Gene LRRK1 (Mouse)

LRRK1

Species: Mouse
Alias: LRRK1, D130026O16Rik
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TKL
Family: LRRK

Sequence

Name Sequence Type Origin Length Description Download
LRRK1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 284 Kinase domain by global Sugen HMM Fasta, JSON
LRRK1.NA RNA Sugen 7454 None Fasta, JSON
LRRK1.AA Protein Sugen 2014 None Fasta, JSON

Protein domain

Protein domains of LRRK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ank LRRK1.AA Ank 91-107 41 23.52461 1.93 Pfam 6-22 (33) Show / Hide 
Range on Protein: 91-107
Range on HMM: 6-22/33
Sequence Identity: 41% (7 aa)

LSIAAAHGDLETVQFLL
| .|. .|..| |..||
LHLACRCGHTEVVKMLL
Ank LRRK1.AA Ank 126-141 50 7.179782 3.79 Pfam 8-23 (33) Show / Hide 
Range on Protein: 126-141
Range on HMM: 8-23/33
Sequence Identity: 50% (8 aa)

VAAHFGHAEVVRELLE
.|.. ||.|||..||.
LACRCGHTEVVKMLLQ
Ank LRRK1.AA Ank 157-180 62 0.002722 16.13 Pfam 6-28 (33) Show / Hide 
Range on Protein: 157-180
Range on HMM: 6-28/33
Sequence Identity: 62% (15 aa)

LALACQRGHLEVVKLLVLTHGADP
| |||..||.||||.|.  ||||.
LHLACRCGHTEVVKMLLQ-HGADV
Ank LRRK1.AA Ank 197-218 40 0.368945 8.44 Pfam 5-26 (33) Show / Hide 
Range on Protein: 197-218
Range on HMM: 5-26/33
Sequence Identity: 40% (9 aa)

PLYAAIKAGNEDIAIFLLRHGA
||  |.. |..... .|| |||
PLHLACRCGHTEVVKMLLQHGA
LRR_1 LRRK1.AA LRR_1 303-323 33 0.001798 16.48 Pfam 1-26 (26) Show / Hide 
Range on Protein: 303-323
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

NLKKLNLSN-N--QL-GELPC--VQSS
||..|.||. |  .| |..|.    . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRRK1.AA LRR_TYP 301-325 48 0.021005 13.6 SMART 1-24 (24) Show / Hide 
Range on Protein: 301-325
Range on HMM: 1-24/24
Sequence Identity: 48% (12 aa)

LINLKKLNLSNNQLGELPCVQSSDE
| ||..|.|||||| .||  .  . 
LPNLRELDLSNNQLTHLP-PGAFQG
LRR_BAC LRRK1.AA LRR_BAC 301-320 60 0.061137 10.49 SMART 1-20 (20) Show / Hide 
Range on Protein: 301-320
Range on HMM: 1-20/20
Sequence Identity: 60% (12 aa)

LINLKKLNLSNNQLGELPCV
  .||.|| ||||| |||  
PPHLKWLNVSNNQLTELPEL
LRR_1 LRRK1.AA LRR_1 279-301 29 0.229869 9.01 Pfam 1-26 (26) Show / Hide 
Range on Protein: 279-301
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

QITELDLSA-N--CL-PSLPSIIPWGL
....||||  |  .| ...|. .  .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRRK1.AA LRR_TYP 278-300 43 0.761991 0.82 SMART 2-24 (24) Show / Hide 
Range on Protein: 278-300
Range on HMM: 2-24/24
Sequence Identity: 43% (10 aa)

CQITELDLSANCLPSLPSIIPWG
 . .||||| | | .||. . .|
PNLRELDLSNNQLTHLPPGAFQG
LRR_BAC LRRK1.AA LRR_BAC 277-296 30 0.965591 1.34 SMART 1-20 (20) Show / Hide 
Range on Protein: 277-296
Range on HMM: 1-20/20
Sequence Identity: 30% (6 aa)

SCQITELDLSANCLPSLPSI
  ....|. | | | .||  
PPHLKWLNVSNNQLTELPEL
LRR_1 LRRK1.AA LRR_1 330-351 37 0.001642 16.62 Pfam 1-26 (26) Show / Hide 
Range on Protein: 330-351
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

RLLEIDISS-N--KLS-HLPPG-FLHL
.| ..|.|. |  .|. |.||. | .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRRK1.AA LRR_TYP 328-351 45 0.086831 8.55 SMART 1-24 (24) Show / Hide 
Range on Protein: 328-351
Range on HMM: 1-24/24
Sequence Identity: 45% (11 aa)

CSRLLEIDISSNKLSHLPPGFLHL
 . | | | |.|.|.||||| .. 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_BAC LRRK1.AA LRR_BAC 328-347 30 0.666396 2.57 SMART 1-20 (20) Show / Hide 
Range on Protein: 328-347
Range on HMM: 1-20/20
Sequence Identity: 30% (6 aa)

CSRLLEIDISSNKLSHLPPG
 ..| ....|.|.|. ||  
PPHLKWLNVSNNQLTELPEL
LRR_BAC LRRK1.AA LRR_BAC 351-370 35 1.196045 0.63 SMART 1-20 (20) Show / Hide 
Range on Protein: 351-370
Range on HMM: 1-20/20
Sequence Identity: 35% (7 aa)

LSKLQKLTASKNYLERLFEE
 ..|..| .| | |..| | 
PPHLKWLNVSNNQLTELPEL
LRR_TYP LRRK1.AA LRR_TYP 379-401 50 7e-05 23.47 SMART 1-24 (24) Show / Hide 
Range on Protein: 379-401
Range on HMM: 1-24/24
Sequence Identity: 50% (12 aa)

LRKLQELDLADNRLTELPVQ-FMH
|..|.|||| .|.||.|| . | .
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 LRRK1.AA LRR_1 381-402 37 0.001022 17.35 Pfam 1-26 (26) Show / Hide 
Range on Protein: 381-402
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

KLQELDLAD-N--RLT-ELPVQ-FMHS
.||.||| . |  .|| ..|   | . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_BAC LRRK1.AA LRR_BAC 403-422 40 0.001967 18.65 SMART 1-20 (20) Show / Hide 
Range on Protein: 403-422
Range on HMM: 1-20/20
Sequence Identity: 40% (8 aa)

FKSLTSLNVSRNNLKSFPDP
  .|..||||.|.|...|. 
PPHLKWLNVSNNQLTELPEL
LRR_1 LRRK1.AA LRR_1 405-425 25 0.026273 12.35 Pfam 1-26 (26) Show / Hide 
Range on Protein: 405-425
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

SLTSLNVSR-N--NL-KSFPD--PWSC
.|..|..|. |  || ...|.    ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_BAC LRRK1.AA LRR_BAC 379-398 40 0.058609 10.63 SMART 1-20 (20) Show / Hide 
Range on Protein: 379-398
Range on HMM: 1-20/20
Sequence Identity: 40% (8 aa)

LRKLQELDLADNRLTELPVQ
  .|..|.  .|.|||||  
PPHLKWLNVSNNQLTELPEL
LRR_TYP LRRK1.AA LRR_TYP 403-427 28 0.156662 6.45 SMART 1-24 (24) Show / Hide 
Range on Protein: 403-427
Range on HMM: 1-24/24
Sequence Identity: 28% (7 aa)

FKSLTSLNVSRNNLKSFPDPWSCPL
  .|..|. |.|.|.. | |  .  
LPNLRELDLSNNQLTHLP-PGAFQG
LRR_TYP LRRK1.AA LRR_TYP 472-493 41 0.142386 6.79 SMART 1-24 (24) Show / Hide 
Range on Protein: 472-493
Range on HMM: 1-24/24
Sequence Identity: 41% (10 aa)

LDALMFLRLQGNQLLSLPPQ--EK
| .|  |.|..||| .|||.  . 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_BAC LRRK1.AA LRR_BAC 472-491 35 1.255142 0.47 SMART 1-20 (20) Show / Hide 
Range on Protein: 472-491
Range on HMM: 1-20/20
Sequence Identity: 35% (7 aa)

LDALMFLRLQGNQLLSLPPQ
 ..| .|. ..||| .||  
PPHLKWLNVSNNQLTELPEL
LRR_1 LRRK1.AA LRR_1 451-472 25 4.161463 4.55 Pfam 1-26 (26) Show / Hide 
Range on Protein: 451-472
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

HLRDADFSE-N--SL-KEVPLG-LFQL
.|.  |.|  |  .| ...| . . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRRK1.AA LRR_1 474-490 38 10.737046 3.09 Pfam 1-21 (26) Show / Hide 
Range on Protein: 474-490
Range on HMM: 1-21/26
Sequence Identity: 38% (8 aa)

ALMFLRLQG-N--QLL-SLPP
 |  | |.| |  .|  ..||
NLQHLDLSGCNCCNLTGHIPP
LRR_1 LRRK1.AA LRR_1 498-511 44 0.386454 8.21 Pfam 1-18 (26) Show / Hide 
Range on Protein: 498-511
Range on HMM: 1-18/26
Sequence Identity: 44% (8 aa)

QLKTLDLSR-N--QL-GK
.|..||||. |  .| |.
NLQHLDLSGCNCCNLTGH
LRR_1 LRRK1.AA LRR_1 572-594 33 0.00217 16.19 Pfam 1-26 (26) Show / Hide 
Range on Protein: 572-594
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

NLSELYLGN-N-PGL-RELPPE-LGQL
|| .|.|.. | . | ...||. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRRK1.AA LRR_TYP 570-594 52 0.01577 14.62 SMART 1-24 (24) Show / Hide 
Range on Protein: 570-594
Range on HMM: 1-24/24
Sequence Identity: 52% (13 aa)

LKNLSELYLGNNPGLRELPPELGQL
| || ||.|.||  |..|||.. | 
LPNLRELDLSNNQ-LTHLPPGAFQG
LRR_1 LRRK1.AA LRR_1 549-570 33 0.284805 8.68 Pfam 1-26 (26) Show / Hide 
Range on Protein: 549-570
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLEVLCLND-N--HL-DAVPPS-VCLL
.|..| |.. |  .| . .|||    |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_BAC LRRK1.AA LRR_BAC 547-566 25 0.742806 2.21 SMART 1-20 (20) Show / Hide 
Range on Protein: 547-566
Range on HMM: 1-20/20
Sequence Identity: 25% (5 aa)

SESLEVLCLNDNHLDAVPPS
 ..|. |. ..|.|   |  
PPHLKWLNVSNNQLTELPEL
LRR_TYP LRRK1.AA LRR_TYP 548-569 30 0.790331 0.69 SMART 2-24 (24) Show / Hide 
Range on Protein: 548-569
Range on HMM: 2-24/24
Sequence Identity: 30% (7 aa)

ESLEVLCLNDNHLDAVPPSV-CL
 .|..| |..|.| ..|| .   
PNLRELDLSNNQLTHLPPGAFQG
LRR_BAC LRRK1.AA LRR_BAC 570-591 45 1.321133 0.3 SMART 1-20 (20) Show / Hide 
Range on Protein: 570-591
Range on HMM: 1-20/20
Sequence Identity: 45% (10 aa)

LKNLSELYLGNNPGLRELPPEL
  .| .|. .||  |.|| |||
PPHLKWLNVSNNQ-LTEL-PEL
ROC LRRK1.AA ROC 636-818 20 1e-25 83.39 In-house 1-215 (215) Show / Hide 
Range on Protein: 636-818
Range on HMM: 1-215/215
Sequence Identity: 20% (47 aa)

CKLMKMILVGPPRQGKSTLLEILQTGKAP---------QLAHSEATIR-TTKWELQRP---AGSKAKVESVEFNVWDIGGPASMATVNQCFFTD-KALYV
|. || .|.| .. ||..|.. |  .| .         .  .. . |     |.|. .      ..| . . ||||| ||   .    | |.|  ...|.
CNEMKLMLCGQGGVGKTSLCKQLMHDKFSDCSCYSCDKGNHPTTHGIEPIQQWVLDCKDMMF--RKKEDEIKFNVWDFGGQEIYHATHQFFLTNHRSVYL

VVWNLAL----GEEA----VAN--LQFWLLNIEAKAPN--------AVVLVVGTHLDLIEAKFR-----------VERIATLRAYVLALCRSPSGSRATG
.||....    |..       |  |..|| .|.. .|.        . |..||||.| .. .             ....                     
LVWDCRTKCCDGQPEMIVRECNYELEYWLRFIKSRGPQSEHHCMQPSPVIIVGTHWDKVPRQDNKVYQHKQCCRMWQKL------------------RNK

FPDITF--------KHLHEISCKNL-EGQEGLRQL
||.|..        .  . ..|.   .| ..||. 
FPNICHSWMQIEHYQGFFHVDCETGCKGIDKLRHH
Miro LRRK1.AA Miro 640-760 18 1.1e-07 29.7 Pfam 1-140 (140) Show / Hide 
Range on Protein: 640-760
Range on HMM: 1-140/140
Sequence Identity: 18% (26 aa)

KMILVGPPRQGKSTLLEILQTGKAP------------QLAHSEATIRTTKWELQRPAGS--KAKVESVEFNVWDIGGPASMATVNQCF--FTDKALYVVV
|  ..| .. |||.... . ... |            ..   . |.  .. ... . .|    .|    |..||.||.  ..  .. |  ...   ...|
KVVVCGDKGCGKSSFIHQYCGEEFPPNIPRVLPDKTMPREMHGHTYYVDTMQVDWDTQSENVDRVKMCYFHIWDCGGREYWKFEHMHFACMKWADAICFV

WNLALGE--EAVANLQFWLLNIEAKAPN-AVVLVVGTHLD
  .  .|  . | |.  || ...... .  .| |||...|
YDCTDYESFNRVSNYMAWLPHFRKWGKKAIPVIVVGNKCD
COR LRRK1.AA COR 829-1194 15 1e-29 93.31 In-house 1-386 (434) Show / Hide 
Range on Protein: 829-1194
Range on HMM: 1-386/434
Sequence Identity: 15% (69 aa)

