Gene LATS2 (Mouse)

LATS2

Species: Mouse
Alias: LATS2, Lats2
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP ,
Annotation:

Classification

Group: AGC
Family: NDR
Subfamily: LATS

Sequence

Name Sequence Type Origin Length Description Download
LATS2.NA RNA Sugen 5213 None Fasta, JSON
LATS2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 306 Kinase domain by global Sugen HMM Fasta, JSON
LATS2.AA Protein Sugen 1042 None Fasta, JSON

Protein domain

Protein domains of LATS2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
UBA LATS2.AA UBA 98-135 20 1.2e-05 24.15 Pfam 1-38 (38) Show / Hide 
Range on Protein: 98-135
Range on HMM: 1-38/38
Sequence Identity: 20% (8 aa)

VNRQMLQELVNA-GCDQEMAGRALKQTGSRSIEAALEYI
.. .|...|.   | . . . .||....  ..|.|.|..
IDEEMVKQLMEMTGFSMMQCKKALRACNN-NVERAVEWL
Kinase LATS2.AA NDR 626-931 54 4.8e-231 720.89 In-house 1-350 (350) Show / Hide 
Range on Protein: 626-931
Range on HMM: 1-350/350
Sequence Identity: 54% (189 aa)

FVKIKTLGIGAFGEVCLACKLDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEAD--NEWVVKLYYSFQDKDSLYFVMDYIPGGDMMS---LLIRMEV
|..||..|.||||||.|..| ||...||||..||......||||||.|||||.||||  |.||||||||||||..||.||.|.||||||.   ||..|..
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

FPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTG---------------------FRWTHNSKYYQ-KGNHMRQDSMEPGD
|.|..|||||||...|||||||||.|||||||||.||| ||||||||||||||                     |.|||||.||| ...| .||.|.. .
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFGLCTGGMIRRHWKQNKQKKPMTTYSTFHWTHNSWYYQNMKEHRPQDFMDNWN

LWDDVSNCRCGD-----R---LKTLEQRAQKQHQRCLAHSLVGTPNYIAPEVLLR-KGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWEST
 ......|.|.      .   .|.|..|. ||..||||.|.||||.|.||||... .||.|.|||||.|.|..|||||.|||.. ||.||. |..||. |
SNPMNQKCKCHTQMKDQMKCNVKVLNNRSWKQNRRCLAYSTVGTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQT

L-----HIPTQVRLSAEARDLITKLCC-AADCRLGR--DGADDLKAHPFF
.     |.|... || || |||..|||  .| |||.   |.|. |.||||
WDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKGVDEIKSHPFF
Kinase LATS2.AA AGC 626-931 32 1e-179 469.53 In-house 1-395 (395) Show / Hide 
Range on Protein: 626-931
Range on HMM: 1-395/395
Sequence Identity: 32% (139 aa)

FVKIKTLGIGAFGEVCLACKL------DTHALYAMKTLRKKD---VLNRNQVAHVKAE------------RDILAEAD----------NEWVVK-LYYSF
|  .|..| |.||.|.|. |       ||  .|||| |.||.    ...|.|.|...|            |.||....          . ..|| |.|||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDKDS--LYFVMDYIP--------GGDMMSLLIRME-----VFPEHLARFYIAE-------LTLAIESVHK-MGFIHRD-IKPDNILIDLDGHIKLTDFG
||||   |||||.|.|        ||.....|. ..     .|.|  ||||.||       ..||.|. |. ||.|||| .||.|||.| ||||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LCTG----------------FRWTHNSKYYQKGNHMRQDSMEPGDLWDDVSNCRCGDRLKTLEQRAQKQHQ-----------RCLAHSLVG--TPNYIAP
||.                 |.| ||.|| ||.  |  . .                  | ....  ....           | ......|  ||.|.||
LCKEGMNDGEKGQQSQSNMKFHW-HNKKY-QKS-NMD-T-N------------------K-CNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAP

EVLLRKGYTQLCDWWS--VGVILFEMLVGQPPFLAPTPT----------ETQLKVI------NWESTL------HIPTQVRLSAEARDLITKLCC-AADC
|.|    |.. |||||  .|....|||.|.||| . .|           |.  |..      ||. ..      ..|... .| ||.|||.||.|   . 
EIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEK

RLG---RD----GADDLKAHPFF
|||   .|    ||...|.||.|
RLGCGGNDFGDKGAEEIKNHPWF
Kinase LATS2.AA DMPK 626-771 49 2.6e-105 261.1 In-house 1-147 (270) Show / Hide 
Range on Protein: 626-771
Range on HMM: 1-147/270
Sequence Identity: 49% (73 aa)

FVKIKTLGIGAFGEVCLACKLDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRME-VFPEH
|  .|  | |.||||..     |   |||| . |.. | | ..| .. ||||.. .. .|...|.| |||.. ||.||.| ||||. .|. | | ..|| 
FEILKVIGRGHFGEVQVVRHKQTNDVYAMKMMNKWEMLKRAETACFWEERDIMVHGNSRWITQLHYAFQDENYLYMVMEYMPGGDLLTLMSRYEDRIPED

LARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLC
.||||.||..||| |.|.||..||||||||.|.|  ||||| ||| |
MARFYLAEMVLAIHSIHQMGYVHRDIKPDNMLLDRHGHIKLADFGSC
Kinase LATS2.AA S_TKc 626-931 30 1.8e-96 327.69 SMART 1-231 (231) Show / Hide 
Range on Protein: 626-931
Range on HMM: 1-231/231
Sequence Identity: 30% (97 aa)

FVKIKTLGIGAFGEVCLACKLDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPG--GDMMSLLIRMEV---
. .....| ||||.|... . .|. ..|.| ..           |.. |..|| . . ...||||..||| |.||.||.|..|  ||..... ..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGNHMRQDSMEPGDLWDDVSNCRCGDRLKTLEQ
   |||  ||||.... .|.|  |..|.||||.||.|||.|   |||..||||.. .                                           
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------------------------------

RAQKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQ-LCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWESTLHIPTQVRLSAEARDLITKLCC-AADC
           ....|||.|.|||||   ||.   |||||.|.||.|||.|.|||      .. .|.|              | ||.|.| |...   . 
-----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEK

RLGRDGADD----LKAHPFF
|..   |       |.||.|
RPTA-EALQDEWDIKCHPWF
Kinase LATS2.AA RSK 629-931 33 1.2e-93 317.37 In-house 1-278 (278) Show / Hide 
Range on Protein: 629-931
Range on HMM: 1-278/278
Sequence Identity: 33% (108 aa)

IKTLGIGAFGEVCLACKL---DTHALYAMKTLRKKDVLNRNQ-VAHVKAERDILAEAD-NEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEV---
.| || |..|.| |  |    ||  .|||| |.|. . .|.  ..|...||.||..      .|.|.|.||... || .|.|..||..   | . .    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDL---DGHIKLTDFGLCTGFRWTHNSKYYQKGNHMRQDSMEPGDLWDDVSNCRCGDRLKTLEQ
| |. |.||.||..||.|  |. |.||||.||.||| |    .|||||||||.|  |                                           
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF-------------------------------------------

RAQKQHQRCLAHSLVGTPNYIAPEVLL----RKGYTQLCDWWSVGVILFEMLVGQPPFLA---PTPTETQLKVINWESTLHIPTQVRLSAEARDLITK-L
   . ..  .... ..| .|.|||.|     ..|... ||||| ||...|||.|.||| .    .. |.  .. . . .| .|    ||.||.|||.| |
---RCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKML

CCAADCRLG--RDGADDLKAHPFF
.     |||  ...|...|.||.|
HRDPHKRLGCGPQDAEEIKQHPWF
Kinase LATS2.AA AktR 626-931 34 8.3e-92 311.31 In-house 1-268 (268) Show / Hide 
Range on Protein: 626-931
Range on HMM: 1-268/268
Sequence Identity: 34% (108 aa)

FVKIKTLGIGAFGEVCLACKL-DTHALYAMKTLRKKDVLNRNQVAHVKAERDILA-EADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPE
|. .| || ||||.| |. |. |.  .|||| ..||.  .|||  |.  ||.|.. ....   |||.|.||.|. |.|.|.|.|||.. . | . . | |
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

HLARFYIAELTLAIESVHKM-GFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGNHMRQDSMEPGDLWDDVSNCRCGDRLKTLEQRAQKQ
  ||||.|.  ||.|  |.    | ||.||.|||.|.|||.|.|||||                                                 |..
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK----------------------------------------------LQFM

H-QRCLAHSLVGTPNYIAPEVLLR-KGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWESTLHIPTQVRLSAEARDLIT-KLCCAADC-RLG
   . .|.|..||| |.|||.... ||..  .|||..|. ..||..|.||| .   ..  .| .. .  . .|. . .| ...|||. || |     |||
MHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQ-QNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLG

--RDGADDLKAHPFF
  . |....| ||.|
YYCNGWEEIKSHPWF
Kinase LATS2.AA MAST 626-770 47 2.7e-80 244.89 In-house 1-148 (337) Show / Hide 
Range on Protein: 626-770
Range on HMM: 1-148/337
Sequence Identity: 47% (71 aa)

FVKIKTLGIGAFGEVCLACKLDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQD--KDSLYFVMDYIPGGDMMSLLIRME-VFP
|  || .. ||.| |.|. . .|  ..|||.... | . .||| .|..||.||....|..|||..||||   |. |..||.|  |||  |||  .   .|
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

EHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGL
|..|..||||. |..|  |..| .|||.||||.||| .||||||||||
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGL
Kinase LATS2.AA MAST 626-770 50 7.4e-78 250.5 In-house 1-145 (334) Show / Hide 
Range on Protein: 626-770
Range on HMM: 1-145/334
Sequence Identity: 50% (73 aa)

FVKIKTLGIGAFGEVCLACKLDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHL
|  || .. ||.| |.|. . .|  ..|||...| | .|.|.| .|..||.|||...|..|||..|||| |. |..||.|  |||  |||  .  |.|..
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

ARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGL
|..||||. |..|  |..| .|||.||||.||| .||||||||||
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGL
Kinase LATS2.AA Akt 626-771 52 1.2e-70 225.08 In-house 1-148 (264) Show / Hide 
Range on Protein: 626-771
Range on HMM: 1-148/264
Sequence Identity: 52% (78 aa)

FVKIKTLGIGAFGEVCLACKLDTHALY-AMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEH
|  .| || |.|| | |. | ||  .| ||| |.|.  ...|||.|.|.|| ||   ..  .|.|.||||..| |||||||..||.  ..| | ..|.| 
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

LARFYIAELTLAIESVHKMGFIHRD-IKPDNILIDLDGHIKLTDFGLC
 ||||.||. ||||  |... | ||  || |||.| ||||.|||||||
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLC
Kinase LATS2.AA ROCK 626-771 52 1.1e-60 205.37 In-house 1-145 (263) Show / Hide 
Range on Protein: 626-771
Range on HMM: 1-145/263
Sequence Identity: 52% (76 aa)

FVKIKTLGIGAFGEVCLACKLDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHL
|  || .| |||||| |  .  ..  |||| | | ... |   |    ||||.| |  ||.|.|.| |||.  || ||||.||||...|.   .| ||  
FHMIKVIGRGAFGEVQLVRHKSSKKVYAMKMLSKFEMIKRSDSAFFWEERDIMAHANSEWIVQLHYAFQDDRYLYMVMDYMPGGDLVNLMSNYDV-PEKW

ARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLC
|||| .|. ||....| |||||||.||||.|.|  ||.|| ||| |
ARFYTMEVVLALDAIHSMGFIHRDVKPDNMLLDKYGHLKLADFGTC
Kinase LATS2.AA GEK 626-771 50 1.1e-60 202.34 In-house 1-147 (269) Show / Hide 
Range on Protein: 626-771
Range on HMM: 1-147/269
Sequence Identity: 50% (74 aa)

FVKIKTLGIGAFGEVCLACKLDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRME-VFPEH
|  .| .| ||||||.     .|  .|||| | | ..| |  .|  . |||.| . |. |. .| | ||| . ||.||||  |||.. || . |   || 
FEILKVIGRGAFGEVAVVKMKNTDQVYAMKILNKWEMLKRAETACFREERDVLVNGDRRWITNLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDRLPED

LARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLC
.|||||||. .||.|||.....||||||||.|.|  |||.| ||| |
MARFYIAEMVMAIDSVHQLHYVHRDIKPDNVLLDMNGHIRLADFGSC
Kinase LATS2.AA DMPK 832-931 46 4.2e-54 131.61 In-house 162-270 (270) Show / Hide 
Range on Protein: 832-931
Range on HMM: 162-270/270
Sequence Identity: 46% (51 aa)

VGTPNYIAPEVL--LRKG----YTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINW-ESTLHIPTQVR--LSAEARDLITKLCCAADCRLGRDGA
|||| ||.||||  .  .    |   ||||||||...|||.|. || | .  ||  |  |  .  |  |...   .|.||.||| .| |... |||| |.
VGTPDYISPEVLQAMEDDGKGRYGPECDWWSVGVCMYEMLYGETPFYADSLVETYGKIMNHCKNHLSFPDDPKWDVSEEAKDLICQLLCDREERLGRNGY

DDLKAHPFF
.|.|.||||
EDFKCHPFF
Kinase LATS2.AA Pkinase 626-771 33 3.5e-42 150.22 Pfam 1-159 (293) Show / Hide 
Range on Protein: 626-771
Range on HMM: 1-159/293
Sequence Identity: 33% (54 aa)

FVKIKTLGIGAFGEVCLACKLDTHALYAMKTLRKKDVLNRNQVAHVK-AERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGG----DMMSLLI--RM
.......| |.||.|..... .|  ..|.|...|..     ...|.. .|  |... . . .|.||..|.|||..|.||.| .||    | ....   | 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

EVF--PEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHI----KLTDFGLC
 .|  .|. ..||. ..  ..|  |.||.||||.||.||||| .|||    |..||||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLA
Kinase LATS2.AA MAST 832-931 45 6.9e-37 109.76 In-house 229-337 (337) Show / Hide 
Range on Protein: 832-931
Range on HMM: 229-337/337
Sequence Identity: 45% (50 aa)

VGTPNYIAPEVLLRKG-YTQLCDWWSVGVILFEMLVGQPPFLAPTPTE-TQLKVINWESTLHIPTQ------VRLSAEARDLITKLCCAA-DCRLGRDGA
.||| ||||||.|..| | .  ||||.|.|..| ||| ||| . || | .  ..|| .  .  |          .|.||.||| ||       |||  ||
CGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLGANGA

DDLKAHPFF
|. | ||||
DEIKQHPFF
Kinase LATS2.AA GEK 832-931 46 3.4e-35 115.29 In-house 162-269 (269) Show / Hide 
Range on Protein: 832-931
Range on HMM: 162-269/269
Sequence Identity: 46% (50 aa)

VGTPNYIAPEVL--LRKG---YTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWESTLHIPTQVR---LSAEARDLITKLCCAADCRLGRDGAD
|||| ||.||.|  .  |   | . |||||.||...||| |. || |    ||  |..|..  ...| |.    .|.||.||| .| | .. ||||.|..
VGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKDHFQFPSQETDWDVSEEAKDLIRQLICSQEHRLGRNGIQ

DLKAHPFF
| | ||||
DFKKHPFF
Kinase LATS2.AA MAST 830-931 42 2.5e-34 107.84 In-house 223-334 (334) Show / Hide 
Range on Protein: 830-931
Range on HMM: 223-334/334
Sequence Identity: 42% (48 aa)

SLVGTPNYIAPEVLLRKG-YTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWE-STLHIPTQ------VRLSAEARDLITK-LCCAADCRLGRD
...||| ||||||.|..| . .  ||||.|.|..| ||| |||   ||.|.  ...| .     .|          .| ||.||| | | .    |||  
QCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLGAN

-GADDLKAHPFF
 |||. | ||||
NGADEVKQHPFF
Kinase LATS2.AA ROCK 832-931 48 7.3e-34 112.5 In-house 160-263 (263) Show / Hide 
Range on Protein: 832-931
Range on HMM: 160-263/263
Sequence Identity: 48% (50 aa)

VGTPNYIAPEVLLRKG----YTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWESTLHIPTQVRLSAEARDLITKLCCAADCRLGRDGADDLKA
|||| ||.||||  .|    | . |||||||| ..|||||. || | .   |  |...    |. | .| .| .|.||| |   ... |||| | ||.|.
VGTPDYISPEVLKSQGQDGEYGRECDWWSVGVFIYEMLVGDTPFYADSLVGTYSKIMDHKNSLKFPDDVEISKQAKDLICKFLTDREQRLGRNGVDDIKQ

HPFF
|.||
HKFF
Kinase LATS2.AA Pkinase 828-931 25 4.5e-24 86.2 Pfam 168-293 (293) Show / Hide 
Range on Protein: 828-931
Range on HMM: 168-293/293
Sequence Identity: 25% (33 aa)

AHSLVGTPNYIAPEVLL-RKGYTQLCDWWSVGVILFEMLVGQPPFLAP---TPTETQLKVINWESTLHIPTQVRLS---------------------AEA
.....|||.|.||||.. ...|.. .|.||.|.||.||| |.|||       .  .|...|.      .. .   .                      |.
MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEEC

RDLITKLCC-AADCRLGRDGADDLKAHPFF
.|.|....|    .|..   |.... ||.|
KDFIKWCLCKDPKKRPT---AEQILQHPWF
Kinase LATS2.AA Akt 828-871 44 7.4e-23 69.82 In-house 159-203 (264) Show / Hide 
Range on Protein: 828-871
Range on HMM: 159-203/264
Sequence Identity: 44% (20 aa)

AHSLVGTPNYIAPEVLLRKGYTQLCDWWS-VGVILFEMLVGQPPF
. .. ||| |.|||.|. .|.|. .|||. .|....||. |.|||
TKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPF
Kinase LATS2.AA TyrKc 626-917 18 5.2e-11 -44.61 SMART 1-280 (280) Show / Hide 
Range on Protein: 626-917
Range on HMM: 1-280/280
Sequence Identity: 18% (62 aa)

FVKIKTLGIGAFGEVCLACKLDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEA--DNEWVVKLYYSFQDK-------DSLYFVMDYIPGGDMMSLLI
 ...|.|| ||||||...         | |.|..        ..    |  |. .   ... .|.||    ..       . |. || | |.||  . | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RMEV-FPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGNHMRQDSMEPGDLWDDVSNC-RCGDRLKT
. .  ..      .        |  |....||||.   |.|.. ....| .||||.                              |. .  ..|     
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLS-----------------------------RDIYDDDQQG-----

LEQRAQKQHQRC----LAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEML-VGQPPFLAP----TPTETQLKVINWESTLHIPTQ------VRLS
    . |.  |      .....      |||..  . .|   | || || ..|..  ||.|   .     . .  .. .     . .|        |. .
----ESKDYYRKKEHKGGKTMLPI-RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCP

AEARDLITKLCCAAD-----------CRL
.|  . | | |...|            ..
DEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase LATS2.AA Pkinase_C 950-1004 23 3.6e-09 35.55 Pfam 1-46 (46) Show / Hide 
Range on Protein: 950-1004
Range on HMM: 1-46/46
Sequence Identity: 23% (13 aa)

TISHPMDTSNFDPVDEESPWHEASGESAKAWDTLASPSSKHPEHAFYEFTFRRFF
....| ||||||| ... |  . .           . .|.   ..|  ||.....
QVKSPTDTSNFDPEFTDEPPMDTP--------PDWR-MSSGDQEPFRGFTYVNPD
Kinase LATS2.AA Akt 890-931 33 3.7e-07 18.84 In-house 220-264 (264) Show / Hide 
Range on Protein: 890-931
Range on HMM: 220-264/264
Sequence Identity: 33% (15 aa)

LHIPTQVRLSAEARDLITKLCC-AADCRLG--RDGADDLKAHPFF
. .|   ..| |..|||..|.    . |||   ..|...|.||.|
VKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase LATS2.AA S_TK_X 932-1002 24 6e-06 26.91 SMART 1-79 (79) Show / Hide 
Range on Protein: 932-1002
Range on HMM: 1-79/79
Sequence Identity: 24% (21 aa)

NTIDFSRDI---RKQPAPYVPTIS----HPMDTSNFDPVDEESPWHEASGESAKAWDTLASPSSKHPEHA--------FYEFTFRR
  ||. .     .. ..|..|.|.    .| |||||||  .| ..       ..  |. .|.|.  .| .        | .||...
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM------LTPDDPPLSNSMWQNE-METEIPPDPFRGFTYVF
Kinase LATS2.AA Pkinase_Tyr 741-771 35 0.000214 15.51 Pfam 128-158 (270) Show / Hide 
Range on Protein: 741-771
Range on HMM: 128-158/270
Sequence Identity: 35% (11 aa)

HKMGFIHRDIKPDNILIDLDGHIKLTDFGLC
. ...||||.   |.|.. ....| .||||.
ESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase LATS2.AA Pkinase_Tyr 626-711 28 0.001716 12.45 Pfam 1-94 (270) Show / Hide 
Range on Protein: 626-711
Range on HMM: 1-94/270
Sequence Identity: 28% (27 aa)

FVKIKTLGIGAFGEVCLACKL----DTHALYAMKTLRKKDVLNRNQ--VAHVKAERDILAEA-DNEWVVKLYYSFQ-DKDS--LYFVMDYIPGGDM
 ...|.|| ||||||...       .|.   | |.|  |.     |   .   .|  |. .  ... .|.||     ....  .| || | |.||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML--KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL
Kinase LATS2.AA Pkinase_Tyr 839-871 34 5.338159 0.62 Pfam 182-216 (270) Show / Hide 
Range on Protein: 839-871
Range on HMM: 182-216/270
Sequence Identity: 34% (12 aa)

APEVLLRKGYTQLCDWWSVGVILFEMLV-GQPP-F
|||..  . .|   | || || ..|..  |. | .
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTY