Gene JAK2 (Mouse)
JAK2
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| JAK2.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 278 | Kinase domain by global Sugen HMM | Fasta, JSON |
| JAK2.AA | Protein | Sugen | 1132 | None | Fasta, JSON |
| JAK2.NA | RNA | Sugen | 5030 | None | Fasta, JSON |
| JAK2.kin_dom2 | Protein Kinase Domain | Sugen global kinase HMM prediction | 265 | Kinase domain by global Sugen HMM | Fasta, JSON |
Protein domains of JAK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | JAK2.AA | Jak | 545-807 | 40 | 3.4e-146 | 491.97 | In-house | 1-299 (299) | Show / Hide |
Range on Protein: 545-807 Range on HMM: 1-299/299 Sequence Identity: 40% (120 aa) LIFNESLGQGTFTKIFKGVRREVGDY----GQLHK--TEVLLKVLDKAHRNYSESFFEAASMMSQLSHKHLVLNYGVC--VCGEENILVQEFVKFGSLDT |...|.||.|.|............|. .| |. ..|..||....|...|..|....|.|||.||||.|...||| .|. |...|.|....|.||. LKWHEHLGEGHFGMVYRCRYDWIQDMTDDEDQWHEQKQVVVKKVQHPCHPQHSCDFHREISIMSQWSHKHIVKYHGVCCHWCQDEYCMVMEYWCYGPLDD YLK----KNKNSINI--LWKLGVAKQLAWAMHFLEEKSLIHGNVCAKNILLIREEDRRTGNPPFIKLSDPGISITVLPKDIL--QERIPWVPPECIEN-P ||. ..|. .|. ||. .|||..|.||.||.|..|||.|||.|||. ||........||.||.||..|......... .|||||..|||..| . YLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILVDREGHWCCVKIPFFKLMDPWCSDKEYYREMMDRDERIPWYAPECLTNCK KNLNLATDKWSFG-TTLWEIC----------------SGGDKPLSALDSQRKLQFYEDKHQLPAPK--WTELANLINNCMDYEPDFRPAFRAVIRDLNS ..|.||.|||||| .|||||| ..|..|....|..|||.|||..|.||.|. |.|..||...|..|.|..||.||..|||||. FYLTLAMDKWSFGRVTLWEICNCYCDESHSPYAIFLCMIGCCPQRQMDHCRKLNFYENGHRLPHPDSCWDEIYNLMQQCWHYDPNQRPSFRTIIRDLNQ |
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| Kinase | JAK2.AA | Jak | 266-544 | 15 | 5.1e-96 | 325.31 | In-house | 1-287 (299) | Show / Hide |
Range on Protein: 266-544 Range on HMM: 1-287/299 Sequence Identity: 15% (44 aa) YTEQFEVKESARGPSGEEIFATIIITGNGGIQWSR-GKHKESETLTEQDVQLYCDFPDIIDVSIKQANQECSNESRIVTVHKQDGKVLEIELSSLKEALS ........|...|.........|........||.. ..............|..|||...|......................||......|......... LKWHEHLGEGHFGMVYRCRYDWIQDMTDDEDQWHEQKQVVVKKVQHPCHPQHSCDFHREISIMSQWSHKHIVKYHGVCCHWCQDEYCMVMEYWCYGPLDD FVS----LIDGYYRLTADAHHYLCKEVAPPAVLENIHSNCHGPISMDFAISKLKKAG--NQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNE ... ........|.|......|...............||.......... .... .......|.........|........|....|.....|... YLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILVDREGHWCCVKIPFFKLMDPWCSDKEYYREMMDRDERIPWYAPECLTNCK NGEYNLSGTKRNFS--NLKDLLNCYQMETVRSDSIIFQFTKCCPPKPKDKSNLLVFRTNGISDVQISPTLQRHNNVNQMVFHKIRNED .... |...|..|. .|....|||..|......|......|||....|....|.|..||..............|..|...|...|.. FYLT-LAMDKWSFGRVTLWEICNCYCDESHSPYAIFLCMIGCCPQRQMDHCRKLNFYENGHRLPHPDSCWDEIYNLMQQCWHYDPNQR |
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| Kinase | JAK2.AA | Pkinase_Tyr | 545-805 | 27 | 7e-83 | 281.33 | Pfam | 1-270 (270) | Show / Hide |
Range on Protein: 545-805 Range on HMM: 1-270/270 Sequence Identity: 27% (78 aa) LIFNESLGQGTFTKIFKGVRREVGDYGQLHKTEVLLKVL--DKAHRN-YSESFFEAASMMSQL-SHKHLVLNYGVCVCGEEN---ILVQEFVKFGSLDTY ..|.. ||.| | ...||. . .. .|..| |.| . |.. ..|.|.. |..|.|| .|...| ||||.. .| ..| |... |.|..| ITFGKKLGEGAFGEVYKGTWKG---DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY LKKN---KNSINILWKLGVAKQLAWAMHFLEEKSLIHGNVCAKNILLIREEDRRTGNPPFIKLSDPGISITV-------LPKDILQERIPWVPPECIENP |.|. |..... ..|. . | |..| .||.| .|| ..|.|.|. . . ..| .| | . .. .. |.| .|||| . LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE--------NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYG KNLNLATDKWSFGTTLWEICSGGDKP-LSALDSQRKLQFY-EDKHQLPAPK--WTELANLINNCMDYEPDFRPAFRAVIRDL | . ..| |||| ..|||.. |..| .. .. ... || ...|.|. . |. .|. |..|.|. || |......| K-FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | JAK2.AA | TK | 545-805 | 16 | 2.4e-58 | 193.86 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 545-805
Range on HMM: 1-486/486
Sequence Identity: 16% (78 aa)
LIFNESLGQGTFT---KIFKGVRREVGDY------------------GQLHKTEVLLKVLDKAHRNYSESFFE--------------AASMMSQLS----
... . ||.| | ...|| |. ... . ||.| |.| . . . .| ||. |..|....
