Gene LOK (Mouse)

LOK

Species: Mouse
Alias: LOK, Stk10
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: STE
Family: STE20
Subfamily: SLK

Sequence

Name Sequence Type Origin Length Description Download
LOK.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 259 Kinase domain by global Sugen HMM Fasta, JSON
LOK.NA RNA Sugen 5026 None Fasta, JSON
LOK.AA Protein Sugen 966 None Fasta, JSON

Protein domain

Protein domains of LOK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase LOK.AA SLK 36-294 73 9.90000000001e-185 620.0 In-house 1-259 (259) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-259/259
Sequence Identity: 73% (191 aa)

WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYYDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQ
|||.||||||||||||||..||....||||.||.|.|||||||.|||.||..|.||.||||..|||||.|||.|||||.|||||.||.||...|||.|||
WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQ

VVCRQMLEALNFLHGKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVLCETMKDAPYDYKADIWSLGITLIEMAQIEP
.||..|.||||.|| ...|||||||||.|||..||.||||||||||| .|.||||.|||||||||||||.|||.||.||||||||||||||||||||.||
YVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEP

PHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLQHPFV
||||.|||||||||.||.||||..||.||.||.||||..|.|.|..|...|||.||..|
PHHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase LOK.AA STE20 36-294 45 1.1e-147 496.94 In-house 1-288 (288) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-288/288
Sequence Identity: 45% (131 aa)

WEIVGELGDGAFGKVYKAKNKETGAL----AAAKVIETKSE----EELEDYIVEIEILATCDHPYIVKLLGAYYYD----GKLWIMIEFCPGGAVDAIML
.|.. ..| |..|||||| .|.|| .    .| |... ...    .|.|| . || |.. |.||.||| .|.|..|     .||| .|.| || .  || 
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---ELDR-----GLTEPQIQVVCRQMLEALNFLHGKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLK----TLQ-KRDSFIGTPYWMAPEVVLCETMK
   ....      ..|.|| ..||..|..|..|| ..|||||.||.|.|.| .|.. ||||||.|.  |    | | ||..|.||||||||||..|....
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

DAPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIA--KSDPPTLLT--PSKWSVEFRDFLKIALDKNPETRPSAAQLLQHPFV
| .||||.||||||||.||||  |||.....|||....|.  . .||||    |.||| ||.||..  |.|.|| ||.| |||.|||.
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase LOK.AA STE 36-294 33 2.3e-123 416.13 In-house 1-359 (359) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-359/359
Sequence Identity: 33% (121 aa)

WEIVGELGDGAFGKVYKAKNK------ETGAL---------AAAKVIETKSE-----------------EELEDYIVEIEILATCD--HPYIVKLLGAYY
||.....| ||||.||||.|.      .|| .          | |... ...                 ||..... ||.|.  |.  ||.||| .|.|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

YDG-------KLWIMIEFCPGGAVDAIML---ELDRGLT----------EPQIQVVCRQMLEA-LNFLHGKRIIHRDLKAGNVLMTLEGDIRLADFGVSA
..|       .|||  |...|| .| |.    .  ..|.          |.|| ..||| |.. |..|| ..|||||.|..|.|.     . |.||||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

KNLK---------------TLQ-KRDSFIGTPYWMAPEVVLCETMK-DAPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKS-----------
.  .               | | ||..|.||| ||||||..... . | .||.|.||||||.|.||||  .||.|...|||... |...           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----DPPTLLT-----------------PSKWSVEFRDFLKIALDKNPETRPSAAQLLQ--HPFV
    .||.| .                 |.||| ||.||..  |.|.|. ||.| |||.  |||.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase LOK.AA MST 36-294 47 8.9e-114 363.05 In-house 1-254 (254) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-254/254
Sequence Identity: 47% (124 aa)

WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYY--YDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQ
 .||. || |..|.|||| .|.|| . | |.. .  .| |.. | || |.  |. .||||. | |.  ..  .|| .|.| .| |  ||   .| |.| |
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPV--NEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQ

IQVVCRQMLEALNFLHGKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVLCETMKDAPYDYKADIWSLGITLIEMAQI
| ..... |  |  ||  ..||||.|||| |.  ||   |||||||.    |  ||...|||||||||||   .  |   ||.|||||||||| ||||  
IACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVI--QEIK---YDCKADIWSLGITAIEMAEG

EPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLQHPFV
.|| ... |||.. .| .. |||.  |..|| || ||..  | |||| |..| |||||||.
MPPYSDIHPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase LOK.AA YSK 36-294 44 8.70000000001e-108 325.67 In-house 1-257 (257) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-257/257
Sequence Identity: 44% (117 aa)

WEIVGELGDGAFGKVYKAKNKETGALAAAKVIE-TKSEEELEDYIVEIEILATCDHPYIVKLLGAYYYDGKLWIMIEFCPGGAVDAIMLE-LDRGLTEPQ
. .    | | || |||. .. |.   | |.|.  ..|.| ||   || .|. || ||| | .|.|  | ||||  |.| || .   |      .. |..
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKY

IQVVCRQMLEALNFLHGKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVLCETMKDAPYDYKADIWSLGITLIEMAQI
| .. |  | .| .||  | |||| || |||.. .||. |.||||...   | .||. |.||||||||||. .|  .   ||.|||||||||| .|||  
IAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSY---YDFKADIWSLGITAYEMAKG

EPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLQHPFV
|||. .. ||||.  | |. ||.|   ...|  | .|  . |.|.|| |||| .|| | |.
EPPYCDYHPMRVMFLIPKNNPPKLEG-RSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase LOK.AA KHS 36-294 45 7.8e-96 322.84 In-house 1-258 (258) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-258/258
Sequence Identity: 45% (120 aa)

WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYYDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQ
.|..  .| | .| ||||...... ||| |||    .....    || .. .| || ||   |.|    ||||..|.| ||..  |  ..   |.| || 
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIY-HVTGPLSELQIA

VVCRQMLEALNFLHGKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVLCETMKDAPYDYKADIWSLGITLIEMAQIEP
 |||. |..|..|| .  .|||.|  |.|.| .||..||||||||.   |. || |||||||||||||   |  .   |.   |||..||| ||.| . |
YVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVE--RKGGYNQLCDIWAVGITAIELAELQP

PHHELNPMRVLLKIAKSD--PPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLQHPFV
|  .| |||.|. ..||.  ||.|   .|||  | .|.|.|| |||  ||.| .|||||||
PMFDLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase LOK.AA S_TKc 36-294 32 5.2e-94 319.55 SMART 1-231 (231) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-231/231
Sequence Identity: 32% (89 aa)

WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYYDGKLWIMIEFCPG--GAVDAIMLELDRG-----
.||. ..| ||||||||...|.|| . | |.|        |. . ||.||   .||.||||.....  ..|..  |.|.|  | .  .. .  |.     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LTEPQIQVVCRQMLEALNFLHGKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVLCETMKDAPYDY-KADIWSLGITL
..| ... ...|...||...| ..|||||||  |.|..    | ..|||....        ..|.|||..|||||.        .|.. |.|.||.|..|
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL--------GYGKCKCDWWSCGCIL

IEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLQ-------HPFV
.||.  .|| .    | ...|. .            | |..||..  |.|.|| ||.| ..||       ||..
YEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LOK.AA PAKL 36-294 42 4.1e-87 295.72 In-house 1-256 (256) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-256/256
Sequence Identity: 42% (110 aa)

WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYYD-GKLWIMIEFCPGGAVDAIMLELDRGLTEPQI
 |.   ||.|..| ||||  |.|.   | |||| |   | .|   ||.||  |  |.||   |       ..||  ..|  | .  .|      |.| ||
FEFQEKLGQGSYGSVYKAIHKDTNFPLAIKVIEIKESNEIKDIEKEIQILKKCKCPNIVSYFGSIQQKLNHYWILMDYCSLGSINDMMESCCKTLNEKQI

QVVCRQMLEALNFLHGKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQ-KRDSFIGTPYWMAPEVVLCETMKDAPYDYKADIWSLGITLIEMAQI
 |. .| |  |  || | ||||| || |.|..  ... .|||||| .   ..     . ||||||||||...      ..|..|.||||||||.||||  
SVILQQTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVSQQLQDEYDGQANQMIGTPYWMAPEIINK-----QNYNNKCDIWSLGITAIEMADG

EPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLQHPFV
.||| ...||| .. |    |||.  | .|| .| |||   . | || |.|. .|| ||| 
FPPHYDMPPMRAMYMIPNWPPPTFSNPKHWSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI
Kinase LOK.AA NinaC 36-294 41 2.7e-85 289.67 In-house 1-267 (267) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-267/267
Sequence Identity: 41% (111 aa)

WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSE--EELEDYIVEIEILAT-CDHPYIVKLLGAYYYD-----GKLWIMIEFCPGGAVDAI---MLE
|||. . | | .|||.|.|||. | .|| |. .  ..  || |.   |  || . |||| .|.  | ||       ..||. .|.| || |  .   .| 
WEIYETIGKGTYGKVFKVKNKDNGQIAAVKIQHYIHDHDEEIEA---EYNILRDYCDHPNVVRFYGMYYKKDKCNGDQLWFVMEYCNGGSVTDMVKGLLK

LDRGLTEPQIQVVCRQMLEALNFLHGKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVLCETMKDAPYDYKADIWSLG
..| . |. |  . .  . .|  ||  ..|||| |  |.|.| || ..| ||||||    |. .|   .|||.||||||. |.   |  ||  .|.||||
CGRRMREEHIAYILHEACMGLQHLHCNHVIHRDVKGNNILLTTEGGVKLCDFGVSAQLDSTRHRRNTCVGTPCWMAPEVIACMQQYDPDYDARCDVWSLG

ITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLQHPFV
|| ||..  .||  .. ||| . ||    ||||. | .|. || ||    | |. | ||.  ..|.|||.
ITAIELGDGDPPFADMHPMRAMFKIPRNPPPTLMHPENWCQEFNDFISQCLEKDYEKRPMMVHMLEHPFI
Kinase LOK.AA Pkinase 36-294 29 1.1e-83 289.07 Pfam 1-293 (293) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-293/293
Sequence Identity: 29% (89 aa)

WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIV----EIEILATCDHPYIVKLLGAYYYDGKLWIMIEFCPGG----AVDAIML-ELD
..|.. .| |.||.|||...| || . | |.|. ..|.. .|..     ||.|.. ..||.||.|............  |.|.||       ...  . .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RGL--TEPQIQVVCRQMLEALNFLHGKRIIHRDLKAGNVLMTLEGDI----RLADFGVSAKN-LKTLQKRDSFIGTPYWMAPEVVLCETMKDAPYDYKAD
...  .| ... ...|.|..|...| ..|||||||  |.|.  .|.|    ...|||....  .   .  ..| |||..|||||..    .. .|..|.|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR----GGQYYGPKVD

IWSLGITLIEMAQIEPPHHEL------NPMRVLLKIAK----SDPPTLLTPS--------------KWSVEFRDFLKIALDKNPETRPSAAQLLQHPFV
.||.|..|.||.  .||  .       ..| .. .| .    .| |.. ..|              .|| |..||.|  |.|.|. ||.|.|.||||..
MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase LOK.AA PAKA 36-294 38 2.5e-83 283.14 In-house 1-260 (260) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-260/260
Sequence Identity: 38% (102 aa)

WEIVGELGDGAFGKVYKAKNKETGAL--AAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYYDGKLWIMIEFCPGGAVDAIMLELDR----GL
 . . ..| || |.||.|.|..|.     | |... | .   |  | || .. .| |. ||. . .| .| .||. .|.  ||    .  . ..     .
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYM

TEPQIQVVCRQMLEALNFLHGKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVLCETMKDAPYDYKADIWSLGITLIE
.| ||  |||. | .|.|.| | .||||.|  |.|.  .|.. ..|||  |   .  |||..  ||||||||||..        ||.| ||||||| .||
DEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQ-----YDEKVDIWSLGIMAIE

MAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLQHPFV
|.  |||. . .| | .  ||.   | .. | ||| ||.|||.  |..... |.|| .||.||| 
MIEGEPPYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase LOK.AA Ste20-DD1 36-294 44 5.5e-79 268.73 In-house 1-268 (268) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-268/268
Sequence Identity: 44% (121 aa)

WEIVGELGDGAFGKVYKA-------KNKETGALAAAKVIETKS---EEELEDYIVEIEIL-ATCDHPYIVKLLGAYYYDGKLWIMIEFCPGGAVDAIMLE
  ||   | | || |           |     . | | .|      || .     ||.||  | | |||||  | |  .  | |  |.| || .  ||  
FQIVEVIGQGSFGVVCTCRWMKKKDRNTNNNRVIACKFVEMNADDVEENSN-LKKEIDILKNTMDCPYIVKYHGCYIKENMLMIVMEYCDGGSILDIMQM

LDRGLTEPQIQVVCRQMLEALNFLHGKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVLCETMKDAPYDYKADIWSLG
    |.| ||  .| |  . | .|| .||.||| ||||||.  ||  .|||||||.    . .|    || ||||.||..      .  || ||||||||
CSKRLIEEQIAAICYQIVKGLVYLHSNRITHRDIKAGNVLVNKEGQPKLADFGVSTIAVNQGFKMNTVIGSPYWMSPEIIMPPKGSQG-YDQKADIWSLG

ITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLQHPFV
|| ||||   ||  ..|| ||   |    ||||  || || || || |  | .||. |||| ||| |||.
ITAIEMAESKPPRFNVNPVRVIFVIPHQQPPTLKIPSNWSPEFNDFIKQCLNMNPDKRPSAQQLLNHPFI
Kinase LOK.AA Pkinase_Tyr 36-179 29 2.9e-22 76.04 Pfam 1-158 (270) Show / Hide 
Range on Protein: 36-179
Range on HMM: 1-158/270
Sequence Identity: 29% (47 aa)

WEIVGELGDGAFGKVYKAKNK----ETGALAAAKVI-ETKSEEE--LEDYIVEIEILATC-DHPYIVKLLGAYY-YDGK--LWIMIEFCPGGAVDAIMLE
 ..  .|| ||||.|||.. |    .|.   | |.. |. ..|.  .|| . |..|. .  .|| ||.|.|. .  ..   ..|  |..|.|  .    .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

L---DRGLTEPQIQVVCRQMLEALNFLHGKRIIHRDLKAGNVLMTLEGDIRLADFGVS
    .. || ...   |.|  .....|. |..||||| | |.| | .. .. .||| .
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase LOK.AA TyrKc 36-297 22 1.1e-17 63.5 SMART 1-280 (280) Show / Hide 
Range on Protein: 36-297
Range on HMM: 1-280/280
Sequence Identity: 22% (67 aa)

WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATC--DHPYIVKLLGAYYYD-------GKLWIMIEFCPGGAVDAIMLELD
 .   .|| ||||.|||.. |      | |..   .   .|| . |..|.     .|| ||.|.|.   .       . |.|  |..|.|. .    .  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

RGLTEPQIQVVCRQMLEALNFLHGKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKT-------LQKRDSF-IGTP-----YWMAPEVVLCETMKDAP
. |. ..    | |  .  ..|| |..||||| | |.| . .. .. .||| | .             .| .   |.       |||||.      ..  
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-----NYGK

YDYKADIWSLGITLIEMA-QIEPPHHE-----LNPMRVLLKIAKSDPPTLLTPSK--------WSVEFRDFLKIALDKNPETRPSAAQLLQHPFVSRV
.  | |.|| |... |.    ..|. .     ... .|. .. . .   .  |           . |  .  |   . .|| ||. ...     ... 
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGY--RMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-----HECF
Kinase LOK.AA Pkinase_Tyr 198-294 24 0.001189 12.99 Pfam 180-270 (270) Show / Hide 
Range on Protein: 198-294
Range on HMM: 180-270/270
Sequence Identity: 24% (24 aa)

WMAPEVVLCETMKDAPYDYKADIWSLGITLIEMAQ-IEPP-HHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLQHPFV
|||||.          .  | |.|| |... |.    | |   .. . .|. .|...    .  | . . |  | .|   ...|| ||. ...  | . 
WMAPECINYGK-----FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYR-MPCPENCPDEIYDLMKQCWHYDPEDRPTFSEI--HEQL
PKK LOK.AA PKK 585-724 45 2e-58 205.19 Pfam 1-144 (144) Show / Hide 
Range on Protein: 585-724
Range on HMM: 1-144/144
Sequence Identity: 45% (66 aa)

KHELQLEQMHKRFEQEINAKKKFYDVELENLERQQKQQVEKMEQDHSVRRKEEAKRIRLEQDRDYAKFQEQLKQMKK--EVKSEVEKLP--RQQRKESMK
||.||.|||...|.|. ....|... |.|..|||||||.|||||.....|....|||| ||......|.|.||..||  |.| ||||.|  |.|||. ||
KHQLQKEQMKDQFFQQRHQMLKRHEKEMEQMERQQKQQIEKMEQRQTQERRRLPKRIRAEQEKRMKMFKESLKIEKKNMEPKQEVEKMPQFREQRKDRMK

QKMEEHSQKKQRLDRDFVAKQKEDLELAMRKLTTENRREICDKE
|.|||. ||.|.  ..|||...|..|..|.... |.|.... .|
QEMEEMEQKHQEQEQEFVAQCEENHEEMMQQMQNEHRHMLMEHE
PKK LOK.AA PKK 753-894 46 1.7e-66 232.04 Pfam 1-144 (144) Show / Hide 
Range on Protein: 753-894
Range on HMM: 1-144/144
Sequence Identity: 46% (67 aa)

RHQLVKQQLKDQYFLQRHDLLRKHEKEREQMQRYNQRMMEQLKVRQQQEKARLPKIQRSDGKTRMAMYKKSLHINGAG-SASEQREKIKQFSQQEEKRQK
.|||.|.|.|||.|.||| .|..|||| |||.|......|... ||.||. ||||..|.. ..||.|.|.||.|.  . .. ...||..||..|...|.|
KHQLQKEQMKDQFFQQRHQMLKRHEKEMEQMERQQKQQIEKMEQRQTQERRRLPKRIRAEQEKRMKMFKESLKIEKKNMEPKQEVEKMPQFREQRKDRMK

AERLQQQQKHENQMRDMVAQCESNMSE-LQQLQNEKCHLLVEHE
.|.....|||..|....|||||.|..| .||.|||..|.|.|||
QEMEEMEQKHQEQEQEFVAQCEENHEEMMQQMQNEHRHMLMEHE