Gene MarkmC2 (Mouse)
MarkmC2
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
---|---|---|---|---|---|
MarkmC2.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 174 | Kinase domain by global Sugen HMM | Fasta, JSON |
MarkmC2.AA | Protein | Sugen | 259 | None | Fasta, JSON |
MarkmC2.NA | RNA | Sugen | 1322 | None | Fasta, JSON |
Protein domains of MarkmC2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | MarkmC2.AA | MARK | 57-231 | 50 | 1.4e-114 | 375.94 | In-house | 1-186 (262) | Show / Hide |
Range on Protein: 57-231 Range on HMM: 1-186/262 Sequence Identity: 50% (94 aa) YKMLNTLGEGNFSVVKRAFHVPTSTSVAVKILQ---NTK-EYTSPICREARIMKSLSHPNIIKLFHVVQ--RRET-TYLVMEYASEGELLDCIINV--GS |||| |.|.|....|| | |..| . ||.||.. .. . ....||..|||.|.||||||||||.. ... .||.|||||.|||.|.|... | YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR LEESETRRLFAQIVHAVQYCHDHHIVHRDIKASNILIDCRG--NAKLCDFGLAAEVIPGQKLAGFCGTLPYCAPELLQAEKYEGPP |.|.|.||.| |||.||.|||...|||||||. |||||..| |.|..|||......||||| ||||.||.|||... ..|.||. LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPK |
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Kinase | MarkmC2.AA | CAMKL | 57-231 | 42 | 1.2e-99 | 318.69 | In-house | 1-216 (297) | Show / Hide |
Range on Protein: 57-231 Range on HMM: 1-216/297 Sequence Identity: 42% (92 aa) YKMLNTLGEGNFSVVKRAFH-VPTSTSVAVKILQNTKEYTSPICR----------------EARIMKSLS---HPNIIKLFHVVQRRET------TYLVM |... |||.|.|..|| | | | . ||.||. | |... |..|||.|. |||||||..|.. .|. |||| YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM EYASEGE--LLDCIINV----GSLEESETRRLFAQIVHAVQYCHDHHIVHRDIKASNILIDCRG--NAKLCDFGLAAEVIP-----GQKLAGFCGTLPYC ||.| || |.| |.. |...|.|.||.| |||.||.|||.|.|||||||. |||.|..| |.|..|||.... .| |||| |||..||. EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM APELLQA--EKYEGPP |||..| ..|.||. APEIFQGNNKPYDGPK |
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Kinase | MarkmC2.AA | CAMK | 62-232 | 27 | 6.3e-81 | 260.37 | In-house | 1-315 (425) | Show / Hide |
Range on Protein: 62-232 Range on HMM: 1-315/425 Sequence Identity: 27% (86 aa) TLGEGNFSVVKRAFHVPTS------------TSVAVKI-----LQN------------------------TKEYTSPICREARIMKSLS-------HPNI |||.|.|..||...| | . ||.|| |.. . . . || .|||.|. |||| TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI IKLFHVVQ------------RRET--------TYLVM---EYASEGEL----LDCIINVGS---------------LEESETRRLFAQIVHAVQYCHDHH |||..| . .. |.|| ||.| ||| .| |. |. ..|.|.||.| ||. ||.|||.|. IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN IVHRDIKASNILIDCR-----------------GNAKLCDFGLAAEVIP------------------------GQKLAGFCGTLPYCA-PELLQA----- |||||.| |||.| . .| |..|||.|....| |||. ||||..|.| ||.|. IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN --------EKYEGPPC ..| ||.| MQNATDEEKPYYGPKC |
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Kinase | MarkmC2.AA | QIK | 57-230 | 41 | 1.3e-67 | 230.93 | In-house | 1-197 (272) | Show / Hide |
Range on Protein: 57-230 Range on HMM: 1-197/272 Sequence Identity: 41% (81 aa) YKMLNTLGEGNFSVVKRAFHVPTSTSVAVKILQNT---KEYTSPICREARIMKSLSHPNIIKLFHVVQRRETTYLVMEYASEGELLDCIINVGS------ | . |.| ||| |||.| | | | ||.||. . .|. . || |||.|.||.||||. | . |.|.||.|.||. | ... | YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEENLQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKMV --------------LEESETRRLFAQIVHAVQYCHDHHIVHRDIKASNILIDCRGNAKLCDFGLAAEVIPGQKLAGFCGTLPYCAPELLQAEKYEGP ..|.|.|| | ||. ||.|||...|||||.|| |||.| | |. |||. .|| |. .||. || |||... ..|.|| NSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGP |
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Kinase | MarkmC2.AA | NuaK | 57-230 | 43 | 1.6e-65 | 170.97 | In-house | 1-178 (252) | Show / Hide |