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
-HKHLVLNYGVCVCG------------EENILVQEFVKFGS----LDTYLKKNKNS--------------------------------------------
|...| ||||. | | ..| |... |. |..||.|...
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
-------------------------------INILWKLGVAKQLAWAMHFLEEK------SLIHGNVCAKNILLIREEDRR---TGNPPFIKLSDPGIS-
.. ..| . |.| .| .|..| ..|....| |.|. .. .. .|..|..|..| | |
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR
-------ITVLPKDIL------------------------------QERIPWVPPECIEN--------PKNLNLATDKWSFGTTLWEICSGGDKPLSALD
. ..| . | | .|||.. . ..| |||| ..|||.. |..|
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM
SQ---------RKLQFYEDK---------------HQLP----APKW------------TELANLINNCMDYEPDFRPAFRAVIRDL
| . . | . ...| .| | .|.. |. | .|.|. || |... . |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| B41 | JAK2.AA | B41 | 33-270 | 22 | 2.8e-58 | 200.87 | SMART | 1-232 (232) | Show / Hide |
Range on Protein: 33-270
Range on HMM: 1-232/232
Sequence Identity: 22% (59 aa)
KQIEPVLQVYLYHSLGQAEGEYLKFPSG-EYVAEEICVAASKACGITPVYHNMFALMSETE---RIWY-PPNHVFHIDES----TRHDILYRIRFYFPHW
. . .. ||.... .|.| .. .. ....|... . |||.|..|..|.|. | . | |. ........|.. ..|..||.|.|
SPKPRFCRVYFMDGT------TLEFEVDSSTTGQDLCDHVCRHCGISPREHWYFGLWYEDPHEDRHWLDHWKTIMKQDVKWHKSEPWTLHFRVKFYPPDW
YCSGSSRTYRYGVSRGAEAPLLDDFVMSYLFVQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKEKDQT-------PLAVYNSVSYKTFLPKCVRA
.. ... .|. ...|...|.|||...|....| ..||||..|.|.... ....|.. . | . .|||.|||| ..
HG-------------FPNQLQEDPTRYNYFYLQCRHDILQGRHPCP----HEEECLQLAALQVQIEYGDYDPEETNNKKMTKHVQKYKSYKRFLPKQWID
-------KIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEQF
..| .| .||||. ..... |. | .||||| ..... .....| |
SIKQSFMHYQMHHKEWRKRIMEWHKNH------CGMTPEEAKLKYLQICQRWPPMYGVEHF
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| Kinase | JAK2.AA | TyrKc | 545-805 | 23 | 6e-29 | 103.41 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 545-805 Range on HMM: 1-280/280 Sequence Identity: 23% (70 aa) LIFNESLGQGTFTKIFKGVRREVGDYGQLHKTEVLLKVLDKAHRNYSESFFEAASMMSQL--SHKHLVLNYGVCVCG-------EENILVQEFVKFGSLD . ... || | | ...||. . ..| |.| . . | | . |..|..| .|...| ||||. . | .| |... |.|. ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK TYLKKNKNSINILWKLGVAKQLAWAMHFLEEKSLIHGNVCAKNILLIREEDRRTGNPPFIKLSDPGISITVLPK-------DIL------QER--IP--W ||.|... .. .| . | | | .|..| .|| | |.|. .. .| || | | . . | ... .| | DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW VPPECIENPKNL--NLATDKWSFGTTLWEICSGGDKPLSA-----LDSQRKLQFYEDKHQLPAPKW----------TELANLINNCMDYEPDFRPAFRAV .|||| . . ..| |||| ..|||.. |..| . .. |. ... .. . .| |. .|. ... | ...|. || |... MAPECI---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI IRDL .... HECF |
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| Kinase | JAK2.AA | TKL | 551-805 | 15 | 4e-26 | 91.06 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 551-805
Range on HMM: 1-364/364
Sequence Identity: 15% (59 aa)
LGQGTFTKIFKGVRRE---VGDYGQLHK----TEVLLKVLDKAHRNYS---------------------------ESFFEAASMMSQLSHKHLVLNYGVC
.|.|.| ...||. | .. . ..| |.. . . . . . . | . |||.|.| ..|. .|.|
IGSGGFGEVYKGKWRGWGGKC------PSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYC
VCGEE-------------NILVQEFVKFGS-LDTYLKKNKNSINILWKLGVAKQLAWAMHFLEE--------KSLIHGNVCAKNILLIREEDRRTGNPPF
|.. .| |... || |.... . .. |.. | .|..| . .|| . ||||. . . | ..
CCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVS-NYMY
-------IKLSDPGISITVLPKD--------------------ILQERI---PWVPPECIENP---------------KNLNLATDKWSFGTTLWEICSG
.|..| |.| .. .. . .. | .||.... . . ..| .||| ||||...
NPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTR
GDKPLSALDSQRK---------LQFYEDKHQLPAP--------------KWTELANLINNCMDYEPDFRPAFRAVIRDL
.... . .......| | ......|. |.|..|. || | .. |
CRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | JAK2.AA | TK-Unique | 545-805 | 23 | 4.2e-24 | 80.07 | In-house | 1-294 (294) | Show / Hide |
Range on Protein: 545-805 Range on HMM: 1-294/294 Sequence Identity: 23% (71 aa) LIFNESLGQGTFTKIFKGVRREVGDYGQLHKT-EVLLKVLD-KAHRNYSESFFEAASMMSQLS-HKHLVLNYGVCVCG-EENILVQEFVKFGSLDTYLKK | .....|.| | ...| ... . |. |..| | .|. |. ..||..| |...| .|.|. | .. |.. |.|..||.. LEVGDVIGEGAFGQVWRGEVWGIW--KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRT NK-------------------NSINILWKLG------VAKQLAWAMHFLEE--KSLIHGNVCAKNILLIREEDRRTGNPPFIKLSDPGISI-----TVLP .. .... . . |.|.| .| .|.. | .|...||.|.|| . .|..| |.. .|. CRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE--------DKVCKICDFGMARDVYTNGVYS KDILQERIP--WVPPECIE-NPKNL-NLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDKHQLPAPKWT---ELANLINNCMDYEPDFRPAFRAV . |.||| | .|| . .. . .| |||| ..|||.. | | . ... . .. .| . .| |. |. ||. .| .||. || ||.. MMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQI IRDL . | KHRL |
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| Kinase | JAK2.AA | Frk | 545-809 | 24 | 1.9e-21 | 70.83 | In-house | 1-260 (260) | Show / Hide |
Range on Protein: 545-809 Range on HMM: 1-260/260 Sequence Identity: 24% (69 aa) LIFNESLGQGTFTKIFKGVRREVGDYGQLHKTEVLLKVLDKAHRNYSESFFEAASMMSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLK---KN . . || | | ... | .| | .| | |. . | | .| .| | |. | || | ... | .. ||| .||. .. IQLIRRLGSGQFGEVWEGLWNN--------TTPVAVKTL-KPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDK KNSINILWKLGVAKQLAWAMHFLEEKSLIHGNVCAKNILLIREEDRRTGNPPFIKLSDPGISITVLPKDI------LQERIP--WVPPECIENPKNLNLA ..... . .| |.| | .||.. || . |.|.|. |. .|. | |. .. .. . |.| | || . | . . GRQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLV--------GEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAA-NYNKFTIK TDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDKHQLPAPK--WTELANLINNCMDYEPDFRPAFRAVIRDLNSLF | |||| | || | | . . . || . .| | .| ... .| .|. || | . |. | SDVWSFGILLTEIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF |
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| Kinase | JAK2.AA | SH2 | 397-487 | 28 | 1.2e-20 | 75.83 | SMART | 1-87 (87) | Show / Hide |
Range on Protein: 397-487 Range on HMM: 1-87/87 Sequence Identity: 28% (26 aa) HSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENGEYNLSG-TKRNFSNLKDLLNCYQMETVR . .||.|| . | ..||. |.. | ...| | .. ..| |.. .. ..||..| .|..| | . . ..| |..| .|.| || . QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK----GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG |
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| Kinase | JAK2.AA | EGFR | 545-806 | 25 | 2.1e-19 | 60.95 | In-house | 1-258 (258) | Show / Hide |
Range on Protein: 545-806 Range on HMM: 1-258/258 Sequence Identity: 25% (70 aa) LIFNESLGQGTFTKIFKGVRREVGDYGQLHKTEVLLKVL-DKAHRNYSESFFEAASMMSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKN | || | | ...||. . . |. | | ||| .. .. .| . . | .| . |.||| |||. . || . .|.| |....|. LKKVKVLGSGAFGTVYKGIW--IPE-GENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQ-MQLVTQYMPYGCLLDYVRQHKD SINILWKLGVAKQLAWAMHFLEEKSLIHGNVCAKNILLIREEDRRTGNPPFIKLSDPGIS--ITVLPKDILQER----IPWVPPECIENPKNLNLATDKW | | . | | | .|||....| . | |.|. | .| | |.. . |.. . | |. |||.. . . | | NIGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKS--------PNHVKITDFGLAKLLEHDEKEYHAQGGKMPIKWMALECIHH-RCYTHQSDVW SFGTTLWEICSGGDKPLSALDSQRKLQFYEDKHQLPAPKW--TELANLINNCMDYEPDFRPAFRAVIRDLN |.| |.||. | || . . .. |. .|| |. . .. | .| || |. . .. SYGVTCWELMTFGQKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK |
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| Kinase | JAK2.AA | UTK | 545-681 | 24 | 4.2e-19 | 62.01 | In-house | 1-151 (296) | Show / Hide |
Range on Protein: 545-681 Range on HMM: 1-151/296 Sequence Identity: 24% (37 aa) LIFNESLGQGTFTKIFKGVRREVGDYGQLHKTEVLLKVLD--KAHRNYSE---SFFEAAS---MMSQLS-HKHLVLNYGVCVCGEENILVQEFVKFGSLD ... . |||| | ..|. .... . . . | .||.. .. . .| | | | ||.|.. | ... .|||. .| ..| |. . |.|. VQLGRQLGQGAFGEVHKARFTQCSE--HMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLR TYLKKNKNSIN----ILW---KLGVAKQLAWAMHFLEEKSLIHGNVCAKNILL .|| ... . . .| .|. | . | .|..|... ..|....|.|.|. SYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLV |
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| Kinase | JAK2.AA | S_TKc | 545-809 | 17 | 6.9e-15 | 41.44 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 545-809
Range on HMM: 1-231/231
Sequence Identity: 17% (50 aa)
LIFNESLGQGTFTKIFKGVRREVGDYGQLHKTEVLLKVLDKAHRNYSESFFEAASMMSQLSHKHLVLNYGVCVCGEENILVQEFVKF--GSLDTYLKKNK
. . .|.|.| | .|.. .. . .| .|... |.. ..... |...| |.|.. .. .| |.. |.| .|.||..
YEILRKIGKGAFGKVYKCRHKK-------TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG
NS-----INILWKLGVAKQLAWAMHFLEEKSLIHGNVCAKNILLIREEDRRTGNPPFIKLSDPGISITVLPKDILQERI---PWVPPECIENPKNLNL-A
.. . ...|.. |. .. .. || . |||| . ||..| |.. . . ...|| . . .
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----------HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCK
TDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDKHQLPAPKWTELANLINNCMDYEPDFRPAFRAVIR-----DLNSLF
| ||.| .|.| .. | | . | .. | . |. ..|..|....|. || . . . |
CDWWSCGCILYEMLC-GYPPFP----QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | JAK2.AA | Fer | 718-806 | 22 | 4.6e-13 | 40.93 | In-house | 184-283 (283) | Show / Hide |
Range on Protein: 718-806 Range on HMM: 184-283/283 Sequence Identity: 22% (23 aa) WVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSA---------LDSQRKLQFYEDKHQLPAP--KWTELANLIN-NCMDYEPDFRPAFRAVIRDL | .||.... . .|| |||| ..|||.. |..| . .. |.. . .. . .| | .|..... .|....|. || . ... | WLAPETWQTGI-YSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKL N . K |
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| Kinase | JAK2.AA | Src | 545-680 | 29 | 2.8e-12 | 37.96 | In-house | 1-129 (255) | Show / Hide |
Range on Protein: 545-680 Range on HMM: 1-129/255 Sequence Identity: 29% (41 aa) LIFNESLGQGTFTKIFKGVRREVGDYGQLHKTEVLLKVLDKAHRNYSESFFEAASMMSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLK--KNK . . . |||| | ..|. . .|.| |.| ... | | . | | .|.|..|| | || .| |.|. . ||| .||| . IKLCRKLGQGQFGEVWMGYWNG--------NTKVAVKTLKPGT-MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEG NSINILWKLGVAKQLAWAMHFLEEKSLIHGNVCAKNIL .... . | | | | .||.. .|| |.|.| RHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVL |
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| Kinase | JAK2.AA | Ack | 589-699 | 31 | 1.4e-11 | 35.39 | In-house | 44-149 (266) | Show / Hide |
Range on Protein: 589-699 Range on HMM: 44-149/266 Sequence Identity: 31% (36 aa) NYSESFFEAASMMSQLSHKHLVLNYGVCVCGEEN-ILVQEFVKFGSLDTYLKKNKN----SINILWKLGVAKQLAWAMHFLEEKSLIHGNVCAKNILLIR | ...|. .. | .| | ||| ||| | . .| |. ||| . |.| . .| .|. . |.| .| .|| | .|| . | |||| . NCMDDFLREVAIMHSLDHPHLVRLYGV-VLDQPMLMMVTELAPCGSLLDCLRKHCRTAFFLIHTLCDF--CMQIAMGMRYLEMKRCIHRDLAARNILLFS EEDRRTGNPPFIKLSD . .| .| DD-------RKVKICD |
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| Kinase | JAK2.AA | Fer | 600-671 | 40 | 5.3e-11 | 33.83 | In-house | 61-134 (283) | Show / Hide |
Range on Protein: 600-671 Range on HMM: 61-134/283 Sequence Identity: 40% (30 aa) MMSQ-LSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKN-SINILWKLGVAKQLAWAMHFLEEKSLIH .| . ..|.. | ||||| . .| ||.. ||||.||||||| .. . |. . | |. | .|..| || IMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYLKKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIH |
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| Kinase | JAK2.AA | UTK | 737-805 | 24 | 4.3e-09 | 27.25 | In-house | 224-296 (296) | Show / Hide |
Range on Protein: 737-805 Range on HMM: 224-296/296 Sequence Identity: 24% (18 aa) WSFGTTLWEICSGGDKPLSALDSQRKLQFYEDK--HQLPAPKW--TELANLINNCMDYEPDFRPAFRAVIRDL |||| ..|||...| .| . .. ... ... ...|.|. .. .| . |. |.|..|| |. . . WSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM |
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| Kinase | JAK2.AA | Ack | 716-805 | 30 | 1.2e-08 | 25.25 | In-house | 175-266 (266) | Show / Hide |
Range on Protein: 716-805 Range on HMM: 175-266/266 Sequence Identity: 30% (28 aa) IPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYE-DKHQLPAPKW--TELANLINNCMDYEPDFRPAFRAVIRDL ..| .|||. . . | | |.|| |||| |.| .| .. || . .. || |. .. .. .| . .| || | |. .| FAWCAPECL-RHRQFSHASDVWMFGVTLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL |
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| Kinase | JAK2.AA | Pkinase | 545-643 | 18 | 6e-06 | 22.18 | Pfam | 1-102 (293) | Show / Hide |
Range on Protein: 545-643 Range on HMM: 1-102/293 Sequence Identity: 18% (20 aa) LIFNESLGQGTFTKIFKGVRREVGDYGQLHKTEVLLKVLDKAHRNYSE---SFF--EAASMMSQLSHKHLVLNYGVCVCGEENILVQEFVKFG----SLD . . . .|.|.| . .|.... |. .| .|...| |.. .. . |.. .| |.|.. | |... . . .|.|.. | .| YHIGRKIGSGSFGCVYKCHHKGTGK-------IVAVKIIKKRHEKSWKDQTHRRLSEIQ-IMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF TYLK--KNKN .|.. .... DYISTWRHGC |
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| Kinase | JAK2.AA | Src | 734-805 | 30 | 0.161365 | 0.87 | In-house | 181-255 (255) | Show / Hide |
Range on Protein: 734-805 Range on HMM: 181-255/255 Sequence Identity: 30% (23 aa) TDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDKHQLPAPKW--TELAN-LINNCMDYEPDFRPAFRAVIRDL .| |||| |.|| . | | . . || | .| |. || . .. | . .|. || | | SDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL |
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| Kinase | JAK2.AA | Pkinase | 737-805 | 16 | 2.726302 | 2.11 | Pfam | 196-293 (293) | Show / Hide |
Range on Protein: 737-805 Range on HMM: 196-293/293 Sequence Identity: 16% (16 aa) WSFGTTLWEICSGGDKPLSAL----DSQRKLQFYEDKHQ----LPAPKW---------------------TELANLINNCMDYEPDFRPAFRAVIRD--L ||.| .|.| .. | | . . ...| .. . . . |.| |. .|..| .. | || .. . . . WSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | JAK2.AA | Jak | 849-1125 | 42 | 1.8e-153 | 516.14 | In-house | 1-299 (299) | Show / Hide |
Range on Protein: 849-1125 Range on HMM: 1-299/299 Sequence Identity: 42% (127 aa) LKFLQQLGKGNFGSVEMCRYDPLQ------DNTGE--VVAVKKLQHS-TEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRD ||....||.|.||.|..||||..| |...| .|.|||.||. ...| .||.|||.|.....|..||||.|||.. ........|||..||.|.| LKWHEHLGEGHFGMVYRCRYDWIQDMTDDEDQWHEQKQVVVKKVQHPCHPQHSCDFHREISIMSQWSHKHIVKYHGVCCHWCQDEYCMVMEYWCYGPLDD YLQ----KHKERIDH--KKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENR---VKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESK ||. .||....| ....|...|||.||.||. |||||.|...|||||..|.. |||..|.|......|||||.........|.|||||.||..| YLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILVDREGHWCCVKIPFFKLMDPWCSDKEYYREMMDRDERIPWYAPECLTNCK FSV--ASDVWSFG-VVLYELF-TYIEKSKSPPVEFMRMIGNDKQGQMIVFHLIELLKSNGRLPRPEGCPDEIYVIMTECWNNNVSQRPSFRDLSLRVDQ |. |.|.|||| |.|.|.. .|...|.||. .|..|||...|.|| ............|||.| |.|||| .|..||... .||||||.. ...| FYLTLAMDKWSFGRVTLWEICNCYCDESHSPYAIFLCMIGCCPQRQMDHCRKLNFYENGHRLPHPDSCWDEIYNLMQQCWHYDPNQRPSFRTIIRDLNQ |
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| Kinase | JAK2.AA | Pkinase_Tyr | 849-1123 | 40 | 3.5e-127 | 431.37 | Pfam | 1-270 (270) | Show / Hide |
Range on Protein: 849-1123 Range on HMM: 1-270/270 Sequence Identity: 40% (116 aa) LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKL-QHSTEEH--LRDFEREIEILKSL-QHDNIVKYKGVCYSAGRR-NLRLIMEYLPYGSLRDYLQK ..|...||.|.||.| ........|||. ||||.| .....|. ..|| ||..|.|.| .|.|||.. |||.. |. .. ..||| |.|.|.|||.| ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK H---KERIDHKKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYY-KVKEPGESPIFWYAPESLTESKFSVASDVWS | |.....| |||. ||.|||||| |..||||||.||.||...| |||.||||.. . ....|| .... | ||.|.|||.. ..||...||||| HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS FGVVLYELFTYIEKSKSPPVEFMRMIGNDKQGQMIVFHLIELL-KSNGRLPRPEGCPDEIYVIMTECWNNNVSQRPSFRDLSLRV |||...|.||| |. | . ..|.. ....|.|.||.|||||| .|..||. . ..||.|... . FGVLMWEIFTYGEQP--------------TYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | JAK2.AA | TyrKc | 849-1123 | 37 | 2.7e-121 | 410.18 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 849-1123 Range on HMM: 1-280/280 Sequence Identity: 37% (113 aa) LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSL--QHDNIVKYKGVCYSAGR-----RNLRLIMEYLPYGSLRDYL ......|| |.|| | .... . ||||.|.... ..|| ||..|...| .|.|||. ||| . || | ..||| |.|.|.||| ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL QKHKERIDHKKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQD------KEYYKVKE--PGE--SPIFWYAPESLTESKF .||.... .|.||.. ||..||||| |..||||||.||.|| ....|||.||||.. . | |.||..|| | || |.|||.. ..|| RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF SVASDVWSFGVVLYELFTYIEKSKSPPVEFMRMIGNDKQGQMIVFHLIELLKSNGRLPRPEG--------CPDEIYVIMTECWNNNVSQRPSFRDLSLRV . .||||||||...|.||| .. . ... | | ...||..|. .|.|.|. ||||.| ||..||. . ..||.|... . TTKSDVWSFGVCMWEIFTYGQQPYPGMIQ---------Q-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | JAK2.AA | TK | 849-1123 | 19 | 3.3e-97 | 326.43 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 849-1123
