Gene MAK (Mouse)

MAK

Species: Mouse
Alias: MAK, Mak
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP ,
Annotation:

Classification

Group: CMGC
Family: RCK
Subfamily: MAK

Sequence

Name Sequence Type Origin Length Description Download
MAK.AA Protein Sugen 646 None Fasta, JSON
MAK.NA RNA Sugen 3562 None Fasta, JSON
MAK.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 281 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of MAK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MAK.AA MAK 4-284 64 1.8e-246 793.43 In-house 1-352 (352) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-352/352
Sequence Identity: 64% (226 aa)

YTTMKQLGDGTYGSVLMGKS------------------------------NESGELVAIKRMKRKFYSWDECMNLREVKSLKKLN-HANVIKLKEVIR--
|...|||||||||.|...|.                              ...||.|||||||.|||||.||||||||||||||| |.|..|||||||  
YQMIKQLGDGTYGCVMLAKRQFPLSNILGKQHDIRGTLMDQPKNGHQNYIIDTGEKVAIKRMKKKFYSWEECMNLREVKSLKKLNAHPNIVKLKEVIRDS

ENDHLYFVFEYMKENLYQLMKDRNK-LFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGP-----------------ELVKIADFGLARELRS
||||||||||||||||||.||||.. .|||.|||||||||||||||.||||||||||||||..||||                 ||.||||||||||.||
ENDHLYFVFEYMKENLYQMMKDRDRRHFPEPVIRNIMYQILQGLAFMHKHGFFHRDMKPENIMCMGPTQYFEKEYMNQIGYQDNELIKIADFGLAREIRS

QPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELYTFRPLFPGTSEVDEIFKICQVLGTPKKSD----------------WPEGYQLASSMNF
.|||||||||||||||||||||..||||||.||||.||||||||||||||.||.|.|||||||||||||.|                ||.|||||..|||
KPPYTDYVSTRWYRAPEVLLRSTYYSSPIDMWAVGCIMAELYTFRPLFPGSSEIDQIFKICQVLGTPKKDDDFVNTNHITAPPPGGFWPDGYQLAHMMNF

RFPQCIP---INLKTLIPNASS-EAIQLMTEMLNWDPKKRPTASQALKHPYF
|||||.|   ..||.||||.|. .||.||..||.|||.|||||.|..|.|||
RFPQCVPPSIMPLKHLIPNCSQSDAIELMKDMLQWDPNKRPTAQQCCKYPYF
Kinase MAK.AA RCK 4-284 66 2.4e-238 764.39 In-house 1-298 (298) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-298/298
Sequence Identity: 66% (199 aa)

YTTMKQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLN-HANVIKLKEVIREND--HLYFVFEYMKENLYQLMKD---RNKLF
|...|||||||||.|..... |.||.||||.||.|||||.|||||||.|||.||| |.|.||||||||.||  .||||||||..||||.|||   |.|..
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMKQKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKYL

PESV--IRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMG---------PELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAV
||..  |.|||||||||||..|||||||||.||||..|.|         ....|||||||.|| ||.||||||||||||||||.|||.  |.||.|.|||
PENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNSPMDIWAV

GSIMAELYTFRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCIPINLKTLIPNASSEAIQLMTEMLNWDPKKRPTASQALKHPYF
| ||.|||..||||||.||.|.|||||.|.|||.| |||.||.|||.|||.||||....||.||||.|...|.||..||.|||.||.||.|||.||||
GCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPNCSQDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase MAK.AA CMGC 4-284 27 1.6e-138 458.3 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-513/513
Sequence Identity: 27% (140 aa)

YTTMKQLGDGTYGSVLMGKS--------------NESGELVAIKRMKRKFYSWDEC----------MNLREVKSLKKLN-----------------HANV
|. .|..| |||| |  ..               .|..|.||||..|..|| ....          . |||.| ||.||                 | |.
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

IKLKEVIREND-----------------HLYFVFEYMKENLYQLMKD--------RNKLFPESV------------IRNIM------YQILQGLA--FIH
.||..... ..                 |||.|||||  .|||..|.        |.. ..| .            |...|      ||||.||.  ..|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

KHG--FFHRDMKPENLLCMGPELV--------------------KIADFGLARELRSQP----------------------PYTDYVSTRWYRAPEVLLR
.|.  ..|||.||||.|      .                    ||.|||||| . . .                      |||.||.||||||||.||.
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

SSVYS---------SPIDVWAVGSIMAELYT--------FRPLFPGTSE-----------VDEIFKICQVLGTPK---------------KSDWPE----
.. |.         .|||.|.|| |.||.||         .||||| ||           .| .|||..|||||                . .||.    
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

---------------------GYQLASSMNFRFPQCIPINLKTLIPN-----------------------------------ASSEAIQLMTEMLNWDPK
                     ..... ..|.|||.. |...| |.|.                                   ....|| |.  || .||.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

KRPTASQALKHPYF
||.||.|||.||||
KRITAEQALQHPYF
Kinase MAK.AA Pkinase 4-284 32 2.3e-115 394.39 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-293/293
Sequence Identity: 32% (99 aa)

YTTMKQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLR---EVKSLKKLNHANVIKLKEVIRENDHLYFVFEYMKE-----NLYQLMK-DRN
|.. ...| |..|.|  ..   .|..||.|..|..  ........|   |.. .|.||| |...|... ...||.|.|.||.        |. ... .|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KLF--PESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELV----KIADFGLARE--LRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAV
. |  .| .....|||||.||...|..|. |||.||||.|.     .    ||.|||||.   . ... .|... |.||.||||.. .. |....|.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GSIMAELYTFRPLFPGT----SEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCIPINLKTLIPNASSEAIQLMTEMLNWDPKKRPTASQALKHP
| |..|... ||.|||     . .|....||...|.| ..|||. .    .. ||. .   . ..|. .|.|.|...... .|..|||||||| |.|.||
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

YF
.|
WF
Kinase MAK.AA CDK 4-284 34 1.6e-112 361.38 In-house 1-284 (284) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-284/284
Sequence Identity: 34% (112 aa)

YTTMKQLGDGTYGSVLMGKSNESG-----ELVAIKRMK---RKFYSW-DECMN---LREVKSLKKLNHANVIKLKEVIREN-----------DHLYFVFE
|   ...| |||| |  ... ..|     ..||.|. .    .  .  .| ..   .||.. ||.| |.|..||..|.  .             ||.|||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEG-REEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE

YMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPEL-----VKIADFGLARELRS-------QPPYTDYVSTRWYRAP
||   |...|.          |...|.|.|.||...|.... |||.|| |.| .         .|||||||||.  .       . .||  | |.|||||
YMDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAP

EVLLRSSVYS--SPIDVWAVGSIMAELYT---FRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCIPINLKTLIPNASSEAIQLMTE
|.|| |. ||   |||.|.|| |.||..|    .|||||.|| | .|||....|||  ..||.  .|                            .|.  
ELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------DLLNK

MLNWDPKKRPTASQALKHPYF
||  ||||| .|.|||.||||
MLCYDPKKRISAEQALQHPYF
Kinase MAK.AA CDK7 4-284 36 8.60000000001e-104 277.3 In-house 1-288 (288) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-288/288
Sequence Identity: 36% (105 aa)

YTTMKQLGDGTYGSVLMGKSNESGELVAIKRMK--RKFYSWDECMN---LREVKSLKKLNHANVIKLKEVIRENDHLYFVFEYMKENLYQLMKDRNKLFP
|...|..| |... |  .   ..|. ||||. |        .  .|   .||.| |. . | ||| |  ..   . .. ||..|   |    ||   .. 
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

ESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRS-QPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELYTFR
 . | ..| ..|||| . |..   |||.|| |||      .|||||||||   |    ||  | |||||||| |     | . .|.|.|| |.|||    
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRV

PLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFR-FPQCIPINLKTLIPNASSEAIQLMTEMLNWDPKKRPTASQALKHPYF
| .||.|..| . .|.| ||||  ..||.  .... . |. ||    . |. .   || ... ||  |.  .| || |..|.||.|||
PYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase MAK.AA CDC2 4-284 39 1.5e-103 319.18 In-house 1-301 (301) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-301/301
Sequence Identity: 39% (121 aa)

YTTMKQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDE---CMNLREVKSLKKLN-HANVIKLKEVIRENDHLYFVFEYMKENLYQLMK---DRNKL
|.  . .| |||| |  .| ......||.|. . .  . ..      .||   ||.|. | |..||..|| .   || ||||.  .| ..|.     || 
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

FPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRS-QPPYT--DYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAEL
.|.......|||||||..| | .. .||| || |.|      .|||||||||       .||    | |.||||||.||... || |.|.|..| |.||.
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---YTFRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCIPINLKTLIPN---------ASSEAIQLMTEMLNWDPKKRPTASQALKH
    |..|||.| || |..||| ..||||. ..||. .||    |  ||.  |..|....||         .  |.|.|  .||  || || .| .||.|
FMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKN-TFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQH

PYF
|||
PYF
Kinase MAK.AA S_TKc 4-284 32 3.2e-102 346.83 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-231/231
Sequence Identity: 32% (96 aa)

YTTMKQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHANVIKLKEVIRENDHLYFVFEYMKE---NLYQLMKDRNKL----
|. ....| |..|.|  .. ...|..||||..|        .. .||.. ||| .| |..||..|... ||||.|.||.     .|....|.|..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-FPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSS-PIDVWAVGSIMAELY
 ||| ..| .||||...|...|.||. ||| ||||.|.     .||.||||||.|      | .. |.||.|||||     |.  ..|.|..| |..|..
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEML

TFRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCIPINLKTLIPNASSEAIQLMTEMLNWDPKKRPTASQALK-------HPYF
. .|.||   .....||..                                        |.||....  .|..||.||||| .||.       ||.|
CGYPPFP---QMQMMFKKIG---------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MAK.AA MOK 4-284 39 2.1e-89 280.36 In-house 1-283 (283) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-283/283
Sequence Identity: 39% (111 aa)

YTTMKQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLN-HANVIKLKEVI--RENDHLYFVFEYMKENLYQLMKDRNKLFPES
| .. ..|.||.  |.  .|   |.  | |.||..| | ..  ||||.. ...|| |.|...|.||.  |    |  . | |  |.| |.. |    |. 
YKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQHFESIEQVNNLREIQAMRRLNPHPNILMLHEVVFDRKTGNLALICELMDMNIYELIRGRRHYLPQK

VIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELYTFRPLF
 |.. |||... |  .|. | ||||.||||.|    . .|.||||  |   |. |||.|.||||||||| ||    |.  .|.|.|| .  |.   .|||
KIMHYMYQLCKSLDHMHRNGIFHRDVKPENILIKQ-DHLKLADFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGYYTYQMDMWSVGCVFYEIASLHPLF

PGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCIPINLKTLIPNASSEAIQLMTEMLNWDPKKRPTASQALKHPYF
||  ||| | ||  |.|||..       . . .||. ||      .. |.||..  ....| .|  .||  | || |...||||
PGVNEVDQISKIHDVMGTPCQKILNKFKNQSRAMNYDFPFKKGSGIEKLTPNLTKQCLEIMHKMCTYDPDERITAHQVIQHPYF
Kinase MAK.AA MAPK 4-284 33 3.7e-86 292.56 In-house 1-328 (328) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-328/328
Sequence Identity: 33% (111 aa)

YTTMKQLGDGTYGSVLMGKSNE------SGELVAIKRMKRKFYSWDECMN-LREVKSLKKL-NHANVIKLKEVIRE------NDH-----LYFVFEYMKE
|.  |..| | || | . . ..      .|. ||||.. | | .   |   .||.| |. . .| |.|||.....       |..     .|.|.|.|  
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

NLYQLMKDRNKLFPESVIRNIMYQILQG--LAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQPPY---------------TDYVSTRWYRA
.|.|..| ..    .  |. .||||| |  | .||  .  ||| ||.|.|.    ..||.|||||| . ..  .               |.||.||||||
DLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRA

PEVLLR--SSVYSSPIDVWAVGSIMAELYT-FRPLFPGTSEVDEIFKICQVLGTPKKSDW-PEG-YQLASSMNFRF---PQCIPINLKTLIPN----ASS
||..|   .  |.  .|.|.|| |.||..|  .|||||.. .| ...| .|||||.. ..   . .. | ..  ..   |.. ........||    |..
PEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANP

EAIQLMTEMLNWDPKKRPTASQALKHPYF
.|| |.  || .||.|| |. .|| ||||
QAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase MAK.AA CDK5 4-284 37 4.4e-86 271.94 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-287/287
Sequence Identity: 37% (109 aa)

YTTMKQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDE---CMNLREVKSLKKLNHANVIKLKEVIRENDHLYFVFEYMKENLYQLMKDRNKLFPES
|  |  .|.|||| |  ..  |..|.||.||   .  | ||   .  .||.  || | | |.. |  ||  .  |  |||.. . |   | ..|      
YEKMEKIGEGTYGTVYKARNKETHEIVALKRV--RLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMH

VIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARE----LRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELY-T
.|. .||| |.|||| |.|   |||.|| |||       | |||||||      |    |.  | | |||.| ||. | .|| .||.| .| |.||.  .
IIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRC---YSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANA

FRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSM--NFRFPQCIPIN-LKTLIPNASSEAIQLMTEMLNWDPKKRPTASQALKHPYF
 ||||||... |. ..| ...|||  . ||   .|         .|   .   .. ..|. ...   |. .||  .|..| .| .||.||||
GRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase MAK.AA CDKL 4-218 40 2.8e-73 249.78 In-house 1-218 (286) Show / Hide 
Range on Protein: 4-218
Range on HMM: 1-218/286
Sequence Identity: 40% (90 aa)

YTTMKQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMN---LREVKSLKKLNHANVIKLKEVIRENDHLYFVFEYMKENLYQLMKDRNKLFPES
| ..  .| | || |.  .  |.|..||||. |   .  |.  .   .||.| || | | |   |.|| | .  |. ||||.  ..  . . . .  .|.
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESED--DPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHELEEYPNGVDEH

VIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCM-GPELVKIADFGLARELRSQPP--YTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELYTFR
|.|..|.|||....| |||   ||| ||||.|       ||. |||.|| . ..|   ||||| |||||||| |.    |..|.|.||.| .|||. .  
VVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFAR-MLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQ

PLFPGTSEVDEIFKICQVLGT
||.|| |..|  ..| ..||.
PLWPGQSDIDQLYHIQKCLGP
Kinase MAK.AA TyrKc 4-284 23 2.5e-16 41.4 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-280/280
Sequence Identity: 23% (75 aa)

YTTMKQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKL--NHANVIKLKEVIREN-------DHLYFVFEYMKE-NLYQLMKDR
 |  |.|| | .| |  |. .   . ||.| .|       . . .|| . ..||  .| |...|  |...        . |. |.|||.  .| .  ...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

NKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQ-------PPYT------DY--VSTRWYRAPEVLLRSSVYS
 . .. .   ....|| .| ...|.... |||    | |   .  |||.||||.|.. .          |.          .  ||. |||.. . ....
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKFT

SPIDVWAVGSIMAELYTF-RPLFPG-------TSEVDEIFKICQVLGTPKK----SDWPEGYQLASSMNFRFPQCIPINLKTLIPNASSEAIQLMTEMLN
.  |||. |  | |..|.  .  ||        .|| |  |    .  |.     |                            . ...|  |.|..  .
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------------------------FVCCPDEMYQIMKQCWH

WDPKKRPTASQALKHPYF
 ||..||| |.   | .|
EDPEDRPTFSEI--HECF
Kinase MAK.AA Pkinase_Tyr 4-125 23 1.7e-14 49.75 Pfam 1-136 (270) Show / Hide 
Range on Protein: 4-125
Range on HMM: 1-136/270
Sequence Identity: 23% (32 aa)

YTTMKQLGDGTYGSVLMGKSN----ESGELVAIKRMKRKFYSWDE---CMNLREVKSLKKL-NHANVIKLKEVIR-ENDH--LYFVFEYMKE-NLYQLMK
 | .|.|| | .|.| .|. .    . .  ||.| . .  .. ..    . .||.| .|.| .| |...|  |.  . ..  .| |.|||.  .|.   .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

DR---NKLFPESVIRNIMYQILQGLAFIHKHGFFHRD
..   .. .. . . .. .|| .|... . ... |||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRD
Kinase MAK.AA CDKL 243-284 37 2.3e-12 38.56 In-house 244-286 (286) Show / Hide 
Range on Protein: 243-284
Range on HMM: 244-286/286
Sequence Identity: 37% (16 aa)

PINLKTLIPNAS-SEAIQLMTEMLNWDPKKRPTASQALKHPYF
. .|.   ||.| ..|. .|  .|  || .|.|..|...||||
MEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase MAK.AA Pkinase_Tyr 139-185 32 0.006915 10.4 Pfam 150-199 (270) Show / Hide 
Range on Protein: 139-185
Range on HMM: 150-199/270
Sequence Identity: 32% (17 aa)

VKIADFGLARELRSQPPYTDYVST------RWYRAPEVLLRSSVYSSPIDVWA
|||.|||||| . .   |  ....      .|. |||..  .  ...  |||.
VKICDFGLARDIYNDDYY-YRKRGGGKLPIKWM-APECINYGK-FTTKSDVWS