Gene MarkmB2 (Mouse)

MarkmB2

Species: Mouse
Alias: MarkmB2
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , iHOP
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: MARK

Sequence

Name Sequence Type Origin Length Description Download
MarkmB2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 249 Kinase domain by global Sugen HMM Fasta, JSON
MarkmB2.NA RNA Sugen 1473 None Fasta, JSON
MarkmB2.AA Protein Sugen 490 None Fasta, JSON

Protein domain

Protein domains of MarkmB2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MarkmB2.AA MARK 14-262 48 6.30000000001e-157 516.33 In-house 1-262 (262) Show / Hide 
Range on Protein: 14-262
Range on HMM: 1-262/262
Sequence Identity: 48% (126 aa)

YRVLFYLGEGTFGTVKLALHLKTEALVAVKMIE---VNE-KTLKAILVEQEILATLNHPNIIRLFQVIL--TPGC-VNFILEYASGGNLFDLIQEH--GP
|..| ..|.|....||||.|..|.  ||.|..|    |. ...| .  | ||.  |.|||||.||.||   |... ...|.||||||.|.| |..|  |.
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

LQEEEAKHIFGQLVASVKYCHNLNIVHRDIKPQNVLLDEER--NVKLTDFGLAIKCNPGRLLSRKCGTKRFWAPEILLGEPYDSRKTDVWSLGVLLFFIT
|.||||..|| |.|  |.|||. |||||||||.|.|.||..  |.|..|||..|...||..|.. |||. ..||||.|..||| .|.|.|||||.|.|..
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV

TGDYPFAGST--LIEFEQKLTTGSYCIPPYISVKLENLIHQILTVPPEKRPSIEDIEKHPWV
.| .|| |.|  . | ..| ..|.|.||...|....|||...|||.||.||.||.|.||||.
CGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase MarkmB2.AA CAMKL 14-262 36 1.6e-134 431.76 In-house 1-297 (297) Show / Hide 
Range on Protein: 14-262
Range on HMM: 1-297/297
Sequence Identity: 36% (110 aa)

YRVLFYLGEGTFGTVKLALH-LKTEALVAVKMIEVNEKTLKAILV----------------EQEILATLN---HPNIIRLFQVILTPGC------VNFIL
||..  ||.|.||.||||.| . |.  ||.|.|. . .... .                  | .|.  ||   |||||.|..|| || .      .. ..
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYASGGN--LFDLIQEH----GPLQEEEAKHIFGQLVASVKYCHNLNIVHRDIKPQNVLLDEER--NVKLTDFGLAIKCNP-----GRLLSRKCGTKRFW
||.|||.  ||| |..|    |...|.||...| |.|. |.|||...|||||||| |.||||    |.|..|||..... |     |..|.  ||.  ..
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEILLG--EPYDSRKTDVWSLGVLLFFITTGDYPFAGST---------LIEFEQKLTTGSYCIPPYISVKLENLIHQILTVPPEKRPSIEDIEKHPWV
||||..|  .||| .|.|.||.||.|... .| .|| . |         . . ... . . ..|....|  ...||...|.| |||||.|..|..|||.
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase MarkmB2.AA CAMK 19-262 26 5.2e-114 368.9 In-house 1-425 (425) Show / Hide 
Range on Protein: 19-262
Range on HMM: 1-425/425
Sequence Identity: 26% (113 aa)

YLGEGTFGTVKLALHLKTE------------ALVAVKMIEVN-----------------------------EKTLKAILVEQEILAT-------LNHPNI
 ||.|.||.|||. | .|               ||.|.|. .                             .|..| .. | ||. .       |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IRLFQVIL------------TPGC--------VNFIL---EYASGG----NLFDLIQEHGP---------------LQEEEAKHIFGQLVASVKYCHNLN
|.|..|.             |  .        . ...   ||.|||     ||| |.|||.               ..|.||...| |..  |.|||..|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDIKPQNVLLDEE-----------------RNVKLTDFGLAIKCNP------------------------GRLLSRKCGTKRFWA-PEILLG-----
|||||.|| |.|||.                   |.|..|||.|.|..|                        | ...  |||  . | ||.|.|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------EPYDSRKTDVWSLGVLLFFITTGDYPFAGS-------------TLIEFEQKLTTGSYC-IPPY---------------ISVK--------LE
        .||...|.|.||.||.|..  .| .|| |.             .. |  .| ..| |  .|||               ||            
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

