Gene IRR (Mouse)

IRR

Species: Mouse
Alias: IRR, Insrr
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: InsR

Sequence

Name Sequence Type Origin Length Description Download
IRR.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 270 Kinase domain by global Sugen HMM Fasta, JSON
IRR.NA RNA Sugen 5102 None Fasta, JSON
IRR.AA Protein Sugen 1300 None Fasta, JSON

Protein domain

Protein domains of IRR.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Recep_L_domain IRR.AA Recep_L_domain 47-159 30 6.6e-40 135.89 Pfam 1-121 (121) Show / Hide 
Range on Protein: 47-159
Range on HMM: 1-121/121
Sequence Identity: 30% (38 aa)

NCSVVEGHLQILLMFAATGEDFRGL---SFPRLTQVTDYLLLFRVYGLESLRDLFPNLTVIRGTRLFL--GYALIIFEMPH--LRDVGLPSLGAVLR--G
||.|..|.|.|....  .    .     .|| .. .|.|||..|. ..... ..||||..|||. ||    |||.|...|.  |.. ....|  ..|  |
NCTVIYGNLEITWRDEHNE---LEEDLSFFPNIREITGYLLIYRT-YNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNMGLQELWMWNLKNITRKNG

AVRVEKNQ--ELCHLST-IDWGLLQ
 |....|   .||.. | |.| .. 
GVYIHNNPHPKLCYTHTEIMWWMIY
Furin-like IRR.AA Furin-like 173-329 41 2e-78 257.74 Pfam 1-182 (182) Show / Hide 
Range on Protein: 173-329
Range on HMM: 1-182/182
Sequence Identity: 41% (76 aa)

GEECADVCPGVLGAAGEPCSRTTFSGRTDYRCWTSS--HCQ----KVCP--CPRGMACT--AGGDCCHSECLGGCSQPEDPRACVACRHLYFQGVCLRAC
..||.||||| . . ..|| .||..| ..||||...  |||    ||||  |.. ..||  . |.|||..|||||..| ....||||||.|..|.|. .|
NRECPDVCPGTC-EPCHPCCKTTINGHYGYRCWGPNPQHCQTLTKKVCPEQCKH-RRCTGPKPGECCHEQCLGGCTGPNNDTDCVACRHFYHNGTCVDQC

PP----------------GTYQYESWRCVTAELCAHLREVPGLATTFGIYEGSCLAQCPPGFTRN--GSSIFCHKCEGLCPKECK
||                ||||.| |||||.. |. | . ..  . . |. |.|.  ||.|.|.|  ... .|..|||.|||.|.
PPMMIYNPTTFQMEPNPDGTYQFEGWRCVTFKECPKL-SHNPDCNYYVIHNGECMRECPSGYTENEENNTMMCEPCEGPCPKVCY
FU IRR.AA FU 225-268 42 3.8e-13 50.93 SMART 1-48 (48) Show / Hide 
Range on Protein: 225-268
Range on HMM: 1-48/48
Sequence Identity: 42% (21 aa)

GGDC--CHSECLGGCSQPEDPRACVACRHLYFQ---GVCLRACPPGTYQ
.| |  ||.||..||. |  | .|..|.| |..   |.|.  ||||.| 
DGVCKPCHPECATGCWGPG-PDQCTSCPHGYYLHHNGTCVSQCPPGYYP
Recep_L_domain IRR.AA Recep_L_domain 346-461 33 1.2e-39 135.04 Pfam 1-121 (121) Show / Hide 
Range on Protein: 346-461
Range on HMM: 1-121/121
Sequence Identity: 33% (41 aa)

GCTHVEGNLILNLRQGYNLEPELQR---NLGLVETITGFLKIKHSFALVTLGFFKNLKLIRGDSMVDG-NYTLYVLDNQN--LQQLGSWVTAGLTIPVGK
.||...|||....| ..|    |..    ......|||.|.|... .|. | ||.||. |||..  .. ||.||..||.|  ||.|. |    .|.  |.
NCTVIYGNLEITWRDEHNE---LEEDLSFFPNIREITGYLLIYRTYNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNMGLQELWMWNLKNITRKNGG

IYFAFNP--RLCLEHIYQLEEVTG
.|. .||  .||. |.........
VYIHNNPHPKLCYTHTEIMWWMIY
FN3 IRR.AA FN3 483-586 13 0.004921 17.31 SMART 1-69 (69) Show / Hide 
Range on Protein: 483-586
Range on HMM: 1-69/69
Sequence Identity: 13% (16 aa)

QTRTLR---FVFNLTEED------RILLRWERYEPLEARDLLSFIVYYKESPFQNATEHVGPDACGTQSWNLLDVELPLSRTQEPGVTLAPLKPW----T
     .   ...  . ..       . |.|.  .|         ||.|.                                     .|.  |||.    |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWK--PP---------IVGYR-------------------------------------YTVTGLKPGQYPWT

QYAVFVRAITLTTAEDS
.| . |||.. . |  .
EYEFRVRAVNGNDAGEG
FN3 IRR.AA FN3 605-798 8 3.5e-07 31.12 SMART 1-69 (69) Show / Hide 
Range on Protein: 605-798
Range on HMM: 1-69/69
Sequence Identity: 8% (18 aa)

PTVPQD---VISTSNSSS------HLLVRWKPPVQRNGNITYYLVLWQRLAEDGDLYINDYCHRGLRLPTSSHDTRFDREDPALEAEPEQGCCPCQHSPP
|  |..   .  |. .|.      .. ..||||      |..|                                                         
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR--------------------------------------------------------

GQALPALEAQEVTFQKKFENFLHHAITIPKAPWKVTSINKNPQRDSERHRREAGLLRLGKNNSDFEIQEDKVPRERAILSGLRHF----TEYRIDIHACN
                                                                            ....||.      |||.. . | |
----------------------------------------------------------------------------YTVTGLKPGQYPWTEYEFRVRAVN

HAAHTVG
. ..  |
GNDAGEG
FN3 IRR.AA FN3 816-899 20 3e-06 27.88 SMART 1-69 (69) Show / Hide 
Range on Protein: 816-899
Range on HMM: 1-69/69
Sequence Identity: 20% (20 aa)

DGIPGK---VAWKAAGKS------SVTLHWLEPPDPNGLILKYEIKYRRLGEEATVLCVSRLRYAKVGGVHLALLPPG-----NYSAKVRATSL--AGNG
 | |.    . ... ...      ||||.| .|      |. |.                         . .  | ||     .|. .||| .   || |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR-------------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase IRR.AA InsR 979-1248 71 1.5e-227 762.23 In-house 1-278 (278) Show / Hide 
Range on Protein: 979-1248
Range on HMM: 1-278/278
Sequence Identity: 71% (200 aa)

IAIIRELGQGSFGMVYEGLARGLEAGEEST--PVALKTVNELASARERVEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRP
|..|||.|||||||||||.|.|....||..  ..|.||||| ||.|||.|||.||||||.|.||||||||||.|.|||..|.||.||.|||||.|||.||
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRRP

EAE-NNPGLP----QPALSDMIQMAGEIADGMAYLAAKKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTT
|.| ||||..    .|.|..|.|||.||.|||||||||||||||||.|||||..||||||||||||||.||.|||||||||.||||||||||||||.|||
EEEFNNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLKDGVFTT

HSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFV-MDGGVLEELENCPIQLQELMRLCWQHSPRLRPTFVHILDRIQD
|||||||||||||.|||.||||||||||||||.. |||.||...|||| ..||||. |||..|..||||..|.. ..|
HSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase IRR.AA Pkinase_Tyr 979-1246 44 3.8e-147 498.99 Pfam 1-270 (270) Show / Hide 
Range on Protein: 979-1246
Range on HMM: 1-270/270
Sequence Identity: 44% (123 aa)

IAIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASARE--RVEFLKEASVMKAF-KCHHVVRLLGVVS-QGQP--TLVIMELMTRGDLKSHLR
| ....||.|.||.||.| ..| . ... .||| |...| |. ..  | .|..||..|| . .....|||.||.. ||.|   ...||.|  |||...||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

SLRPEAENNPGLPQPALSDMIQMAGEIADGMAYLAAKKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYY-RKGGKGLLPVRWMAPESLKDGIFTT
. |      .. ... ..|..||. .||.||.||..|...|||||||||.|. ...|||.|||..||.|..||| ||.|.| ||..|||||....|.|||
KHR------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTT

HSDVWSFGVVLWEIVTLAEQP-YQGLSNEQVLKFV-MDGGVLEELENCPIQLQELMRLCWQHSPRLRPTFVHILDRI
 ||||||||..|||.|. ||| |.|.|||.|....  ||. ..  ||||  . .||..||.. |  ||||  |. ..
KSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase IRR.AA TyrKc 979-1246 39 1.4e-130 440.99 SMART 1-280 (280) Show / Hide 
Range on Protein: 979-1246
Range on HMM: 1-280/280
Sequence Identity: 39% (118 aa)

IAIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASARERVEFLKEASVMKAF--KCHHVVRLLGVVSQG-------QPTLVIMELMTRGDLKS
|  ...|| | || ||.| ..        ..|| |...| |    | .|..||..|. .  .  ..|||.||..|.       .| ...||.|  ||||.
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

HLRSLRPEAENNPGLPQPALSDMIQMAGEIADGMAYLAAKKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYET-------DYYRK----GGKGLLPVRW
.||. ||.           ..|.....  ||.||.||. |...|||||||||.|. ..||||.|||..||.|.        |||||    |||..||.||
YLRKHRPK---------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

MAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQG-----LSNEQVLKFVMDGGVLEELEN--------CPIQLQELMRLCWQHSPRLRPTFVHILDR
||||....|.||| ||||||||..||| |. .||| |     .||..|...|..|. ..  .|        ||  . ..|. ||.. |  ||||  | ..
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

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Kinase IRR.AA TK 979-1246 24 1.5e-117 395.84 In-house 1-486 (486) Show / Hide 
Range on Protein: 979-1246
Range on HMM: 1-486/486
Sequence Identity: 24% (120 aa)

IAIIRELGQGSFG---MVYEGLARGLE--------------------AGEESTPVALKTVNEL--ASARERVE-----------FLKEASVMKAFK----
| ....||.| ||   .||.|..||.                      ... |||| |.. |   .|..|. .           ||.||..|| ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-CHHVVRLLGVVSQG------------QPTLVIMELMTRGD----LKSHLRSLRPEAENNPGLPQ-----------------------------------
 . ..|||.||..||            .| ...||.|  ||    |...||. ||.. ...  |.                                   
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------PALSDMIQMAGEIADGMAYLAAK------KFVHRDLAARNCMVSQDFT-----------VKIGDFGMT-
                               . . ... |.  ||.||.||..|      .|||||||||||.|... .           .||.|||.. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-------RDVYETDYYRKGG------------------------KGLLPVRWMAPESLKDGI---------FTTHSDVWSFGVVLWEIVTLAEQPYQG-L
       ||.|. |.|.. .                        .| ||.||||||.|.|..         ||| ||||||||..|||.|....|| | .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SN---------EQVLKFVMDGGVL--------------EELENCP--------------IQLQELMRLCWQHSPRLRPTFVHILDRI
||         ..|.... .|| |              .  ..||                ...||. ||.. |. ||||  .....
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRR.AA UTK 979-1246 36 8.99999999999e-106 357.7 In-house 1-296 (296) Show / Hide 
Range on Protein: 979-1246
Range on HMM: 1-296/296
Sequence Identity: 36% (111 aa)

IAIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVN-ELASARERV---EFLKEAS---VMKAFK-CHHVVRLLGVVSQGQPTLVIMELMTRGDLKSH
... |.|||| ||.|... ..     ..   ||.|. . . .. .|.    .|..||    .||.|. . .|.||.||..|..|.....|.| .||| | 
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRSLRPEAENNPGLPQPALSD---MIQMAGEIADGMAYLAAKKFVHRDLAARNCMVSQD-------FTVKIGDFG---MTRDVY---------ETDYYRK
||. ||...     ..|.. .   ...||  ||.||.||. ..||||||||||| | ..        ..||.|||   |.|.|.         |..||..
LRRHRPTPP-----ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMA

GGKGLLPVRWMAPESLKDG-IFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGG--VLEELENCPIQLQELMRLCWQHSPRLRPTFVHILDR
 . . .|.||||||.| ..  |||.|||||||||.|||.| . .|| |.||.||...|..||   ..  . || .. .||. ||. .|. ||.|. ....
QHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQ

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Kinase IRR.AA ALK 979-1248 43 1.2e-104 353.93 In-house 1-273 (273) Show / Hide 
Range on Protein: 979-1248
Range on HMM: 1-273/273
Sequence Identity: 43% (119 aa)

IAIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASARERVEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEA
|  .| ||.| || ||.|. ....      .||.||  |..|  .   |..|| .|  |.   |||..|.  | || ... |.|  ||.|| ||  ||. 
ITLVRALGHGAFGEVYMGQYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPYMIVLEYMEGGDMKSFLRECRPHP

E--NNPGLPQPALSDMIQMAGEIADGMAYLAAKKFVHRDLAARNCMVSQDFT---VKIGDFGMTRDV-YETDYYRKGGKGLLPVRWMAPESLKDGIFTTH
|  .   |   . .| .| .  .| |  ||  ..|.||| |||||  .       .||.|||| ||. | .|||||||. ..|| || || . |||||. 
ESLQPSQL---TMKDLLQCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKGPGRVAKIADFGMARDITYRADYYRKGGRAMMPVKWMPPEAFMDGIFTSK

SDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELENCPIQLQELMRLCWQHSPRLRPTFVHILDRIQD
.||||||| .|||  |   || | .|..|..||  || ..   |||     .|. |||| | .||.|| || .||.
TDVWSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEGGRMDPPRNCPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY
Kinase IRR.AA Sev 979-1246 46 1e-99 332.88 In-house 1-277 (277) Show / Hide 
Range on Protein: 979-1246
Range on HMM: 1-277/277
Sequence Identity: 46% (131 aa)

IAIIRELGQGSFGMVYEGLARGLE-AGEESTPVALKTVNELASARERVEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPE
    | || | || |||| |      |||   || ||    . . |  |||||| .|  ||   .| ..||   . |  .|||.|  ||| . ||  |  
LKLRRFLGSGAFGEVYEGQAKDIDGVGEEEQRVAIKTLRKGSTDQEKQEFLKEAHLMSKFKHPNIVCQMGVCLDNEPQYIIMEHMEGGDLLCYLRAARMT

AENNPG----LPQPALSDMIQMAGEIADGMAYLAAKKFVHRDLAARNCMVSQ-------DFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKD
.  ||     |    |.|.. |   |. |  ||    |||||||.||| ||          .|||||||  ||.|  ||||| | ||||||||||||| |
TFQNPQPTAGL---TLMDLVEMCIDISKGCEYLEDMHFVHRDLACRNCLVSVKDYTTHRRRVVKIGDFGLARDIYKNDYYRKEGEGLLPVRWMAPESLMD

GIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELENCPIQLQELMRLCWQHSPRLRPTFVHILDRI
|.||| ||||.||.  ||| ||  |||   ||  ||..|  || |.  ..||  |  .||.||. .|  ||.|  . . .
GYFTTQSDVWAFGILCWEIMTLGHQPYPAHSNFEVLNHVQAGGRLQQPRMCPDDLWMMMRQCWRQDPWQRPSFHMCQNML
Kinase IRR.AA Musk 979-1246 41 9.3e-96 316.92 In-house 1-282 (282) Show / Hide 
Range on Protein: 979-1246
Range on HMM: 1-282/282
Sequence Identity: 41% (116 aa)

IAIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASARERVEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEA
|  .|..|.| || |.   | || ..|| | || |   . ||.     |  ||  |  |    .|.||||   |.|    .| |  |||   |.|  | .
IIYVRDIGEGAFGRVFQARAPGLVPYEEETMVAVKMLKDDASKQMQMDFQREACMMAEFDHPNIVKLLGVCFVGRPMCLLFEYMAYGDLNEFLHSCSPHR

ENN--------------PGLPQPALSDMIQMAGEIADGMAYLAAKKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESL
 .               || ||    .  .|| .|| |||||  ..||||||| |||..     ||| |||. | .|  |||.  .    |.|||.|||.
TCSRTHQDRGMRAQVSSPGPPQLKCYHQLCMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYKGHENDHIPIRWMPPESI

KDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELENCPIQLQELMRLCWQHSPRLRPTFVHILDRI
 .  ||. ||||..||.||||   |.||| |.. | |.... .| .|  .||||... .|||.|||  |  || |  | . |
WYNQFTYESDVWAYGVCLWEIFSYALQPYYGMTHEEVIYYIRQGNILSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI
Kinase IRR.AA TK-Unique 979-1246 37 4.8e-95 322.07 In-house 1-294 (294) Show / Hide 
Range on Protein: 979-1246
Range on HMM: 1-294/294
Sequence Identity: 37% (110 aa)

IAIIRELGQGSFGMVYEGLARGLEAGEEST-PVALKTVNELASARERVEFLKEASVMKAFKCH-HVVRLLGVVSQGQ-PTLVIMELMTRGDLKSHLRSLR
. . ...|.|.|| |. | ..|. .... .  ||.|.... |.  .. .||||...||. ..| ..|..||.    . |.. ||| . .|.| ..||. |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

PE-------------AENNPGLPQPA-LS--DMIQMAGEIADGMAYLAA--KKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVY-ETDYYRKGGKGLLPV
|.             ....|  |... .|  |... | .|| ||.|||   ||.|||||.|||.... |...||.||||.|||| ...| .....| .|.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

RWMAPESLK--DGIF-TTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELENC-PIQLQELMRLCWQHSPRLRPTFVHILDRI
|||||||||  .|.. || ||||||||..|||.|| ..|| |........ . ||  ..  |.| . .. .||. |||..|  ||.|  |..|.
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase IRR.AA Trk 979-1246 41 8.6e-95 321.23 In-house 1-275 (275) Show / Hide 
Range on Protein: 979-1246
Range on HMM: 1-275/275
Sequence Identity: 41% (114 aa)

IAIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASARERVEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEA
| ...||| | || |. .    |   .. . ||.||  . ||   | .| .|| ..   . .|.|.. ||   ..| | . | |  |||.  ||.  | |
IVLKWELGEGAFGKVFLAECYNLCPEQDKMMVAVKTLKD-ASENARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQHGPDA

----ENNP--GLPQPALSDMIQMAGEIADGMAYLAAKKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYE-TDYYRKGGKGLLPVRWMAPESLKDGIFTT
    ...|   .    ...|   | .|| || |.|   |||||.|.|||.| |.  |||||||| ||||. ||||| |... ||.||| |||     ||.
MCYAQYQPRQAPGPLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMPPESIMYRKFTY

HSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGV-LEELENCPIQLQELMRLCWQHSPRLRPTFVHILDRI
 |||||||||.||. |   ||. .|||  |  ... | . ||  . ||  . ..|. |||  |  | .   | |.|
ESDVWSFGVVMWECFTYGKQPWYQLSNHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase IRR.AA CTKB 979-1239 42 1.8e-84 286.93 In-house 1-260 (269) Show / Hide 
Range on Protein: 979-1239
Range on HMM: 1-260/269
Sequence Identity: 42% (111 aa)

IAIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASARERVEFLKEASVMKAFKC-HHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPE
| .   || | ||.|| | |. .      ||||.| . . .|.    .|.||  .|.       .|||||.     | |...||| .||||  ||  || 
IVLKQKLGEGHFGVVYAGEAKKIMPDQAVTPVAIKMLQD-SSSEATNDFMKEVKIMQTIDGDQKIVRLLGICTRETPFLMVLELMAKGDLKTLLRNSRPK

AENNPGLPQPALSDMIQMAGEIADGMAYLAAKKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWS
      |   .   .  ||  .||||||.| |. ||||||||||.| |.. | |||||. ||||   ||   .   ||.|||.|||. ||..|| |||||
TSKPSAL---SPRRLALMAADVADGMAYIASKRIVHRDLAARNCLVHQNWRVCIGDFGISRDVYMREYYKMQASNPLPIRWMSPESINDGVYTTQSDVWS

FGVVLWEIVTLAEQPYQG-LSNEQVLKFVMDG-GVLEELENCPIQLQELMRLCWQHSPRLRPTF
.|.|.|||.| |  || . ..|  |   . |.   .   . ||  . .||  ||   |  |. |
YGIVIWEIMTFAKMPYPEYETNMEVVERICDEDYRMWQPKECPDEFYDLMMQCWDEEPDDRISF
Kinase IRR.AA Src 979-1246 37 1.1e-80 273.91 In-house 1-255 (255) Show / Hide 
Range on Protein: 979-1246
Range on HMM: 1-255/255
Sequence Identity: 37% (103 aa)

IAIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASARERVEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEA
|  .|.|||| || |..|. .|      .|.|| ||  .     .   ||.|| .|| ..  ..|.|. |.||. | . . |.|..| |   |.      
IKLCRKLGQGQFGEVWMGYWNG------NTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK-----

ENNPGLPQPALSDMIQMAGEIADGMAYLAAKKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYE--TDYY--RKGGKGLLPVRWMAPESLKDGIFTTHSD
  ..   .  | . | ||  .|.||||| .....||||||||  |...  .|..|||  | . .   | |  |.| |  .|..|.||| .  | ||. ||
--DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLAR-LIKEDDDEYCARHGAK--FPIKWTAPEAINYGRFTIKSD

VWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELENCPIQLQE-LMRLCWQHSPRLRPTFVHILDRI
|||||. |.||||    || | .|..||. |. |  .   .||| .| | .|. ||. .|. ||||  . .  
VWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase IRR.AA S_TKc 979-1254 21 7.7e-34 119.66 SMART 1-231 (231) Show / Hide 
Range on Protein: 979-1254
Range on HMM: 1-231/231
Sequence Identity: 21% (59 aa)

IAIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASARERVEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTR--GDLKSHLRSLRP
  |.|..|.|.|| || .  ..         ||.| ..          ...| ...|  .. ..|.|..|    .   ..||..    |||...... ..
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

EAENNPGLPQPALSDMIQMAGEIADGMAYLAAKKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTT-HSDV
.  . |        .   .. .|.....|.  ....||||   | ....  ..||.|||. | .                 .|||| |    ...  .|.
HGLRFPF----PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDW

WSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELENCPIQLQELMRLCWQHSPRLRPTFVHILDRIQDEL-RPSF
||.|..|.| ..  . |..    ....| ..           . .. ...| |.|  |. |||   .| . .|    | |
WSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRR.AA Pkinase 979-1246 19 1.7e-29 105.34 Pfam 1-293 (293) Show / Hide 
Range on Protein: 979-1246
Range on HMM: 1-293/293
Sequence Identity: 19% (61 aa)

IAIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASAR-ERVEFLK--EASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRG----DLKSHL
. |.| .|.|||| ||..  .| .       ||.|...       .... ..  |...|| ... ..|||....  ..   ..||..  |    ||....
YHIGRKIGSGSFGCVYKCHHKGTGK-----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

RSLRPEAENNPGLPQPALSDMIQMAGEIADGMAYLAAKKFVHRDLAARNCMVSQDFTV----KIGDFGMTRDV-YETDYYRKGGKGLLPVRWMAPESLK-
.      ... ..      . . .. .|. |..|. .....||||   |...... ..    ||.|||  . . |  .   ..  | .  ..|||| .. 
ST-----WRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTP--WYMAPEVIRG

DGIFTTHSDVWSFGVVLWEIVTLAEQPYQGL------SNEQVLKFVMDGGVLEELE--------------------NCPIQLQELMRLCWQHSPRLRPTF
.   .. .|.||.|..|.| ..  . |..|       .  |... .|.. . .. .                    | .  ...... |..  |  |||.
GQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTA

VHILDR--I
 .||    .
EQILQHPWF