Gene IKKe (Mouse)
IKKe
Sequence
Protein domains of IKKe.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | IKKe.AA | IKK | 9-293 | 53 | 3.6e-186 | 624.76 | In-house | 1-297 (297) | Show / Hide |
Range on Protein: 9-293 Range on HMM: 1-297/297 Sequence Identity: 53% (160 aa) WHTDDLLGQGATASVYKARNKKSGEVVAVKVFNSASYRRPPEVQVREFEVLRRLNHQ-------NIVKLFAVEET---GGSRQKVLIMEYCSSGSLLSVL |...|.|||||...||..|.||.|..||||..|..|. |. .|..||||...||||| ||..|...||. ..|.|..||||..|.|...| WEMCDRLGQGAFGNVYHWRHKKTGRKVAVKHCNHMSWMRCRWVWCREFEWMKRLNHQRQFVWFPNIWCLCDIEEDMQWQICKQPVIVMEYCTGGDLYKYL EDPENTFGLSE-EEFLVVLRCVVAGMNHLR-ENGIVHRDIKPGNIMRLVGEEGQSIYKLSDFGAARKLDDDEKFVSVYGTEEYLHPDMYERAVLRKPQQK ..|.|..|| | .|||.|.|...|||.||. .||||||||||||||...||.|..|||. |||.||..||||.|.|.||||||||||||||||||||.|| NSPWNCCGLKEGHEFLQVCRDCCAGMHHLHSQNGIVHRDIKPGNIMCQKGEDGKTIYKITDFGYAREWDDDEMFMSFYGTEEYLHPDMYERAVLRKPHQK AFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTEKPAGAISGTQKQENGPLEWSYSLPITCRLSMGLQNQLVPILANILEVEEDKCW ....|||.||.|||.||.|||.|||.|...|||..|.|..||||||.|...|.|...|||.|||..||..|.|......|..|.....||...|.|| PYCATVDYWSFGVTFYHCATGELPFMPHWQPRRWHEKMKHITTEKPSGVCIGVQEEMNGPVEWSSHLPQYCHLCQIIHEQMEPWCIMMLEWHQDQCW |
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Kinase | IKKe.AA | S_TKc | 9-311 | 21 | 2.7e-49 | 170.98 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 9-311 Range on HMM: 1-231/231 Sequence Identity: 21% (67 aa) WHTDDLLGQGATASVYKARNKKSGEVVAVKVFNSASYRRPPEVQVREFEVLRRLNHQNIVKLFAVEETGGSRQKVLIMEYCSS--GSLLSVLEDPENT-- .. ...|.|| ..|||.|.||.|..||.|. . | || ..|.. .| |||||. | .. ..||||. |.|...... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGL -FGLSEEEFLVVLRCVVAGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLSDFGAARKLDDDEKFVSVYGTEEYLHPDMYERAVLRKPQQKAFGV-TV |...| . ... .. ..... ..||.|||.|| ||. |..||| ||.| .. || .|. | . .| . RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMAPEVL-----------GYGKCKC DLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTEKPAGAISGTQKQENGPLEWSYSLPITCRLSMGLQNQLVPILANILEVEEDKCWGFDQFFAET | ||.|..|| ..| || . . |... .. .. ..|... .| .. . ... DWWSCGCILYEMLCGYPPFP-------QMQMMFKKIG----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDE SDILQRTVI .|| . . WDIKCHPWF |
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Kinase | IKKe.AA | CAMK | 14-221 | 19 | 3.4e-46 | 146.44 | In-house | 1-334 (425) | Show / Hide |
Range on Protein: 14-221 Range on HMM: 1-334/425 Sequence Identity: 19% (65 aa) LLGQGATASVYKARNKKSG------------EVVAVKVFNSASYR-------------------------RPPEVQ--VREFEVLRR-------LNHQNI ||.|. . |.....|... . ||.|. . . || . || |.... |.| || TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VKLFAVEETGG---------SRQK---------VLIM---EYCSSG----SLLSVLEDPEN------------TFGLSEEEFLVVLRCVVAGMNHLRENG .||. | |.. . .| ...| |||| | |.. . . .. .. ..|.| . | .. ..... ... IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN IVHRDIKPGNIMRLVGEEGQ-------------SIYKLSDFGAARKLDD------------------------DEKFVSVYGTEEYLH-PDMYER----- |||||.|| ||. .... |..||| |.|.|. ..|. . || || | . .. IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN ----AVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPF ... | .| ||.|| || .| .|| MQNAT---DEEKPYYGPKCDMWSCGVILYIMLCGYPPF |
