase MarkmE2.AA AGC 55-302 23 2.1e-89 230.6 In-house 1-395 (395) Show / Hide 
Range on Protein: 55-302
Range on HMM: 1-395/395
Sequence Identity: 23% (93 aa)

YKILTTLGQGSFGEVKLASHL------LTNIKVAIKILPQSR--------RNPLVQSE------------IEIMKSLD----------HPHIIK-VLHII
...|...|.||||.| |. .        |.   |.|.|  ..            ...|             .|.. ..          || |.|   .  
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

DTTRN--IFIILEHAV---------GG-ELLSRIE---KFGYIGEKDCHRLFSQ-------IVYALKYCHE-KGIVHRD-LKPENILLAHRGDVKLADFG
 . ..  .....| .          || ||....    | |.  |. .   ...       || || | |. .||.||| |||||||| ..| .||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LGTKIIMG---------------------------------------------------QKLVEFCG--TLPYCAPEMLEGRGYDGRATDVWS--LGVVL
| ......                                                   ..   |||  |  | |||.|      |.| | ||  ||...
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-----YGKACDWWSFGLGCLM

YFMATGRLPFEG----------YSYEATKQKIFAGRYPRSFS----------------LSPELWDVIDNLLTVNPGDRPT----------VHEITRFKWT
| | ||. || |          .. . . |||  |||  ..                 .|||..| |  ||...| .|..          . || . .| 
YEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase MarkmE2.AA QIK 55-302 38 8.5e-87 294.66 In-house 1-272 (272) Show / Hide 
Range on Protein: 55-302
Range on HMM: 1-272/272
Sequence Identity: 38% (104 aa)

YKILTTLGQGSFGEVKLASHLLTNIKVAIKILPQSRRNPL----VQSEIEIMKSLDHPHIIKVLHIIDTTRNIFIILEHAVGGELLSRIEKFGY------
| |  |.| | |. |||| |  |  ||||||.  |. .      .  |..|||.|.|||||| . .. | . ..|. | . .||.   . |.|       
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEENLQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKMV

--------------IGEKDCHRLFSQIVYALKYCHEKGIVHRDLKPENILLAHRGDVKLADFGLGTKIIMGQKLVEFCGTLPYCAPEMLEGRGYDGRATD
              . |..  | |.||. | .|||...||||||| |||||    ..|.||||..     || |  .||. || ||||.||. |||   |
NSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKVD

VWSLGVVLYFMATGRLPFEGYSYEATKQKIFAGRYPRSFSLSPELWDVIDNLLTVNPGDRPTVHEITRFKWT
.||.||||| . .| ||| | . .  .|..  |..   |..| .. . | . |.|.|. | |.  | . .|.
IWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
Kinase MarkmE2.AA NuaK 55-302 39 4.3e-86 226.23 In-house 1-252 (252) Show / Hide 
Range on Protein: 55-302
Range on HMM: 1-252/252
Sequence Identity: 39% (101 aa)

YKILTTLGQGSFGEVKLASHLLTNIKVAIKILPQSR---RNPLVQ--SEIEIMKSLDHPHIIKVLHIIDTTRNIFIILEHAVGGELLSRIEKFGYIGEKD
|... |||.| .| ||||    |  .||||  . ..    . .|.   ||||| ||.|||||..  .      | |..| | ||||   |.. . . |..
YEFQKTLGKGTYGKVKLATEHSTGREVAIKSIKKCKIEDEQDMVHIRREIEIMSSLNHPHIIHIYEVFENKDKIVIVMEYASGGELYDYISECKSLPERE

CHRLFSQIVYALKYCHEKGIVHRDLKPENILLAHRGDVKLADFGLGTKIIMGQKLVEFCGTLPYCAPEMLEGRGYDGRATDVWSLGVVLYFMATGRLPFE
  ..| ||| |. |||  .|.||||| |||||   ...| |||||      .. |  |||   |  ||  .|. | |   | |||||.|| |  | .||.
ARHFFRQIVSAVHYCHKHRICHRDLKLENILLDQNCNAKIADFGLSNYYHDQKFLHTFCGSPLYASPEIVNGQPYHGPEVDCWSLGVLLYTMVYGTMPFD