VGSTIGCQKL-------AGRLIPRSYISLQEAVLAEQQRRSLGDQVQYLTDRQLDQLVEQTP-------GNDIKDYEDLQSAISFLIETGTLLHFP--DT
.. |.  .|        ... .|.|.  . ... ..   ...    ....  .. |..            | |.| . |. .. .| ..|...||   | 
IRKTAKKIKHKQMFEDYMCQPVPQSWWKCKQKLEEMRKWMNRHNEKPWMSWKEFCQICQEHGPPKRLRHQNIIIDEDELHTVAMYLHDLGHIIHFKIWDH

SHGLRNLYFLDPIWLSECLQRIFNIKGSRSV---AKNGV-IQAEDLRMLLVGT----------GFTQQTEEQYFQFLAKFEIALPVAN----------DS
  .|.....||| |... . .|||.| ||..   ...|. .  .||  .. .            ...   |...... |||...|...          . 
DPMLKDFVVLDPQWFCQMMYHIFNHKESRCFHKLHNKGIFFTHQDLEKIWNPPCRHNPHMNWRRYPDHDHEYLVELMEKFELCYPIDPDWTHFWHQETTT

YLLPHLLP-SKPGLD-THSM-----RHPMANTIQRVFKM------SFVPVGFWQRFIARML-ISLAEMDLQLFENKKNTKSRNRKVTIYSFTGSQRNRCS
|| | ||| ..|. . .. .      .   ....|....       | | |||.||..|.. ... ...                               
YLIPQLLPDDRPQHWEWWQWPQWETNEHDCRYLRRHYHYCMDHHHMFLPAGFWPRFQVRLHHFIHDMFKC------------------------------

TFRVRRN-QTIYWQEGLLVTFDGG---YLSVESSDVNWKKKKSGGIKIICQSEMR-----DFSAMAFITDHVNSLIDQWF--PALTATESDGTPLMEQYV
 |. | . .. ||. |..  . |.   . .|...       .  .|.|  ... .         .. |..|. .. ..|.  | |.  .  .  ... ..
-FYERSCCEWMYWRNGMVLKWEGHNKNEALVKCDN------HDNKIYITVRGCQDCWIDMCCQLWQIIRQHIQHIHNSWWPWPGLQYQCQHW--VCREWI

PCPVCEASWAQHADPNERSE-SVQ--YFDMEDCV
||| |           .... . .  |. ...|.
PCPHC---------IQDHWDTCCDICYYQYDWCI
LRR_1 LRRK1.AA LRR_1 1184-1205 25 2.892906 5.11 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1184-1205
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

SVQYFDMEDC---VLT-AIERD-FISC
. |. |. .|    ||  |  . | ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
Kinase LRRK1.AA LRRK 1242-1522 33 8.70000000001e-152 510.55 In-house 1-351 (351) Show / Hide 
Range on Protein: 1242-1522
Range on HMM: 1-351/351
Sequence Identity: 33% (118 aa)

EGENSILGQGGSGTVIYQARYQGQPVAVKRFHIKKFKN------------SANAPADTMLRH-----------------------------LRAMDAMKN
  ... .|.||.||..|.|...||||.|.|.|.|....            ..........|.                             ....|....
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

FSDFRQEASMLHALQHPCIVSLIGISIHPLCFALELAPLGSLNTVLSENAKDS-SFMP--LGHMLTQKIAYQIASGLAYLHKKN--IIFCDLKSDNILVW
|. ||.|..... |.||.||||.|..|||||...|.||.|.|...|.....|. .||.  ...||..|||.|||.|..|||..|  ||..||||.|||.|
FREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLW

SLS-------AKEHINIKLSDYGISR--QSFHEG-ALGVEGTPGYQAPEIRP---RIVYDEKVDMFSYGMVLYELLSGQRPALGHH--------QLQIVK
|..        ..|...|..|.||||  |.||.| | |..|.||..||||..   ...|.||||..|.||.|.|||..|... ..|        . || .
SSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIED

KLSKGIRPVLG---QPEEVQFHRLQALMMECWDTKPEKRPLALSVVSQMKD
| ..|.||..    .|.....|..|.|...||...|.||| . ..|.....
KIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase LRRK1.AA TKL 1248-1520 22 1.6e-79 270.47 In-house 1-364 (364) Show / Hide 
Range on Protein: 1248-1520
Range on HMM: 1-364/364
Sequence Identity: 22% (88 aa)

LGQGGSGTVIYQARYQG----------QPVAVKRFHIKKFKN--------------SANAPADTMLRHLRAMDAMKNFSDFRQEASMLHALQHPCIVSLI
.|.||.| ..|.....|          ..||||.|...  ..              |     | |   |....|....  ...|. |.. |.|| ||...
IGSGGFG-EVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYS-----D-M--QLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFM

G---------ISIHP------LCFALELAPLGS-LNTVLSENAKDSSFMPLGHMLTQKIAYQIASGLAYLHK--------KNIIFCDLKSDNILVWSL--
|         ...||      ||.  |..| || |....             . .. ..|..||.|..|||         ..|| .||||.||||..   
GYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWT

-------SAKEHINIKLSDYGISRQSFHEG--------------------ALGVEG-TPGYQAPEIR----------------PRIVYDEKVDMFSYGMV
       . ......|..|.|.||  ...|                    ... .. ||.. |||.                 .   |.||.|..|.|.|
NVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIV

LYELLSGQRPALGHHQ----------LQIVKKLSKGIRPVLG---------QPEEVQFHRLQALMMECWDTKPEKRPLALSVVSQM
|.|.|...||  ...           . ...  .|| || .          .|..   ...  ||..|||..||||| .. .....
LWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase LRRK1.AA Pkinase 1242-1520 22 2.4e-39 140.21 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1242-1520
Range on HMM: 1-293/293
Sequence Identity: 22% (73 aa)

EGENSILGQGGSGTVIYQARYQGQP--VAVKRFHIKKFKNSAN-----APADTMLRHLRAMDAMKNFSDFRQEASMLHALQHPCIVSLIGISIHP--LCF
    ...|.|..|.| |... .| .  ||||..  .. | . .     .                      .|..... |.||.|| |...   .  ...
YHIGRKIGSGSFGCV-YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL----------------------SEIQIMKRLNHPNIVRLYDWFEDKDHIYM

ALELAPLG----SLNTVLSENAKDSSFMPLGHMLTQKIAYQIASGLAYLHKKNIIFCDLKSDNILVWSLSAKEHINI----KLSDYGISR---QSFHEGA
 .|... |    .| ...|   .. .|. .     ....|||..||.|.|...|| .|||..|||.     ... .|    |..| |...       . .
VMEYCEGGLYVMDLFDYIST-WRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILI-----DNNGHIDACVKICDFGLAKQFDY-NNS-M

LGVEGTPGYQAPEIRP-RIVYDEKVDMFSYGMVLYELLSGQRPALGH------HQLQIVKKLSKGIRPVLGQPEEVQF------------------HRLQ
 .. |||.| |||.   .  |. ||||.|.| .|||.|.|. |  ||       |.|....  ... .    |..                       ..
TTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLH-FDWPWWCSISYFFFRHWHFHWTFHNWSEECK

ALMMECWDTKPEKRPLALSVVSQ--M
 ..  |.. .|.||| |  ..    .
DFIKWCLCKDPKKRPTAEQILQHPWF
Kinase LRRK1.AA TKL-Unique 1303-1520 26 1.2e-37 130.34 In-house 41-290 (290) Show / Hide 
Range on Protein: 1303-1520
Range on HMM: 41-290/290
Sequence Identity: 26% (67 aa)

DFRQEASMLHALQ-HPCIVSLIGISI----HPL--CFALELAPLGSLNTVLS------ENAKDSSFMPLGHMLTQKIAYQIASGLAYLHKKN--IIFCDL
.|. | . .  |. || || ..|...    .|   |. .|  |.|||. ||.       | .... ...  ..  |.| .||.|. ||| ..  || .||
EFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRV--KMAIDIAQGMYYLHHCEPPIIHRDL

KSDNILVWSLSAKEHINIKLSDYGISRQSF--HEGALG---------VEGTPGYQAPEIRPR--IVYDEKVDMFSYGMVLYELLSGQR------PALGHH
|| |.|| . |    .|||..| |.|. .    .. ..         ..|.. . |||.  .    |.||.| .|.|.||.|......      |  |  
KSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMD

QLQIVKKLSK---GIRPVLGQPEEVQFHRLQALMMECWDTKPEKRPLALSVVSQM
| |. ... .   . || ...  . .   .. |. .||.  |..||   ....  
QEQWCEMVHYMEENYRPPIPNHCPKE---YRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase LRRK1.AA S_TKc 1242-1525 24 5e-37 130.25 SMART 1-231 (231) Show / Hide 
Range on Protein: 1242-1525
Range on HMM: 1-231/231
Sequence Identity: 24% (71 aa)

EGENSILGQGGSGTVIYQARYQG--QPVAVKRFHIKKFKNSANAPADTMLRHLRAMDAMKNFSDFRQEASMLHALQHPCIVSLIGISI-HPLCFALELAP
     ..|.|. |.| |..|  .  . ||.|. .                             ..|.| ..|.  .|| || |...   . |.. .|...
YEILRKIGKGAFGKV-YKCRHKKTGRIVAIKIIK----------------------------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCD

L--GSLNTVLSENAKDSSFMPLGHMLTQKIAYQIASGLAYLHKKNIIFCDLKSDNILVWSLSAKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIR
   |.| ... .. .     |.    .....|||...|.|.|...|| .||| .|||. .       .||..| |..||        . ||| | |||. 
GDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL-----TTFCGTPWYMAPEVL

PRIVYDE-KVDMFSYGMVLYELLSGQRPALGHHQLQIVKKLSKGIRPVLGQPEEVQFHRLQALMMECWDTKPEKRPLALSVVS----QMKDPTF
    |.  |.|. | | .|||.|.|. |    .. .. ||.                . .  ... |..  ||||| |  .       ...| |
---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LRRK1.AA Dicty4-Unclassified 1303-1520 31 4.1e-34 114.21 In-house 44-263 (263) Show / Hide 
Range on Protein: 1303-1520
Range on HMM: 44-263/263
Sequence Identity: 31% (71 aa)

DFRQEASMLHALQHPCIVSLIGISIHP------LCFALELAPLGSLNTVLS-ENAKDSSFMPLGHMLTQKIAYQIASGLAYLHKKNIIFCDLKSDNILVW
||. |  .|  .|||  | . | .| |      .|   |. . | |  |     .     . |   |  |.|  || |...|| .|.|  |.|| |||. 
DFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILM-

SLSAKEHINIKLSDYGISRQ-SFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRPALGHH-QLQIVKKL-SKGIRPVLGQPEEVQF
      | |||  | ||||  .|      . |||   .||.     |  | | .||.|.||||. |  | ..    . .     .|. || .  |. .  
----DKHFNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYELATGDEPYQEIQSIMNAARSVCDKKLRPKI--PDNCD-

HRLQALMMECWDTKPEKRPLALSVVSQM
  .. |   ||   | |||    ..  .
NFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase LRRK1.AA TK 1288-1520 15 4.4e-33 107.67 In-house 59-486 (486) Show / Hide 
Range on Protein: 1288-1520
Range on HMM: 59-486/486
Sequence Identity: 15% (66 aa)

MLRHLRAMDAMKNFS-------------DFRQEASMLH--ALQHPCIVSLIGISIHP--------------LCFALELAPLGS----LNTVLSENAK---
||.   ||...  |               . .|..|..  ...|| ||.|.|.. ..              ..  .|..|.|.    | . | .. .   
MLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQ

-----------------------------------------------DSSFMPLGHMLTQK-------------------IAYQIASGLAYLHKK-----
                                               . ...||..                        ...|||.|..|||.|     
HEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFI

-NIIFCDLKSDNILVWS-LSAKEHIN------IKLSDYGIS--------RQSFHEGALGVEGTPG----------------------------YQAPEIR
 |..  ||   |.|| . .  | | .      .|..|.| |        |   ...   . ...|                            . |||  
QNFVHRDLAARNCLVGENNVCKWH-FDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECL

P---------RIVYDEKVDMFSYGMVLYELLS-G-QRPALGHHQ---------LQIVKKLSK------------GIRPVLGQPEEVQF------------
            .. .| |..|.| ...|... | . .. |..           .....| .            | |  . ||.                
NDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCP

-HRLQALMMECWDTKPEKRPLALSVVSQM
   .. ||..||. .||.||    ...|.
PEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase LRRK1.AA Dicty4 1302-1463 29 4.2e-31 101.1 In-house 43-216 (277) Show / Hide 
Range on Protein: 1302-1463
Range on HMM: 43-216/277
Sequence Identity: 29% (53 aa)

SDFRQEASMLHALQHPCIVSLIGISI----HP--LCFALELAPLGSLNTVLSE---NAKDSSFMPLGHMLT-QKIAYQIASGLAYLHKKN--IIFCDLKS
..||.|.. .  ..|| |. . | ..    ||  .|   |. | |.| ..|       ..|  .... ..   ..|  .| |...||  |  ||  ||||
NEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKS

DNILVWSLSAKEHINIKLSDYGISR-----QSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRP
.|.||      .. ..| .| |.|.      ..  .. .. |||.. |||.     |.||.| .|.|.||.|.| .| |
HNLLV-----DKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEP
Kinase LRRK1.AA STE 1243-1511 17 2.5e-30 104.34 In-house 1-346 (359) Show / Hide 
Range on Protein: 1243-1511
Range on HMM: 1-346/359
Sequence Identity: 17% (65 aa)

GEN-SILGQGGSGTVIYQARY----------------QGQPVAVKRFHIKKFKNSANAPADTMLRHLRAMDAM------KNFSDFRQEASMLHALQ--HP
 |. ...|.|..||| . ..                 .|. .|.|. .... .|.        .    .   .      ... .. .| .... ..  ||
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-E-----N-Q-EN-Q-ELENKNHEEMQQILKEIKIMKKCNHMHP

CIVSLIGISIHP---------LCFALELAPLGSLNTVLSENAKDSSFMPLGH--------MLTQKIAYQIASG-LAYLHKKNIIFCDLKSDNILVWSLSA
 ||  .|  ..          |. ..|. . |||  .. .. .    ...           .  .|..||  | |.|||...||  |.|..|||.     
NIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----

KEHINIKLSDYGISRQSFHEGA-------------LGVE-----GTPGYQAPEI-RP-----RIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQIVKK
     .||.| |.. |  ...|              . .     ||| . |||. ..     .  ||.|.|. | | .. |.. |. |    | ..    
-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFM

LSKGIRPVL---------GQPEEVQF----------------------HRLQALMMECWDTKPEKRP
  ......          |.|   .                         ..  .  | .  |.|||
IPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRP
Kinase LRRK1.AA MLK 1303-1463 30 5.1e-28 94.35 In-house 51-235 (291) Show / Hide 
Range on Protein: 1303-1463
Range on HMM: 51-235/291
Sequence Identity: 30% (57 aa)

DFRQEASMLHALQHPC----IVSLIGISIHP---LCFALELAPLGSLNTVLSENAKDSS----------FMPLGHMLTQKIAYQIASGLAYLHKKN---I
||..|.  |  |.||     |. . |... |   .|  .| .. |||..|| .. . ..           ....|...  .|.|.|.|..|||..    |
DFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMN--WALQCARGMHYLHSMAPKPI

IFCDLKSDNILVWS--LSAKEHINIKLSDYGISRQSFHEG---ALGVEGTPGYQAPEIR---PRIVYDEKVDMFSYGMVLYELLSGQRP
|  |||| |||.        .| . | .| |.|| ..|.      .  ||. . |||..   .   |.||.|..|.|.||.|.|... |
IHRDLKSHNILIDEICH-DMHHGTLKICDFGTSR-DWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase LRRK1.AA Ciliate-E2 1364-1475 25 2.9e-25 83.66 In-house 148-302 (365) Show / Hide 
Range on Protein: 1364-1475
Range on HMM: 148-302/365
Sequence Identity: 25% (44 aa)

QKIAYQIAS---------------GLAYLHKKN-IIFCDLKSDNILVWSLSAKEHINIKLSDYGISRQ-----------SFHEGALGVE-----------
..| .||..               .| |||.|| ||  |.| .|||.          ||..| |.|..           . ..  .              
KYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD

------------GTPGYQAPEIRP---------RIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQIVKK
            |||||.||||           .  ||.|.|..| |..|||.|.|..|      .|. |.
QIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-----QQQIKQ
Kinase LRRK1.AA MLK 1245-1472 29 5.7e-24 75.91 In-house 4-234 (280) Show / Hide 
Range on Protein: 1245-1472
Range on HMM: 4-234/280
Sequence Identity: 29% (74 aa)

NSILGQGGSGTVIYQARYQGQPVAVKRFHIKKFKNSANAPADTMLRHLRAMDAM-KNFSDFRQEASMLHALQHPCIVSLIGISIH--PLCFALELAPLGS
  |.| || | | | | ..|. ||||. .        .  .|        | .. .   . |||| .. .|.|| |. | |. ..   ||  .|..  ||
KEIIGNGGFGKV-YRAQWKGEEVAVKAHR-------QDPEQD--------MQQTDEQAEQVRQEARLFWMLKHPNIIALRGVCLEDPHLCLVMEYCRGGS

LNTVLSENAKDSSFMPLGHMLTQKIAYQIASGLAYLHKKN---IIFCDLKSDNILVWSLSA-----------------KEHIN---IKLSDYGISRQSFH
|| |..         |. | |    | ||| |. |||.     ||  ||||.|||.                      .....    |  |.|. |.  .
LNRVCAGK-----RIPP-HVLVN-WAVQIARGMNYLHNEAPVPIIHRDLKSSNILILEKICLCMDEEMFQYAYCLKCGHHDMCNKQLKITDFGLAREWHK

EGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQI
.  .   ||    |||.    .. .  |  ||| .| ||| |  |  |.  | .
TTRMSAAGTYAWMAPEVIKESTWSKGSDVWSYGVLLWELLTGEVPYRGIDPLAV
Kinase LRRK1.AA TyrKc 1242-1520 23 2.4e-21 78.15 SMART 1-280 (280) Show / Hide 
Range on Protein: 1242-1520
Range on HMM: 1-280/280
Sequence Identity: 23% (75 aa)

EGENSILGQGGSGTVIYQARYQGQPVAVKRFHIKKFKNSANAPADTMLRHLRAMDAMKNFSDFRQEASMLHAL--QHPCIVSLIGISI---------HPL
   . .|| |  |.| |....  ..||||  .  .                          ||..||.... |  .||.|| |.|. .         .||
ITLGKKLGEGAFGEV-YKGTWK-IQVAVKMLKEDA------------------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPL

CFALELAPLGSLNTVLSENAKDSSFMPLGHMLTQKIAYQIASGLAYLHKKNIIFCDLKSDNILVWSLSAKEHINIKLSDYGISRQSFHE------GALGV
.  .|..|.|.|.  | .. ..     | .    ....|||.| .|||.||.|  ||   |.||    ...|  .| || | ||   ..      .   .
MIVMEYMPHGDLKDYLRKHRPK-----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLV----GENH-TVKISDFGLSRDIYDDDQQGESKDYYR

E----GTPG-----YQAPEIRPRIVYDEKVDMFSYGMVLYELLS-GQRPALG-----HHQLQIVKKLSKGIRPVLGQPEEV-------QFHRLQALMMEC
     |. .       |||     .. .| | .|.| ...|... || |  |         ...... .| |  . ||...           .  .| .|
KKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYR--MPQPPNDYPMSFVCCPDEMYQIMKQC

WDTKPEKRPLALSVVSQM
|. .||.||    .....
WHEDPEDRPTFSEIHECF
Kinase LRRK1.AA Pkinase_Tyr 1296-1414 30 8.1e-19 64.35 Pfam 39-159 (270) Show / Hide 
Range on Protein: 1296-1414
Range on HMM: 39-159/270
Sequence Identity: 30% (39 aa)

DAMKN---FSDFRQEASMLHAL-QHPCIVSLIGISI---HP--LCFALELAPLGSLNTVLSENAKDSSFMPLGHMLTQKIAYQIASGLAYLHKKNIIFCD
.||.      || .||.... | .|| ||.|.|. .    |  ..  .|..|.|.| . | ..   ..  || .    ....|||.|..||. ||.|  |
GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR--EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRD

LKSDNILVWSLSAKEHINIKLSDYGISR
|   |.|| .        .| .| | .|
LAARNCLVTE-----NNVVKICDFGLAR
Kinase LRRK1.AA Pkinase_Tyr 1440-1520 25 2.6e-07 25.39 Pfam 190-270 (270) Show / Hide 
Range on Protein: 1440-1520
Range on HMM: 190-270/270
Sequence Identity: 25% (21 aa)

VYDEKVDMFSYGMVLYELLS-GQRP-ALGHHQLQIVKKL-SKGIRPVLGQPEEVQFHRLQALMMECWDTKPEKRPLALSVVSQM
.. .| |  |.| ...|... |. |   |    ......  .| |  . .||      .  ||..||. .||.||    ...|.
KFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYR--MPCPENCP-DEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase LRRK1.AA MLK 1493-1520 32 1.9e-05 15.02 In-house 264-291 (291) Show / Hide 
Range on Protein: 1493-1520
Range on HMM: 264-291/291
Sequence Identity: 32% (9 aa)

HRLQALMMECWDTKPEKRPLALSVVSQM
...  ||..||...|.|||   ..|.. 
EHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase LRRK1.AA MLK 1496-1520 36 1.9e-05 13.69 In-house 256-280 (280) Show / Hide 
Range on Protein: 1496-1520
Range on HMM: 256-280/280
Sequence Identity: 36% (9 aa)

QALMMECWDTKPEKRPLALSVVSQM
..|| .||.. | |||   ... |.
AKLMQDCWNQDPHKRPKFSEILQQL
Kinase LRRK1.AA MLK 1242-1296 23 8.8e-05 12.66 In-house 1-63 (291) Show / Hide 
Range on Protein: 1242-1296
Range on HMM: 1-63/291
Sequence Identity: 23% (15 aa)

EGENSILGQGGSGTVIYQARYQGQP-----VAVKRFHIKKFKNSANA-----PADTMLRHLRAMD
  .  ..| |..| | . .|....      |||||... .|  .. .       ..  |||| ..
IQFHEWIGSGSFGKV-WKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILS
Kinase LRRK1.AA Dicty4 1494-1511 38 0.000716 8.99 In-house 247-264 (277) Show / Hide 
Range on Protein: 1494-1511
Range on HMM: 247-264/277
Sequence Identity: 38% (7 aa)

RLQALMMECWDTKPEKRP
.. .|. .|||. |..||
SWKHLIQWCWDHDPQHRP
Kinase LRRK1.AA TKL-Unique 1246-1274 41 0.001052 9.15 In-house 3-30 (290) Show / Hide 
Range on Protein: 1246-1274
Range on HMM: 3-30/290
Sequence Identity: 41% (12 aa)

SILGQGGSGTVIYQARYQGQPVAVKRFHI
. .|.||.| ..|.. . | |||.|.||.
NKIGEGGYG-QVYKGKWRGYPVAIKQFHP