Range on Protein: 57-230 Range on HMM: 1-178/252 Sequence Identity: 43% (77 aa) YKMLNTLGEGNFSVVKRAFHVPTSTSVAVKILQNTK----EYTSPICREARIMKSLSHPNIIKLFHVVQRRETTYLVMEYASEGELLDCIINVGSLEESE |... |||.| . ||.| | ||.| . | . | || .|| || ||.||. . | .. .|||||| ||| | | . .|| | | YEFQKTLGKGTYGKVKLATEHSTGREVAIKSIKKCKIEDEQDMVHIRREIEIMSSLNHPHIIHIYEVFENKDKIVIVMEYASGGELYDYISECKSLPERE TRRLFAQIVHAVQYCHDHHIVHRDIKASNILIDCRGNAKLCDFGLAAEVIPGQKLAGFCGTLPYCAPELLQAEKYEGP .|..| ||| || ||| | |.||| | ||| | .||| |||| .. | ||| | || . |.|| ARHFFRQIVSAVHYCHKHRICHRDLKLENILLDQNCNAKIADFGLSNYYHDQKFLHTFCGSPLYASPEIVNGQPYHGP |
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Kinase | MarkmC2.AA | AMPK | 57-230 | 42 | 9.3e-65 | 191.2 | In-house | 1-179 (254) | Show / Hide |
Range on Protein: 57-230 Range on HMM: 1-179/254 Sequence Identity: 42% (76 aa) YKMLNTLGEGNFSVVKRAFHVPTSTSVAVKILQNTK----EYTSPICREARIMKSLSHPNIIKLFHVV-QRRETTYLVMEYASEGELLDCIINVGSLEES | . |.||| | || . | |.. ||.||| .| . | || .|.|.. ||.||.|. |. . ..||||.| ||| | |. | |.| YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQER ETRRLFAQIVHAVQYCHDHHIVHRDIKASNILIDCRGNAKLCDFGLAAEVIPGQKLAGFCGTLPYCAPELLQAEKYEGP |..|.|.||. .| |||.| ||||| | |.|.|. | |. |||| |..| || | |||. . .|.|| EACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGP |
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Kinase | MarkmC2.AA | Pkinase | 57-232 | 35 | 6.7e-61 | 213.44 | Pfam | 1-193 (293) | Show / Hide |
Range on Protein: 57-232 Range on HMM: 1-193/293 Sequence Identity: 35% (69 aa) YKMLNTLGEGNFSVVKRAFHVPTSTSVAVKILQNTKEYTSPICR------EARIMKSLSHPNIIKLFHVVQRRETTYLVMEYASEG----ELLDCII--N |. . ..|.|.|..|... |. |. |||||. . | .. |..|||.|.||||..|....... |.||||. | .| | | . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR VGSL--EESETRRLFAQIVHAVQYCHDHHIVHRDIKASNILIDCRGNA----KLCDFGLAAE--VIPGQKLAGFCGTLPYCAPELLQAEKYEGPPC |.. .| | .. . ||. ...|||.. |.|||.| .||||| .|. |.||||||. ... . .||||..|.|||... .| ||.. HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV |
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Kinase | MarkmC2.AA | NIM1 | 57-231 | 40 | 1.9e-54 | 158.37 | In-house | 1-184 (258) | Show / Hide |
Range on Protein: 57-231 Range on HMM: 1-184/258 Sequence Identity: 40% (75 aa) YKMLNTLGEGNFSVVKRAFHVPTSTSVAVKILQ--NTK---EYTSPICREARIMKSLSHPNIIKLFHVVQRRETTYLVMEYASEGELLDCIINVGSLEES | . .| |||| || . | | ||.||. || || | . ||||..|. || .||||||. ||| | . | | | YRFCGEIGRGNFSKVKLGVHQLTKEKVAIKIMDLDKTKMDQKTQRMLSREIQCMECMHHPNIVRLYEVVETLTRVHLVMEYARGGELYTHIHQEGKLREI ETRRLFAQIVHAVQYCHDHHIVHRDIKASNILIDCRGNAKLCDFGLAAEVIP----GQKLAGFCGTLPYCAPELLQAEKYEGPP . .||||| ||. | |||||||| |.. .. |. ||| .. .|.| ||| || |||| | | | |.. HCKPIFAQIVSAVKHMHSRNIVHRDIKAENVMYTSNNCVKVGDFGFSCYCKMGTGANQMLNTFCGSPPYAAPELFQDEHYIGEY |
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Kinase | MarkmC2.AA | CAMK-Unique | 57-230 | 23 | 4.5e-53 | 173.46 | In-house | 1-269 (363) | Show / Hide |
Range on Protein: 57-230 Range on HMM: 1-269/363 Sequence Identity: 23% (63 aa) YKMLNTLGEGNFSVVKRAFHVPTSTSVAVKILQN-TKEYTSPIC--------------------REARIMKSLSHPNIIKLFHV----VQRRE------- |||.. .|.|||..|.... | . |.|.... | . . . ||..|.|...|||||||... .. |. YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI --------TTYLVMEYASEGELLDCIIN--------------------VGSLEE--SETRRLFAQIVHAVQYCHDHHIVHRDIKASNILIDCRGN----- |.||||. .|.|.| |. |...| ..|........ || | |. |||||.|. ||.. ... IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH -----------AKLCDFGLAAEVIPGQKLA---GFCGTLPYCAP--------------ELLQAEKYEGP |||||||.... .. . .|||..|.|| |.. . .| .. RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQ |
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Kinase | MarkmC2.AA | SNRK | 57-230 | 40 | 3.8e-49 | 158.91 | In-house | 1-179 (254) | Show / Hide |
Range on Protein: 57-230 Range on HMM: 1-179/254 Sequence Identity: 40% (72 aa) YKMLNTLGEGNFSVVKRAFHVPTSTSVAVKILQNTK---EYTSPICREARIMKSLSHPNIIKLFHVVQRRETTYLVMEYASEGELLDCIINVGS-LEESE | . .|||.| | ||| | || | ||||.. || .. . .| | || ||||..|. |. ||..| ... | |. . |.|. YDLEKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKMDEVSKAHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGYDMYDYIMKHEKGLCEDL TRRLFAQIVHAVQYCHDHHIVHRDIKASN-ILIDCRGNAKLCDFGLAAEVIPGQKLAGFCGTLPYCAPELLQAEKYEGP |. |.||.||..||| |.||||.| | . . | || ||| . . ||.|| .|| | | |||.| ..|. | ARKYFCQIMHAIDYCHQLHVVHRDLKPENVVFFEKQGMVKLTDFGFSNKFMPGEKLETSCGSLAYSAPEILLGDSYDAP |
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Kinase | MarkmC2.AA | RSK | 57-222 | 31 | 7.2e-46 | 158.71 | In-house | 1-180 (278) | Show / Hide |
Range on Protein: 57-222 Range on HMM: 1-180/278 Sequence Identity: 31% (57 aa) YKMLNTLGEGNFSVVKRAFHVPTSTSVAVKILQNTKEYTSPI----CR-EARIMKSLS-HPNIIKLFHVVQRRETTYLVMEYASEGELLDCIINVGS--- |.| ..| | ...... | | . |.|.|. | .. .. | .|.. ||.|..|... | . .||.||| . |||.. . . .. LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC LEESETRRLFAQIVHAVQYCHDHHIVHRDIKASNILIDC---RGNAKLCDFGLAAE-VIP-GQKLAGFCGTLPYCAPELL . |.| . .|.|| ||.. |...|.|||.| .||| | .| ||.|||.. . .. .|.. ||.|. |.|||.| FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEML |
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Kinase | MarkmC2.AA | S_TKc | 57-259 | 29 | 7.2e-44 | 152.98 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 57-259 Range on HMM: 1-231/231 Sequence Identity: 29% (74 aa) YKMLNTLGEGNFSVVKRAFHVPTSTSVAVKILQNTKEYTSPICREARIMKSLSHPNIIKLFHVVQRRETTYLVMEYASE--GELLDCIINVGS------L |..|...|.| |..|... |. | ||.||. |.|| .|.|. ||||.||. | | . |.||||.. |.|.| | . |. . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF EESETRRLFAQIVHAVQYCHDHHIVHRDIKASNILIDCRGNAKLCDFGLAAEVIPGQKLAGFCGTLPYCAPELLQAEKYEG------------------- | ..|....||. |..|||.|.|.|||.| .|||.| . |.||||||... ||||. |.|||.| .| . PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGY ----PPCRYLEFRGPPVPHGI------WEL-------AFPKAS-------LLWT . . .. | | .. .. | | PPFPQMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | MarkmC2.AA | Pkinase_Tyr | 57-198 | 33 | 9.2e-32 | 108.19 | Pfam | 1-158 (270) | Show / Hide |
Range on Protein: 57-198 Range on HMM: 1-158/270 Sequence Identity: 33% (53 aa) YKMLNTLGEGNFSVVKRAFHV----PTSTSVAVKIL--QNTKEY--TSPICREARIMKSL-SHPNIIKLFHVVQ-RRET--TYLVMEYASEGELLDCIIN ... .||||.| .|... | . ||||.| . ..| |||.|||.| .||||..| |. ..| |.||||. | ||| . ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK ----VGSLEESETRRLFAQIVHAVQYCHDHHIVHRDIKASNILIDCRGNAKLCDFGLA ..| .. .|| . .| ......|||. | |.|... . .| |||||| HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA |
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Kinase | MarkmC2.AA | TyrKc | 57-258 | 21 | 6.3e-16 | 34.82 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 57-258 Range on HMM: 1-280/280 Sequence Identity: 21% (61 aa) YKMLNTLGEGNFSVVKRAFHVPTSTSVAVKILQNTKEYTSPICREARIMKSL--SHPNIIKLFHVVQRR-------ETTYLVMEYASEGELLDCIINVGS ... .||||.| .| .. . |||| |.. . ..||||||..| .||||..|. |. | ..||||.. | |.| . . . ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP -LEESETRRLFAQIVHAVQYCHDHHIVHRDIKASNILIDCRGNAKLCDFGLAAEVIPG--------QKLAGF--CGT--LPY--CAPELLQ--------- | .. || .| |.....|||. | |.|.. .. .| .||||. .. . . . .| ||. .||| .. KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD ---------------AEKYEG-----PPCRYL------EFRGPPVPH------------------GIWEL------AFPKASLLW .. |.| . . . .| |. |. |. | .. VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |