Gene MAP3K6 (Mouse)

MAP3K6

Species: Mouse
Alias: Map3k6, MAP3K6
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: STE
Family: STE11
Subfamily: ASK

Sequence

Name Sequence Type Origin Length Description Download
MAP3K6.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 262 Kinase domain by global Sugen HMM Fasta, JSON
MAP3K6.AA Protein Sugen 1291 None Fasta, JSON
MAP3K6.NA RNA Sugen 4333 None Fasta, JSON

Protein domain

Protein domains of MAP3K6.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ASK_nterm_v5 MAP3K6.AA ASK_nterm_v5 96-150 52 4.7e-26 92.88 In-house 1-55 (55) Show / Hide 
Range on Protein: 96-150
Range on HMM: 1-55/55
Sequence Identity: 52% (29 aa)

PFATLALGDTAALDSFYNADVVVLEVSSSLAQPSLFYHLGVRESFSMTNNVLLCS
.| .|  |.|. .|.|||||||. ..|    ||.||||||||.|| |.||..|. 
EFMRLDFGETDMFDEFYNADVVIVDMSIDHQQPNLFYHLGVRHSFKMRNNIILYC
TPR_ASK_1 MAP3K6.AA TPR_ASK_1 275-308 50 1.7e-20 67.64 In-house 1-38 (38) Show / Hide 
Range on Protein: 275-308
Range on HMM: 1-38/38
Sequence Identity: 50% (19 aa)

PDIVMNLLLSYRDVQDYSAIIELVETLQ---ALPTC-D
.|||.|...||||.|||...|||||.|.   ..|.| .
GDIVHNFMHSYRDIQDYDSMIELVEDLKEGEHIPNCCK
TPR_ASK_2 MAP3K6.AA TPR_ASK_2 351-393 50 5.5e-31 98.05 In-house 1-46 (46) Show / Hide 
Range on Protein: 351-393
Range on HMM: 1-46/46
Sequence Identity: 50% (23 aa)

PDLYCMCGRIYKDMFFTSGFQN---AGHLEQAYHWYRKAFDVEPSL
||..|||||||||||. |....   .....||.|||||.|...|..
PDMWCMCGRIYKDMFLESQYTDEAARESRDQAIHWYRKGFEIQPNH
TPR_ASK_3 MAP3K6.AA TPR_ASK_3 439-472 38 3.6e-17 63.35 In-house 1-34 (34) Show / Hide 
Range on Protein: 439-472
Range on HMM: 1-34/34
Sequence Identity: 38% (13 aa)

YWDVGFYLGAQILANDPIQVVLAAEQLYKLNAPI
||||.......|||.|. ....|.|...||..|.
YWDVATFFEISILACDYHKCMQACECMFKLKPPN
Kinase MAP3K6.AA ASK 654-907 78 1.4e-189 635.99 In-house 1-254 (254) Show / Hide 
Range on Protein: 654-907
Range on HMM: 1-254/254
Sequence Identity: 78% (200 aa)

VLGRGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHKRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYT
|||.||||.||||||.||.||||||||||||||..|||||||||||.|||.|||.|||..|..||.|||||.|||||||.||||.|||.||||.|..|||
VLGKGTYGIVYAGRDMHTQVRIAIKEIPERDSRYVQPLHEEIALHKQLRHRNIVQYLGCCSENGYFKIFMEQVPGGSLSALLRSKWGPMKDNENTMNFYT

RQILQGLSYLHENRIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHEL
.|||.||.|||||.||||||||||||.||.||..|||||||.||||||.||||||||||||||||.||||.|||||.|||||.|||..|||||.||||||
KQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTCKRLAGINPCTETFTGTLQYMAPEVIDQGQRGYGKPADIWSFGCTMVEMATGKPPFHEL

GSPQAAMFQVGMYKVHPPVPGSLSAEAQAFLLRTFEPDPRLRASAQELLGDPFL
|.||||||.|||||.||..| .||||...|.||.|||||. |||||.|| ||||
GEPQAAMFKVGMYKKHPEIPEELSAECKNFILRCFEPDPCKRASAQDLLQDPFL
Kinase MAP3K6.AA STE11 649-907 42 6.8e-158 530.84 In-house 1-303 (303) Show / Hide 
Range on Protein: 649-907
Range on HMM: 1-303/303
Sequence Identity: 42% (130 aa)

TGERLVLGRGTYGVVYAGRDRHTRVRIAIKEIPERDSR--------FSQP------LHEEIALHKRLRHKNIVRYLGS---ASQGGYLKIFMEEVPGGSL
  .. ..|.|..|.||.... .| ...|.|.|......        . |.      ..|||.|.| |.|||||||.|.    .| ....|||| .|||||
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

SSLLRSVWGPLKDNESTISFYTRQILQGLSYLHENRIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTET----------FTGTLQ--------
||.||. |||.|..|..|..||.|||.||.|||...|.||||||.|.|... ....|..|||..||||.|..||..          .|||..        
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPM

YMAPEIIDQGPRG-YGKAADIWSLGCTVIEMATGRPPFHELGS-PQAAMFQVGMY-KVHPPVPGSLS------AEAQAFLLRTFEPDPRLRASAQELLGD
.||||.|.|..|. ||..||||||||||||||||.||.|.... ..|||| .||. | ||| | ..|      .|...||...||.||  |..|..|| .
WMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQH

PFL
||.
PFI
Kinase MAP3K6.AA STE 650-907 27 4.3e-104 352.13 In-house 1-359 (359) Show / Hide 
Range on Protein: 650-907
Range on HMM: 1-359/359
Sequence Identity: 27% (101 aa)

GER-LVLGRGTYGVVYAGRDRH---------------TRVRIAIKEIPERDS-----------------RFSQPLHEEIALHKRLR--HKNIVRYLGSAS
 |.  ..|.|..|.|| .....               | ...|||... ...                    | . .|| ..|...  |.|||.|.|.  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

QGG-------YLKIFMEEVPGGSLSSLLRSVWGPLKDN-----------ESTISFYTRQILQG-LSYLHENRIVHRDIKGDNVLINTFSGLLKISDFGTS
..|       .| |.|| ..||||........|..|..           || |....||||.| |.|||...|.|||||..|.|.       |..|||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVC

KRLAGITP----------------CTETFTGTLQYMAPEIIDQGPRG----YGKAADIWSLGCTVIEMATGRPPF---HELGSPQAAMFQVGMY------
..|. . .                 . ||.||  .||||.|.|. .|    |.  .||||||||.||||||.||.   | .    ...|  .|.      
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

----KVHPPVPG-------------------SLSAEAQAFLLRTFEPDPRLRASAQELLG--DPFL
    . .|| |                    ..| | . |. . .. ||. |..|..||    ||.
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MAP3K6.AA S_TKc 649-907 30 2.1e-89 304.21 SMART 1-231 (231) Show / Hide 
Range on Protein: 649-907
Range on HMM: 1-231/231
Sequence Identity: 30% (82 aa)

TGERLVLGRGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHKRLRHKNIVRYLGSASQGGYLKIFMEEVPG--GSLSSLLRSVWGPLK---
     ..|.|..|.|| .|...|  . |||.|.       . .  ||...|. .|.|||.....    ..| ..|| ..|  |.| .....  .. .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

DNESTISFYTRQILQGLSYLHENRIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGK-AADIWSLGCTVIE
 .| .. ||..||...| |.|...|.|||.| .|.|...    .||.||| ...|        || ||. |||||..     |||| ..|.||.||...|
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYE

MATGRPPFHELGSPQAAMFQVGMYKVHPPVPGSLSAEAQAFLLRTFEPDPRLRASAQELLG-------DPFL
|..|.|||.     ...||.. .           | ||  |. . .. ||. | .| |.|        .|..
MLCGYPPFP----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MAP3K6.AA STE11-Unclassified 652-907 33 5.4e-88 298.64 In-house 4-308 (308) Show / Hide 
Range on Protein: 652-907
Range on HMM: 4-308/308
Sequence Identity: 33% (104 aa)

RLVLGRGTYGVVYAGRDRHTRVRIAIKEIPERDSR-----FSQP----LHEEIALHKRLRHKNIVRYLGSA--SQGGYLKIFMEEVPGGSLSSLLRSVWG
. ..|.|..| || . . .|   .|.|.| . |.      . .     . .|... | |.|||||.|.|     ... . |||| .||||..|.|.   |
GEFIGKGSFGQVYKCMNCNTGEFMAVKQIEIHDYNSQQEDMQKEMIQSIQKEMKVLKQLNHKNIVQYYGCEIHKHEDCINIFMEYMPGGSIWSMLNK-YG

PLKDNESTISFYTRQILQGLSYLHENRIVHRDIKGDNVLINTFSGLLKISDFGTSKRLA------------------GIT-PCTE------TFTGTLQ--
..  .|..|. ||.|||.||.|||.. |.||||||.|.||  | |  |..|||..|  .                   |. .  .      .  ||..  
CF--DEMVIKKYTKQILEGLAYLHSHGIIHRDIKGANILID-FDGICKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHINSQQNHCKSMQGTPYQP

-YMAPEIID---QGPRGYGKAADIWSLGCTVIEMATGRPPFHELGS--PQAAMFQVGMYKVHPPVPGSLS-----------AEAQAFLLRTFEPDPRLRA
 .||||.|.   |.  |.. ..|||||||||||||||..|.  .    ...|.. ..| .  |. |  ||           .|...|| ..|. ||  |.
FWMAPEVIKNSTQT--GHCRKSDIWSLGCTVIEMATGKHPWSNCQNDNFMWAIMKIVMSNQIPQIPEHLSPVCDFISCWISQECKDFLRKCFQIDPKKRP

SAQELLGDPFL
.|..|| .||.
TANQLLQHPFI
Kinase MAP3K6.AA Pkinase 654-907 29 1.8e-76 265.19 Pfam 6-293 (293) Show / Hide 
Range on Protein: 654-907
Range on HMM: 6-293/293
Sequence Identity: 29% (86 aa)

VLGRGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHE----EIALHKRLRHKNIVRYLGSASQGGYLKIFMEEVPGG----SLSSLLR-SVWGPLKD
..|.|..|.|| .... |. . |.|.|. |. . ... .     ||...|||.|.||||....   .... . || ..||    .|..... .  |..  
KIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYF

NESTISFYTRQILQGLSYLHENRIVHRDIKGDNVLINTFSGL---LKISDFGTSKRL-AGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTV
 | .. || .|||.|| |.|...|.|||.| .|.||.    .   .||.||| .| .     . . ||.||. |||||.|  | ..||...|.||.||..
SEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-GGQYYGPKVDMWSCGCIL

IEMATGRPPFHEL-----GSPQAAMFQVGMYKVHPPVPGSLS-------------------AEAQAFLLRTFEPDPRLRASAQELLGDPFL
.||..||||| .       .... ...... ..| . | . |                    |.. |. . ...||  | .|...| .|..
YEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MAP3K6.AA MEKK15 648-907 41 5.7e-67 228.8 In-house 2-264 (264) Show / Hide 
Range on Protein: 648-907
Range on HMM: 2-264/264
Sequence Identity: 41% (113 aa)

ETGERLVLGRGTYGVVYAGRDRHTRVRIAIKEIP------ERDSRFSQPLHEEIALHKRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGP
. |.  .||.| || || |      . ||.| .       |.  .  . | ||. | | |.||||| ||| . .   . |||. |||||.||..   .||
KKGN--ILGKGAYGTVYCGLTNTGQL-IAVKQVELDEIDKEKAKQQYRKLQEEVDLLKTLKHKNIVAYLGVCLEDNVVNIFMQFVPGGSISSII-NRFGP

LKDNESTISFYTRQILQGLSYLHENRIVHRDIKGDNVLINTFSGLLKISDFGTSKRLA--GITPCT----ETFTGTLQYMAPEIIDQGPRGYGKAADIWS
|  .|     ||.|||||  ||||| .||||||| ||..    |..|. |||  |||.  ||            ||  .||||.|     |||. .||||
L--DEMVFCKYTKQILQGVQYLHENCVVHRDIKGNNVMLMP-TGIIKLIDFGCAKRLCWQGINRTHSDMLKSMRGTPYWMAPEVIME--TGYGRKSDIWS

LGCTVIEMATGRPPFHELGSPQAAMFQVGMY-KVHPPVPGSLSAEAQAFLLRTFEPDPRLRASAQELLGDPFL
.|||| ||||..||. ..  . |||| .|    . |..|   | .|. |       |   |..| .||  ||.
IGCTVFEMATRKPPWADM-DRMAAMFYIGAHRDPMPQLPVKFSEDARMFVRMCLTRDQHERPTASQLLKHPFI
Kinase MAP3K6.AA STE20 654-907 34 2e-61 210.35 In-house 6-288 (288) Show / Hide 
Range on Protein: 654-907
Range on HMM: 6-288/288
Sequence Identity: 34% (100 aa)

VLGRGTYGVVYAGRDRHTRVR----IAIKEIPERDS----RFSQPLHEEIALHKRLRHKNIVRYLGSASQG----GYLKIFMEEVPGGSLSSLLRS--VW
..|.|.||.|| .....|       .||| .. ..        . .  ||   |...|.|||.|.||   .      | | ||   ||||. ...   ..
KIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMKHCMKC

G------PLKDNESTISFYTRQILQGLSYLHENRIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAG-----ITPCTETFTGTLQYMAPEIIDQGP---R
|      |.  ||. |.. .|..||||.|||.|.|.|||||.||.|... .|  |..||| .  |       . .   || ||  .||||.| .      
GKNHKGHPM--NEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTE-DGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGPDK

GYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPP---V--PGSLSAEAQAFLLRTFEPDPRLRASAQELLGDPFL
||.  .|||||| | ||||.|.||.... .|  |||..   .  ||      | . | | . |. .  . ||  |..|..||  ||.
GYDYKCDIWSLGITAIEMAEGEPPYFDM-HPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase MAP3K6.AA CAMK 654-907 18 1.2e-60 193.79 In-house 1-425 (425) Show / Hide 
Range on Protein: 654-907
Range on HMM: 1-425/425
Sequence Identity: 18% (78 aa)

VLGRGTYGVVYAGRDRHTR------------VRIAIKEIP-----------------ERDSRFS-----------QPLHEEIALHKR-------LRHKNI
.||||..|.|. .....|             .. ||| |.                  ..|. .           . .  ||...|.       |.|.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRYLGSASQGGY-------------------LKIFM---EEVPGG----SLSSLLRSV--------------WGPLKDNESTISFYTRQILQGLSYLHEN
.. .     . |                   . ..|   | ..||     | . ...               .| .  .|.  ..| |||.... |.|..
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRF--TEREARRYFRQICSAVHYCHSH

RIVHRDIKGDNVLINTFS----------------GLLKISDFGTSKRLAGI-----------------------TPCTETFTGTLQYMA-PEIIDQGP--
 |||||.| .|.|... .                . .||.||| .... .                        ..  .|| ||. ||| ||.. . .  
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

----------RGYGKAADIWSLGCTVIEMATGRPPFHE-----------LGSPQAAMFQ---VGMYK-VHPPVPG-------------------SLSAEA
          ..||...|.||.|.    | .|.||| .           .|  .  .|.    | |   .|....                    .|.|.
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

QAFLLRTFEPDPRLRASAQELLGDPFL
. .. .  ..||  |..... | .|..
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MAP3K6.AA MEKK2 654-907 40 2.3e-60 206.85 In-house 6-262 (262) Show / Hide 
Range on Protein: 654-907
Range on HMM: 6-262/262
Sequence Identity: 40% (107 aa)

VLGRGTYGVVYAGRDRHTRVRIAIKEIPERDSRFS-----QPLHEEIALHKRLRHKNIVRYLGSASQGG--YLKIFMEEVPGGSLSSLLRSVWGPLKDNE
.|| | .|.||   |  |   .|.| ..  ..        | |. || | | |.|. || | |   . .   | |||| .||||.   |. ..|.| .. 
LLGQGAFGRVYVCYDVDTGRELAVKQVQFDPDNPETRKEVQALECEIQLLKNLQHERIVQYYGCLRDNQEKTLSIFMEYMPGGSVKDQLK-AYGALTET-

STISFYTRQILQGLSYLHENRIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCT---ETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEM
     |||||| |..|||.. |||||||| |.| .  || .|..||| ||||  |        . |||  .|.||.|.    |||. ||.||.||||.||
-VTRKYTRQILEGMHYLHDHMIVHRDIKGANILRDS-SGNVKLGDFGASKRLQTICMHITGMKSVTGTPYWMSPEVING--EGYGRKADVWSIGCTVVEM

ATGRPPFHELGSPQAAMFQVGMYKVHPPVPGSLSAEAQAFLLRTFEPDPRLRASAQELLGDPFL
 | .||. |     ||.|..   .  | .| ..| .|  || | |      | ||.|||   | 
LTEKPPWAEYEA-MAAIFKIATQPTNPQLPQHVSQHARDFLKRCFVEIKQDRPSAEELLRHHFV
Kinase MAP3K6.AA Ciliate-E2 654-907 19 2.4e-55 188.45 In-house 6-365 (365) Show / Hide 
Range on Protein: 654-907
Range on HMM: 6-365/365
Sequence Identity: 19% (73 aa)

VLGRGTYGVVYAGRDRHTRVR-----------------------IAIKEIPERD-SRFSQPLHEEIALH------------KRLRHKNIVRYLGSAS--Q
..|.|..|.|| .... .. .                       .|.| . ...   ..| .|.   ..            ..| |.||...  .    .
KIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKD

GGYLKIFMEEVPGGSLSSLLRSVWGPLKDN--------ESTISFYTRQILQ---------------GLSYLHENR-IVHRDIKGDNVLINTFSGLLKISD
  .. . || . ||.| ..... .   . .        |  |.....||||               .| |||..  |.||||| .|.|.      .||.|
DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------IKIID

FGTSKRLAGI----------TPCTETF----------------------TGTLQYMAPEIIDQGP-------RGYGKAADIWSLGCTVIEMATGRPPFHE
||.||..               ... .                       ||. ||||||.  ..        ||....||||||..  || .|.|||  
FGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--

LGSPQAAMFQVGMYKVHPP--------------VPGSLSAEAQAFLLR----TFEPDPRLRAS-AQELLGDPFL
         . . ..  .|               . ..| |.. .. .     .. ||  | . ....|  |..
-----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase MAP3K6.AA Dicty2 654-907 37 2e-53 183.78 In-house 7-264 (264) Show / Hide 
Range on Protein: 654-907
Range on HMM: 7-264/264
Sequence Identity: 37% (98 aa)

VLGRGTYGVVYAGRDRHTRVRIAIKEIP----ERDSRFSQP--LHEEIALHKRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNES
..|.|  |.|| | .  |    ||| |           .|   .  || | |.|.| |||.|...     .| |..| . .||||  .    |..   ||
KIGKGAFGTVYKGLHIETGDFVAIKQINIMKKKTKISEEQHQSIMQEIHLLKKLNHHNIVKYIEHIETENHLYIILEYIENGSLSKIIKK-FGCFP--ES

TISFYTRQILQGLSYLHENRIVHRDIKGDNVLINTF--SGLLKISDFGTSKRLA--GITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEM
 .. | .|.|.|| |||.. ..|||||..| ||..   ||  | .|||.   ..   ... . |. ||   ||||.|         | ||||||||.||.
LCCIYIYQVLKGLVYLHRQGVIHRDIKAANILITKEGKSGVIKLADFGVATHIDYSDDDSRY-TVVGTPYWMAPEVIQMSGNHCCTACDIWSLGCTIIEL

ATGRPPFHELGSPQAAMFQVGMYKVHPPVPGSLSAEAQAFLLRTFEPDPRLRASAQELLGDPFL
 || ||   |. | .|||       ||| |   |.|   ||.. |  || .|..|..||  | .
LTGNPPYWDLN-PMHAMFRM-VQDDHPPLPNDISPECKDFLMQCFCKDPNQRMTAKQLLHHPWI
Kinase MAP3K6.AA Pkinase_Tyr 654-850 27 7e-22 74.72 Pfam 6-216 (270) Show / Hide 
Range on Protein: 654-850
Range on HMM: 6-216/270
Sequence Identity: 27% (59 aa)

VLGRGTYGVVYAGRDR----HTRVRIAIKEIPERDSRF---SQPLHEEIALHKRL-RHKNIVRYLGSAS-QGGY--LKIFMEEVPGGSLSSLLRSV--WG
.||.| .|.|| |. .     |..  |.| ..|  .     .. . .|... | | .|.||||..|  . ||.   . | || .|.|.| . ||.   ..
KLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDK

PLKDNESTISFYTRQILQGLSYLHENRIVHRDIKGDNVLINTFSGLLKISDFGTSKRL-----AGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWS
.  . .  ...  .|| .|..||......|||.   |.|..  ..  ||.||| .. .       ..  ...       |||| |  |   .  . |.||
QPLTMKDLLQM-CWQIAKGMEYLESKNCIHRDLAARNCLVTE-NNVVKICDFGLARDIYNDDYY-YRKRGGGK-LPIKWMAPECINYGK--FTTKSDVWS

LGCTVIEMAT-GRPP-F
 | .  |. | |. | .
FGVLMWEIFTYGEQPTY
Kinase MAP3K6.AA TyrKc 649-905 23 1.1e-16 46.8 SMART 1-280 (280) Show / Hide 
Range on Protein: 649-905
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

TGERLVLGRGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHKRL--RHKNIVRYLGSASQG-------GYLKIFMEEVPGGSLSSLLRSVW
     .||.| .|.|| |. .   .  |.| . |      . ...|. . ..|  .|.|||| .| ..|.       . | | || .|.|.| . ||.  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

GPLKDNESTISFYTRQILQGLSYLHENRIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGI---------TPC----TETFTGTLQYMAPEIIDQGPRG
.    . ..   .  || .| .|||.....|||.   |.|..      |||||| |. .                    . .   .  |||| |     |
PK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NYG

-YGKAADIWSLGCTVIEMAT-GRPPFHEL----GSPQAAMFQVGMYKVHPPVPG-------SLSAEAQAFLLRTFEPDPRLRASAQELLGDP
 .  . |.|| | .  |. | | .|  .      |.| .. .|   .  |. |          ..|     ..  . ||  | . .|.  . 
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Sam7 MAP3K6.AA sam7 1215-1277 19 2.3e-09 31.24 In-house 1-70 (70) Show / Hide 
Range on Protein: 1215-1277
Range on HMM: 1-70/70
Sequence Identity: 19% (14 aa)

PKDQNLVRWLQELSV--DPATIQTLLSHSF-----TLQTLLTCATQDDLVYTRI-RGGMVCRIWRAILAQR
. ..... ||...    ..  ......| .     ....|.   |..||    | |.|  ..||..|   |
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLC-HMTEEDLMEMGITRPGHRKKIWNHIQQMR