Gene LYN (Mouse)

LYN

Species: Mouse
Alias: LYN, Lyn
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Src
Subfamily: SrcB

Sequence

Name Sequence Type Origin Length Description Download
LYN.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 252 Kinase domain by global Sugen HMM Fasta, JSON
LYN.NA RNA Sugen 3456 None Fasta, JSON
LYN.AA Protein Sugen 512 None Fasta, JSON

Protein domain

Protein domains of LYN.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 LYN.AA SH3 66-122 44 3.7e-23 84.18 SMART 1-58 (58) Show / Hide 
Range on Protein: 66-122
Range on HMM: 1-58/58
Sequence Identity: 44% (26 aa)

DIVVALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLSSKREGFIPSNYVAKVN
  |.|||.|.. .||.||||||... |||.  ..|||..  .. .||..|||||....
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 LYN.AA SH3_1 69-115 44 1.5e-22 78.89 Pfam 1-49 (49) Show / Hide 
Range on Protein: 69-115
Range on HMM: 1-49/49
Sequence Identity: 44% (22 aa)

VALYPYDGIHPDDLSFKKGEKMKVLE-EHG-EWWKAKSLSSKREGFIPS
||||.|.. .||.||||||....|.| ... .|||........||..||
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH3_2 LYN.AA SH3_2 67-121 22 1.2e-09 36.66 Pfam 1-68 (68) Show / Hide 
Range on Protein: 67-121
Range on HMM: 1-68/68
Sequence Identity: 22% (15 aa)

IVVALYPYDG-IHPDD-----LSFKKGEKMKVL----EEHGEWWKA-KSLSSKRE--GFIPSNYVAKV
 ....  |..   ...     |.||||.. ||.    .. ..||..  ... .|.  |..||..|...
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC
SH2 LYN.AA SH2 129-211 49 1.9e-48 144.07 Pfam 1-81 (81) Show / Hide 
Range on Protein: 129-211
Range on HMM: 1-81/81
Sequence Identity: 49% (41 aa)

WFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDYDPMHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHY
|....|.|..|||.|..|||  |.||.||||. .|...||||| .|  ||..|||.|...|||||||. | .|. ..... ||
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGP--GDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 LYN.AA SH2 127-217 38 2.2e-35 124.82 SMART 1-87 (87) Show / Hide 
Range on Protein: 127-217
Range on HMM: 1-87/87
Sequence Identity: 38% (36 aa)

EEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDYDPMHGDVIKHYKIRSLDNGGYYISP--RITFPCISDMIKHYQKQSDG
..|.. .|.|..||. |..||.  |.||.|.||. .|...||||.      . .|||.||..|.|.|||    | .||.. ... |||. ..|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK-----GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase LYN.AA SrcB 247-498 84 2.6e-203 681.7 In-house 1-251 (251) Show / Hide 
Range on Protein: 247-498
Range on HMM: 1-251/251
Sequence Identity: 84% (212 aa)

IKLVKKLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTKEEPIYIITEFMAKGSLLDFLKSDEGGKVLLPKLID
.|||||||||||||||||||||..||||||.|.||||..|||.|||.|||||||.||||||||||| |||||||.||||.||||||.|||.|. ||||||
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKLSLPKLID

FSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPG
.|||||||||||||.|||||||||||.||||.|.||||||||||.||||||||||||||||||||||||||||||||||||||||||.||||||.|||||
MSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYPG

RTNADVMSALSQGYRMPRMENCPDELYDIMKMCWKEKAEERPTFDYLQSVLD
.||..|...|..||||||..|||.|||.||.|||||..||||||||||||||
MTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase LYN.AA Src 247-497 68 1.8e-197 662.29 In-house 1-255 (255) Show / Hide 
Range on Protein: 247-497
Range on HMM: 1-255/255
Sequence Identity: 68% (175 aa)

IKLVKKLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTKEEPIYIITEFMAKGSLLDFLK-SDEGGKVLLPKLI
|||..|||.||||||||||.|..||||||||||||||..|||.||..||.|.|.|||.||||...||||||.||.|..|||||.|| ..||... ||.||
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

DFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIE--DNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIP
|..||.||||||.|..|||||||.|.||||.|...||.|||||||.|.  |.||.||.|||||||||||||||.|.||||||||||||||.||||||..|
DMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVP

YPGRTNADVMSALSQGYRMPRMENCPDELYD-IMKMCWKEKAEERPTFDYLQSVL
||| ||..|. ....|||||...|||||||. ||..||....|.||||.|||..|
YPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase LYN.AA SFK-Src 247-501 59 2.4e-174 521.63 In-house 1-259 (259) Show / Hide 
Range on Protein: 247-501
Range on HMM: 1-259/259
Sequence Identity: 59% (153 aa)

IKLVKKLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTKEEPIYIITEFMAKGSLLDFLKSDEGGKVLLPKLID
|.| ||||.||||.|| |  ||.| |||||||||.|| . ||.|| .|| |.|..|..|||| |  |||||||| |. |||||.|.. .|    .|.|.|
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLVD

FSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIE-DNE-YTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPY
  ||.| |||| | .|..|||| | |||| ..  ||..|||..||.. |.| |||.|||||||||||||| |   | |||||||||||..|||||| |||
MAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPY

PGRTNADVMSALSQ--GYRMPRMENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFY
|| ||. |.  . .  |||||   |||||.| ||  ||......||||. |.  ..||.
PGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase LYN.AA SrcA 247-497 68 1.7e-167 533.73 In-house 1-250 (250) Show / Hide 
Range on Protein: 247-497
Range on HMM: 1-250/250
Sequence Identity: 68% (172 aa)

IKLVKKLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTKEEPIYIITEFMAKGSLLDFLKSDEGGKVLLPKLID
|.| ..|| |.||||||| .| .||||.||||||||| .|||||| .|| |.|||||.|||||  ||||||.||.|.||||||||| .|| .. ||.|.|
IRLERRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVVS-EEPIYIVTEYMCKGSLLDFLKDEEGKYLKLPQLVD

FSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPG
 .||.||||||.|| |||||||||||.|| | |.||||||||||.||||||||| |||||||||||||  .| |||||||||||||| |.|| |..||||
MAAQVAEGMAYMERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPG

RTNADVMSALSQGYRMPRMENCPDELYDIMKMCWKEKAEERPTFDYLQSVL
  | .|.    .||.||  ..||  |...|. ||.   ||||||.|||| |
MNNREVLEQVERGYHMPCPQDCPESLHELMCQCWRKDPEERPTFEYLQSFL
Kinase LYN.AA Pkinase_Tyr 247-497 49 1.8e-155 527.14 Pfam 1-270 (270) Show / Hide 
Range on Protein: 247-497
Range on HMM: 1-270/270
Sequence Identity: 49% (133 aa)

IKLVKKLGAGQFGEVWMGYYN-----NSTKVAVKTLKPGTMSV----QAFLEEANLMKTL-QHDKLVRLYAVVT-KEEP--IYIITEFMAKGSLLDFLKS
|.. ||||.|.||||..|...     . ..||||.||.|.|.     ..|..||..||.| .|...||||.|.| ..||  |||..|.|..|.|||.|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

D--EGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVI-EDNEY-TAREGAKFPIKWTAPEAINFGCFTIKSDVWSF
   ..... .. |.....|||.||.| |.||.|||||.| |.||.|.. .||.|||||| | .| .| ..|.|.|.||||.|||.||.| ||.|||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GILLYEIVTYGKIP-YPGRTNADVMSAL-SQGYRMPRMENCPDELYDIMKMCWKEKAEERPTFDYLQSVL
|.|..||.|||..| ||| .|..|. ..  .|||||. ||||||.||.||.||....|.|||| .... |
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase LYN.AA Frk 247-501 60 9.60000000001e-142 477.2 In-house 1-260 (260) Show / Hide 
Range on Protein: 247-501
Range on HMM: 1-260/260
Sequence Identity: 60% (157 aa)

IKLVKKLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTKEEPIYIITEFMAKGSLLDFLK--SDEGGKVLLPKL
|.|...||.||||||| | .||.| |||||||||||  . || || .|| |.| ||..|||| | ||||||||| | .|||...|.  .|.| .. ...|
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

IDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLAR-VIEDNE--YTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGK
.| .||.| ||||.| .||||||| | |||| |...|||||||||| .. |||  | .| ||.||||||||||.|   ||||||||||||||.||.|||.
VDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGR

IPYPGRTNADVMSALSQGYRMPRMENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFY
.|||| |||.|.  ...|||||.  ||| .||.||  ||......||||. ||  |.|..
MPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase LYN.AA Src-Unclassified 247-497 45 2e-141 476.15 In-house 1-284 (284) Show / Hide 
Range on Protein: 247-497
Range on HMM: 1-284/284
Sequence Identity: 45% (130 aa)

IKLVKKLGAGQFGEVWMGYYNNSTKVAVKTLKPG---TMSVQAFL--------EEANLMKTLQHDKLVRLYAVVTKEEPIYIITEFMAKGSLLDFLKSDE
..|..||| ||||||| | . ..  |||||..||   |||  |||        .||..|| ..| .|| |||| ..|||.|||||.| .||||..|. . 
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

GGKVLLPKL------------IDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESL-----MCKIADFGLA--RVIEDNEYTAREGAKFPIKWTAPEAIN
|    .. .            .| .||.| || | | | |.|||| | |||. .         |..|||||  ....| .| .| ||.||.||.|||.. 
GQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECFI

FGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMSALSQGYRMPRM--ENCPDELYD-IMKMCWKEKAEERPTFDYLQSVL
 | |.|||||||.||||.|| |.|..||||  |  |   .. |||||.   . ||| .|. ||| || .  . ||||| |   .
YGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase LYN.AA TyrKc 247-497 43 1e-139 471.37 SMART 1-280 (280) Show / Hide 
Range on Protein: 247-497
Range on HMM: 1-280/280
Sequence Identity: 43% (125 aa)

IKLVKKLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTL--QHDKLVRLYAVVTKE-------EPIYIITEFMAKGSLLDFLKSDEGG
|.| |||| |.||||. | ..  ..||||.||...  ...|..||..|. |  .|. .||||.|.|..       ||..|..|.|..|.|.|.|.. .. 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

KVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDN--------EYTARE--GAK--FPIKWTAPEAINFGCFTIKSD
 . ...|..|. |||.||.|...||.||||| | |.||.| . .||.||||.| |.|          |...|  |.|  .||.|.|||.||.|.||.|||
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

VWSFGILLYEIVTYGKIPYPG-----RTNADVMSALSQGYRMPRMEN--------CPDELYDIMKMCWKEKAEERPTFDYLQSVL
|||||....|| |||. ||||      .|..|.  . ||||||...|        ||||.|.|||.||.|..|.||||  . . .
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase LYN.AA Src-Echino1 247-497 52 2.6e-126 425.94 In-house 1-252 (252) Show / Hide 
Range on Protein: 247-497
Range on HMM: 1-252/252
Sequence Identity: 52% (133 aa)

IKLVKKLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTKEEPIYIITEFMAKGSLLDFLKSDEGGKVLLPKLID
 .. ||.| |..|||| | .|  |.|||||||..|||  .|| |||.||...|. .|..|||   .|||||.|| | .|.|.|.||.... .| ...|||
LRMDKKIGKGHCGEVWKGVWNGNTPVAVKTLKEKTMSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHVKMTTLID

FSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPG
  |.|| || |...||..|||| | |||| .  .||||||||||......| ...|||.|||||||||. .| |||||||||||||. |.||.|..||||
MGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFGRYPYPG

RTNADVMSALSQGYRMPRMENCPDELYDI-MKMCWKEKAEERPTFDYLQSVL
 .| .|.  . .|||||.|..||| ||.. |  ||   .  ||||..| . .
MMNREVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF
Kinase LYN.AA TK 247-497 26 7.89999999999e-124 417.26 In-house 1-486 (486) Show / Hide 
Range on Protein: 247-497
Range on HMM: 1-486/486
Sequence Identity: 26% (128 aa)

IKLVKKLGAGQFG---EVWMGYYNNS--------------------------TKVAVKTLKPG-TMSVQA--------------FLEEANLMKTLQ----
|.|.||||.||||   ||..| ...                           |.||||.||.| .|| ..              |||||. || ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HDKLVRLYAVVTKE------------EPIYIITEFMAKGS----LLDFLK--SDEGGK-----------------------------------------
 |. .||||.|.|..            ||..|..|.|..|.    |.|.|.  .... .                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------VLLPKLIDFSAQIAEGMAYIERK------NYIHRDLRAANVLVSESLM-----------CKIADFG---
                               . .. |. ...|||.||.|...|      |..|||| | |.||.|..            |||||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARVI-EDNEYTARE------------------------GAKFPIKWTAPEAIN---------FGCFTIKSDVWSFGILLYEIVTYG-KIPYPGR
     ||| | .| .|....                        |.|.||.|.|||..|         .| ||.||||||||.|..||.||| . .|.| 
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TN---------ADVMSALSQG--------------YRMPRMENCP--------------DELYDIMKMCWKEKAEERPTFDYLQSVL
.|         ..||  | .|              .|||. ..||              .|.||.|..||....|.||||. |.. |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase LYN.AA Tec 247-499 42 4.1e-115 388.72 In-house 1-254 (254) Show / Hide 
Range on Protein: 247-499
Range on HMM: 1-254/254
Sequence Identity: 42% (108 aa)

IKLVKKLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTKEEPIYIITEFMAKGSLLDFLKSDEGGKVLLPK--L
....| || |||| | .|.. .. .||.|..| |.||   |.|||  |. |.| |||.|| | ... ||||.||.|..|.||..|.. . ..       |
LTFMKELGSGQFGVVHLGKWRHQYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHK-HHFQKNMAIL

IDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPY
..   .. ||||| ||...||||| | | ||..    |..|||..| . | .||   |.|||.|| .||  ..  .  |||||.||.|  |. . ||.||
LEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPY

PGRTNADVMSALSQGYRMPRMENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDD
. ..| .|  . |||.|. | . |....|.||. ||.||.||||||  | . . .
ENMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase LYN.AA SRM 248-498 46 4.4e-114 383.06 In-house 2-253 (253) Show / Hide 
Range on Protein: 248-498
Range on HMM: 2-253/253
Sequence Identity: 46% (117 aa)

KLVKKLGAGQFGEVWMGYYNNSTKVAVKTLKPGT-MSVQAFLEEANLMKTLQHDKLVRLYAVVTKEEPIYIITEFMAKGSLLDFLKSDEGGKVLLPKLID
 | .|||.| ||||| |    . .||.|  |    |  . .  |   || | | ...||.||..  .|.||||| |.||.|. .|.. ..    .|.|.|
TLCRKLGEGYFGEVWEGLWKGQVHVAIKVIKRDNLMHQHMLQKEIQAMKKLRHKHIIRLHAVCSVGDPVYIITELMRKGNLQQYLRDSDEKALPIPHLLD

FSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPG
|  |.||||.| | .||||||| | |||| . ..||..|||||| | |  |    . . |.|||||||.| . . .|||||||||||.|. ||| .||||
FACQVAEGMCYLEEQNYIHRDLAARNVLVGDNNLCKVGDFGLARLIKDDIYSPSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILLHEMFTYGQCPYPG

RTNADVMSALSQGYRMPRMENCPDELYDIMKMCWKEKAEERPTFDYLQSVLD
 ||   .   . |||||.   || | .  |  ||.   |.||.|  |   | 
MTNHETFQQIDRGYRMPCPAECPPEVHKLMLECWCRDPEQRPCFKDLREKLT
Kinase LYN.AA S_TKc 247-502 23 8.5e-56 192.6 SMART 1-231 (231) Show / Hide 
Range on Protein: 247-502
Range on HMM: 1-231/231
Sequence Identity: 23% (64 aa)

IKLVKKLGAGQFGEVWMGYYNN-STKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTKEEPIYIITEFMAK--GSLLDFLKSDEGGK----V
 ....|.| | ||.|. .. ..   .||.| .|      . .. | ...|  .|. .|.|| |    . .|...|..    |.|.|..|.  ...     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

LLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTI-KSDVWSFGILLYEIVT
       . .||.....|. ... |||||  .|.|..|    ||.||||||..                . ||| .    ..  |.|.||.|..||| ..
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

YGKIPYPGRTNADVMSALSQGYRMPRMENCPDELYDIMKMCWKEKAEERPTFDYLQS----VLDDFYT
 |. |.|   . ..|  .            ..|. |... |..   |.|||   .      .  . . 
-GYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LYN.AA Pkinase 247-500 25 3.7e-48 171.09 Pfam 1-293 (293) Show / Hide 
Range on Protein: 247-500
Range on HMM: 1-293/293
Sequence Identity: 25% (76 aa)

IKLVKKLGAGQFGEVWMGYYNNSTK-VAVKTLKPGTMSVQAFLE-----EANLMKTLQHDKLVRLYAVVTKEEPIYIITEFMAKG----SLLDFLKSDEG
.....|.|.| ||.|. ..  .. | ||||..|  . . .   .     |. .|| |.|.  |||| ... .  ||...|.. .|    .| |... ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GKV--LLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMC----KIADFGLARVIEDNEYTAREGAKFP---IKWTAPEAIN-FGCFTIKSDV
|..      ....  ||..|..|. ... |||||  .|.|...   .    ||.|||||....   |   . .. .   . . ||| |.     . |.|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSFGILLYEIVTYGKIPYPGR----TNADVMSALSQGYRMPRMENCP-----------------------DELYDIMKMCWKEKAEERPTFDYLQSVLDD
||.|..||| .. |. |.||.    . .| |  . .  . | ....|                       .|. |..| |.. . ..|||    . .| .
WSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQH

--F
  |
PWF