Gene MEKK15 (Mouse)

MEKK15

Species: Mouse
Alias: MEKK15
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , iHOP
Annotation:

Classification

Group: STE
Family: STE11
Subfamily: MEKK15

Sequence

Name Sequence Type Origin Length Description Download
MEKK15.NA RNA Sugen 4571 None Fasta, JSON
MEKK15.AA Protein Sugen 1514 None Fasta, JSON
MEKK15.kin_dom Protein Kinase Domain None 264 None Fasta, JSON

Protein domain

Protein domains of MEKK15.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ank MEKK15.AA Ank 43-75 39 2.8e-07 30.51 Pfam 1-33 (33) Show / Hide 
Range on Protein: 43-75
Range on HMM: 1-33/33
Sequence Identity: 39% (13 aa)

TGNTPLITAAEENLAEVVEILLEGGADITLCNY
 |.|||  |.. . .|||. ||. |||. . . 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank MEKK15.AA Ank 76-84 44 75.502822 0.1 Pfam 1-9 (33) Show / Hide 
Range on Protein: 76-84
Range on HMM: 1-9/33
Sequence Identity: 44% (4 aa)

SNQTALHVA
  .|.||.|
DGFTPLHLA
Ank MEKK15.AA Ank 135-180 32 0.017113 13.25 Pfam 1-33 (33) Show / Hide 
Range on Protein: 135-180
Range on HMM: 1-33/33
Sequence Identity: 32% (15 aa)

HGLTPLMLAVRDVDLFESLDLLTAYRPDEVLAELLRHHADPKLCDF
.| |||.||.|                 ||. .|| | ||. . | 
DGFTPLHLACRCG-------------HTEVVKMLLQHGADVNAQDD
Kinase MEKK15.AA MEKK15 1248-1511 81 1.1e-219 736.12 In-house 1-264 (264) Show / Hide 
Range on Protein: 1248-1511
Range on HMM: 1-264/264
Sequence Identity: 81% (216 aa)

WTKGEILGRGAYGTVYCGLTSLGQLIAVKQVALDTSDKLATEKEYRKLQEEVDLLKALKHVNIVAYLGTCLEENTLSIFMEFVPGGSISSIINRFGPLPE
|.||.|||.|||||||||||..|||||||||.||..||......||||||||||||.|||.|||||||.|||.|...|||.|||||||||||||||||.|
WKKGNILGKGAYGTVYCGLTNTGQLIAVKQVELDEIDKEKAKQQYRKLQEEVDLLKTLKHKNIVAYLGVCLEDNVVNIFMQFVPGGSISSIINRFGPLDE

MVFCKYTRQILQGVAYLHDNCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLAWAGLNGTHSDMLKSMRGTPYWMAPEVINESGYGRKSDIWSIGCTVFEM
|||||||.||||||.|||.||||||||||||||||||||||||||||||||.|.|.|.|||||||||||||||||||||.|.||||||||||||||||||
MVFCKYTKQILQGVQYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLCWQGINRTHSDMLKSMRGTPYWMAPEVIMETGYGRKSDIWSIGCTVFEM

ATGKPPLASMDRMAAMFYIGAHRGLMPPLPARFSEPAADFVRLCLTRDQHERPSALQLLKHSFL
||.|||.|.||||||||||||||..||.||..|||.|..|||.||||||||||.|.|||||.|.
ATRKPPWADMDRMAAMFYIGAHRDPMPQLPVKFSEDARMFVRMCLTRDQHERPTASQLLKHPFI
Kinase MEKK15.AA STE11 1248-1511 47 2.7e-166 558.75 In-house 1-303 (303) Show / Hide 
Range on Protein: 1248-1511
Range on HMM: 1-303/303
Sequence Identity: 47% (145 aa)

WTKGEILGRGAYGTVY-CGLTSLGQLIAVKQVALDTSDKL--ATEKEYRK------LQEEVDLLKALKHVNIVAYLGTCL---EENTLSIFMEFVPGGSI
|.||||.|.||.|||| |  .. |.|.||||.... ....   .||||..      .|||. |.| |.| ||| |.|.||   ......||||..||||.
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

SSIIN-RFGP--LPEMVFCKYTRQILQGVAYLHDNCVVHRDIKGNNVMLMPTGI-IKLIDFGCAKRLAWAGLNGTHSDM----LKSMRGTPY--------
||... ..||  ..|||..|||.|||.|..|||.....|||||| |..|. .|. .||.|||||||||| ........|    .|||.||||        
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPM

WMAPEVINESG---YGRKSDIWSIGCTVFEMATGKPPLASMDR--MAAMFYIGAHRGLMPPLPARFS------EPAADFVRLCLTRDQHERPSALQLLKH
|||||||...|   ||||.||||.||||.|||||||| . .|.  |||||.||.... .||.| ..|      |.. ||.|.|...|...||.| |||.|
WMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQH

SFL
.|.
PFI
Kinase MEKK15.AA STE 1248-1511 30 1.5e-117 396.82 In-house 1-359 (359) Show / Hide 
Range on Protein: 1248-1511
Range on HMM: 1-359/359
Sequence Identity: 30% (113 aa)

WTKGEILGRGAYGTVYCGLTS----------------LGQLIAVKQVALDTSDKLATE------------KEYRKLQEEVDLLKALK--HVNIVAYLGTC
|.. |..|.||.||||...                   |...|.||. |.....   |            .|  ....|....| ..  | ||| |.|..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

LEE-------NTLSIFMEFVPGGSISSIIN-RF-------------GPLPEMVFCKYTRQILQG-VAYLHDNCVVHRDIKGNNVMLMPTGIIKLIDFGCA
. |       ..| |.||...|||...||. ..             ...|| . ....||||.|  .|||.. ..|||||. |..|     .||.|||..
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC

KRLAWAGLNG----------THSDMLKSMRGTPYWMAPEVINE------SGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHR---------
..|.  . |.          | . . ... ||| |||||||.       .||..|.||||.|||. ||||||||.. |  | |||.|             
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

----GLMPPLP-------------------ARFSEPAADFVRLCLTRDQHERPSALQLLK--HSFL
    |  ||||                    ..|..  ||...||..| ..||.| ||||  |.|.
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MEKK15.AA STE11-Unclassified 1248-1511 40 2.2e-114 386.32 In-house 1-308 (308) Show / Hide 
Range on Protein: 1248-1511
Range on HMM: 1-308/308
Sequence Identity: 40% (124 aa)

WTKGEILGRGAYGTVYCGL-TSLGQLIAVKQVALDTSD--KLATEKE-YRKLQEEVDLLKALKHVNIVAYLGTC--LEENTLSIFMEFVPGGSISSIINR
| |||..|.|..|.|| .. .. |...||||.    ..    . .|| .  .|.|. .|| | | ||| |.|.    .|. ..|||| .|||||.| .|.
WQKGEFIGKGSFGQVYKCMNCNTGEFMAVKQIEIHDYNSQQEDMQKEMIQSIQKEMKVLKQLNHKNIVQYYGCEIHKHEDCINIFMEYMPGGSIWSMLNK

FGPLPEMVFCKYTRQILQGVAYLHDNCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLA----------------WAGLN-GTHS--DMLKSMRGTPY---
.|.. |||  |||.|||.|.|||| . ..|||||| |. .   ||.|| ||||||  .                   .   . |   ..|||.||||   
YGCFDEMVIKKYTKQILEGLAYLHSHGIIHRDIKGANILIDFDGICKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHINSQQNHCKSMQGTPYQPF

WMAPEVIN---ESGYGRKSDIWSIGCTVFEMATGKPPLASMDR---MAAMFYIGAHRGLMPPLPARFS-----------EPAADFVRLCLTRDQHERPSA
|||||||.   . |..|||||||.|||| ||||||.| .  .    |.|...|..  .  |..| . |           . . || |.|...| ..||.|
WMAPEVIKNSTQTGHCRKSDIWSLGCTVIEMATGKHPWSNCQNDNFMWAIMKIVM-SNQIPQIPEHLSPVCDFISCWISQECKDFLRKCFQIDPKKRPTA

LQLLKHSFL
 |||.|.|.
NQLLQHPFI
Kinase MEKK15.AA MEKK2 1248-1511 50 5.6e-99 335.13 In-house 1-262 (262) Show / Hide 
Range on Protein: 1248-1511
Range on HMM: 1-262/262
Sequence Identity: 50% (134 aa)

WTKGEILGRGAYGTVY-CGLTSLGQLIAVKQVALDTSDKLATEKEYRKLQEEVDLLKALKHVNIVAYLGTCLEENT---LSIFMEFVPGGSISSIINRFG
| .| .|| ||.| || |     |  .|||||  |  |   | || . |. |..||| |.|  || | | ||..|    ||||||..||||.   .  .|
WRRGKLLGQGAFGRVYVCYDVDTGRELAVKQVQFDP-DNPETRKEVQALECEIQLLKNLQHERIVQYYG-CLRDNQEKTLSIFMEYMPGGSVKDQLKAYG

PLPEMVFCKYTRQILQGVAYLHDNCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLAWAGLNGTHSDMLKSMRGTPYWMAPEVINESGYGRKSDIWSIGCT
.| | |  ||||||| |..||||. .||||||| |..   .| .|| ||| .|||    . .|    .||. ||||||.|||||  ||||| |.||||||
ALTETVTRKYTRQILEGMHYLHDHMIVHRDIKGANILRDSSGNVKLGDFGASKRLQTICMHIT---GMKSVTGTPYWMSPEVINGEGYGRKADVWSIGCT

VFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPARFSEPAADFVRLCLTRDQHERPSALQLLKHSFL
| || | ||| |  . |||.| | | .   | ||   |. | ||...|  . . .||||  ||.| | 
VVEMLTEKPPWAEYEAMAAIFKI-ATQPTNPQLPQHVSQHARDFLKRCFVEIKQDRPSAEELLRHHFV
Kinase MEKK15.AA S_TKc 1248-1511 28 1.8e-92 314.39 SMART 1-231 (231) Show / Hide 
Range on Protein: 1248-1511
Range on HMM: 1-231/231
Sequence Identity: 28% (81 aa)

WTKGEILGRGAYGTVYCGLTSL-GQLIAVKQVALDTSDKLATEKEYRKLQEEVDLLKALKHVNIVAYLGTCLEENTLSIFMEFVPG--GSISSIINRFGP
.......|.||.|.||..     |.. |.|..              .... |...||  .| ||| ..... . . | ..||...|  |.  ..| . |.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

------LPEMVFCKYTRQILQGVAYLHDNCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLAWAGLNGTHSDMLKSMRGTPYWMAPEVINESGYGR-KSDI
      .|| . ..|..||.....|.|.. ..|||.|  |..|     ||..||| |..|             ... |||..|||||.   |||. |.|.
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------TTFCGTPWYMAPEVL---GYGKCKCDW

WSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPARFSEPAADFVRLCLTRDQHERPSALQLLK-------HSFL
||.||...||..|.||      |..|| .              |..| ||.| ||..|  .||.| ..|.       | ..
WSCGCILYEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MEKK15.AA Pkinase 1248-1511 28 6e-82 283.35 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1248-1511
Range on HMM: 1-293/293
Sequence Identity: 28% (85 aa)

WTKGEILGRGAYGTVYCGLTSLGQL-IAVKQVALDTSDKLATEKEYRKLQEEVDLLKALKHVNIVAYLGTCLEENTLSIFMEFVPGG----SISSIIN--
...|...|.|..|.|| .     .   |||.. .. ..|   ... |.|  |. ..| |.| ||| ..... ... . . ||...||    . ...|   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

RFGPL--PEMVFCKYTRQILQGVAYLHDNCVVHRDIKGNNVMLMPTGII----KLIDFGCAKRLAWAGLNGTHSDMLKSMRGTPYWMAPEVIN-ESGYGR
| |..  .| . ..| .|||.|..|.|.. ..|||.|  |...  .| |    |..|||.|| .        ..  ...  |||..||||||.  ..||.
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

KSDIWSIGCTVFEMATGKPPLA------SMDRMAAMFYIGAHRGLMPPLPARFS-------------------EPAADFVRLCLTRDQHERPSALQLLKH
|.|.||.||...||..|.||        . ... .|..   .. |. . |   |                   |.. ||.. ||..| ..||.| |.|.|
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

SFL
 ..
PWF
Kinase MEKK15.AA STE20 1248-1511 36 7.4e-81 274.94 In-house 1-288 (288) Show / Hide 
Range on Protein: 1248-1511
Range on HMM: 1-288/288
Sequence Identity: 36% (108 aa)

WTKGEILGRGAYGTVYCGLT-SLGQL----IAVKQVALDTSD--KLATEKEYRKLQEEVDLLKALKHVNIVAYLGTCLEE----NTLSIFMEFVPGGSIS
... | .|.|.||.|| .   . |..    .|.|.. |.. |  .    .| . .| |.. .| .|| |||.|.|. | .    . | | ||.  |||..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQ----DEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLT

SIINRFG---------PLPEMVFCKYTRQILQGVAYLHDNCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLAWAGLNGTHSDM--LKSMRGTPYWMAPEV
 |....          |. |      .|..||| .||| | ..|||||..|..|   | .||.||| .  |   |   . ..    ... ||||||||||
DIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHG-R-D-TMQFKRNTFVGTPYWMAPEV

INE-----SGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPL------PARFSEPAADFVRLCLTRDQHERPSALQLLKHSFL
|..     .||. |.|||| | |  |||.|.||.. | .| |||.|   .. .||.      | ..|    ||| .||..| ..||.| |||||.|.
IQCMEGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIP--KNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase MEKK15.AA ASK 1253-1511 43 1.1e-78 261.33 In-house 1-254 (254) Show / Hide 
Range on Protein: 1253-1511
Range on HMM: 1-254/254
Sequence Identity: 43% (115 aa)

ILGRGAYGTVYCGLTSLGQL-IAVKQVALDTSDKLATEKEYRKLQEEVDLLKALKHVNIVAYLGTCLEENTLSIFMEFVPGGSISSIIN-RFGPLP--EM
.||.|.||.|| |     |  ||.| .    |       . . |.||. | | |.| ||| |||.| |.. . |||| |||||.|...  ..||.   | 
VLGKGTYGIVYAGRDMHTQVRIAIKEIPERDSR------YVQPLHEEIALHKQLRHRNIVQYLGCCSENGYFKIFMEQVPGGSLSALLRSKWGPMKDNEN

VFCKYTRQILQGVAYLHDNCVVHRDIKGNNVMLMP-TGIIKLIDFGCAKRLAWAGLNGTHSDMLKSMRGTPYWMAPEVINES--GYGRKSDIWSIGCTVF
    ||.|||.|. |||.| .||||||| ||..    |..|. ||| .|||  ||.|     . .. .||  .|||||| .   |||.  ||||.|||. 
TMNFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTCKRL--AGIN----PCTETFTGTLQYMAPEVIDQGQRGYGKPADIWSFGCTMV

EMATGKPPLASMDR-MAAMFYIGAHRGLMPPLPARFSEPAADFVRLCLTRDQHERPSALQLLKHSFL
||||||||   ..   |||| .| ..   |..|  .|. . .|.. |   | ..|.|| .||.  ||
EMATGKPPFHELGEPQAAMFKVGMYK-KHPEIPEELSAECKNFILRCFEPDPCKRASAQDLLQDPFL
Kinase MEKK15.AA Dicty2 1248-1511 39 8.6e-75 254.78 In-house 1-264 (264) Show / Hide 
Range on Protein: 1248-1511
Range on HMM: 1-264/264
Sequence Identity: 39% (108 aa)

WTKG-EILGRGAYGTVYCGL-TSLGQLIAVKQVALDTSDKLATEKEYRKLQEEVDLLKALKHVNIVAYLGTCLEENTLSIFMEFVPGGSISSIINRFGPL
 . | |..|.|| |||| || .  |.  | ||. .    ..  |.    .  |..||| |.| ||| |..    || | |..|.. .|| | ||..||..
YQIGDEKIGKGAFGTVYKGLHIETGDFVAIKQINIMKKKTKISEEQHQSIMQEIHLLKKLNHHNIVKYIEHIETENHLYIILEYIENGSLSKIIKKFGCF

PEMVFCKYTRQILQGVAYLHDNCVVHRDIKGNNVMLMPTGI---IKLIDFGCAKRLAWAGLNGTHSDMLKSMRGTPYWMAPEVINESG--YGRKSDIWSI
||   | | .|.|.| .||| . |.|||||. |      |    ||| ||| |  ..        .|   .  |||||||||||  ||     ..|||| 
PESLCCIYIYQVLKGLVYLHRQGVIHRDIKAANILITKEGKSGVIKLADFGVATHIDY-----SDDDSRYTVVGTPYWMAPEVIQMSGNHCCTACDIWSL

GCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPARFSEPAADFVRLCLTRDQHERPSALQLLKHSFL
|||. |. || ||      |.||| .       ||||   | . .||   |  .|  .|..| |||.|  .
GCTIIELLTGNPPYWDLNPMHAMFRMVQDD--HPPLPNDISPECKDFLMQCFCKDPNQRMTAKQLLHHPWI
Kinase MEKK15.AA YSK 1248-1511 37 2e-72 217.26 In-house 1-257 (257) Show / Hide 
Range on Protein: 1248-1511
Range on HMM: 1-257/257
Sequence Identity: 37% (101 aa)

WTKGEILGRGAYGTVYCGLTSL-GQLIAVKQVALDTSDKLATEKEYRKLQEEVDLLKALKHVNIVAYLGTCLEENTLSIFMEFVPGGSISSIINR--FGP
.|| |  ||| .| || |     .. .|.| . |. .     | |   .| |.  |  ..  .|  |.|. |.   | | ||.  |||... . .   |.
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHA-----EDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQ

LPEMVFCKYTRQILQGVAYLHDNCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLAWAGLNGT-HSDMLKSMRGTPYWMAPEVINE--SGYGRKSDIWSIG
..|.      | ||.|  ||| . ..|||||  || |   | .|| ||| | ..       |  .  .  . ||||||||||| .  |.|  | ||||.|
FDEKYIAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQI-------TDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLG

CTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPA-RFSEPAADFVRLCLTRDQHERPSALQLLKHSFL
 |  |||.| ||.. .. | .|| |       | |    .| .. .|| .||  |  .|||| .||||.| 
ITAYEMAKGEPPYCDYHPMRVMFLIPKNNP--PKLEGRSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase MEKK15.AA STE-Unique 1321-1511 30 5.7e-54 185.63 In-house 367-616 (616) Show / Hide 
Range on Protein: 1321-1511
Range on HMM: 367-616/616
Sequence Identity: 30% (77 aa)

NTLSIFMEFVPGGSISSIINRFGP---------LPEMVFCKYTRQILQGVAYLHDNC--VVHRDIKGNNVMLMPTG-----IIKLIDFGCAKRLAWAGL-
|.. ||||. ..|. . ||.| |.         .||    .||.||| |  |||     ..|||.| .|...|  |      .|. ||| |....  .. 
NWVWIFMEYCEHGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFE

------------NGTHS-------------------DMLKSMRGTPYWMAPEVINES-----GYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIG
            | . .                     .|...||| .|.|||||       .|..|.||||.||..|.|..| ||     .| | ... 
KDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMC

AHRGLMPP------LPARFSEPAADFVRLCLTRDQHERPSALQLLKHSFL
 |    ||       |  .. . ..| ..|| |. | |||| |||.| .|
IHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase MEKK15.AA TyrKc 1248-1511 24 5.1e-26 93.67 SMART 1-280 (280) Show / Hide 
Range on Protein: 1248-1511
Range on HMM: 1-280/280
Sequence Identity: 24% (72 aa)

WTKGEILGRGAYGTVYCGLTSLGQLIAVKQVALDTSDKLATEKEYRKLQEEVDLLKAL--KHVNIVAYLGTCLEE-------NTLSIFMEFVPGGSISSI
 |.|..||.||.|.|| |  .  .  ||| .  |.          . . .|  ... |  .| |||. .| |...         | | ||..|.|.  . 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

INRFGP-LPEMVFCKYTRQILQGVAYLHDNCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLAWA---GLNGTHSDMLKSMR--GTP-----YWMAPEVIN
. . .| |.   ....  || .| .|||.....|||.   |...   ...|  ||| .. .      |     .|. ...   |.       |||||.||
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG---ESKDYYRKKEHKGGKTMLPIRWMAPECIN

ESGYGRKSDIWSIGCTVFEMAT-GKPPLAS-----MDRMAAMFYIGAHRGLMPPLP------ARFSEPAADFVRLCLTRDQHERPSALQLLKHSFL
.. .  |||.|| | . .|. | |..|        |.   .. |. . . ...|         . ..   .  . |  .| ..||.  ..  |...
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase MEKK15.AA Pkinase_Tyr 1248-1374 26 2.4e-21 72.92 Pfam 1-137 (270) Show / Hide 
Range on Protein: 1248-1374
Range on HMM: 1-137/270
Sequence Identity: 26% (38 aa)

WTKGEILGRGAYGTVYCGLTS-----LGQLIAVKQVALDTSDKLATEKE--YRKLQEEVDLLKAL-KHVNIVAYLGTCL-EENT--LSIFMEFVPGGSIS
 |.|. ||.||.|.|| |         ..  ||| .  .     |....   ... .|. ..| | .| ||| ..| |. ..    . | ||..|.|.  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE----GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

SIINR----FGPLPEMVFCKYTRQILQGVAYLHDNCVVHRDI
.   .     .||.    ... .|| .| .||...  .|||.
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase MEKK15.AA Pkinase_Tyr 1420-1475 37 5.6e-09 31.02 Pfam 180-237 (270) Show / Hide 
Range on Protein: 1420-1475
Range on HMM: 180-237/270
Sequence Identity: 37% (22 aa)

WMAPEVINESGYGRKSDIWSIGCTVFEMAT-GKPP-LASMDRMAAMFYIGAHRGLMPP
|||||.||.. .  |||.|| | . .|. | |. |  . |.    . ||. ... ||.
WMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPC
Kinase MEKK15.AA STE-Unique 1249-1320 26 1.8e-08 25.62 In-house 1-73 (616) Show / Hide 
Range on Protein: 1249-1320
Range on HMM: 1-73/616
Sequence Identity: 26% (19 aa)

TKGEILGRGAYGTVYCGL-TSLGQLIAVKQVALDTSDKLATEKEYRKLQEEVDLLKALKHVNIVAYLGTCLEE
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NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYGHWLWG