Gene MarkmA1 (Mouse)

MarkmA1

Species: Mouse
Alias: MarkmA1
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , iHOP
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: MARK

Sequence

Name Sequence Type Origin Length Description Download
MarkmA1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 248 Kinase domain by global Sugen HMM Fasta, JSON
MarkmA1.NA RNA Sugen 2356 None Fasta, JSON
MarkmA1.AA Protein Sugen 497 None Fasta, JSON

Protein domain

Protein domains of MarkmA1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MarkmA1.AA MARK 28-275 46 6.4e-150 493.09 In-house 1-262 (262) Show / Hide 
Range on Protein: 28-275
Range on HMM: 1-262/262
Sequence Identity: 46% (123 aa)

YTVLKTLSQHGTTEVRLCSHHLTGVTVAVKALK---YQR-WW-EPKVSEVEIMKMLSHPNIVSLLQVIE--TEQN-IYLIMEVAQGTQLHNRVQEA--RC
| .|||. ...  .|.|. |..||. ||.| ..    .. .| ..  .|.||||.|.||||..|..|||  |||. |||||| | |. |.......  ..
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

LKEDEARSIFVQLLSAIGYCHGEGVVHRDLKPDNVIVDEHG--NVKIVDFGLGARFMPGQKLERLCGAFQFIPPEIFLGLPYDGPKVDIWALGVLLYYMV
|.|.||| || |..||. |||  ..||||.||.|. .||.|  |.|| |||......|||||.. ||.  . .|||||. ||||||||||.|||.||.||
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV

TGIFPFVGST--LSEISKEVLQGRYEIPYNLSKDLRSMIGLLLATNARQRPTAQDLLSHPWL
.| ||| |.|  . |. |..| |.|.||...||..|..| .|| .|  .|||......|||.
CGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase MarkmA1.AA CAMKL 28-275 37 1e-125 403.2 In-house 1-297 (297) Show / Hide 
Range on Protein: 28-275
Range on HMM: 1-297/297
Sequence Identity: 37% (112 aa)

YTVLKTLSQHGTTEVRLCSH-HLTGVTVAVKALKYQRWW-EPKVS----------------EVEIMKMLS---HPNIVSLLQVIETEQN------IYLIM
|...||| . .  .|.|. |  .||. ||.| .. .. | .|...                |..|||||.   ||||..|..||||...      |||.|
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EVAQGTQ--LHNRVQEARC----LKEDEARSIFVQLLSAIGYCHGEGVVHRDLKPDNVIVDEHG--NVKIVDFGLGARFMP-----GQKLERLCGAFQFI
| ..|    |...... ..    ..|.||| .| |..||. |||  |.||||.||.|. .||.|  |.||.|||... ..|     ||||.  ||   . 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

PPEIFLG--LPYDGPKVDIWALGVLLYYMVTGIFPFVGSTL--------SEISKEVLQGRYE-IPYNLSKDLRSMIGLLLATNARQRPTAQDLLSHPWL
.||||.|   ||||||||||..||.|| ||.| .|| . |.         .  |.  .  |. |.| .| |.|..|  .| .|  .|||......|||.
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase MarkmA1.AA CAMK 33-275 22 3.4e-103 333.41 In-house 1-425 (425) Show / Hide 
Range on Protein: 33-275
Range on HMM: 1-425/425
Sequence Identity: 22% (96 aa)

TLSQHGTTEVRLCSHHLTG------------VTVAVKALKY------------------------------QRWWEPKVSEVEIMKMLS-------HPNI
|| . .  .|.|| | .|.            . ||.| ..                               ... .   .|.||||.|.       ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VSLLQVIE------------TEQN--------IYLIM---EVAQGT----QLHNRVQEARC---------------LKEDEARSIFVQLLSAIGYCHGEG
..|..|.|            | ..        .|..|   | ..|      | ....| .|               ..|.||| .| |..||. |||  .
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

VVHRDLKPDNVIVDEH-----------------GNVKIVDFGLGARFMP------------------------GQKLERLCGAFQFIP-PEIFLG-----
.|||||||.|. .|..                 .|.||.|||. ..|.|                        |||..  ||   ... ||...|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------LPYDGPKVDIWALGVLLYYMVTGIFPFVGS-------------TLSEISKEVLQGRYE-IPYN-----------------------LSKDLR
         ||.|||.|.|..||.|| |..| .|| |.             ...|. . ...|.|. .|.                        .|.. .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

SMIGLLLATNARQRPTAQDLLSHPWL
..|  .| ..  .|.|... |.|||.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MarkmA1.AA AGC 28-275 19 1.3e-81 209.96 In-house 1-395 (395) Show / Hide 
Range on Protein: 28-275
Range on HMM: 1-395/395
Sequence Identity: 19% (76 aa)

YTVLKTLSQHGTTEVRLCSHH------LTGVTVAVKALKYQR--------WWEPKVSE------------VEIMKMLS----------HPNIVS-LLQVI
. .||.... .  .|.|. .        ||   |.| || ..          |   .|             .|.....          ||.||. |    
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETEQN--IYLIMEVAQ----------G--TQLHNRVQ-EARCLKEDEARSIFVQ-------LLSAIGYCHG-EGVVHRD-LKPDNVIVDEHGNVKIVDFG
.....  .|..|| ..          |  . ||.. .   ... |..|| .. .       ...|. | |   |..||| |||.|.  ||.|..|..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LGARFMPG---------------------------------------------------QKLERLCG--AFQFIPPEIFLGLPYDGPKVDIWA--LGVLL
|  ..| .                                                   ..   .||    ....|||.      |. .|.|.  ||.|.
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-----YGKACDWWSFGLGCLM

YYMVTGIFPFVGSTLS----------EISKEVL------QGRYEIP----------YNLSKDLRSMIGLLLATNARQRPT----------AQDLLSHPWL
| |.||. || | .            |. . ..      . . ..|           ..|..... |  ||  . ..|..          |... .||| 
YEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase MarkmA1.AA NuaK 28-275 38 3.5e-80 210.38 In-house 1-252 (252) Show / Hide 
Range on Protein: 28-275
Range on HMM: 1-252/252
Sequence Identity: 38% (98 aa)

YTVLKTLSQHGTTEVRLCSHHLTGVTVAVKALKYQRWWEPK-----VSEVEIMKMLSHPNIVSLLQVIETEQNIYLIMEVAQGTQLHNRVQEARCLKEDE
| ..||| .     |.|   | ||  ||.|  | ..  ...       |.|||  | ||.|..   | |  . | ..|| | |  | . . | . | | |
YEFQKTLGKGTYGKVKLATEHSTGREVAIKSIKKCKIEDEQDMVHIRREIEIMSSLNHPHIIHIYEVFENKDKIVIVMEYASGGELYDYISECKSLPERE

ARSIFVQLLSAIGYCHGEGVVHRDLKPDNVIVDEHGNVKIVDFGLGARFMPGQKLERLCGAFQFIPPEIFLGLPYDGPKVDIWALGVLLYYMVTGIFPFV
|| .| |  ||. ||| ....|||||  |.  |. .|.|| ||||   .  .. |.  ||   .  |||  | || || || |.|||||| || |  || 
ARHFFRQIVSAVHYCHKHRICHRDLKLENILLDQNCNAKIADFGLSNYYHDQKFLHTFCGSPLYASPEIVNGQPYHGPEVDCWSLGVLLYTMVYGTMPFD

GSTLSEISKEVLQGRYEIPYNLSKDLRSMIGLLLATNARQRPTAQDLLSHPWL
|.   .. | . ||.|  |   | | . .|  .|  | |.| |  |  .|.|.
GHDFKHLVKQISQGAYYEPCKPS-DACMLIRWMLMVNPRRRATIYDICHHWWV
Kinase MarkmA1.AA QIK 28-275 34 3.4e-78 266.07 In-house 1-272 (272) Show / Hide 
Range on Protein: 28-275
Range on HMM: 1-272/272
Sequence Identity: 34% (95 aa)

YTVLKTLSQHGTTEVRLCSHHLTGVTVAVKALKYQRWWEPKVS----EVEIMKMLSHPNIVSLLQVIETEQNIYLIMEVAQGTQLHNRVQEARC------
|.. .|.       |.|  |  |   ||.| .   .  |        ||.|||||.||.|. |.||.||.. .|...| ...  .   . .         
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEENLQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKMV

--------------LKEDEARSIFVQLLSAIGYCHGEGVVHRDLKPDNVIVDEHGNVKIVDFGLGARFMPGQKLERLCGAFQFIPPEIFLGLPYDGPKVD
              ..|.||| .| |..||. |||  ..||||||  |.  |.  |.||.|||..  | .|| |.  ||   .  ||.|.|  |||||||
NSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKVD

IWALGVLLYYMVTGIFPFVGSTLSEISKEVLQGRYEIPYNLSKDLRSMIGLLLATNARQRPTAQDLLSHPWL
|| .||.|| .|.| .|| |.|| .  . || |.. ||. .|.|. ..|   |  .. .| | .  . |.|.
IWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
Kinase MarkmA1.AA S_TKc 28-275 29 1.2e-77 265.23 SMART 1-231 (231) Show / Hide 
Range on Protein: 28-275
Range on HMM: 1-231/231
Sequence Identity: 29% (78 aa)

YTVLKTLSQHGTTEVRLCSHHLTGVTVAVKALKYQRWWEPKVSEVEIMKMLSHPNIVSLLQVIETEQNIYLIMEVAQG--TQLHNRVQEARC------LK
|..|... . .  .|..| |. ||  ||.| .|     |   .|..|.|.  ||||| |. |... ...|..|| . |    |. . .. ..      . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

EDEARSIFVQLLSAIGYCHGEGVVHRDLKPDNVIVDEHGNVKIVDFGLGARFMPGQKLERLCGAFQFIPPEIFLGLPYDGPKVDIWALGVLLYYMVTGIF
| .||... |...|. |||  |..||||||.|. .||  ..|| |||| ...        .||   ...||..   .|...|.|.|..|..|| |..|  
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYP

PFVGSTLSEISKEVLQGRYEIPYNLSKDLRSMIGLLLATNARQRPTAQDLLS-------HPWL
||   .. .. | ..          |......|  .|  . ..|||| ..|        |||.
PFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MarkmA1.AA Pkinase 28-275 28 1.2e-75 262.44 Pfam 1-293 (293) Show / Hide 
Range on Protein: 28-275
Range on HMM: 1-293/293
Sequence Identity: 28% (85 aa)

YTVLKTLSQHGTTEVRLCSHHLTGVTVAVKALKYQRWWEPKV------SEVEIMKMLSHPNIVSLLQVIETEQNIYLIMEVAQGT----QLHNRVQ--EA
|...... . .  .|..| |. || .|||| .|...  . |       ||..|||.|.||||| |. . |....||..|| ..|.     |. ...  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RCL--KEDEARSIFVQLLSAIGYCHGEGVVHRDLKPDNVIVDEHGNV----KIVDFGLGAR--FMPGQKLERLCGAFQFIPPEIFLGLPYDGPKVDIWAL
.|.   |.|..... |.|... ||| .|..||||||.|. .|..|..    || |||| .     ... .  .||   ...||. .| .|.|||||.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVLLYYMVTGIFPFVGS------TLSEISKEVLQGRYEIPYNLS---------------------KDLRSMIGLLLATNARQRPTAQDLLSHPWL
|..||.|..| .|| |.      .  .. ......... ..  .                     ..... |  .|. .  .||||...| |||.
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MarkmA1.AA AMPK 28-275 36 2.5e-72 214.03 In-house 1-254 (254) Show / Hide 
Range on Protein: 28-275
Range on HMM: 1-254/254
Sequence Identity: 36% (93 aa)

YTVLKTLSQHGTTEVRLCSHHLTGVTVAVKALKYQRWWEPKV-----SEVEIMKMLSHPNIVSLLQVI-ETEQNIYLIMEVAQGTQLHNRVQEARCLKED
| . ||.       | .  | |||  ||.| |  |.  . ..     .|..|.|.. ||.|. | .|| ||.. |...|| ..|  |   .   . |.|.
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQER

EARSIFVQLLSAIGYCHGEGVVHRDLKPDNVIVDEHGNVKIVDFGLGARFMPGQKLERLCGAFQFIPPEIFLGLPYDGPKVDIWALGVLLYYMVTGIFPF
||.  | | .|.. |||  ..||||||| |.  |.. |.|||||||      |..|   ||      ||.  | .| ||.||||  || || |. |  ||
EACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYLPF

VGSTLSEISKEVLQGRYEIPYNLSKDLRSMIGLLLATNARQRPTAQDLLSHPWL
  .  ..  | ...|.|.||..||.. ...|  .| ..  .| | .|.  |||.
DDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase MarkmA1.AA SNRK 28-275 40 6.7e-69 224.67 In-house 1-254 (254) Show / Hide 
Range on Protein: 28-275
Range on HMM: 1-254/254
Sequence Identity: 40% (102 aa)

YTVLKTLSQHGTTEVRLCSHHLTGVTVAVKALKYQRWWEPKVS----EVEIMKMLSHPNIVSLLQVIETEQNIYLIMEVAQGTQLHNRV-QEARCLKEDE
| . ||| .     |.|  |  ||  |||| .   .  |   .    ||  ||.  ||||| |  ||.|   .|||.|.  |  ..  . .  . |.|| 
YDLEKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKMDEVSKAHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGYDMYDYIMKHEKGLCEDL

ARSIFVQLLSAIGYCHGEGVVHRDLKPDNVI-VDEHGNVKIVDFGLGARFMPGQKLERLCGAFQFIPPEIFLGLPYDGPKVDIWALGVLLYYMVTGIFPF
||  | |.. || |||   ||||||||.||.  .  | ||. |||   .||||.|||  ||.  .  ||| ||  || | ||||.|||.|| .| |  ||
ARKYFCQIMHAIDYCHQLHVVHRDLKPENVVFFEKQGMVKLTDFGFSNKFMPGEKLETSCGSLAYSAPEILLGDSYDAPAVDIWSLGVILYMLVCGQAPF

VGSTLSEISKEVLQGRYEIPYNLSKDLRSMIGLLLATNARQRPTAQDLLSHPWL
     ||    ..  .| .|  .|.. | .|  .|  . ..| .  .. ||.|.
QEANDSETLTMIMDCKYTVPDHVSDECRDLIQSMLVRDPKKRASLEEIVSHSWV
Kinase MarkmA1.AA Ciliate-E2 28-275 20 6e-60 204.46 In-house 1-365 (365) Show / Hide 
Range on Protein: 28-275
Range on HMM: 1-365/365
Sequence Identity: 20% (78 aa)

YTVLKTLSQHGTTEVRLCSHHLTG--------------------VTVAVKALKYQ--RWWEPKVSEVEIMK----------------MLSHPNIVSLLQV
| ..| . | .   |..|.. ...                    |..  .|.|..  .  | . .|  ||.                 |.||||. .  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

IE--TEQNIYLIMEVAQGTQLHNRVQ------------EARCLKEDEARSIFVQLLS---------------AIGYCHGEG-VVHRDLKPDNVIVDEHGN
 .  ...||||.|| .||  |  . .            .  ...| |.. |. |.|.               |. |.| .. ..|||.||.|...     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

VKIVDFGLGARFMPG--------------------------------QKLERLCGAFQFIPPEIFLGLPYDG--------PKVDIWALGVLLYYMVTGIF
.||.||||  .. .                                 .   ..||   . .|||. | .||.         |.|||.|||.||.|..| .
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFVGSTLSEISKEVLQGRYEIPYN------------------LSKDLRSMIGL----LLATNARQRPT-AQDLLSHPWL
||         .. .|. ...| .                  .|..   .|      .|  .  .|.| ....| |||.
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase MarkmA1.AA Ciliate-E2-Unclassified 28-275 21 2.9e-58 199.86 In-house 1-352 (352) Show / Hide 
Range on Protein: 28-275
Range on HMM: 1-352/352
Sequence Identity: 21% (75 aa)

YTVLKTLSQHGTTEVRLCSHHLTG--------VTVAVKALKYQRW----------WEP--KVSEVE--------IMKMLSHPNIVSLLQVIETEQNIYLI
|...|.. | |  .|..| |  ..          . ... |...           ..   | . ..        |.... ||.|| .. . ...||||..
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MEVAQGTQLHNRVQE-----------------ARCLKEDEAR-----SIFVQLLSAIGYCHGEG-VVHRDLKPDNVIVDEHG---NVKIVDFGL--GARF
|| ..|  |..  ..                  ... | .|.      .| |.|... |.| .. ..|||.||.|...|. |   ..|| |||.      
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

MPGQKLERL---------------CGAFQFI----PPEIFLGLPYDGP---KVDIWALGVLLYYMVTGIFPFVGSTLSE----------------ISKEV
..... ..                ||  ...    .||.. |  ||..   |.|||.|||.||.|..| .|| . .  .                . .. 
NNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

LQGRYE--------IPYNLSKDLRSMIG----LLLATNARQRPTAQDLLSHPWL
.|. ..        ||...|.    .|      .|  |  .|.|....| |||.
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase MarkmA1.AA TyrKc 28-275 23 3.5e-14 6.54 SMART 1-280 (280) Show / Hide 
Range on Protein: 28-275
Range on HMM: 1-280/280
Sequence Identity: 23% (69 aa)

YTVLKTLSQ-------HGTTEVRLCSHHLTGVTVAVKALKYQRWWEPKVSEVEIMKML--SHPNIVSLLQVIETE-------QNIYLIMEVAQGTQLHNR
 | .|.|         .||            ..|||| ||     |   .| .||..|  .||||| |. |. ..       . ....|| . .  |...
ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

VQEARC-LKEDEARSIFVQLLSAIGYCHGEGVVHRDLKPDNVIVDEHGNVKIVDFGLGARFMPGQ----------K-----LERLCGAFQFIPPEIFLGL
 .. |  |. ..  |. .|  .   | |  ...||||   |. |.| . ||| |||| .|.              .      ..        .|| .   
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGL-SRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

PYDGPKVDIWALGVLLYYMVT-GIFPFVG-----STLSEISKEVLQG-RYEIPYN--------LSKDLRSMIGLLLATNARQRPTAQDLLSHPWL
 .  .| |.|. ||... . | |  |  |      . .|. . | || | ..| |         .... ...    . .. .||| ...  |  .
KFT-TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase MarkmA1.AA Pkinase_Tyr 70-167 32 7e-10 34.09 Pfam 52-157 (270) Show / Hide 
Range on Protein: 70-167
Range on HMM: 52-157/270
Sequence Identity: 32% (34 aa)

SEVEIMKML-SHPNIVSLLQVIE-TEQN--IYLIMEVAQGTQLHNRVQE----ARCLKEDEARSIFVQLLSAIGYCHGEGVVHRDLKPDNVIVDEHGNVK
.|..||| | .|||||.|. |.   ..   ||..|| ...  |..  ..     . |.  .  .. .|  ..  | .  . .||||   |. |.| . ||
REAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVK

IVDFGL
| ||||
ICDFGL
Kinase MarkmA1.AA APH 140-166 25 0.000922 13.71 Pfam 170-200 (248) Show / Hide 
Range on Protein: 140-166
Range on HMM: 170-200/248
Sequence Identity: 25% (8 aa)

EGVVHRDLKPDNVIVD--EHGNVK--IVDFG
....|.|..|.||..|  . |.    ..|..
PCWCHGDFHPGNVMWDPRPDGGRVTGVIDWD
UBA_CAMKL MarkmA1.AA UBA_CAMKL 294-331 36 5.3e-13 44.77 In-house 1-41 (41) Show / Hide 
Range on Protein: 294-331
Range on HMM: 1-41/41
Sequence Identity: 36% (15 aa)

DPDIMAAMKNI--GFHVQDIRESLKHRKF-DETMATYNLLR
|..|.. |...  ||. ..|.|||. .|. .. .||| || 
DEEIIQEMCKMWHGFDREEIIESLRNNKYHNHITATYYLLL