Range on HMM: 1-486/486
Sequence Identity: 19% (96 aa)
LKFLQQLGKGNFG---SVEMCRYDPLQ---------------------DNTGEVVAVKKLQHSTEEHLRD-----------------FEREIEILKS--L
......||.|.|| | .... .. ... . |||| | .... .. . .|...... .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
QHDNIVKYKGVCYSAGR----------RNLRLIMEYLPYGS----LRDYLQKHKER--------------------------------------------
.|.|||. ||| . . . ..||| |.|. |||||.|....
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
-------------------------------IDHKKLLQYTSQICKGMEYLGTK------RYIHRDLATRNILVENENR-----------VKIGDFG---
.. . || . ||..||||| | ...|||||.||.|| ..|. .||.|||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR
-----LTKVLPQDKEYYKVKEPG-----------------------ESPIFWYAPESLT---------ESKFSVASDVWSFGVVLYELFTYIEKSKSPPV
|.. ...|..||.....| || |.|||.|. . ||. .||||||||...|.||| .. . .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM
EF---------MRMIGNDKQGQMIVFH--LIELLKSNGRLPRP--EGCP--------------DEIYVIMTECWNNNVSQRPSFRDLSLRV
.. . ..|.. .. | . . .|...| ..|| .|.| .|..||. . ..||.|..| .
SNQDVWKDGDNQEVMEYLRRGGRL-CRSGL-N--EVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | JAK2.AA | UTK | 849-1050 | 30 | 4.3e-63 | 214.67 | In-house | 1-236 (296) | Show / Hide |
Range on Protein: 849-1050 Range on HMM: 1-236/296 Sequence Identity: 30% (73 aa) LKFLQQLGKGNFGSVEMCRYDPLQDNTGE-VVAVKKLQ--HSTEEHLR---DFEREIE---ILKSLQ-HDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLR .....|||.|.|| | ..|... . .| .||||..| .... . || .| ..| .. | |... ||| . . . ...|| . |.|| VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP--WMIVTEYMENGDLR DYLQKHKERID-------HKKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENE-------NRVKIGDFG---LTKVLP--------QDKEYYKVKEP .||..|.. . ..|.. ..| ||.|| .....||||| ||.|| . .||.||| ... .. .. .||. . SYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQ GESPIFWYAPESLTES-KFSVASDVWSFGVVLYELFTY .. || |.|||.||. .|. .|||||||||..|..|. DRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTW |
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| Kinase | JAK2.AA | Frk | 849-1127 | 34 | 1.9e-61 | 210.43 | In-house | 1-260 (260) | Show / Hide |
Range on Protein: 849-1127 Range on HMM: 1-260/260 Sequence Identity: 34% (97 aa) LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQ---KHK ......|| | || | .. | ||||.|. | . .|| || |.|.|.| ... || . . .| | . ||| .||| .. IQLIRRLGSGQFGEVWEGLW-----NNTTPVAVKTLKPGTMDP-NDFLREAQIMKKLRHPKLIQLYAVC--TVEEPIYIITELMRHGSLQEYLQAINDKG ERIDHKKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKE-YYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVL ... ..|.. . |. || || . ||||||| ||.||...| .|| |||| .|| .|.| | . || | ||| .||.. |||||||..| RQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILL YELFTYIEKSKSPPVEFMRMIGNDKQGQMIVFHLIELLKSNGRLPRPEGCPDEIYVIMTECWNNNVSQRPSFRDLSLRVDQIR .|. || | | | . .. .. . |.|.| .|| ..| || |||. . .|| | | .... TEIITYGR---------MPYPG------MTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF |
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| Kinase | JAK2.AA | EGFR | 849-1050 | 39 | 8.5e-61 | 200.53 | In-house | 1-199 (258) | Show / Hide |
Range on Protein: 849-1050 Range on HMM: 1-199/258 Sequence Identity: 39% (80 aa) LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHST-EEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKER || .. || | || | . | .| ||.| |. .| .. .. .| .. |..|...|. ||| . ...|. |.|||.| ||...||.. LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHS---QMQLVTQYMPYGCLLDYVRQHKDN IDHKKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYEL | ..|| . || |||.|| .| .|||||.||.|| |.||| |||| |.|..|.. |.... | || | | |.. . .. .|||||.|| . || IGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQG-GKMPIKWMALECIHHRCYTHQSDVWSYGVTCWEL FTY |. MTF |
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| Kinase | JAK2.AA | TK-Unique | 849-1050 | 33 | 9.5e-61 | 208.14 | In-house | 1-235 (294) | Show / Hide |
Range on Protein: 849-1050
Range on HMM: 1-235/294
Sequence Identity: 33% (79 aa)
LKFLQQLGKGNFGSVEMCRYDPLQ--DNTGEVVAVKKLQ-HSTEEHLRDFEREIEILKSLQ-HDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQ--
|......|.|.|| | . . .. .. .||||.|. ..|.. .|| .||...|.| | |||. |.| . . . .||||.|.|.|..||.
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD-EPWMIIMEYCPCGNLQHYLRTC
--------------------KHKER---IDHKKLLQYTSQICKGMEYLGT--KRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESP
..| | |. | |... ||..||||| |. .||||..||.|. . ...||.|||... . ...| . .. |. |
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIP
IFWYAPESLT--ESKF-SVASDVWSFGVVLYELFTY
| | ||||| . . . ||||||||...|.||.
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTL
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| Kinase | JAK2.AA | TKL | 855-1123 | 22 | 6.4e-59 | 202.07 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 855-1123
Range on HMM: 1-364/364
Sequence Identity: 22% (86 aa)
LGKGNFGSVEMCRYD------PLQDNTGEVVAVKKLQH---------------------------STEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAG
.|.| || | .. | .||..|||||. .. .|.|| ....|.|.|||...|.| . .
IGSGGFGEVYKGKWRGWGGKCP-S-DTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPP
-----------RRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICKGMEYLGTKR--------YIHRDLATRNILVENENR-------------
.| ..||| | |||..||. . .... .|..||.|| ... ||||| ..|||| . ..
CGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW
-VKIGDFGLTKVLPQDKE---------------YYKVKEPGES-PIFWYAPESLTES----------------KFSVASDVWSFGVVLYELFTYIEKSKS
.||.|||| ... |... .. . . . | ||| | .. ..| ..||.|||.||.|..| .
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR----
PP--VEFMRMIGNDKQGQMIVFHLIELLKSNGRLP----------RPEGCPDEIYVIMTECWNNNVSQRPSFRDLSLRV
| .| ||..| . . | .. . . .| .. ||... .|..||. . ..|||| .. |
PYYDYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | JAK2.AA | Src | 849-1050 | 38 | 1.5e-57 | 194.03 | In-house | 1-196 (255) | Show / Hide |
Range on Protein: 849-1050 Range on HMM: 1-196/255 Sequence Identity: 38% (78 aa) LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQ-KHKER .|....||.|.|| | | . ..|| |||| | | . .| .|..|.|.|.|...|. || | . . || ||| |||. . ..| IKLCRKLGQGQFGEVWMGYW---NGNT--KVAVKTLKPGT-MSPEAFLQEAQIMKKLRHEKLVQLYAVC-SQEE-PIYIVTEYMSHGSLLDYLKKDGEGR -IDHKKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYE . ..|. . |. .||.||. ..||||||| ||.|| ..| .|..|||| ... .|.. | .. || | ||| ... .|.. |||||||. |.| HLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTE LFTY ..|| IVTY |
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| Kinase | JAK2.AA | Ack | 849-1050 | 39 | 1.7e-56 | 189.09 | In-house | 1-207 (266) | Show / Hide |
Range on Protein: 849-1050
Range on HMM: 1-207/266
Sequence Identity: 39% (82 aa)
LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHS---TEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHK
.. . .|| | ||.| . .. |||| | . . || || |. ||.| ..|. || . |....| | ||| | | ||.
ITLCEKLGDGCFGVVWRGEWTN-PGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPM--LMMVTELAPCGSLLDCLRKHC
E--RIDHKKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENE-NRVKIGDFGLTKVLPQDKEYYKVKEPG--ESPIFWYAPESLTESKFSVASDVWSF
|... ||..|| ||. || ||||||.||||. . |||.|||| |.| . ||. ... |. | |||.|. .|| |||||.|
RTAFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMF
GVVLYELFTY
|| | | |.|
GVTLWEMFSY
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| Kinase | JAK2.AA | S_TKc | 849-1130 | 24 | 3e-54 | 187.48 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 849-1130 Range on HMM: 1-231/231 Sequence Identity: 24% (73 aa) LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPY--GSLRDYLQKHKE ..|...||| ||.| || ||..||.|.. ....|||.|||. .|.||||...|... .| ..|||.. |.|.||..|.. YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGR R-----IDHKKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSV-ASDVWSF . .. |. |||...||. .. ||||| |||. . ..||.|||| ..| .. ||| | ... ..|.||. HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSC GVVLYELFT----YIEKSKSPPVEFMRMIGNDKQGQMIVFHLIELLKSNGRLPRPEGCPDEIYVIMTECWNNNVSQRPSFRDLSL--RVDQIRDSI |..|||... . . . ...|| ..| .. |.. . ..||. .. .. . . GCILYEMLCGYPPFP-----QMQMMFKKIG----------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | JAK2.AA | Fer | 849-1049 | 32 | 4.9e-54 | 182.43 | In-house | 1-213 (283) | Show / Hide |
Range on Protein: 849-1049 Range on HMM: 1-213/283 Sequence Identity: 32% (70 aa) LKFLQQLGKGNFGSVEMCR-----YDPLQDN-TGEVVAVKKL--QHSTEEHLRDFEREIEILKS-LQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRD .. .||.|.|| | | ... . . . |.|||. ..|.| ...| .| |... ..|.|.||. | ... . . ..||. . |||.. VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYG--VCVDEQPIMIVMEFCNGGSLDS YLQKHKER-IDHKKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVEN-ENRVK--IGDFGLTKVLPQDKEYYKVK-EPGESPIFWYAPESLTESKFSVA ||.| |.. . ....... |...||||| | ||||.| ||.|. . .. .| | |||. . . ... || | . || | |||... .| . YLKKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPK SDVWSFGVVLYELFT .|||||||...| || TDVWSFGVMCWEIFT |
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| Kinase | JAK2.AA | Pkinase | 849-1123 | 21 | 1.6e-42 | 151.41 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 849-1123 Range on HMM: 1-293/293 Sequence Identity: 21% (70 aa) LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRD--FER--EIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYG----SLRDY .......|.|.||.| |. .||..||||.. ..|.. | | ||.|.|.|.|.|||........ .... ..|||.. | .| || YHIGRKIGSGSFGCVYKCH----HKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDY LQ-KHKERI--DHKKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRV----KIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLT-ESKFS .. . . .. . . . | ||..|.||. .. ||||| |||. |.. . ||.|||| |.. . ... ||| . .. . ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYG VASDVWSFGVVLYELFTYIEKSKSPPVEFMRMIGNDKQGQMIVFHL--------IELLKSNGR----LPRPEGCP-------------------DEIYVI ..|.||.|..|||... |. . . ..... ... ..|. |. .| . PKVDMWSCGCILYEMLC---------------------GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDF MTECWNNNVSQRPSFRDLSLR--V .. |.. . ..||..... . IKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | JAK2.AA | UTK | 1084-1123 | 37 | 3.3e-16 | 51.94 | In-house | 254-296 (296) | Show / Hide |
Range on Protein: 1084-1123 Range on HMM: 254-296/296 Sequence Identity: 37% (16 aa) SNG---RLPRPEGCPDEIYVIMTECWNNNVSQRPSFRDLSLRV .|| |.|.|..||...| .|..||. ... ||.|.|| .. CNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM |
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| Kinase | JAK2.AA | Src | 1087-1123 | 44 | 4.3e-14 | 44.24 | In-house | 218-255 (255) | Show / Hide |
Range on Protein: 1087-1123 Range on HMM: 218-255/255 Sequence Identity: 44% (17 aa) RLPRPEGCPDEIYV-IMTECWNNNVSQRPSFRDLSLRV |.|.|..||||.| ||..||.. ||| | | RMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL |
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| Kinase | JAK2.AA | TK-Unique | 1078-1123 | 36 | 6.7e-14 | 44.43 | In-house | 248-294 (294) | Show / Hide |
Range on Protein: 1078-1123 Range on HMM: 248-294/294 Sequence Identity: 36% (17 aa) LIELLKSNGRLPRPEGC-PDEIYVIMTECWNNNVSQRPSFRDLSLRV ..|... |.|.||.| ..|.| .| .||. . ..|||||.. | IMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
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| Kinase | JAK2.AA | Ack | 1087-1123 | 40 | 2.4e-12 | 37.96 | In-house | 230-266 (266) | Show / Hide |
Range on Protein: 1087-1123 Range on HMM: 230-266/266 Sequence Identity: 40% (15 aa) RLPRPEGCPDEIYVIMTECWNNNVSQRPSFRDLSLRV |||||. || .|| .| .|| .. ||.| .. RLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL |
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| Kinase | JAK2.AA | Fer | 1083-1124 | 27 | 1.8e-10 | 31.99 | In-house | 241-283 (283) | Show / Hide |
Range on Protein: 1083-1124 Range on HMM: 241-283/283 Sequence Identity: 27% (12 aa) KSNGRLPRPEGCPDEIYVIMT-ECWNNNVSQRPSFRDLSLRVD |.. ..| |...|.||. ||. ||. . ..||.. .. .. KKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK |
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| Kinase | JAK2.AA | EGFR | 1080-1124 | 33 | 3.8e-09 | 26.34 | In-house | 214-258 (258) | Show / Hide |
Range on Protein: 1080-1124 Range on HMM: 214-258/258 Sequence Identity: 33% (15 aa) ELLKSNGRLPRPEGCPDEIYVIMTECWNNNVSQRPSFRDLSLRVD .||. ||| |. | .|..| || || |. | . . DLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK |
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