Gene MAP2K6 (Mouse)
MAP2K6
Sequence
Protein domains of MAP2K6.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | MAP2K6.AA | MEK3 | 53-314 | 76 | 3e-236 | 791.13 | In-house | 1-264 (264) | Show / Hide |
Range on Protein: 53-314 Range on HMM: 1-264/264 Sequence Identity: 76% (201 aa) LEPIVELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDVSMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVID-KGQTIP ...|.||||||||.|.||||..||.||||||||.|||||||||.|||.|..||..|||.||.||||.|||||||||||.|||.|||||..|.. .|..|| MVVICELGRGAYGIVDKMRHRQSGTIMAVKRIRMTVNSQEQKRMLMDMDICMRSSDCPYTVHFYGAMFREGDVWICMEVMDTCLDKFYRHVYKPHGMHIP EDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINTLGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELA ||||||||.|||.||...|..|.||||||||||||||. |||||||||||||||||.|||||||||||||||||.||.|||||.||||.|||||||||.| EDILGKIAMSIVSALHYMHEQLKVIHRDVKPSNVLINHHGQVKMCDFGISGYLVDSMAKTIDAGCKPYMAPERIDPEMNQKGYDVKSDVWSLGITMIEMA ILRFPYDSWGTPFQQLKQVVEEPSPQLPADK-FSADFVDFTSQCLKKNSKERPTYPELMQHPFF |.|.|||.|.|||||||||||||.||||..| ||.|..||..||||||..|||.|||||.|||. IGRYPYDNWHTPFQQLKQVVEEPPPQLPMEKGFSPDCQDFINQCLKKNYMERPSYPELMEHPFM |
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Kinase | MAP2K6.AA | STE7 | 53-314 | 55 | 4.6e-184 | 617.79 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 53-314 Range on HMM: 1-288/288 Sequence Identity: 55% (161 aa) LEPIVELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNS-QEQKRLLMDLDVSMRTVDCPFTVTFYGALFREGD--VWICMELMD-TSLDKFYKQVID--- || | |||.|.||||.||||.|||.||||||||.|.|. .|||..||.||| ... |||..|.||||...||| .|||||.|| ..|||||| | . LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR --KGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINTLGQVKMCDFGISGYLVDSV-AKTIDAGCKPYMAPERINPELNQKGYSVKSDIWS |. .|||.|||||||...|.|..||.|...|||||||||.|.|. ||||.|||||.|.||||. |.| ..||.||||||||.. |...|.|.||.|| GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDG--NKQHYDVRSDVWS LGITM-IELAILRFPYDSWGT-----------------PFQQLKQVVEE-PSPQLPADKFSADFVDFTSQCLKKNSKERPTYPELMQ-HPFF ||||| ||.|..|.||..| | .|.||...|.| |.|.|| |||..|.|| ..||.|. .|||.|..||. |||. LGITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQPEMAIFEQLTCIVNENPPPRLP--KFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPFI |
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Kinase | MAP2K6.AA | MEK4 | 53-314 | 52 | 2.7e-151 | 497.19 | In-house | 1-275 (275) | Show / Hide |
Range on Protein: 53-314 Range on HMM: 1-275/275 Sequence Identity: 52% (144 aa) LEPIVELGRGAYGVVEKMRHVPSGQIMAVKRIR-ATVN-----SQEQKRLLMDLDVSMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDK |. . |.|.||.|.| ||.| .||.|||||||| .| |||||||..|| |. .|| | ||||.|.||| ||||||||.|.||||| | .. LQDLGEIGNGAFGTVNKMWHKESGKIMAVKRIRCNNVDPDDAFHKEQKRLLMEHDVVMKSENCPYIVKFYGACFKEGDCWICMELMDISMDKFYKYVYMV GQT-IPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINTLGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGI .. |||.|.|.|.| .|.||..| .. .|||||||||.|.. | || |||||.|.||||.||| ||||.|||||||| || |. || ..||.||||| QKSRIPENIMGHITVCTVDALNYLKETHKIIHRDVKPSNILLDRHGCVKLCDFGICGQLVDSIAKTHDAGCRPYMAPERIDPEQNMDGYDIRSDVWSLGI TMIELAILRFPYDSWG--TPFQQLKQVVEEPSPQLPADKF----SADFVDFTSQCLKKNSKERPTYPELMQHPFF ||.|.| .|||. | | |...||. .|.| |.. | ....| || |. ..|| | .| ..||. TMYEVATGKFPYRKWNDASVFDQICMVVKGDPPILHHDHHDMHYSMPMCRFINTCLTKDRNHRPKYDNLKKFPFY |
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Kinase | MAP2K6.AA | MEK7 | 53-314 | 47 | 2.7e-118 | 399.3 | In-house | 1-269 (269) | Show / Hide |
Range on Protein: 53-314 Range on HMM: 1-269/269 Sequence Identity: 47% (127 aa) LEPIVELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDVSMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDK-GQTIP |. | ..| | | | |||| || ||||| | | |. | || |||||| |||. |. .|.. .. |||||||.| | .|| | . || LHHIGDMGHGSCGHVWKMRHKSSGVIMAVKQMRRTGNKEENKRILMDLDVMCMCHDCPYIVQCFGYFMTDSDVWICMECMSTCCDKLLKRIKHPKLDFIP EDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINTLGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINP-ELNQKGYSVKSDIWSLGITMIEL | |.||. |.|..||. | | ...||||||||.|. |..| ||||||| .||| |.| ||| .||||||| | . |. | . .|.||||||..|| EQIIGKMVVAIINALHYLKEKHGIMHRDVKPSNILLDWRGNIKLCDFGISGRMVDSKAHTRSAGCPAYMAPERIDPPDPNNPKYDIRADVWSLGITLVEL AILRFPYDSWGTPFQQLKQVVEE--PSPQLPADK---FSADFVDFTSQCLKKNSKERPTYPELMQHPFF | ..|| . | . . .. ..| || . || || .| .||.|. ..|| |..|||||| ATGQYPYPGCDMEFEMMTKILNDNLEPPCLPEHMKYNFSPDFCQFVDKCLQKDHRMRPKYRMLMQHPFI |
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Kinase | MAP2K6.AA | STE | 53-314 | 29 | 2.7e-109 | 369.38 | In-house | 1-359 (359) | Show / Hide |
Range on Protein: 53-314 Range on HMM: 1-359/359 Sequence Identity: 29% (110 aa) LEPIVELGRGAYG-VVEKMRHVPS--------------GQIMAVKRIR----------------ATVNSQEQKRLLMDLDVSMRTVD-CPFTVTFYGALF .| | ..|.||.| |. .|.| .. |.|||.|... ..|..|....|..... .. . .|. |..||. | WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF REG-------DVWICMELMD-TSLDKFYKQVIDKGQT----------IPEDILGKIAVSIVKA-LEHLHSKLSVIHRDVKPSNVLINTLGQVKMCDFGIS .|| ..|||||.|| |||...|.. .|.. .||.....|...|.|. |..|||. .||||.||.|.|. || ||||.. KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL-----VKLCDFGVC GYLVDSVA----------------KT-IDAGCKPYMAPERINPELNQ--KGYSVKSDIWSLGITMIELAILRFPY-------DSWGTP--------FQQL | |.||.| |. ..|. .||||.|... . |||..|.||||||.|.||.| . |. . .| |.|| GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL KQVVEEPSPQLPAD------------------KFSADFVDFTSQCLKKNSKERPTYPELMQ--HPFF ..|..|.|.|| . |.| .| || ..||.|. ..|||. .|.. |||. -CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI |
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Kinase | MAP2K6.AA | STE7-Unclassified | 53-314 | 38 | 7.50000000001e-103 | 347.99 | In-house | 1-301 (301) | Show / Hide |
Range on Protein: 53-314 Range on HMM: 1-301/301 Sequence Identity: 38% (116 aa) LEPIVELGRGAYGVVEKMRHVP------SGQIMAVKRIRATVN-SQEQKRLLMDLDVSMRTVDCPFTVTFYGALFREGD---VWICMELMDT-SLD---K || . .||.|..|.|.| .|.. .| ||| | |. | . .| .|. | . . .|. |..||| . |. . ||||.|| ||| . LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID FYKQVID----KGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINTLGQVKMCDFGISGYLVDSV--AKTIDAGCKPYMAPERINPE-LNQ ||.. .| .||| .||||| .. ..|..|| |. .||||.||.|.|.| |||| ||||..| |.... ||| .|| ||.||||. . . IYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKT-WVGCQMYMSPERIQGQMPHR KGYSVKSDIWSLGITMIELAILRFPYD------SWGTP--------FQQLKQVVEEPSPQLPADK----FSADFVDFTSQCLKKNSKERPTYPELMQ-HP .|||||||||||.| .|.|....||. .. | .|..|.|.|| |. .|..| || |.|.||...|||.. .| || PSYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQLLNEHP FF . WI |
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Kinase | MAP2K6.AA | MEK5 | 53-314 | 44 | 2.9e-83 | 282.92 | In-house | 1-254 (254) | Show / Hide |
Range on Protein: 53-314 Range on HMM: 1-254/254 Sequence Identity: 44% (119 aa) LEPIVELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDVSMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPE . || | | | | |||||.|.||| | . . ||... .|.. . | |. . |||| | | . || | || |.. ||| IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEI-LYKCDSPYIIGFYGAFFVENRISICTEFMDGGSLDMYRC-------IPE DILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINTLGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAI |||...|.||| |. | . | ..||||||||.|.|| ||.|.||||.| ||.|...| | ||||||| . | . ||.||||| ..|.|. HILGRMTVAIVKGLNYLWN-LKIMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSITRTY-IGTNAYMAPERISGDQ----YGIHSDVWSLGIFFMEMAT LRFPY-----DS-WGTPFQQLKQVVEEPSPQLPADKFSADFVDFTSQCLKKNSKERPTYPELMQHPFF |||| | | | |. .|.| .| || ||||. ||.| ||..| |.|| .|||||| GRFPYPQIQRDQGELMPIQLLQCIVDEHPPRLPVDKFSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI |
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Kinase | MAP2K6.AA | S_TKc | 53-314 | 27 | 1.7e-75 | 258.02 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 53-314 Range on HMM: 1-231/231 Sequence Identity: 27% (76 aa) LEPIVELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDVSMRTVDCPFTVTFYGALFREGDVWICMELMDT---SLDKFYKQVIDKG-- | . ..|.||.|.| | ||. .|.|.|.|.|. .... ... .. ..|. |..|.. ......||..|. .| .. |. .| YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR QTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINTLGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSV-KSDIWSLGIT . .|| ... |..|||..||. .||||.||.|.|... ..| ||||.. | | | ||||| . ||. |.|.||.|.. FPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL-------GYGKCKCDWWSCGCI MIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSADFVDFTSQCLKKNSKERPTYPELMQ-------HPFF ..|.. . |.. .... .|... | .. || ..||.|. ..||| |..| ||.| LYEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | MAP2K6.AA | MEK1 | 53-256 | 43 | 6.2e-65 | 220.77 | In-house | 1-195 (297) | Show / Hide |
Range on Protein: 53-256 Range on HMM: 1-195/297 Sequence Identity: 43% (90 aa) LEPIVELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDVSMRTVDCPFTVTFYGALFREGDVWICMELMD-TSLDKFYKQVIDKGQTIP .| | ||| | ||| |.|| ..| ||| | |. . .. .. .| | . |. | |||| . .|.. |||| || ||| |.. . || FEKIGELGHGNGGVVMKCRHRHTGMIMARKLIHLEIKPAIRNQIIRELQV-LHECNSPYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKA----GRIP EDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINTLGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELA |.||||..| ... | |. | ..||||||||.|.| | .|.||||.|| |.||.| | . ||.||| | |.|.|||||.|. ..|.| EKILGKVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPER----LQGTHYTVQSDIWSMGLSLVEMA ILRFP | |.| IGRYP |
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Kinase | MAP2K6.AA | STE20 | 53-314 | 30 | 2e-58 | 200.44 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 53-314 Range on HMM: 1-288/288 Sequence Identity: 30% (89 aa) LEPIVELGRGAYGVVEKMRHVPSGQI----MAVKRIRATVNS---QEQKRLLMDLDVSMRTVDCPFTVTFYGALFRE----GDVWICMELMDT-SLDKFY | . ..|.|.||.| | .|.|.|.. |.|.. . .|.. .. .. |. ..| |..||. ... . ||.||... || . YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISI-MKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIM KQVIDKGQ-----TIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINTLGQVKMCDFGISGYLVD-------SVAKTIDAGCKPYMAPERINPE |... .|. .. |. | ....|..|||. .||||.| |.|... |.|| .||| .. | . . .|. | .|||| |. . KHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSN-HIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTF-VGTPYWMAPEVIQCM LN-QKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVV--EEPSPQLP---ADKFSADFVDFTSQCLKKNSKERPTYPELMQHPFF . ||| |.|||||||| ||.| . || . |.. . .. .|.| | .|.| .| || ..|| |. ..||| .|..|||. EGPDKGYDYKCDIWSLGITAIEMAEGEPPY-FDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI |
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Kinase | MAP2K6.AA | Pkinase | 53-314 | 25 | 9.2e-55 | 193.05 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 53-314 Range on HMM: 1-293/293 Sequence Identity: 25% (78 aa) LEPIVELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLL---MDLDVSMRTVDCPFTVTFYGALFREGDVWICMELMDT-----SLDKFYKQVI .. . .|.|..|.| | .|. .|.| |||.|. .. .... . . . . |. ...|. |..|.. ........||... .| .| YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQI-MKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF----DYI D--KGQTI--PEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINTLGQV----KMCDFGISG---YLVDSVAKTIDAGCKPYMAPERINPELNQKG .. .. .|. . ... |...||..|| ..||||.||.|.||. |.. | ||||.. | .| ..|. .| .||||| |. ... STWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTF-CGTPWYMAPEVIR---GGQY YSVKSDIWSLGITMIELAILRFPYDSWG----TPFQQLKQVVEEPSPQLPADKF----------------------SADFVDFTSQCLKKNSKERPTYPE |. |.|.||.|....|.. |.|.. . |.. ... .|.|. | . | .. || . ||.|. |.||| .. YGPKVDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ LMQHPFF ..|||.| ILQHPWF |
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Kinase | MAP2K6.AA | TKL | 59-312 | 16 | 1.2e-42 | 147.96 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 59-312 Range on HMM: 1-364/364 Sequence Identity: 16% (61 aa) LGRGAYGVVEKMRHVP--------SGQIMAVKRIRATV----------------------NSQEQKRLLMDLDVSMRT---VDCPFTVTFYGALFREGD- .|.|..|.| | .. .|. .|||... . |..|.... . . .. ..| | |.|. ..... IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG ------------VWICMELM-DTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHS-------KLSVIHRDVKPSNVLINTLGQ------------ .| ||.. || .. . . ..| .| .....||| | .|||| |..|.|.. .. CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD --VKMCDFGISGYL--------------------VDSVAKTIDAGCKPYMAPERINPELN------------QKGYSVKSDIWSLGITMIELAILRFPYD .| ||||.| . . . .. | . .|||| .. ..| .. || |.|..| || . |.. . ||. WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY SWGTPFQQ---------LKQVVEEPSPQLP-----------ADKFSADFVDFTSQCLKKNSKERPTYPELMQHP . . .. . ... | .| . . .. . .| . . ..||. |.... DYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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Kinase | MAP2K6.AA | TyrKc | 53-314 | 23 | 2.5e-15 | 25.22 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 53-314 Range on HMM: 1-280/280 Sequence Identity: 23% (71 aa) LEPIVELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDVSMRTV--DCPFTVTFYGALFRE-------GDVWICMELMDT-SLDKFYKQ .. . .||.||.|.| | . . ||| ... .. .. . . |. . . | | .||. . . ..| ||.|. .|... . ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARI-MCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK VIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINTLGQVKMCDFGISGYLVDS-------VAKTIDA--GCKP-----YMAPERINPE .| .. . | .... | . |.|||| .|||| |.|.. ..|| .||| | .. | .. |.| |||| | HRPK---LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--- LNQKGYSVKSDIWSLGITMIELAIL-RFPYDSWG-----TPFQQLKQVVEEP-SPQLPAD-------KFSADFVDFTSQCLKKNSKERPTYPELMQHPFF | . .. |||.|| |..| |. . || .| . |.. . |.. . |.. ... . .|| . . ..||| |. | .| -NYGKFTTKSDVWSFGVCMWEIFTYGQQPY--PGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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Kinase | MAP2K6.AA | MEK1 | 264-314 | 45 | 3.9e-14 | 44.21 | In-house | 247-297 (297) | Show / Hide |
Range on Protein: 264-314 Range on HMM: 247-297/297 Sequence Identity: 45% (23 aa) FQQLKQVVEEPSPQLPADKFSADFVDFTSQCLKKNSKERPTYPELMQHPFF | | .|.|| |.|| || .|.|| ..||.|| .|| . .||.|.|. FEMLDYIVNEPPPKLPHRVFSEEFQDFVDKCLIKNPDERADLKQLMVHTFI |
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Kinase | MAP2K6.AA | Pkinase_Tyr | 53-250 | 26 | 6.9e-12 | 40.89 | Pfam | 1-207 (270) | Show / Hide |
Range on Protein: 53-250 Range on HMM: 1-207/270 Sequence Identity: 26% (57 aa) LEPIVELGRGAYGVVEKMRHV----PSGQIMAVKRIRATVNSQE--QKRLLMDLDVSMRTV-DCPFTVTFYGALF-REGD--VWICMELMDT-SLDKFYK .. . .||.||.|.| | . .. ||| .. . ... .. .. . . |.. ..| | .||. ... ..| ||.| .|... . ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKI-MKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR QV-IDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINTLGQVKMCDFGISGYL-VDS---VAKTIDAGCKPYMAPERINPELNQKGYSV . ||.. ..| | .... | |..|.|.|| ||||. |.|.. ..|| |||| . .. |. .... . |||| || ... KHREDKQPLTMKD-LLQMCWQIAKGMEYLESKN-CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK----FTT KSDIWSLGITMIEL |||.|| |..| |. KSDVWSFGVLMWEI |