NLIHQILTVPPEKRPSIEDIEKHPWV
.|| ..|.| ||||..||.. .|||.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MarkmB2.AA AMPK 14-262 40 1.9e-92 274.79 In-house 1-254 (254) Show / Hide 
Range on Protein: 14-262
Range on HMM: 1-254/254
Sequence Identity: 40% (103 aa)

YRVLFYLGEGTFGTVKLALHLKTEALVAVKMIE----VNEKTLKAILVEQEILATLNHPNIIRLFQVI-LTPGCVNFILEYASGGNLFDLIQEHGPLQEE
| .   .|||||| ||.. |  |   ||.| ..     .... . |  | .||  ..||.||.|..||  || .   ..||.||| ||| |  || |||.
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQER

EAKHIFGQLVASVKYCHNLNIVHRDIKPQNVLLDEERNVKLTDFGLAIKCNPGRLLSRKCGTKRFWAPEILLGEPYDSRKTDVWSLGVLLFFITTGDYPF
||.  | | .. | |||...||||| || |.|||.. |.|. ||||   .. | .|.  ||     |||.  | .| ....|.|| || |.    |  ||
EACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYLPF

AGSTLIEFEQKLTTGSYCIPPYISVKLENLIHQILTVPPEKRPSIEDIEKHPWV
  .   .  .| . | | || ..| . ..||...|.| |.|| .|.|| .||| 
DDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase MarkmB2.AA NuaK 14-262 39 7.7e-90 236.3 In-house 1-252 (252) Show / Hide 
Range on Protein: 14-262
Range on HMM: 1-252/252
Sequence Identity: 39% (101 aa)

YRVLFYLGEGTFGTVKLALHLKTEALVAVKMIEVN----EKTLKAILVEQEILATLNHPNIIRLFQVILTPGCVNFILEYASGGNLFDLIQEHGPLQEEE
|...  ||.||.| ||||   .|  .||.| |  .    |. .  |  | ||. .||||.||  . |      .  ..||||||.|.| | | . | |.|
YEFQKTLGKGTYGKVKLATEHSTGREVAIKSIKKCKIEDEQDMVHIRREIEIMSSLNHPHIIHIYEVFENKDKIVIVMEYASGGELYDYISECKSLPERE

AKHIFGQLVASVKYCHNLNIVHRDIKPQNVLLDEERNVKLTDFGLAIKCNPGRLLSRKCGTKRFWAPEILLGEPYDSRKTDVWSLGVLLFFITTGDYPFA
|.|.| | |  | |||  .|.||| |  |.|||.. |.|  ||||    . ...|   ||   .  |||  |.||     | |||||||. .  |  || 
ARHFFRQIVSAVHYCHKHRICHRDLKLENILLDQNCNAKIADFGLSNYYHDQKFLHTFCGSPLYASPEIVNGQPYHGPEVDCWSLGVLLYTMVYGTMPFD

GSTLIEFEQKLTTGSYCIPPYISVKLENLIHQILTVPPEKRPSIEDIEKHPWV
|.   .  .  . | |  |.  |.  . || ..|.| |..| .|.|| .|.||
GHDFKHLVKQISQGAYYEPCKPSDACM-LIRWMLMVNPRRRATIYDICHHWWV
Kinase MarkmB2.AA S_TKc 14-262 32 3.5e-88 300.18 SMART 1-231 (231) Show / Hide 
Range on Protein: 14-262
Range on HMM: 1-231/231
Sequence Identity: 32% (85 aa)

YRVLFYLGEGTFGTVKLALHLKTEALVAVKMIEVNEKTLKAILVEQEILATLNHPNIIRLFQVILTPGCVNFILEYASG--GNLFDLIQEHGP------L
|..|  .|.|.||.|... | ||  .||.|.|       . |. | .||   .||||..|. |. . ... ...||..|  |.|||.|...|.      .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

QEEEAKHIFGQLVASVKYCHNLNIVHRDIKPQNVLLDEERNVKLTDFGLAIKCNPGRLLSRKCGTKRFWAPEILLGEPYDSRKTDVWSLGVLLFFITTGD
 | .|.... |..  ..|||...|.|||.||.|.||||  ..|..||||| .       .  |||  . |||.|   .|. .| |.||.|..|.   .| 
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGY

YPFAGSTLIEFEQKLTTGSYCIPPYISVKLENLIHQILTVPPEKRPSIEDIEK-------HPWV
 ||   .. .  .|.           |  . ..| ..|.. |||||.. .. .       |||.
PPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MarkmB2.AA QIK 14-262 37 1.7e-82 280.38 In-house 1-272 (272) Show / Hide 
Range on Protein: 14-262
Range on HMM: 1-272/272
Sequence Identity: 37% (101 aa)

YRVLFYLGEGTFGTVKLALHLKTEALVAVKMIEV---NEKTLKAILVEQEILATLNHPNIIRLFQVILTPGCVNFILEYASGGNLFDLIQEHGP------
| .   .| | |..|||| |  | . ||.| | .   .|. |. .  | .|.  |.||.||.|.||. |      . ||.|.| .|| . .||       
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEENLQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKMV

--------------LQEEEAKHIFGQLVASVKYCHNLNIVHRDIKPQNVLLDEERNVKLTDFGLAIKCNPGRLLSRKCGTKRFWAPEILLGEPYDSRKTD
              ..|.||. .| |... |.|||..||||||.|  |.|||.. |.|. |||.     .| ||.  ||.  . |||...|. ||  | |
NSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKVD

VWSLGVLLFFITTGDYPFAGSTLIEFEQKLTTGSYCIPPYISVKLENLIHQILTVPPEKRPSIEDIEKHPWV
.||.||.|.   .|  || |.|| .  |.   | . ||...|. .| || . |.| ||.| .|. | .|.| 
IWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
Kinase MarkmB2.AA Pkinase 14-262 28 2e-78 271.68 Pfam 1-293 (293) Show / Hide 
Range on Protein: 14-262
Range on HMM: 1-293/293
Sequence Identity: 28% (84 aa)

YRVLFYLGEGTFGTVKLALHLKTEALVAVKMIEVNEKTLKA---ILV--EQEILATLNHPNIIRLFQVILTPGCVNFILEYASGG----NLFDLIQ--EH
|...  .|.|.||.|... | .|. .|||| |.. ..  .     .   | .|.. ||||||.||. .  ... . ...||. ||     |||.|.  .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GPL--QEEEAKHIFGQLVASVKYCHNLNIVHRDIKPQNVLLDEERNV----KLTDFGLAIK--CNPGRLLSRKCGTKRFWAPEILLGEPYDSRKTDVWSL
|..  .|.|.|... |..  ..|||. .|.|||.||.|.|.|.. ..    |..||||| .    ... ..  ||| .. |||...| .|...| |.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVLLFFITTGDYPFAGS------TLIEFEQKLTTGSYCIPPYIS---------------------VKLENLIHQILTVPPEKRPSIEDIEKHPWV
|..|.   .|  || |.      . ..  ..   . .  . . .                       .  .|  .|.. |.|||..|.| .|||.
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MarkmB2.AA Ciliate-E2 14-262 24 3.5e-71 242.81 In-house 1-365 (365) Show / Hide 
Range on Protein: 14-262
Range on HMM: 1-365/365
Sequence Identity: 24% (90 aa)

YRVLFYLGEGTFGTVKLALHLKTEA-----------------------LVAVKMIEVN----EKTLKAIL----------VEQEILATLNHPNIIRLFQV
| ..  .|.|.||.|... . |.                         ..|.|... |     |  . |.           |..|| .|||||||... .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

IL--TPGCVNFILEYASGGNLFDLIQEH-----------GPLQEEEAKHIFGQLVA---------------SVKYCHNLN-IVHRDIKPQNVLLDEERNV
    .  .. ...||..||.|||.|...           ... |.|.|.|. |..                 ..|.|. | |.||||||.|.|.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLTDFGLAIKCNP-----------GRLLSRK----------------------CGTKRFWAPEILLGEPY--------DSRKTDVWSLGVLLFFITTGDY
|..||||. |...           . ..  |                      |||  . ||||| |..|         . | |.|||||.|..  .| .
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFAGSTLIEFEQ-KLTTGSYC-------------IPPYISVKLENLIHQ----ILTVPPEKRPS-IEDIEKHPWV
||    ... .| |.   ...             .. ..| .  .|| .    .| . ||||.. .|.| .||| 
PF----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase MarkmB2.AA ULK 14-262 27 2e-66 227.01 In-house 1-324 (324) Show / Hide 
Range on Protein: 14-262
Range on HMM: 1-324/324
Sequence Identity: 27% (89 aa)

YRVLFYLGEGTFG-TVKLALHLKTE---ALVAVKMIE---VNEKTLK--------AILVEQEILATLN---HPN--IIRLFQVILTP--GCVNFILEYAS
| .   ||.|.|| .|  . . ||.    .||.|||.    |.| ..         .  | .|. .|.   |||  |..|. .  |.    . .|.||  
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGNLFDLIQEHGP---------LQEEEAKHIFGQLVASVKYCHNLNIVHRDIKPQNVLLDEERN------------VKLTDFGLAIKCNPGRLLSRKC--
||.|...|.....         | |.||...| |...  |. |. ||.|||||||| |. .               .|..|||.| ... . .   .|  
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

--------GTKRFWAPEILL----GEPYDSRKTDVWSLGVLLFFITTGDYPFAGSTLIEFE----QKLTTG--------SYCIPPY-------ISVKLEN
        ||  . ||.||     ..||.. |.|.||||.... . .| ||| ..   . .    . .  |           |...       || ....
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LIHQILTVPPEKRPSIEDIEKHPWV
|| . |.. ...| |.|.| .|||.
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase MarkmB2.AA Ciliate-E2-Unclassified 14-262 22 2e-65 223.64 In-house 1-352 (352) Show / Hide 
Range on Protein: 14-262
Range on HMM: 1-352/352
Sequence Identity: 22% (79 aa)

YRVLFYLGEGTFGTVKLALHLKTEALV-----AVKMIEVNEKTLKA---------ILVEQE-------------ILATLNHPNIIRLFQVILTPGCVNFI
|...  .|.| ||.|... | |.  ..     . |..... |  .          .. ...             ||  ..||.|...| .  .  .. ..
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

LEYASGGNLFDLIQEHGP-----------------LQEEEAK-----HIFGQLVASVKYCHNLN-IVHRDIKPQNVLLDEER---NVKLTDFGLAIKCN-
.||. ||.|.. |.. .                  ..|..||     ..| |..   .|.|  | |.||||||.|.|.|..    ..|..|||...| . 
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

---------------PGRLLSRKCGTKRFW----APEILLGEPYDSR---KTDVWSLGVLLFFITTGDYPFAGSTLIE----------------FEQKLT
               .  ... .||| ..     |||.| |. || .   | |.|||||.|... .| ||| . . ..                ..|.  
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

TGSYCIPPYIS----VKLE--------NLIHQILTVPPEKRPSIEDIEKHPWV
 . ...|..       ..         .|....| . |.||...|.| .||| 
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase MarkmB2.AA ULK 14-262 26 2.3e-65 223.46 In-house 1-329 (329) Show / Hide 
Range on Protein: 14-262
Range on HMM: 1-329/329
Sequence Identity: 26% (86 aa)

YRVLFYLGEGTFGTVKLALHLKTE----ALVAVKMIE---VNEKT--------LKAILVEQEILATLN--------HPNIIRLFQVILTP--GCVNFILE
| .   ||.|.||.|  . . ||.     .||.|||.    |.|         .. .  | .|. .|.        ||||..|. .  |.   .. .|.|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YASGGNLFDLIQEHGP----------LQEEEAKHIFGQLVASVKYCHNLNIVHRDIKPQNVLLDEERN------------VKLTDFGLAIKCNPG-----
|  ||.|...|.....          | |.||...| |...  |. |  ||.||||||||.|...               .|..|||.| ... .     
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

RLLSRK-----CGTKRFWAPEILL----GEPYDSRKTDVWSLGVLLFFITTGDYPFAGSTLIEFE-----QKLTTGSYC----------IPPY-----IS
 ... .     |||  . ||.||     ..||.. |.|.||||.... . .| .|| ..   .       . .  .. .          .|..     ||
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

VKLENLIHQILTVPPEKRPSIEDIEKHPWV
 ....|| . |.. ...| |.|.. .|||.
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase MarkmB2.AA TyrKc 14-262 26 4.2e-19 70.72 SMART 1-280 (280) Show / Hide 
Range on Protein: 14-262
Range on HMM: 1-280/280
Sequence Identity: 26% (75 aa)

YRVLFYLGEGTFGTVKLALHLKTEALVAVKMIEVNEKTLKAILVEQEILATL--NHPNIIRLFQVILTP-------GCVNFILEYASGGNLFDLIQEHGP
 . .  |||| ||.| ..        |||||.  .   ..... | .|.  |  .||||.||. |....       . .  ..||...|.| | ...|.|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

-LQEEEAKHIFGQLVASVKYCHNLNIVHRDIKPQNVLLDEERNVKLTDFGLAIKCNPG-------RLLSRKC--GTK-----RFWAPEILLGEPYDSRKT
 |. ..  ..  |  .   | |  |..|||.   |.|..|.. || .||||. .   .          . |   |.|     |  ||| .    . . |.
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT-KS

DVWSLGVLLF-FITTGDYPFAG-----STLIEFEQKLTTG-SYCIPPY--------ISVKLENLIHQILTVPPEKRPSIEDIEKHPWV
|||| ||...   | |. |  |      . .|  ... .|    .||.         . .. ... |     ||.||. ..|  |   
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase MarkmB2.AA Pkinase_Tyr 20-155 30 2e-16 56.25 Pfam 7-158 (270) Show / Hide 
Range on Protein: 20-155
Range on HMM: 7-158/270
Sequence Identity: 30% (47 aa)

LGEGTFGTVKLALHL----KTEALVAVKMI--EVNEKT--LKAILVEQEILATL-NHPNIIRLFQVIL-TPGC--VNFILEYASGGNLFDLIQEH----G
|||| ||.|...       .|.  |||||.     ..   ... . | .|. .| .||||.||  |..   .   .  ..||. .|.| |  ..|    .
LGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQ

PLQEEEAKHIFGQLVASVKYCHNLNIVHRDIKPQNVLLDEERNVKLTDFGLA
||  ..  ..  |  .   | .. |..|||.   |.|..|.. || .|||||
PLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase MarkmB2.AA Pkinase_Tyr 186-223 36 0.174699 5.65 Pfam 192-232 (270) Show / Hide 
Range on Protein: 186-223
Range on HMM: 192-232/270
Sequence Identity: 36% (15 aa)

SRKTDVWSLGVLLFFITT-GDYP-FAGSTLIEFEQKL-TTG
. |.|||| |||.. | | |. | ..| .  |. ...   |
TTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDG
UBA_CAMKL MarkmB2.AA UBA_CAMKL 276-313 39 1.2e-11 40.01 In-house 1-41 (41) Show / Hide 
Range on Protein: 276-313
Range on HMM: 1-41/41
Sequence Identity: 39% (16 aa)

DYTIIEMLCGM--GFEANKILESLQKKKF-DENMGTYLLLK
|  ||. .| |  ||  ..| |||.. |. .. ..||.|| 
DEEIIQEMCKMWHGFDREEIIESLRNNKYHNHITATYYLLL
UBA MarkmB2.AA UBA 276-313 21 8e-06 26.65 SMART 1-38 (38) Show / Hide 
Range on Protein: 276-313
Range on HMM: 1-38/38
Sequence Identity: 21% (8 aa)

DYTIIEMLCGMGFEANKILESLQKKKFDENMGTYLLLK
. ..|..|..|||  . ....|.. . ...| ...|. 
YEEKIDQLMEMGFDREECVQALRACNWNVEMAMNWLFS