GYSYEATKQKIFAGRY--PRSFSLSPELWDVIDNLLTVNPGDRPTVHEITRFKWT
|  .   .. |  |.|  |.  |   .|   | ..|.|||  | |. .|    | 
GHDFKHLVKQISQGAYYEPCKPSDACML---IRWMLMVNPRRRATIYDICHHWWV
Kinase MarkmE2.AA Pkinase 55-302 31 4.8e-86 296.96 Pfam 1-293 (293) Show / Hide 
Range on Protein: 55-302
Range on HMM: 1-293/293
Sequence Identity: 31% (92 aa)

YKILTTLGQGSFGEVKLASHLLTNIKVAIKILPQSRRNPLVQ------SEIEIMKSLDHPHIIKVLHIIDTTRNIFIILEHAVGG----ELLSRIE--KF
|.|. ..|.||||.|... |  |...||.||.. ..... ..      |||.|||.|.||.|.. ...  . ..| ...|.. ||    .| ..|.  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GYI--GEKDCHRLFSQIVYALKYCHEKGIVHRDLKPENILLAHRGDV----KLADFGLGTK--IIMGQKLVEFCGTLPYCAPEMLEGRGYDGRATDVWSL
| .   |..| . . ||. .|.|||..||.||||||||||. ..|..    |..||||  .  .  .. .  ||||..|.||| . |. |.|.. |.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVVLYFMATGRLPFEGY----SYEATKQKIFAGRY---PRSFSLS---------------------PELWDVIDNLLTVNPGDRPTVHEITRFKWT
|..|| |..||.|| |     .    .|.|.  ..   ..... .                     .|. |.|...|...| .||| ..|   .| 
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MarkmE2.AA Ciliate-E2 55-302 24 5.9e-71 242.03 In-house 1-365 (365) Show / Hide 
Range on Protein: 55-302
Range on HMM: 1-365/365
Sequence Identity: 24% (91 aa)

YKILTTLGQGSFGEVKLASHLLTNI------------------KVAIKILPQSRRNPL----VQSEIEIMK----------------SLDHPHIIKVLHI
||..  .|||.|| |..... ...                   ||.|||    . ..     . .|| ||.                .|.||.|||    
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

ID--TTRNIFIILEHAVGGELLSRIEKF-----------GYIGEKDCHRLFSQIVY---------------ALKYCHEKG-IVHRDLKPENILLAHRGDV
    .. ||....| . ||.|...|...           .|. || . ... ||..               ||.|.|.|. |.|||.||||||.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLADFGLGTKII-----------MGQKLVEF----------------------CGTLPYCAPEMLEGRGYDG--------RATDVWSLGVVLYFMATGRL
|..|||| .|.            .. ..  .                      |||..| |||.|.| .||.         . |.|||||.||.| .|..
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFEGYSYEATKQKIFAGRYPRS------------------FSLSPELWDVIDN----LLTVNPGDRPT-VHEITRFKWT
||         |.|  . .  .                  ...|.|  | | .    .| ..|  |.|   .|   .| 
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase MarkmE2.AA CAMK-Unique 55-302 22 2.1e-69 228.24 In-house 1-363 (363) Show / Hide 
Range on Protein: 55-302
Range on HMM: 1-363/363
Sequence Identity: 22% (81 aa)

YKILTTLGQGSFGEVKLASHLLTNIKVAIKILPQ----SRRNPL------------------VQSEIEIMKSLDHPHIIKVLHI----IDTTR-------
|| .  .|.|.||.|. .    |  | |.|..      . .. .                     |..|.|..|||.|||....      . .       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------NIFIILEHAVGGELLSRIEK--------------------FGYIGE--KDCHRLFSQIVYALKYCHEKGIVHRDLKPENILLAHRGD-----
        ...|..|.. ||.|.. | |                     |.  |   |  ... ... |..| |...|||||||.|||..  ...     
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

-----------VKLADFGLGTKIIMGQKLV---EFCGTLPYCAP--------------EMLEGRGYDGRAT---DVWSLGVVLYFMATGRLPFEGYSYE-
           .||.|||| ...   ..     ..|||..|.||              |......||.      | |||||..|.|..|..||.. . . 
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR

-------ATKQKIFAGRY----PRSFSL----SPELWDVIDNLLTVNPGDRPTVHEITRFKWT
        . ..| .|.|     . ...    |.|..|......|| |  | .  |.  . | 
DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase MarkmE2.AA Ciliate-E2-Unclassified 55-302 25 1.4e-66 227.51 In-house 1-352 (352) Show / Hide 
Range on Protein: 55-302
Range on HMM: 1-352/352
Sequence Identity: 25% (91 aa)

