Gene IRAK3 (Mouse)

IRAK3

Species: Mouse
Alias: IRAK3, Irak3
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TKL
Family: IRAK

Sequence

Name Sequence Type Origin Length Description Download
IRAK3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 279 Kinase domain by global Sugen HMM Fasta, JSON
IRAK3.AA Protein Sugen 609 None Fasta, JSON
IRAK3.NA RNA Sugen 2969 None Fasta, JSON

Protein domain

Protein domains of IRAK3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Death IRAK3.AA Death 26-106 28 7.7e-20 68.86 Pfam 1-87 (87) Show / Hide 
Range on Protein: 26-106
Range on HMM: 1-87/87
Sequence Identity: 28% (25 aa)

GELCGIL-DSCDGPLGWRGLAERLSNSWLDVRHIEKYVNQGK---SGTRELLWSWAQK---NKTIGDLLEVLQDMGHQRAIHLIINYG
 .|| .| .... .  || ||..|  |. ....|| . ....   | |...|| | |.   | |...|.|.|..||. .....| .. 
QKLCRLLDPDHHPGKDWRRLARKLGMSDNEIDQIEHD-QNPHDLRSQTYQMLWKWEQRHGKNATVDHLIEALRKMGRRDCAEKIQSWL
Kinase IRAK3.AA IRAK 178-456 44 1.2e-174 586.49 In-house 1-317 (317) Show / Hide 
Range on Protein: 178-456
Range on HMM: 1-317/317
Sequence Identity: 44% (140 aa)

FHKDFLIGEGEIFEVYRVDIRNQA--YAVKLFKQEKKMQLKKHWKRFLS---ELEVLLLFRHPHILELAAYFTETEKLCLVYPYMSNGTLFDRLQCTNGT
||||..||||....|||....|..  ||||..|....|. ..||.||..   ||.|....|||.|..|..|.||....|||||||.||.|.|||.|..|.
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

TP---LSWHVRISVLIGIAKAIQYLHNTQPC-AVICGNVSSANILLDDQLQPKLTDFAAAHFR---PNLEQQSSTINMTGGGRKHLWYMPEEYIR--QGR
.|   |||| |.|...|.|..||.||...|| ..|.|...|||||||....||..||....|.   ...|.|..|..||   |...||||.|.||  ||.
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LSVKTDVYSFGIVIMEVLTGCKVVLDD-PKHVQLRDLLMELMEKRG-LDSCLS----------------------FLDRKIPPCPRNFSAKLFSLAGRCV
|..||||||||||..||||||..|.|| |.| .|.||..|.||..| ||||.|                      |.|...||||.|........|..|.
LTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPPNMEKEMCQCACCCG

ATKAKLRPTMDEVLSSL
...|..|..|..|...|
HHRANRRCDMAWVMQQL
Kinase IRAK3.AA TKL 184-456 19 8.6e-66 224.88 In-house 1-364 (364) Show / Hide 
Range on Protein: 184-456
Range on HMM: 1-364/364
Sequence Identity: 19% (74 aa)

IGEGEIFEVYRVDIRN----------QAYAVKLFKQEK-----------------------KMQLKKHWKRFLSELEVLLLFRHPHILELAAYFTETEK-
||.|   |||.   |.          .  ||| ||..                         . ...  ...  |. ... .|||.|. . .| .. .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LCLVYPYMSNGTLFDRLQCTNGTTPLSWHVRISVLIGIAKAIQYLHNTQP-----CAVICGNVSSANILLDDQLQ-------------
            ||.|. |...|.|...|.         ||.|..  ..||....|||. .|     ...|  .  |.|||.|. ..             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-PKLTDFAAAHFRPNLEQQSSTINM-------------TGGGRKHLWYMPEEYIR----------------QGRLSVKTDVYSFGIVIMEVLTGCKVVLD
 .|..||  . |  . .... | ..             |.  . .. .|. | .|                ..  | |.||||||||. |.||.|..  |
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD

DP-KHVQLR---DLLMELMEKRGLDSCLS------FLDRKIPPCPRNFSAKLFSLAGRCVATKAKLRPTMDEVLSSL
.|   ....   .. ...  ..||   .       .  . . ... ..   . .|. .| ..... ||...|.|. |
YPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHH--K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK3.AA TK 178-456 14 3.9e-28 90.78 In-house 1-486 (486) Show / Hide 
Range on Protein: 178-456
Range on HMM: 1-486/486
Sequence Identity: 14% (73 aa)

FHKDFLIGEGE---IFEVYRVDIRNQAY---------------------------AVKLFKQEKKMQLKKHWK----------RFLSELEVLLLFR----
 .    .|||.     |||.   |..                             |||  | .  |. . .            .||.|.|.. ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPHILELAAYFTET------------EKLCLVYPYMSNGT----LFDRLQ-CTNGTTP-----------------------------------------
 ||.|. | .. |.             | ...|  ||..|     | | |. | .....                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LSWHVRISVLIGIAKAIQYLHNTQPC----AVICGNVSSANILLDDQLQ-----------PKLTDFAAA
                               |. | ..     ||.. .|||  ..|     .. ...   |.|......            |..||  .
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHS-KNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------HFRPN-LEQQSSTINMTGGGRKHLW----------------------YMPEEYIR---------QGRLSVKTDVYSFGIVIMEVLTGCKVVLDD
      . |    ..   . .  |.||   |                      .|. | ..          |. . |.||.|||... |..| ...    
RQGSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYG

PKHVQL----RDLLMELMEKRGLDSCLSF-------LDRKIPPCPRNFS--------------AKLFSLAGRCVATKAKLRPTMDEVLSSL
  . |        . |.||.    . | .        .|  .|.| . .              . .. |  .| . ... |||...... |
GMSNQDVWKDG-DNQEVMEYLRRGGRL-CRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAK3.AA TKL-Unique 183-384 25 3.3e-22 75.22 In-house 4-225 (290) Show / Hide 
Range on Protein: 183-384
Range on HMM: 4-225/290
Sequence Identity: 25% (57 aa)

LIGEGEIFEVYRVDIRNQAYAVKLFKQEKKMQLKKHWKRFLSELEVLLLFR-HPHILELAAYFT----ETEKLCLVYPYMSNGTLFDRLQ-------CTN
.||||.  .||..  |   .|.| |.  .  . ..  . | .|. ..  .. || |. . .| .       ..|.|  |.. |.| | |.         |
KIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNN

GTTPLSWHVRISVLIGIAKAIQYLHNTQPCAVICGNVSSANILLDDQ-----LQPKLTDFAAAHFRPNLEQQSSTINMTGGGRKHL---WYMPEEYIRQ-
  ..|.. .|..  | ||..  |||...|  .| ..  | |.|.|       .. |. ||  . |. .  . ... .  ...   .    .|. | .|. 
NNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMN

-GRLSVKTDVYSFGIVIMEVLTGC
    | | ||||||||  | .|..
FCQYSEKSDVYSFGIVLWEIATRK
Kinase IRAK3.AA Pkinase 178-456 20 3e-18 65.61 Pfam 1-293 (293) Show / Hide 
Range on Protein: 178-456
Range on HMM: 1-293/293
Sequence Identity: 20% (65 aa)

FHKDFLIGEGEIFEVYRVDIRNQA--YAVKLFKQEKKMQLKKHWKRFLSELEVLLLFRHPHILELAAYFTETEKLCLVYPYMSNG----TLFDRLQ--CT
.|.   ||.|   .||.   ..    .||| .| ...   |.  .| |||..... ..||.|..|  .|..  ....| .|. .|     |||...    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

NGTTPLSWHVRISVLIGIAKAIQYLHNTQPCAVICGNVS-----SANILLDDQLQP----KLTDF-AAAHFRPNLEQQSSTINMTGGGRKHLWYMPEEYI
.. . .|... ....  |.....|.|. .       ..      ..|||.|.. ..    |..||  |..|.      ... ..|  |   .|||. | |
GCFY-FSEWECKFYMYQILRGLEYCHS-M-------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCG--TPWYMAPEVI

R-QGRLSVKTDVYSFGIVIMEVLTGCKVVLDD----PKHVQLRDLLMELMEKRGLDSCLSFLDRKIPPCPR--------NFSAKLFSLAGRCVATKAKLR
| .   . | |..|.|... |.|.|     ..    . | |.  . . .. .   |.  .   .  .  ..        | |  . ..  .| . . | |
RGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRHWHFHWTFHNWSEECKDFIKWCLCKDPKKR

PTMDEVLSS--L
|| ...| .  .
PTAEQILQHPWF
Kinase IRAK3.AA TK-Unique 222-382 20 2.7e-17 56.31 In-house 50-234 (294) Show / Hide 
Range on Protein: 222-382
Range on HMM: 50-234/294
Sequence Identity: 20% (40 aa)

FLSELEVLLLFR-HPHILELAAYFTET-EKLCLVYPYMSNGTLFDRLQCTNGT-----------------------TPLSWHVRISVLIGIAKAIQYLHN
||.|....     ||.|. .  . |.. |  .....|...|.| . |. . ..                       .|.| .  .. ...||.. .||. 
FLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLAS

TQPCAVICGNVSSANILLDDQLQPKLTDFAAA-HFRPNLEQQSSTINMTGG-GRKHLWYMPEEYIR--QGRL-SVKTDVYSFGIVIMEVLT
 |.. .. ..... |.|| . .. |..||  | . .         ..|... || .. .|. |...  .|   . |.||.|||... |..|
-QRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT-----NGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT
Kinase IRAK3.AA Ciliate-E2-Unclassified 178-383 15 2.8e-15 49.48 In-house 1-266 (352) Show / Hide 
Range on Protein: 178-383
Range on HMM: 1-266/352
Sequence Identity: 15% (43 aa)

FHKDFLIGEGEIFEVYRVDIRNQA------YAVKLFKQEKKMQLKKHWKRFLSELEVLLL------------------FRHPHILELAAYFTETEKLCLV
...   ||.|   .||..  ..|       |. |  .. .| ...|.    ....|.  .                  . ||.|. .  .|. ......|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

YPYMSNGTLFDRLQCTNG--------------TTPLSWHVRI-----SVLIGIAKAIQYLHNTQPCAVICGNVSSANILLDDQL---QPKLTDFAAAH--
. |. .|.|.. ..  ..              .  ..    .       .  | ....|||  .   .|  .    |||.|..    ..|..||  .   
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN--NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

-----------FRPNLEQQSSTINMTGGGRKHLWYM----PEEYIRQGRLS----VKTDVYSFGIVIMEVLTG
            . .  .|  .  ..|     . ||    . |....   .     | |..|.|... | |.|
QQNNNCDTNQQQKMQIWKQQMMWTFCG----TPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFG
Kinase IRAK3.AA TyrKc 178-456 19 9.2e-15 15.96 SMART 1-280 (280) Show / Hide 
Range on Protein: 178-456
Range on HMM: 1-280/280
Sequence Identity: 19% (62 aa)

FHKDFLIGEGEIFEVYRVDIRNQAYAVKLFKQEKKMQLKKHWKRFLSELEVLLLF--RHPHILELAAYFTET-------EKLCLVYPYMSNGTLFDRLQC
 ...  .|||.  |||.   . .  |||  | ..        . |..|....  .  .||.|. | .. |.        | |..|  ||..| | |.|. 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

TNGTTPLSWHVRISVLIGIAKAIQYLHNTQPCAVICGNV-----SSANILLDDQLQPKLTDFAAAHFRPNLEQ-----QSSTINMTG--GGR--KHLWYM
. ..  |..   .|  . ||.  .|||          |.        |.|...... | .||  .  |   .       .... ...  ||.    .  |
HRPK--LCMKDLLSFCWQIACGMEYLHSK--------NCIHRDLAARNCLVGENHTVKISDFGLS--RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM

PEEYIRQGRLSVKTDVYSFGIVIMEVLTGCKVVLDD-----PKHVQLRDLLMELMEKRGLDSCLSFLDRKIPPCPRN--------FSAKLFSLAGRCVAT
. | |. |. . |.||.|||... |..| ..    .      .  ... ....               .. .|.| |         .......  .| . 
APECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQ---------------GYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHE

KAKLRPTMDEVLSSL
... |||. |. . .
DPEDRPTFSEIHECF
Kinase IRAK3.AA S_TKc 178-463 18 2.6e-14 32.85 SMART 1-231 (231) Show / Hide 
Range on Protein: 178-463
Range on HMM: 1-231/231
Sequence Identity: 18% (56 aa)

FHKDFLIGEGEIFEVYRVDIRN--QAYAVKLFKQEKKMQLKKHWKRFLSELEVLLLFRHPHILELAAYFTETEKLCLVYPYMSN--GTLFDRLQCTNGTT
...  .||.|   .||..  ..  . .|.|  |           .....|...|   .||.|  |  .| . ..|..|  |...  |.|||...  ..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

P---LSWHVRISVLIGIAKAIQYLHNTQPCAVICGNVSSANILLDDQLQPKLTDFAAAHFRPNLEQQSSTINMTGGGRKH----LWYMPEEYIRQGRLSV
.   ..  .  ...  |..|..|.|.     .|   .  .|||||.  . |..||  | .                  ..    .|||. | .     . 
LRFPFPE-HARFYMYQICCALEYCHS---HGIIHRDLKPENILLDE--HIKICDFGLARQL-----------------TTFCGTPWYMAPEVL---GYGK

-KTDVYSFGIVIMEVLTGCKVVLDDPKHVQLRDLLMELMEKRGLDSCLSFLDRKIPPCPRNFSAKLFSLAGRCVATKAKLRPTMDEVLS--SLESTQPSL
 | |..|.|... | |.|.          |.  ..  ..                       |  . ..  .|     . |||  |.|   ..    | .
CKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG-----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK3.AA UTK 183-383 22 3.4e-14 44.97 In-house 6-236 (296) Show / Hide 
Range on Protein: 183-383
Range on HMM: 6-236/296
Sequence Identity: 22% (54 aa)

LIGEG---EIFEVYRVDIRNQAYA-VKLFKQEKKMQLKKHWKR----FLSELE---VLLLFR-HPHILELAAYFTETEKLCLVYPYMSNGTLFDRLQCTN
..|.|   |...  ........|  ..  |. ..   . . ..    |. |     ..  |. ||..| | .. |  | ...|. ||.|| | . |.   
QLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHR

GTTP-----LSWHVRISVLIGIAKAIQYLHNTQPCAVICGNVSSANILLDDQ-------LQPKLTDFA---AAHFRP-----NLEQQSSTINMTGGGRK-
 |.|     |. | |..    || . ||||.   | .. ...   |.|....       .. |. ||     ..  .     |  ...|   |  . .. 
PTPPACPHWLTLHQRLCMAWDIARGMQYLHS---CGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSN-RYWESYYYMAQHQDRW

-HLWYMPEEYIRQGRLSVKTDVYSFGIVIMEVLTG
   |. || .. . | . |.||.|||.| .|..|.
PIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTW
Kinase IRAK3.AA Ciliate-E2 178-383 15 2.3e-13 42.24 In-house 1-292 (365) Show / Hide 
Range on Protein: 178-383
Range on HMM: 1-292/365
Sequence Identity: 15% (48 aa)

FHKDFLIGEGEIF-----EVYRVDI--------------------RNQAYAVKLFKQ---EKKMQLKKHWK-------RFLSELEVLLLFRHPHILELAA
. .  .||.|        .|..|.                      .. ||.| .|.   | ..| .. ..       .   |...| .  ||.|...  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKI-NEKNILEQLNHPNIIKMYE

YFT--ETEKLCLVYPYMSNGTLFDRLQ--CTN-------GTTPLSWHVRISVLIGIAK---------------AIQYLHNTQPCAVICGNVSSANILLDD
.|    .... ||  | . |.|||...  ...       .  ....  .. .   |..               |..|||.  .  .|  .    |||.  
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN--IIHRDIKPENILF--

QLQPKLTDFAAAHFRPNLEQQSS----TINMTGGG--------------RKHLW--------YMPEEYIR---------QGRLSVKTDVYSFGIVIMEVL
   .|..||  . .  . .|. .      ...  .                ..         ||. | ..         | . . | |..|.|... | |
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

TG
.|
FG
Kinase IRAK3.AA MLK 184-325 20 5.5e-11 34.48 In-house 7-177 (291) Show / Hide 
Range on Protein: 184-325
Range on HMM: 7-177/291
Sequence Identity: 20% (35 aa)

IGEGEIFEVYRVDIRNQA-----YAVKLFKQEKKMQLKKH---WKRFLSELEVLLLFRHPH----ILELAAYFTETEK-LCLVYPYMSNGTLFDRLQCTN
||.|   .|..   ||.       ||| .....     .     . |  | . |  ..||     | .. .  ..... .|.|  |...| |.. |   .
IGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGAR

GTTP-----------LSWHVRISVLIGIAKAIQYLHNTQPCAVICGNVSSANILLDD------QLQPKLTDF
.               . .. ..    .|....|||. .| ..|     | |||.|.      ... | .||
SKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDF
Kinase IRAK3.AA Pkinase_Tyr 203-296 26 4e-10 34.91 Pfam 32-129 (270) Show / Hide 
Range on Protein: 203-296
Range on HMM: 32-129/270
Sequence Identity: 26% (26 aa)

AVKLFKQEKKMQ-LKKHWKRFLSELEVLLLF-RHPHILELAAYFT-ETEK--LCLVYPYMSNGTLFDRLQCT-NGTTPLSWHVRISVLIGIAKAIQYLHN
|||  |.    . .   .. |..|....  . .||.|. | .  | . |   ...| .|| .| | | |.   ..  ||. .  ..  . |||. .||..
AVKMLKEGAMHEQN--CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLES
Kinase IRAK3.AA TKL-ciliate2 178-299 27 9.3e-10 28.14 In-house 1-118 (273) Show / Hide 
Range on Protein: 178-299
Range on HMM: 1-118/273
Sequence Identity: 27% (34 aa)

FHKDFLIGEGEIFEVYRVDIRNQAYAVKLFKQEKKMQLKKHWKRFLSELEVLLLFRHPHILELAAYFTETEKLCLVYPYMSNGTLFDRLQCTNGTTPLSW
   .  | ||    .|.   |    ||| || .   |  .  . |..| . .   ||| |       |.    |..  |   | |.  ||  |   .|.|
LEIQNKITEGGYGIIYKAKWREIVVAVKKFKMDHDNQ--QQIRDFVNECHAMEALRHPNIVMFLGACTKIPNFCIIMEYCQRGSLWSLLQ--NQDVRLTW

HVRISVLIGIAKAIQYLHNTQP
  |  . . ||. . |||  .|
EDRRRIALDIARGVHYLHSSNP
Kinase IRAK3.AA Pkinase_Tyr 359-385 37 5.3e-05 17.56 Pfam 186-212 (270) Show / Hide 
Range on Protein: 359-385
Range on HMM: 186-212/270
Sequence Identity: 37% (10 aa)

IRQGRLSVKTDVYSFGIVIMEVLTGCK
|. |. ..|.||.|||... |..| ..
INYGKFTTKSDVWSFGVLMWEIFTYGE
Kinase IRAK3.AA MLK 359-383 44 0.000146 11.89 In-house 208-232 (291) Show / Hide 
Range on Protein: 359-383
Range on HMM: 208-232/291
Sequence Identity: 44% (11 aa)

IRQGRLSVKTDVYSFGIVIMEVLTG
.| .. | | ||.|.|.|. |.||.
FRCEKYSEKCDVWSWGVVLWEMLTR
Kinase IRAK3.AA TKL-ciliate2 421-457 32 0.000614 8.38 In-house 237-273 (273) Show / Hide 
Range on Protein: 421-457
Range on HMM: 237-273/273
Sequence Identity: 32% (12 aa)

PPCPRNFSAKLFSLAGRCVATKAKLRPTMDEVLSSLE
|  |.|   ..  |  ||      |||...|..  ||
PTIPKNCPPQFADLMQRCWDNNQNLRPSFNEIIKELE
Kinase IRAK3.AA TKL-ciliate2 307-380 31 0.000974 7.7 In-house 145-211 (273) Show / Hide 
Range on Protein: 307-380
Range on HMM: 145-211/273
Sequence Identity: 31% (23 aa)

VSSANILLDDQLQPKLTDFAAAHFRPNLEQQSSTINMTGGGRKHLWYMPEEYIRQGRLSVKTDVYSFGIVIMEV
. | |.|.|| .  |||||     .|.         ||       |  | | |.      | ||.|..|.. |.
INSLNVLVDDNFRCKLTDFGWTRVKPQDNY------MTNKIGTYQWMAP-EVIKAFYYTEKADVFSYSIILWEI
Kinase IRAK3.AA MLK 421-456 22 0.008112 5.76 In-house 256-291 (291) Show / Hide 
Range on Protein: 421-456
Range on HMM: 256-291/291
Sequence Identity: 22% (8 aa)

PPCPRNFSAKLFSLAGRCVATKAKLRPTMDEVLSSL
|| | .... . .|  .|  .... ||....... |
PPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase IRAK3.AA Pkinase_Tyr 417-456 30 0.078321 6.83 Pfam 231-270 (270) Show / Hide 
Range on Protein: 417-456
Range on HMM: 231-270/270
Sequence Identity: 30% (12 aa)

DRKIPPCPRNFSAKLFSLAGRCVATKAKLRPTMDEVLSSL
|.   |||.| .... .|  .| . ... |||. |... |
DGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase IRAK3.AA TKL-Unique 446-456 45 0.137726 1.59 In-house 280-290 (290) Show / Hide 
Range on Protein: 446-456
Range on HMM: 280-290/290
Sequence Identity: 45% (5 aa)

RPTMDEVLSSL
||. ||....|
RPSFDEIIHRL
Kinase IRAK3.AA UTK 421-456 22 0.159899 0.98 In-house 261-296 (296) Show / Hide 
Range on Protein: 421-456
Range on HMM: 261-296/296
Sequence Identity: 22% (8 aa)

PPCPRNFSAKLFSLAGRCVATKAKLRPTMDEVLSSL
.|||.  .. .. |  || ..    ||....... .
MPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM