Gene MarkmA2 (Mouse)

MarkmA2

Species: Mouse
Alias: MarkmA2
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , iHOP
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: MARK

Sequence

Name Sequence Type Origin Length Description Download
MarkmA2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 249 Kinase domain by global Sugen HMM Fasta, JSON
MarkmA2.NA RNA Sugen 1419 None Fasta, JSON
MarkmA2.AA Protein Sugen 472 None Fasta, JSON

Protein domain

Protein domains of MarkmA2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MarkmA2.AA MARK 23-271 54 1.3e-165 545.12 In-house 1-262 (262) Show / Hide 
Range on Protein: 23-271
Range on HMM: 1-262/262
Sequence Identity: 54% (142 aa)

YNILKTIGQGSYAQVKLAHHRLTGTAVAIKVLLKQNIQN----CPVCTEVGIMKRMDHPNIISLHQVIE--TEQN-VFLILELADGHELFDWIVET--GF
| .|||||.||||.||||.|..||. ||||.. |....     ..|. |. |||..||||||.|..|||  |||. ..||.|.| |.||.|.|..   | 
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

LHEGLARKIFRQIVHAMCYCHDIGIVHRDLKPDNIMVDSTG--KVKIIDFGLGALVKPGMKLSRCCGAVLFYPPEIFLGRPYDGTKVDTWTLGVLLYFMV
||| .||.||||||.|..|||...|||||.||.||..|. |  ..||||||... ..||.||...||.  . .|||||..||||.|||.|.|||.|||||
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV

TGKLPFRGKS--YKEIEAKVLLGRYDVPYHLSKELRQIIRYLLTVNPTERPTLKNIMEHSWL
.|..||.|..  |||.. |.| |.||.|.|.|||.|..|. |||||| ||||...||.|.|.
CGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase MarkmA2.AA CAMKL 23-271 41 1.9e-143 460.71 In-house 1-297 (297) Show / Hide 
Range on Protein: 23-271
Range on HMM: 1-297/297
Sequence Identity: 41% (124 aa)

YNILKTIGQGSYAQVKLAHH-RLTGTAVAIKVLLKQNIQNCPVCT----------------EVGIMKRMD---HPNIISLHQVIETEQN------VFLIL
|.|.||.|.||...||||.| |.||. ||||.. |. |.| |...                |. |||...   |||||.|..||||...      ..|..
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ELADGHE--LFDWIVETGF----LHEGLARKIFRQIVHAMCYCHDIGIVHRDLKPDNIMVDSTG--KVKIIDFGLGALVKP-----GMKLSRCCGAVLFY
|...| |  |||.||. |     ..|. ||..|||||.|. |||. ||||||.||.||..|. |  ..||||||.... .|     | ||. .||   . 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

PPEIFLG--RPYDGTKVDTWTLGVLLYFMVTGKLPFRGKSYK---------EIEAKVLLGRYDVPYHLSKELRQIIRYLLTVNPTERPTLKNIMEHSWL
.||||.|  .|||| ||| | .||.||.||.|.|||.. .|.         . . ... ......||.| ..|..|| .|.|||..|||...||.| |.
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase MarkmA2.AA CAMK 28-271 25 1.5e-117 380.56 In-house 1-425 (425) Show / Hide 
Range on Protein: 28-271
Range on HMM: 1-425/425
Sequence Identity: 25% (107 aa)

TIGQGSYAQVKLAHHRLTG------------TAVAIKVLLKQNIQN-----------------------------CPVCTEVGIMKR-------MDHPNI
|.|.||...|||. |..|.            . ||||.. |. ...                               |  |. |||.       .|||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

ISLHQVIE------------TEQN--------VFLIL---ELADGHEL----FDWIVETGF---------------LHEGLARKIFRQIVHAMCYCHDIG
|.|..|.|            | ..        .....   |...| ||    ||.||| |                ..|  ||..||||. |. |||. .
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDLKPDNIMVDST-----------------GKVKIIDFGLGALVKP------------------------GMKLSRCCGAVLFYP-PEIFLG-----
||||||||.||..|.                  ...||||||. . ..|                        | |.. .||   . . ||...|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------RPYDGTKVDTWTLGVLLYFMVTGKLPFRGK-------------SYKEIEAKVLLGRYD-VPYH-----------------------LSKELR
        .||.| |.| | .||.||.|..|..||.|.             ...|.  |.. |.||  |..                       .|.| .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

QIIRYLLTVNPTERPTLKNIMEHSWL
. || .|.|.|..|.|.. ...| |.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MarkmA2.AA NuaK 23-271 41 2.8e-101 267.0 In-house 1-252 (252) Show / Hide 
Range on Protein: 23-271
Range on HMM: 1-252/252
Sequence Identity: 41% (105 aa)

YNILKTIGQGSYAQVKLAHHRLTGTAVAIKVLLKQNIQN----CPVCTEVGIMKRMDHPNIISLHQVIETEQNVFLILELADGHELFDWIVETGFLHEGL
|...|| |.| |  ||||  . ||  ||||   |. |.       .  |. ||  ..||.||. . | |  . . ...| | | ||.|.| | . | |. 
YEFQKTLGKGTYGKVKLATEHSTGREVAIKSIKKCKIEDEQDMVHIRREIEIMSSLNHPHIIHIYEVFENKDKIVIVMEYASGGELYDYISECKSLPERE

ARKIFRQIVHAMCYCHDIGIVHRDLKPDNIMVDSTGKVKIIDFGLGALVKPGMKLSRCCGAVLFYPPEIFLGRPYDGTKVDTWTLGVLLYFMVTGKLPFR
||..||||| |. |||  .|.|||||  ||. |  . .|| ||||  . . .  |   ||  |.  |||  |.|| |  || | |||||| || | .|| 
ARHFFRQIVSAVHYCHKHRICHRDLKLENILLDQNCNAKIADFGLSNYYHDQKFLHTFCGSPLYASPEIVNGQPYHGPEVDCWSLGVLLYTMVYGTMPFD

GKSYKEIEAKVLLGRYDVPYHLSKELRQIIRYLLTVNPTERPTLKNIMEHSWL
|. .|..   .  |.|  | . |.  .. || .|.|||. | |. .| .| |.
GHDFKHLVKQISQGAYYEPCKPSDA-CMLIRWMLMVNPRRRATIYDICHHWWV
Kinase MarkmA2.AA AMPK 23-271 41 6.8e-97 288.19 In-house 1-254 (254) Show / Hide 
Range on Protein: 23-271
Range on HMM: 1-254/254
Sequence Identity: 41% (106 aa)

YNILKTIGQGSYAQVKLAHHRLTGTAVAIKVLLKQNIQNCPVCT----EVGIMKRMDHPNIISLHQVI-ETEQNVFLILELADGHELFDWIVETGFLHEG
| | |||| |..  ||.. | |||..||||.| || |..  .      |. |.| . ||.|| | .|| ||..  |...| . | ||||.||  | | | 
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQER

LARKIFRQIVHAMCYCHDIGIVHRDLKPDNIMVDSTGKVKIIDFGLGALVKPGMKLSRCCGAVLFYPPEIFLGRPYDGTKVDTWTLGVLLYFMVTGKLPF
 |.. | ||. .  |||...|||||||| |.  |   ..|| ||||  . | | .|. .||      ||.  |..| |..||.|  || || |. |.|||
EACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYLPF

RGKSYKEIEAKVLLGRYDVPYHLSKELRQIIRYLLTVNPTERPTLKNIMEHSWL
   .  .  .|.. |.| .|..||.| ...|. .|.|.|..| | . |..|.|.
DDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase MarkmA2.AA QIK 23-271 38 8e-92 311.36 In-house 1-272 (272) Show / Hide 
Range on Protein: 23-271
Range on HMM: 1-272/272
Sequence Identity: 38% (106 aa)

YNILKTIGQGSYAQVKLAHHRLTGTAVAIKVLLKQNIQNCP---VCTEVGIMKRMDHPNIISLHQVIETEQNVFLILELADGHELFDWIVETGF------
| | .||| | .| |||| || | | ||||.. |  .       .  || |||...||.|| | ||.||..  ... | . . |.|| ... |       
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEENLQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKMV

--------------LHEGLARKIFRQIVHAMCYCHDIGIVHRDLKPDNIMVDSTGKVKIIDFGLGALVKPGMKLSRCCGAVLFYPPEIFLGRPYDGTKVD
              . |  ||..| ||. |  |||. .|||||||  ||. |.   .||.|||.. . |.|  |. .||   .  ||.|.|. ||| |||
NSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKVD

TWTLGVLLYFMVTGKLPFRGKSYKEIEAKVLLGRYDVPYHLSKELRQIIRYLLTVNPTERPTLKNIMEHSWL
 | .||.|| .|.|.||| ||. ..  ..|| |.. .|. .|... ..||  |.|.|. | | ..|..| |.
IWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
Kinase MarkmA2.AA S_TKc 23-271 31 5.2e-91 309.59 SMART 1-231 (231) Show / Hide 
Range on Protein: 23-271
Range on HMM: 1-231/231
Sequence Identity: 31% (84 aa)

YNILKTIGQGSYAQVKLAHHRLTGTAVAIKVLLKQNIQNCPVCTEVGIMKRMDHPNIISLHQVIETEQNVFLILELADG--HELFDWIVETGF------L
| ||..||.|....|....|. ||  ||||..       . .. |. |.|. .||||. |. |... .......|..||   .||| |.. |       .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

HEGLARKIFRQIVHAMCYCHDIGIVHRDLKPDNIMVDSTGKVKIIDFGLGALVKPGMKLSRCCGAVLFYPPEIFLGRPYDGTKVDTWTLGVLLYFMVTGK
.|  ||....||. |. |||. ||.||||||.||..|.   .||.|||| ...      . .||   . .||..   .|.. |.| | .|..|| |..|.
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGY

LPFRGKSYKEIEAKVLLGRYDVPYHLSKELRQIIRYLLTVNPTERPTLKNIME-------HSWL
 ||.   ....  |..          |.|....|| .|...|..|||   ...       | |.
PPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MarkmA2.AA Pkinase 23-271 29 2.2e-81 281.5 Pfam 1-293 (293) Show / Hide 
Range on Protein: 23-271
Range on HMM: 1-293/293
Sequence Identity: 29% (87 aa)

YNILKTIGQGSYAQVKLAHHRLTGTAVAIKVLLKQNIQNCPVCT-----EVGIMKRMDHPNIISLHQVIETEQNVFLILELADGH----ELFDWIV--ET
| |...||.||...|...||. ||  ||.|.. |...  .   |     |. ||||..||||. |. . |..... ...|...|     .|||.|   . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GFL--HEGLARKIFRQIVHAMCYCHDIGIVHRDLKPDNIMVDSTGKV----KIIDFGLGAL--VKPGMKLSRCCGAVLFYPPEIFLGRPYDGTKVDTWTL
| .   |  ......||. .. |||. ||.||||||.||..|..| .    ||.|||| ..    ..  ..  ||   . .||. .|..|.|.||| | .
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVLLYFMVTGKLPFRGK------SYKEIEAKVLLGRYDVPYHLS---------------------KELRQIIRYLLTVNPTERPTLKNIMEHSWL
|..|| |..|..||.|.      . ... .... .... ..  .                     .|....|...|...|..||| . |..| |.
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MarkmA2.AA SNRK 23-271 43 1.3e-80 263.66 In-house 1-254 (254) Show / Hide 
Range on Protein: 23-271
Range on HMM: 1-254/254
Sequence Identity: 43% (111 aa)

YNILKTIGQGSYAQVKLAHHRLTGTAVAIKVLLK---QNIQNCPVCTEVGIMKRMDHPNIISLHQVIETEQNVFLILELADGHELFDWIV--ETGFLHEG
| . ||.|.| .| ||||.|  ||  ||.||. |    ..    .  ||  || . ||||. |  ||.|   ..||||| || ...|.|.  | | |.| 
YDLEKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKMDEVSKAHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGYDMYDYIMKHEKG-LCED

LARKIFRQIVHAMCYCHDIGIVHRDLKPDN-IMVDSTGKVKIIDFGLGALVKPGMKLSRCCGAVLFYPPEIFLGRPYDGTKVDTWTLGVLLYFMVTGKLP
|||| |.||.||. ||| . .|||||||.| .  .  | ||. |||     .|| ||   ||.. .  ||| ||  ||   || | |||.|| .| |..|
LARKYFCQIMHAIDYCHQLHVVHRDLKPENVVFFEKQGMVKLTDFGFSNKFMPGEKLETSCGSLAYSAPEILLGDSYDAPAVDIWSLGVILYMLVCGQAP

FRGKSYKEIEAKVLLGRYDVPYHLSKELRQIIRYLLTVNPTERPTLKNIMEHSWL
|.     |  ....  .| || |.|.| |..|  .|  .|  | .| .| .|||.
FQEANDSETLTMIMDCKYTVPDHVSDECRDLIQSMLVRDPKKRASLEEIVSHSWV
Kinase MarkmA2.AA MELK 23-271 39 6.1e-71 241.63 In-house 1-254 (254) Show / Hide 
Range on Protein: 23-271
Range on HMM: 1-254/254
Sequence Identity: 39% (100 aa)

YNILKTIGQGSYAQVKLAHHRLTGTAVAIKVLLKQNI-QNCP-VCTEVGIMKRMDHPNIISLHQVIETEQNVFLILELADGHELFDWIVETGFLHEGLAR
|.. ..|| | .|.|||| | ||.  ||||.. |... .. | | ||.  .| . | .|  |. .||||. .|...|   | |.||.|..   |.|  .|
YEVHDEIGTGGFAKVKLACHILTNQMVAIKIMDKNQLGHDLPRVKTEMDALKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEEEETR

KIFRQIVHAMCYCHDIGIVHRDLKPDNIMVDSTGKVKIIDFGLGALVKPGM---KLSRCCGAVLFYPPEIFLGRPYDGTKVDTWTLGVLLYFMVTGKLPF
..||||| |. | |  |  ||||||.|...|   ..|.||||| |  |  .   .|  |||.  .  ||.  |. | |   | | .|.||| .. | |||
HFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKTKGRKDYHNLQTCCGSPAYAAPELIQGKQYIGSEADVWSMGILLYVLMCGFLPF

RGKSYKEIEAKVLLGRYDVPYHLSKELRQIIRYLLTVNPTERPTLKNIMEHSWL
     . .  |.. | |..| .|| | .|..| .| |.|. |  .||...| |.
DDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISMKNLLNHPWV
Kinase MarkmA2.AA Ciliate-E2 23-271 22 2.4e-69 236.72 In-house 1-365 (365) Show / Hide 
Range on Protein: 23-271
Range on HMM: 1-365/365
Sequence Identity: 22% (83 aa)

YNILKTIGQGSYAQVKLAHHRLTGTAVAIK-------------------VLLKQNIQNCPVCT--EVGIMK----------------RMDHPNIISLHQV
|...| ||||....|... .....  .|||                   . .|....|    .  |  ||.                ...||||| .. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

IE--TEQNVFLILELADGHELFDWIV------------ETGFLHEGLARKIFRQIVH---------------AMCYCHDIG-IVHRDLKPDNIMVDSTGK
 .  ...|..|..|...| .|||.|             . . . |  ...|..||.                |. |.|  . |.|||.||.||..     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

VKIIDFGL-----------------GALVKPG----------------MKLSRCCGAVLFYPPEIFLGRPYDG--------TKVDTWTLGVLLYFMVTGK
.|||||||                 . .   .                .   ..||   . .|||. | .||.        .|.| | |||.||.|..||
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

LPFRGKSYKEIEA-KVLLGRYD-------------VPYHLSKELRQIIRY----LLTVNPTERPT-LKNIMEHSWL
.||    ...|.  |. .  ..              . ..|.|  ..|.     .| ..| .|.|  . |..| |.
PPF----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase MarkmA2.AA GIN4 67-271 38 7.4e-68 215.69 In-house 84-293 (293) Show / Hide 
Range on Protein: 67-271
Range on HMM: 84-293/293
Sequence Identity: 38% (81 aa)

EVGIMKRMDHPNIISLHQVIETEQNVFLILELADGHELFDWIVETGFLHEGLARKIFRQIVHAMCYCHDIGIVHRDLKPDNIMVDSTGK-VKIIDFGLGA
|. ||| ..|||...|..| ||.....|.|| |.. |||...|. | | |  | ..||||.  . ||| ..|.||||||.|...|.  . .|| |||. |
EIVIMKLISHPNVMRLYDVWETNNDLYLVLEYAEKGELFNYLVDHGPLPEREAIHYFRQIIIGVSYCHAFNICHRDLKPENLLLDHKYNRIKIADFGMAA

LVKPGMKLSRCCGAVLFYPPEIFLGRPYDGTKVDTWTLGVLLYFMVTGKLPFRGK--SYKEIEAKVLLGRYDVPYH--LSKELRQIIRYLLTVNPTERPT
|  ..  |   ||.  .  |||  |.||.|   | |  ||.|. ..||.|||       ...  ||  |.|..|    .|.| . .|| .|.| |  | .
LETDNKLLETSCGSPHYAAPEIVMGIPYHGFASDVWSCGVILFALLTGHLPFDEEDGNIRKLLLKVQKGKYEMPSDDEISREAQDLIRKILVVDPEKRIK

LKNIMEHSWL
 ..|..|  .
TRDILKHPLI
Kinase MarkmA2.AA TyrKc 23-271 22 4.4e-16 37.33 SMART 1-280 (280) Show / Hide 
Range on Protein: 23-271
Range on HMM: 1-280/280
Sequence Identity: 22% (64 aa)

YNILKTIGQGSYAQVKLAHHRLTGTAVAIKVLLKQNIQNCPVCTEVGIMKRM--DHPNIISLHQVIETE-------QNVFLILELADGHELFDWIVETG-
   .|..| | . .| ... .   . ||.|.| .        . |  ||..   .||||. |. |. ..       . .....|....  | | . ... 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

FLHEGLARKIFRQIVHAMCYCHDIGIVHRDLKPDNIMVDSTGKVKIIDFGLGALVKPG--------MKLS----RCC--GAVLFYPPEIFLGRPYDGTKV
 |      ..  ||   | | |. ...||||   |..|.. . ||| ||||   .. .        .. .     .     .  ..|| .  . .  || 
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT-TKS

DTWTLGVLLYFMVT-GKLPFRG-----KSYKEIEAKVLLGRYDVPYHL---------SKELRQIIRYLLTVNPTERPTLKNIMEHSWL
| |  ||... . | |. |  |     .| .|. ..|  |..  . .          ..|. ||..     .| .||| ..|  |. .
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase MarkmA2.AA Pkinase_Tyr 23-101 21 1.7e-11 39.6 Pfam 1-91 (270) Show / Hide 
Range on Protein: 23-101
Range on HMM: 1-91/270
Sequence Identity: 21% (20 aa)

YNILKTIGQGSYAQVKLAHHR----LTGTAVAIKVLLKQNIQN----CPVCTEVGIMKRM-DHPNIISLHQVIE-TEQN--VFLILELADG
  ..|..|.|.. .|.... .     |.. ||.|.|  .  .          |. ||| . .||||..|. |.   ..   .....|.. .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPH
Kinase MarkmA2.AA GIN4 23-61 38 4.2e-07 18.28 In-house 1-39 (293) Show / Hide 
Range on Protein: 23-61
Range on HMM: 1-39/293
Sequence Identity: 38% (15 aa)

YNILKTIGQGSYAQVKLAHHRLTGTAVAIKVLLKQNIQN
. . .|.| ||  .|.||..  ||   |.||. |..| |
WKLGETLGFGSTGKVQLAKNMETGQRAAVKVISKKKIFN
Kinase MarkmA2.AA Pkinase_Tyr 129-163 42 0.000174 15.82 Pfam 123-157 (270) Show / Hide 
Range on Protein: 129-163
Range on HMM: 123-157/270
Sequence Identity: 42% (15 aa)

AMCYCHDIGIVHRDLKPDNIMVDSTGKVKIIDFGL
.| | ......||||   |..|.....||| ||||
GMEYLESKNCIHRDLAARNCLVTENNVVKICDFGL
Kinase MarkmA2.AA APH 135-162 25 0.000285 15.45 Pfam 169-200 (248) Show / Hide 
Range on Protein: 135-162
Range on HMM: 169-200/248
Sequence Identity: 25% (8 aa)

DIGIVHRDLKPDNIMVD-STGKVK---IIDFG
. ...|.|..|.|.|.|   .. .   .||..
PPCWCHGDFHPGNVMWDPRPDGGRVTGVIDWD
UBA_CAMKL MarkmA2.AA UBA_CAMKL 291-328 41 2.8e-10 35.1 In-house 1-41 (41) Show / Hide 
Range on Protein: 291-328
Range on HMM: 1-41/41
Sequence Identity: 41% (17 aa)

DPAIMAAMAAM--GFDPLDVQKSLLNKLY-NEPMATYGLLQ
|. |.. |..|  |||. .. .||.|  | |. .||| ||.
DEEIIQEMCKMWHGFDREEIIESLRNNKYHNHITATYYLLL
UBA MarkmA2.AA UBA 291-328 23 0.000992 17.71 SMART 1-38 (38) Show / Hide 
Range on Protein: 291-328
Range on HMM: 1-38/38
Sequence Identity: 23% (9 aa)

DPAIMAAMAAMGFDPLDVQKSLLNKLYNEPMATYGLLQ
.  . . .  ||||   ....| .  .|. ||.. |..
YEEKIDQLMEMGFDREECVQALRACNWNVEMAMNWLFS