YKILTTLGQGSFGEVKLASHLLTNIKVAIKILPQSRRNPLVQSEIE---------------------------IMKSLDHPHIIKVLHIIDTTRNIFIIL
|||. ..|||.||.|... |  .. . |.|.. ... .   | . .                           |.....||.|.| ...  .. ||.|..
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EHAVGGELLSRIEKF-----------------GYIGEKDCH-----RLFSQIVYALKYCHEKG-IVHRDLKPENILLAHRG---DVKLADFGL-------
| . ||.|.  |.|.                   . |. .      ..| ||. .|.|.|.|. |.|||.||||||.   |    .|..|||.       
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

---------GTKIIMGQKLVEFCGTLPYC----APEMLEGRGYDGR---ATDVWSLGVVLYFMATGRLPFEGYSYEA----------------TKQKIFA
          ..|.  |..  ||||. |     |||.|.| .||..   . |.|||||.||.| .|..||.....|                  .|.|..
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

G---RYPRSF-----SLSPELWDVID----NLLTVNPGDRPTVHEITRFKWT
.     . ..      .||| .| |      .| .||. |.|  .|    | 
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase MarkmE2.AA Pkinase_Tyr 55-194 29 2e-24 83.33 Pfam 1-157 (270) Show / Hide 
Range on Protein: 55-194
Range on HMM: 1-157/270
Sequence Identity: 29% (46 aa)

YKILTTLGQGSFGEVKLASHL----LTNIKVAIKILPQSRRNPL-----VQSEIEIMKSL-DHPHIIKVLHIID-TTRN--IFIILEHAVGGELLSRIEK
 ... .||.|.||||...        |.|.||.|.|...   .        .|..|||.| .||.|.. . ..    .   |.|..|.. .| ||.   |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----FGYIGEKDCHRLFSQIVYALKYCHEKGIVHRDLKPENILLAHRGDVKLADFGL
     . .  ||      ||  .. | ..|...||||   |.|... . || .||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGL
Kinase MarkmE2.AA TyrKc 55-301 24 1.1e-23 85.93 SMART 1-280 (280) Show / Hide 
Range on Protein: 55-301
Range on HMM: 1-280/280
Sequence Identity: 24% (69 aa)

YKILTTLGQGSFGEVKLASHLLTNIKVAIKILPQSRRNPLVQSEIEIMKSL--DHPHIIKVLHIIDTT-------RNIFIILEHAVGGELLSRIEKFGY-
 . . .|| | |||| ..      |.||.| |  .       .|..||..|  .||.|.. . .. .          ..|..|.. .| |.... | .  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

IGEKDCHRLFSQIVYALKYCHEKGIVHRDLKPENILLAHRGDVKLADFGLGTKIIMGQ-------KLVEF----CGT--LPY--CAPEMLEGRGYDGRAT
.  || .    ||     | |.|...||||   |.|..... || .|||| .. |          .        .|   ||.  .||| .  . .   ..
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGL-SRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT-TKS

DVWSLGVVLY-FMATGRLPFEG-----YSYEATKQKIFAGRYPRSFSL---------SPELWDVIDNLLTVNPGDRPTVHEITRFKW
|||| ||...  .  |  | .|      | .   ... .|....             ..|. ...      .| ||||  || . ..
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase MarkmE2.AA Pkinase_Tyr 228-252 40 0.070248 6.99 Pfam 194-220 (270) Show / Hide 
Range on Protein: 228-252
Range on HMM: 194-220/270
Sequence Identity: 40% (11 aa)

ATDVWSLGVVLYFMAT-GRLP-FEGYS
..|||| ||... . | |. | ..| |
KSDVWSFGVLMWEIFTYGEQPTYPGMS
UBA_CAMKL MarkmE2.AA UBA_CAMKL 322-359 41 1e-12 43.72 In-house 1-41 (41) Show / Hide 
Range on Protein: 322-359
Range on HMM: 1-41/41
Sequence Identity: 41% (17 aa)

DPSIIVLMGVL--GYNPGEIRESLREKKF-DMVMATYLLLQ
|..|| .|  .  |... ||.||||. |. . ..|||.||.
DEEIIQEMCKMWHGFDREEIIESLRNNKYHNHITATYYLLL