Gene INSR (Mouse)

INSR

Species: Mouse
Alias: INSR, Insr
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: InsR

Sequence

Name Sequence Type Origin Length Description Download
INSR.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 268 Kinase domain by global Sugen HMM Fasta, JSON
INSR.AA Protein Sugen 1385 None Fasta, JSON
INSR.NA RNA Sugen 9394 None Fasta, JSON

Protein domain

Protein domains of INSR.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Recep_L_domain INSR.AA Recep_L_domain 52-164 39 4.7e-45 153.21 Pfam 1-121 (121) Show / Hide 
Range on Protein: 52-164
Range on HMM: 1-121/121
Sequence Identity: 39% (49 aa)

NCSVIEGHLQILLMFKTRPEDFRDL---SFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFF--NYALVIFEMVH--LKELGLYNLMNITR--G
||.||.|.|.|.....      ..    .||..  ||.|||..|. ..... ..||||..|||  ||   ||||.|... .  |.||...||.||||  |
NCTVIYGNLEITWRDEHNE---LEEDLSFFPNIREITGYLLIYRT-YNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNMGLQELWMWNLKNITRKNG

SVRIEKNN--ELCYLAT-IDWSRIL
.|.|..|.  .|||. | |.|. |.
GVYIHNNPHPKLCYTHTEIMWWMIY
Furin-like INSR.AA Furin-like 179-340 46 2.5e-85 280.41 Pfam 1-182 (182) Show / Hide 
Range on Protein: 179-340
Range on HMM: 1-182/182
Sequence Identity: 46% (88 aa)

NEECGDVCPGTAKGKTNCPATVINGQFVERCWTHS--HCQ----KVCPTICKSHGCT--AEGLCCHKECLGNCSEPDDPTKCVACRNFYLDGQCVETCPP
|.||.||||||..... |. |.||| ...|||...  |||    ||||. || ..||  ..| ||| .||| |..|...|.|||||.|| .|.||..|||
NRECPDVCPGTCEPCHPCCKTTINGHYGYRCWGPNPQHCQTLTKKVCPEQCKHRRCTGPKPGECCHEQCLGGCTGPNNDTDCVACRHFYHNGTCVDQCPP

----------------PYYHFQDWRCVNFSFCQDLHFKCRNSRKPGCHQYVIHNNKCIPECPSGYTMN--SSNLMCTPCLGPCPKVCQ
                 .|.|..||||.|..|..|      |. |.|..|||||..|..|||||||.|  ....||.|| ||||||| 
MMIYNPTTFQMEPNPDGTYQFEGWRCVTFKECPKL------SHNPDCNYYVIHNGECMRECPSGYTENEENNTMMCEPCEGPCPKVCY
FU INSR.AA FU 231-274 40 6.8e-13 50.09 SMART 1-48 (48) Show / Hide 
Range on Protein: 231-274
Range on HMM: 1-48/48
Sequence Identity: 40% (20 aa)

EGLC--CHKECLGNCSEPDDPTKCVACRNFYLD---GQCVETCPPPYYH
.| |  || ||.. |. |. |..|..|...|.    |.||..||| ||.
DGVCKPCHPECATGCWGPG-PDQCTSCPHGYYLHHNGTCVSQCPPGYYP
Recep_L_domain INSR.AA Recep_L_domain 359-474 39 5.8e-47 159.62 Pfam 1-121 (121) Show / Hide 
Range on Protein: 359-474
Range on HMM: 1-121/121
Sequence Identity: 39% (49 aa)

GCTVINGSLIINIRGGNNLAAELEA---NLGLIEEISGFLKIRRSYALVSLSFFRKLHLIRGETLEIG-NYSFYALDNQN--LRQLWDWSKHNLTITQGK
.||||.|.|.|..|...|    ||     ...|.||.|.|.|.|.|.|..||||..|  |||..|. . ||..| .||.|  |..||.|. .|.|. .|.
NCTVIYGNLEITWRDEHNE---LEEDLSFFPNIREITGYLLIYRTYNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNMGLQELWMWNLKNITRKNGG

LFFHYNP--KLCLSEIHKMEEVSG
...|.||  |||..... |... .
VYIHNNPHPKLCYTHTEIMWWMIY
FN3 INSR.AA FN3 496-602 8 0.151612 4.4 SMART 1-69 (69) Show / Hide 
Range on Protein: 496-602
Range on HMM: 1-69/69
Sequence Identity: 8% (11 aa)

ENELLK---FSFIRTSFD------KILLRWE-PYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPQRSNDPKSQTPSHPGWLMRGL
         ...  .. .       . |.|. |             . |.                                               .||
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------------IVGYR--------------------------------------------YTVTGL

KPW----TQYAIFVKTL----VTFS
||.    |.| . |.      .  .
KPGQYPWTEYEFRVRAVNGNDAGEG
FN3 INSR.AA FN3 624-833 8 3.9e-09 37.58 SMART 1-69 (69) Show / Hide 
Range on Protein: 624-833
Range on HMM: 1-69/69
Sequence Identity: 8% (18 aa)

PSVPLDP--ISVSNSSS-------QIILKWKPPSDPNGNITHYLVYWERQAEDSELFELDYCLKGLKLPSRTWSPPFESDDSQKHNQSEYDDSASECCSC
|. | .|  ..|.. .|       .. |.||||      |..|                                                         
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR--------------------------------------------------------

PKTDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGNGAEDSRPSRKRRSLEEVGNVTATTLTLPDFPNVSSTIVPTSQEEHRPFEKVVNKESLVISGL
                                                                                               ...||
----------------------------------------------------------------------------------------------YTVTGL

RHF----TGYRIELQACNQ--DSPD
.      | |.. ..| |   . . 
KPGQYPWTEYEFRVRAVNGNDAGEG
FN3 INSR.AA FN3 853-936 19 2e-06 28.8 SMART 1-69 (69) Show / Hide 
Range on Protein: 853-936
Range on HMM: 1-69/69
Sequence Identity: 19% (19 aa)

DDIVGP---VTHEIFENN------VVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPG-----NYSVRVRATSL--AGNG
 . ..    .. .   ..       |.| |..|      || |.                         ....||.||     .|..|||| .   || |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR-------------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase INSR.AA InsR 1026-1295 72 1.9e-229 768.51 In-house 1-278 (278) Show / Hide 
Range on Protein: 1026-1295
Range on HMM: 1-278/278
Sequence Identity: 72% (202 aa)

ITLLRELGQGSFGMVYEGNAKDIIKGEAET--RVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLRP
|.|.||.|||||||||||.||.|...|...  |.|.|||||.||.|||||||||||||| |.||||||||||.|.|||..||||.|..|||||.|||.||
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRRP

DAE-NNPGRP----PPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTA
..| ||||..    .|.|..|.||.|||.||||||.||||||||||.|||||.||||||||||||||||||.|||||||||.||||||.||||||||||.
EEEFNNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLKDGVFTT

SSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFV-MDGGYLDPPDNCPERLTDLMRMCWQFNPKMRPTFLEIVNLLKD
.||.|||||||||...|.||||||||||||||.. |||..|.||.||||....||.||||..||||||||.|...|.|
HSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase INSR.AA Pkinase_Tyr 1026-1293 45 9.5e-151 511.17 Pfam 1-270 (270) Show / Hide 
Range on Protein: 1026-1293
Range on HMM: 1-270/270
Sequence Identity: 45% (126 aa)

ITLLRELGQGSFGMVYEGNAKDIIKGEAETRVAVKTVNESASLRE--RIEFLNEASVMKGF-TCHHVVRLLGVVS-KGQP--TLVVMELMAHGDLKSHLR
||....||.|.||.||.| .|.  ... .. ||||...|.|. ..  | .|..||..|| .  ....|||.||.. .|.|   ..|||.|.||||...||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

SLRPDAENNPGRPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYY-RKGGKGLLPVRWMSPESLKDGVFTA
. |      ....|.|.....|| ..||.||.|| .|...|||||||||.|.....|||.|||..||||..||| ||.|.| ||..||.||....|.|| 
KHR------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTT

SSDMWSFGVVLWEITSLAEQP-YQGLSNEQVLKFV-MDGGYLDPPDNCPERLTDLMRMCWQFNPKMRPTFLEIVNLL
 || |||||..||| .. ||| |.|.|||.|....  ||. ...|.|||. . |||..||...|..|||| ||.. |
KSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase INSR.AA TyrKc 1026-1293 40 9.5e-137 461.52 SMART 1-280 (280) Show / Hide 
Range on Protein: 1026-1293
Range on HMM: 1-280/280
Sequence Identity: 40% (121 aa)

ITLLRELGQGSFGMVYEGNAKDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGF--TCHHVVRLLGVVSKG-------QPTLVVMELMAHGDLKS
|||...|| | || ||.| .|        . ||||...|.|    | .|..||..|. .     ..|||.||....       .| ..|||.|.|||||.
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

HLRSLRPDAENNPGRPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYET-------DYYRK----GGKGLLPVRW
.||. ||.          ........   ||.||.||  |...|||||||||.|....||||.|||..||||.        |||||    |||..||.||
YLRKHRPK---------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

MSPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQG-----LSNEQVLKFVMDGGYLDPPDN--------CPERLTDLMRMCWQFNPKMRPTFLEIVNL
|.||....|.||  || |||||..||| .. .||| |     .||..|...|..|.....|.|        ||. . ..|..||...|..|||| ||. .
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

L
.
F
Kinase INSR.AA TK 1026-1293 25 5.1e-120 404.25 In-house 1-486 (486) Show / Hide 
Range on Protein: 1026-1293
Range on HMM: 1-486/486
Sequence Identity: 25% (126 aa)

ITLLRELGQGSFG---MVYEGNAKDII--------------------KGEAETRVAVKTVNE--SASLRERIE-----------FLNEASVMKGFT----
|||...||.| ||   .||.| .....                    |....|.||||.. |  ..| .|...           ||.||..|| .     
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-CHHVVRLLGVVSKG------------QPTLVVMELMAHGD----LKSHLRSLRPDAEN--------NPGRPP---------------------------
 . ..|||.||...|            .| ..|||.|.|||    |...||. ||.. .        ....||                           
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------PTLQEMIQMTAEIADGMAYLNAK------KFVHRDLAARNCMVAHDFT-----------VKIGDFGMT-
                               .|..... | . ||.||.|| .|      .|||||||||||.|... .           .||.|||.. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-------RDIYETDYYRKGG------------------------KGLLPVRWMSPESLKDGV---------FTASSDMWSFGVVLWEITSLAEQPYQG-L
       ||||. |.|.. .                        .| ||.|||.||.|.|.|         ||  ||.|||||..||| .....|| | .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SN---------EQVLKFVMDGGYL--------------DPPDNCP--------------ERLTDLMRMCWQFNPKMRPTFLEIVNLL
||         ..|.... .|| |               .|..||              | . |||..||...|. |||| .... |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase INSR.AA UTK 1026-1293 37 7.4e-106 357.98 In-house 1-296 (296) Show / Hide 
Range on Protein: 1026-1293
Range on HMM: 1-296/296
Sequence Identity: 37% (111 aa)

ITLLRELGQGSFGMVYEGNAKDIIKGEAETRVAVKTVN-ESASLRERI---EFLNEAS---VMKGFT-CHHVVRLLGVVSKGQPTLVVMELMAHGDLKSH
. |.|.|||| ||.|... ....   . | .||||. . .... .|.    .|..||    .|| |  . .|.||.||.....|...|.|.|. ||| | 
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRSLRPDAENNPGRPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHD-------FTVKIGDFG---MTRDIY---------ETDYYRKGGK
||. ||...  . .   || ....| . ||.||.||  ..||||||||||| |...        ..||.|||   |.|...         |..||.. . 
LRRHRPTPP--ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQ

GLLPVRWMSPESLKDG-VFTASSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDPPD--NCPERLTDLMRMCWQFNPKMRPTFLEIVNLL
. .|.|||.||.| ..  || .||.||||||.||| . . .|| |.||.||...|..||.. .|.   ||... .||. ||. .| .||.| ..|  .
DRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase INSR.AA Sev 1026-1293 47 2.5e-104 348.5 In-house 1-277 (277) Show / Hide 
Range on Protein: 1026-1293
Range on HMM: 1-277/277
Sequence Identity: 47% (132 aa)

ITLLRELGQGSFGMVYEGNAKDII-KGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLRPD
 .|.| || | || |||| ||||   || | |||.||    .   | .||| || .|  |    .| ..||   . |  ..||.|  ||| . ||  |  
LKLRRFLGSGAFGEVYEGQAKDIDGVGEEEQRVAIKTLRKGSTDQEKQEFLKEAHLMSKFKHPNIVCQMGVCLDNEPQYIIMEHMEGGDLLCYLRAARMT

AENNPG-RPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMV------AH-DFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVF
.  ||      || ... |   |. |  ||    |||||||.||| |      .|   .|||||||  ||||  ||||| | ||||||||.|||| ||.|
TFQNPQPTAGLTLMDLVEMCIDISKGCEYLEDMHFVHRDLACRNCLVSVKDYTTHRRRVVKIGDFGLARDIYKNDYYRKEGEGLLPVRWMAPESLMDGYF

TASSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDPPDNCPERLTDLMRMCWQFNPKMRPTFLEIVNLL
|  || |.||.  ||| .|  |||   ||  ||..|  || |..|..||. |  .|| ||.  |  ||.|  . | |
TTQSDVWAFGILCWEIMTLGHQPYPAHSNFEVLNHVQAGGRLQQPRMCPDDLWMMMRQCWRQDPWQRPSFHMCQNML
Kinase INSR.AA ALK 1026-1295 43 4.3e-102 345.47 In-house 1-273 (273) Show / Hide 
Range on Protein: 1026-1295
Range on HMM: 1-273/273
Sequence Identity: 43% (119 aa)

ITLLRELGQGSFGMVYEGNAKDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLRPDA
|||.| ||.| || ||.|  . .     .  ||.||  |..|  .   |..|| .|  |    |||..|.  . || ..| |.|. ||.|| ||  ||  
ITLVRALGHGAFGEVYMGQYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPYMIVLEYMEGGDMKSFLRECRPHP

E-NNPGRPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFT---VKIGDFGMTRDI-YETDYYRKGGKGLLPVRWMSPESLKDGVFTASS
|  .|   . | .  .| .  .| |  ||  ..|.||| |||||          .||.|||| ||| | .|||||||. ..|| || || . ||.||  .
ESLQPS--QLTMKDLLQCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKGPGRVAKIADFGMARDITYRADYYRKGGRAMMPVKWMPPEAFMDGIFTSKT

DMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDPPDNCPERLTDLMRMCWQFNPKMRPTFLEIVNLLKD
|.||||| .||| ||   || | .|..|..||  || .||| ||| .   .|. |||  |  ||.|  |.  ...
DVWSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEGGRMDPPRNCPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY
Kinase INSR.AA Trk 1026-1293 40 6.9e-98 331.51 In-house 1-275 (275) Show / Hide 
Range on Protein: 1026-1293
Range on HMM: 1-275/275
Sequence Identity: 40% (113 aa)

ITLLRELGQGSFGMVYEGNAKDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLRPDA
| | .||| | || |. .. ...   .  . |||||  . ||   | .|  || ..     .|.|.. ||   ..| | | | | ||||.  ||.  |||
IVLKWELGEGAFGKVFLAECYNLCPEQDKMMVAVKTLKD-ASENARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQHGPDA

----ENNP--GRPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYE-TDYYRKGGKGLLPVRWMSPESLKDGVFTA
    ...|   . | |...|     .|| || |.    |||||.|.|||.|...  |||||||| ||.|. ||||| |... ||.||| |||     || 
MCYAQYQPRQAPGPLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMPPESIMYRKFTY

SSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGY-LDPPDNCPERLTDLMRMCWQFNPKMRPTFLEIVNLL
 || ||||||.||. .   ||. .|||  |  ... |   |. |  ||. . |.|. |||  |..| .  .| ...
ESDVWSFGVVMWECFTYGKQPWYQLSNHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase INSR.AA TK-Unique 1026-1293 34 5.9e-96 325.08 In-house 1-294 (294) Show / Hide 
Range on Protein: 1026-1293
Range on HMM: 1-294/294
Sequence Identity: 34% (102 aa)

ITLLRELGQGSFGMVYEGNAKDIIKGEAET-RVAVKTVNESASLRERIEFLNEASVMKGFTCH-HVVRLLGVVSKGQ-PTLVVMELMAHGDLKSHLRSLR
.......|.|.|| |. | .. |.|.. .. .||||.....|.. .. .||.|...||  ..| ..|..||.  | . |.. .|| .. |.| ..||. |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

PD-------------AENNPGRPPPT-LQ--EMIQMTAEIADGMAYLNA--KKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIY-ETDYYRKGGKGLLPV
|.             ....| .|... ..   ...   .|| ||.||    ||.|||||.|||.....|...||.||||.||.| ...| .....| .|.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

RWMSPESLK--DGVF-TASSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDPPDNC-PERLTDLMRMCWQFNPKMRPTFLEIVNLL
|||.|||||  .|.. |  || |||||..||| .| ..|| |........ . ||  .. |..| ..... ||. ||| .|..||.| .|.. |
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase INSR.AA Musk 1026-1293 40 1.6e-94 312.78 In-house 1-282 (282) Show / Hide 
Range on Protein: 1026-1293
Range on HMM: 1-282/282
Sequence Identity: 40% (115 aa)

ITLLRELGQGSFGMVYEGNAKDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLRPDA
|   |..|.| || |.   |   . .|.|| ||||   . ||      |  ||  |  |    .|.||||   |.|    .| || |||   |.|  | .
IIYVRDIGEGAFGRVFQARAPGLVPYEEETMVAVKMLKDDASKQMQMDFQREACMMAEFDHPNIVKLLGVCFVGRPMCLLFEYMAYGDLNEFLHSCSPHR

ENN--------------PGRPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESL
 .               || |.    .  .| ..|| |||||. ..||||||| |||..     ||| |||. | ||  |||.  .    |.||| |||.
TCSRTHQDRGMRAQVSSPGPPQLKCYHQLCMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYKGHENDHIPIRWMPPESI

KDGVFTASSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDPPDNCPERLTDLMRMCWQFNPKMRPTFLEIVNLL
 .  ||  || |..||.|||| | |.||| |.. | |.... .|  |  |.|||  .  ||| ||| ||  || | .| . .
WYNQFTYESDVWAYGVCLWEIFSYALQPYYGMTHEEVIYYIRQGNILSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI
Kinase INSR.AA CTKB 1026-1286 43 2.1e-85 290.01 In-house 1-260 (269) Show / Hide 
Range on Protein: 1026-1286
Range on HMM: 1-260/269
Sequence Identity: 43% (115 aa)

ITLLRELGQGSFGMVYEGNAKDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTC-HHVVRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLRPD
| |   || | ||.|| | || |.   | | ||.| . .|.|     .|. |  .|.       .|||||.  .  | |.|.|||| ||||  ||  || 
IVLKQKLGEGHFGVVYAGEAKKIMPDQAVTPVAIKMLQDSSS-EATNDFMKEVKIMQTIDGDQKIVRLLGICTRETPFLMVLELMAKGDLKTLLRNSRPK

AENNPGRPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTASSDMWS
        |     .  | | .||||||.  |. ||||||||||.|  .. | |||||. ||.|   ||   .   ||.|||||||. |||.|  || ||
TSKPSALSP---RRLALMAADVADGMAYIASKRIVHRDLAARNCLVHQNWRVCIGDFGISRDVYMREYYKMQASNPLPIRWMSPESINDGVYTTQSDVWS

FGVVLWEITSLAEQPYQG-LSNEQVLKFVMDGGYLDP-PDNCPERLTDLMRMCWQFNPKMRPTF
.|.|.|||   |  || . ..|  |   . |. |  . |  ||  . |||  ||   |  |. |
YGIVIWEIMTFAKMPYPEYETNMEVVERICDEDYRMWQPKECPDEFYDLMMQCWDEEPDDRISF
Kinase INSR.AA FGFR 1026-1293 36 7.1e-83 281.64 In-house 1-293 (293) Show / Hide 
Range on Protein: 1026-1293
Range on HMM: 1-293/293
Sequence Identity: 36% (106 aa)

ITLLRELGQGSFGMVYEGNAKDIIKG--EAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHH-VVRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLR
 ||   || | || |  . || | .   |.|. |||| . .... .. .    |  .||    |  ...|||. . . |  |. |. .|| |.  ||. |
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR

PDA-ENNPGRP--------PPTLQ------------EMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLL
| . .  .  .        .|. |            . ....  .| || ||  .| .||||||||  |  |.  || |||  ||| ..||||| . | |
PPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRL

PVRWMSPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQGLS-NEQVLKFVMDGGYLDPPDNCPERLTDLMRMCWQFNPKMRPTFLEIVNLL
|. || ||.| | |.|  || ||.|| ||||  . .||| .    |.  |. . |  ...| ||.. .  .|. || |.|. |||| ..|  |
PIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase INSR.AA S_TKc 1026-1301 21 4.3e-44 153.73 SMART 1-231 (231) Show / Hide 
Range on Protein: 1026-1301
Range on HMM: 1-231/231
Sequence Identity: 21% (61 aa)

ITLLRELGQGSFGMVYEGNAKDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAH--GDLKSHLRSLRP
 ..||..|.|.|| || .  |.        .||.| ..        . ...| ...|   . ..|.|..|    .   .|||.. .  |||...... ..
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

DAENNPGRPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTA-SSDM
   . |     .  .   ....|.....|.  ....||||   | .. .  ..||.|||. | .                 .|.|| |    ..  ..|.
HGLRFPF----PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDW

WSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDPPDNCPERLTDLMRMCWQFNPKMRPTFLEIVN-LLKDDLHPSF
||.|..|.|  .  . |..    ....| ..           .. . |..| |.|..|. |||  |. .  ..  .|| |
WSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase INSR.AA Pkinase 1026-1293 20 5.1e-37 131.97 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1026-1293
Range on HMM: 1-293/293
Sequence Identity: 20% (63 aa)

ITLLRELGQGSFGMVYEGNAKDIIKGEAETRVAVKTVNESASLR-ERIEFLN--EASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHG----DLKSHL
....| .|.|||| ||.  ....  |.   .||||... .     .... ..  |...|| . . ..|||....  ..   .|||.. .|    ||....
YHIGRKIGSGSFGCVYK--CHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

RSLRPDAENNPGRPPPTL----QEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTV----KIGDFGMTRDI-YETDYYRKGGKGLLPVRWMSPE
.           .   ..    .| . .  .|. |..|. .....||||   |... .. ..    ||.|||  . . |  .   ..  | .  ..|.||
ST----------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTP--WYMAPE

SLK-DGVFTASSDMWSFGVVLWEITSLAEQPYQGL----SNEQVLKFVMDGGYLDPPDNCP-----------------------ERLTDLMRMCWQFNPK
 .. .   . ..||||.|..|.|  .  . |..|     .    .. .   .. ... ..|                       | . |... |....||
VIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPK

MRPTFLEIVNL--L
 |||. .|..   .
KRPTAEQILQHPWF