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Kinase | IKKe.AA | Pkinase | 9-221 | 29 | 2.3e-44 | 157.95 | Pfam | 1-212 (293) | Show / Hide |
Range on Protein: 9-221 Range on HMM: 1-212/293 Sequence Identity: 29% (66 aa) WHTDDLLGQGATASVYKARNKKSGEVVAVKVFNSASYRRPPEVQVR---EFEVLRRLNHQNIVKLFAVEETGGSRQKVLIMEYCSSG----SLLSVLE-D .|. .|.|. ..|||...|..|..||||... . . ... | | ....|||| |||.|. . |. .. ..|||| | .| .... . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW PENTFGLSEEEFLVVLRCVVAGMNHLRENGIVHRDIKPGNIMRL-VGEEGQSIYKLSDFGAARK--LDDDEKFVSVYGTEEYLHPDMYERAVLRKPQQKA ...| .||.| ... .. |.... ..||.|||.|| ||. |. . . |..||| |.. . .. . .. || .|. | | .| .. RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAP---EV--IR--GGQY FGVTVDLWSIGVTLYHAATGSLPF | || ||.|..|| ..| .|| YGPKVDMWSCGCILYEMLCGRPPF |
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Kinase | IKKe.AA | ULK | 9-221 | 27 | 1.9e-42 | 146.02 | In-house | 1-256 (329) | Show / Hide |
Range on Protein: 9-221 Range on HMM: 1-256/329 Sequence Identity: 27% (72 aa) WHTDDLLGQGATASVYKARNKKS----GEVVAVKVFNSASYRRPPEV---------QVREFEVLRRLN--------HQNIVKLFAVEETGGSRQKVLIME .. .. ||.|. . |||.||||. .|.||.|. . . .. . .| .....|. |.|||||. . || . .||| YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME YCSSGSLLSVLE----DPENT---FGLSEEEFLVVLRCVVAGMNHLRENGIVHRDIKPGNIMRLVGEEG--------QSIYKLSDFGAARKLDDD----E || | | . .. ||.| |||.| . ... ..|. .|....|.|||||| ||. | .. . ..|..||| |...|.| . YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ KFVSVY------GTEEYLHPDMYERAVLRKPQ--QKAFG-VTVDLWSIGVTLYHAATGSLPF ... || | | .. | || .. ..|.||.|. .| .| || MMMTCVNEKRLCGTPLYMAPQILQG------QGEQKPYYDYKCDIWSLGCIFYEMLYGKPPF |
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Kinase | IKKe.AA | ULK | 9-221 | 27 | 8.1e-41 | 141.93 | In-house | 1-252 (324) | Show / Hide |
Range on Protein: 9-221 Range on HMM: 1-252/324 Sequence Identity: 27% (70 aa) WHTDDLLGQGATA-SVYKARNKKS---GEVVAVKVFNSASYRRPPEV---------QVREFEVLRRLN---HQN--IVKLFAVEETGGSRQKVLIMEYCS . .. ||.|. . |||.||||. ...||.|. . . . . . .| .... |. |.| ||||. . || . .||||| YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN SGSLLSVLE----DPENT---FGLSEEEFLVVLRCVVAGMNHLRENGIVHRDIKPGNIMRLVGEEG--------QSIYKLSDFGAARKLDDD----EKFV | | . .. || | |||.| . ... ..|. .|....|.|||||| ||. | .. . ..|..||| |...|.. .. GGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ SVY------GTEEYLHPDMYERAVLRKPQ--QKAFG-VTVDLWSIGVTLYHAATGSLPF . || | | .. | || .. .|.||.|. .| .|. || TCVNEKRIKGTPLYMAPQILQG------QGEQKPYYDYKCDIWSLGCIFYEMLYGKYPF |
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Kinase | IKKe.AA | STE | 9-221 | 22 | 1.3e-39 | 137.57 | In-house | 1-268 (359) | Show / Hide |
Range on Protein: 9-221 Range on HMM: 1-268/359 Sequence Identity: 22% (65 aa) WHTDDLLGQGATASVYKARNKK---------------SGEVVAVKVFNSASYRR--------------PPEVQ--VREFEVLRRLN--HQNIVKLFAVEE | . .|.||. .||||.|.| .||..|.|. | . . . |.| .| ......| |.|||| . .. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF TGGSR-----QKVLIMEYCSSGSLLSVLE---DPENT--------FGLSEEEFLVVLRCVVAG-MNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLSDF .| . ..|||.. ||| .... . .. . ..|.. ...| .. | ...| ...|.||||||.||. ||.|| KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCDF GAARKLDD-----------------DEKFVSVYGTEEYLHPDMYER---AVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPF | . .|.| ..| .. || . | . .. . | .. .| ||.| |. . ||| |. GVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-R----DKGYDTKCDIWSLGCTIIEMATGKPPW |
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Kinase | IKKe.AA | CAMKL | 9-179 | 28 | 2.6e-33 | 103.53 | In-house | 1-199 (297) | Show / Hide |
Range on Protein: 9-179 Range on HMM: 1-199/297 Sequence Identity: 28% (57 aa) WHTDDLLGQGATASVYKARN-KKSGEVVAVKVFNSASYRRPPEVQ--------------VREFEVLRRLN---HQNIVKLFAVEETGGS----RQKVLIM . . ||.|. . | |.. . || ||.|. . . | .. || . ...|| |.||.||. | || . .|.| YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM EYCSSGS--LLSVLEDPENTF-GLSEEEFLVVLRCVVAGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLSDFGAARKLDD-----DEKFVSVYGTEE ||||.|. |. .. .. ..|.| | .|...|.. ..||||||||| || |. | | . |..||| . . .. ..|. |. . EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENI--LLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPP Y | Y |
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Kinase | IKKe.AA | Ciliate-E2b | 14-221 | 26 | 2.6e-31 | 92.51 | In-house | 6-210 (272) | Show / Hide |
Range on Protein: 14-221 Range on HMM: 6-210/272 Sequence Identity: 26% (57 aa) LLGQGATASVYKARN-KKSGEVVAVKVFNSA--SYRRPPEVQVREFEVLRRLNHQNIVKLFAVEETGGSRQKV-LIMEYCSSGSLLSVLEDPENTFGLSE .||.|. ||| .| |.. . | |..... . . ..| .||...|| .|.|.. . . |.. ..||.|. ..|..|. . . ..||. KLGFGQFGSVYLVWNTKNTKQYYAMKCISKNQIIQQNMEKHMLQEKNVLEKCNHPFIMKFI---RSFKDDQHMYFMMEFCNGMELFDVIRE-IGRLLLST EEFLVVLRCVVAGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLSDFGAARKLDDDEK----FVSVYGTEEYLHPDMYERAVLR--KPQQKAFGVTVD .. . .. .. | ...|..||||| ||| | ..|. || |.|.| ... . .. || .|. |. .. .| .| .. || YDSQFYIASICLCLEYLHNQNIIYRDIKPENIM--VDHKGY--MKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPE-----IIQSLQPGGKGYTYKVD LWSIGVTLYHAATGSLPF .||.|..|| | .|. IWSVGICLYEFMCGYVPW |
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Kinase | IKKe.AA | Ciliate-E2 | 9-234 | 20 | 1.3e-28 | 95.27 | In-house | 1-301 (365) | Show / Hide |
Range on Protein: 9-234 Range on HMM: 1-301/365 Sequence Identity: 20% (65 aa) WHTDDLLGQGATASVYKARNKKSGE-----------------------VVAVKVF--NSASYRRPPEVQVREFE----------VLRRLNHQNIVKLFAV ..|||. .||||....| .. .|.|.. | . . . || . .|..||| ||.|.. . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC EETGGSRQKVLIMEYCSSGSLLSVLEDPENTF--------GLSEEEFLVVLRCVVA---------------GMNHLRENG-IVHRDIKPGNIMRLVGEEG .. |.||||. |.|.. ... . ..|.| . . . .. ....| ... |.|||||| ||. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------ QSIYKLSDFGAARKLDDD--------------------------------EKFVSVYGTEEYLHPDMYE-RAVLRKPQQKAFGVTVDLWSIGVTLYHAAT |..||| ..|.||| . | ...|| .|. | ... .|| . .|.||.||.|| . ---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF GSLPFIPFGGPRRNKEIM | .|| ..|. GKPPF--------QQQIK |
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Kinase | IKKe.AA | Dicty2 | 12-176 | 34 | 1e-26 | 90.14 | In-house | 5-170 (264) | Show / Hide |
Range on Protein: 12-176 Range on HMM: 5-170/264 Sequence Identity: 34% (60 aa) DDLLGQGATASVYKARNKKSGEVVAVKVFN-SASYRRPPEVQV----REFEVLRRLNHQNIVKLFAVEETGGSRQKVLIMEYCSSGSLLSVLEDPENTFG |. .|.|| . |||. ....|..|| | .| .| | |.. |..||| |||| ..|| ... |.|| .||| .. . || DEKIGKGAFGTVYKGLHIETGDFVAIKQINIMKKKTKISEEQHQSIMQEIHLLKKLNHHNIVKYIEHIET--ENHLYIILEYIENGSLSKII----KKFG LSEEEFLVV-LRCVVAGMNHLRENGIVHRDIKPGNIMRLVGEEGQ-SIYKLSDFGAARKLD--DDEKFVSVYGT . |. . . .. | | | ..|..||||| || |. || . ||.||| | ..| || . .| || CFPESLCCIYIYQVLKGLVYLHRQGVIHRDIKAANI--LITKEGKSGVIKLADFGVATHIDYSDDDSRYTVVGT |
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Kinase | IKKe.AA | TKL | 15-221 | 18 | 1.7e-26 | 92.46 | In-house | 1-289 (364) | Show / Hide |
Range on Protein: 15-221 Range on HMM: 1-289/364 Sequence Identity: 18% (56 aa) LGQGATASVYKARNKK--------SGEVVAVKVFNSAS--------------------------YRRPPEVQVREFEVLRRLNHQNIVKLFAVEETGGSR .|.|. . |||.. . .|..||||.|.| . ... . ..| ...||.|.|||.. .. .... IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG Q-----------KVLIMEYCSSGSLLSVLEDPENTFGLSEEEFLVVLRCVVAGMNHLRENG--------IVHRDIKPGNIMRLVGEEGQ----------- . ..||||. ||||..| . .. . . |||.| .. |.|||.|. || || | .. CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNI--LVDENWTNVSNYMYNPNA -SIYKLSDFGAARKLDDDE--------------------KFVSVYGTEEYLHPDMYERAVLRKP--------QQKAFGVTVDLWSIGVTLYHAATGSLPF |..||| .| .. .. . .. || .. | . . . . ... . .| .| |. |. .|. .|. DWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPY |
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Kinase | IKKe.AA | Pkinase_Tyr | 9-136 | 28 | 6.4e-14 | 47.76 | Pfam | 1-137 (270) | Show / Hide |
Range on Protein: 9-136 Range on HMM: 1-137/270 Sequence Identity: 28% (40 aa) WHTDDLLGQGATASVYKARNK----KSGEVVAVKVFNSASYRRPPEVQ------VREFEVLRRL-NHQNIVKLFAVEE-TGG-SRQKVLIMEYCSSGSLL . . ||.|| .|||.. | . . ||||. . . | || .... | .|.|||.| .| |. . | ..|||. |.|| ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE----GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLL SVLEDP-ENTFGLSEEEFLVVLRCVVAGMNHLRENGIVHRDI . | .. |. |. .. | . . .||..| .....|||. DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL |
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Kinase | IKKe.AA | TyrKc | 9-326 | 19 | 5.6e-13 | -12.81 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 9-326 Range on HMM: 1-280/280 Sequence Identity: 19% (69 aa) WHTDDLLGQGATASVYKARNKKSGEVVAVKVFNSASYRRPPEVQVREFEVLRRL--NHQNIVKLFAVEETGGS-----RQKVLIMEYCSSGSLLSVLEDP . .. || || |||.. | . ||||. .. . | || .....| .|.|||.|..| ..| . ..|||.. |.|.. | .. ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH ENTFGLSEEEFLVVLRCVVAGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLSDFGAARKLDDD-EKFVSVYGTEEYLHPDMYERAV--LRK------ ... |. ...| . .||..| .....|||. |. ||||.. . | |||| .|...|| .. |.| . .| RPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNC--LVGENH--TVKISDFGLSRDIYDDDQQG---------ESKDYYRKKEHKGGKTMLPIR ------PQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGP----RRNKEIMYRITTE----KPAG----AISGTQKQENGPLEWSYSLPITCRLSMGLQ . . | | || ||... | . | |. |.|.. .. . .|. . WMAPECINYGKFTTKSDVWSFGVCMWEIFT--YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------------- NQLVPILANILEVEEDKCWGFDQFFAETSDILQRTVIHVFSL-----PQAVLHHVYI | . .| . . | | .. -----------------------F-VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | IKKe.AA | CAMKL | 202-221 | 60 | 4.7e-05 | 11.92 | In-house | 217-236 (297) | Show / Hide |
Range on Protein: 202-221 Range on HMM: 217-236/297 Sequence Identity: 60% (12 aa) VDLWSIGVTLYHAATGSLPF || ||.||.|| .| ||| VDIWSCGVILYAMVCGYLPF |