Gene ICK (Mouse)

ICK

Species: Mouse
Alias: ICK, Ick
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP ,
Annotation:

Classification

Group: CMGC
Family: RCK
Subfamily: MAK

Sequence

Name Sequence Type Origin Length Description Download
ICK.AA Protein Sugen 629 None Fasta, JSON
ICK.NA RNA Sugen 2227 None Fasta, JSON
ICK.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 281 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of ICK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ICK.AA MAK 4-284 63 2.3e-246 793.09 In-house 1-352 (352) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-352/352
Sequence Identity: 63% (223 aa)

YTTIKQLGDGTYGSVLLGRS------------------------------IESGELIAIKKMKRKFYSWEECMNLREVKSLKKLN-HANIVKLKEVIR--
|..||||||||||.|.|...                              |..||..|||.||.||||||||||||||||||||| |.||||||||||  
YQMIKQLGDGTYGCVMLAKRQFPLSNILGKQHDIRGTLMDQPKNGHQNYIIDTGEKVAIKRMKKKFYSWEECMNLREVKSLKKLNAHPNIVKLKEVIRDS

ENDHLYFIFEYMKENLYQLIKERNK-LFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGP-----------------ELVKIADFGLAREIRS
|||||||.||||||||||..|.|.. .|||..||||||||||||||.|||||||||.||||..||||                 ||.|||||||||||||
ENDHLYFVFEYMKENLYQMMKDRDRRHFPEPVIRNIMYQILQGLAFMHKHGFFHRDMKPENIMCMGPTQYFEKEYMNQIGYQDNELIKIADFGLAREIRS

RPPYTDYVSTRWYRAPEVLLRSTNYSSPIDIWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTD----------------WPEGYQLSSAMNF
.||||||||||||||||||||||.||||||.|||||||||.||.||||||.||||.|||||||||||||.|                ||.||||...|||
KPPYTDYVSTRWYRAPEVLLRSTYYSSPIDMWAVGCIMAELYTFRPLFPGSSEIDQIFKICQVLGTPKKDDDFVNTNHITAPPPGGFWPDGYQLAHMMNF

LWPQCIP---NNLKTLIPNASS-EAIQLLRDLLQWDPKKRPTASQALRYPYF
 .|||.|   ..||.||||.|. .||.|..|.|||||.|||||.|...||||
RFPQCVPPSIMPLKHLIPNCSQSDAIELMKDMLQWDPNKRPTAQQCCKYPYF
Kinase ICK.AA RCK 4-284 67 1.4e-239 768.36 In-house 1-298 (298) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-298/298
Sequence Identity: 67% (200 aa)

YTTIKQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLN-HANIVKLKEVIREND--HLYFIFEYMKENLYQLIKE---RNKLF
|..||||||||||.|......|.||..||||||.|||||||||||||.|||.||| |.||.|||||||.||  .|||.||||..||||..|.   |.|..
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMKQKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKYL

PESA--IRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMG---------PELVKIADFGLAREIRSRPPYTDYVSTRWYRAPEVLLRSTNYSSPIDIWAV
||.   |.|||||||||||..||||||||||||||..|.|         ....|||||||.|||||.||||||||||||||||.|||.|.|.||.|||||
PENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNSPMDIWAV

GCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFLWPQCIPNNLKTLIPNASSEAIQLLRDLLQWDPKKRPTASQALRYPYF
||||.|.|.|||||||.|||| |||||.|.|||.|.|||.||.|.|.||| .|||....||.||||.|...|.|....|||||.||.||.|||..|||
GCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPNCSQDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase ICK.AA CMGC 4-284 28 1.1e-138 458.8 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-513/513
Sequence Identity: 28% (147 aa)

YTTIKQLGDGTYGSVLLGRS--------------IESGELIAIKKMKRKFYSWEEC----------MNLREVKSLKKLN-----------------HANI
|. ||..| |||| |  .|               .|..|..||||.|..|| ....          . |||.| ||.||                 | ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VKLKEVIREND-----------------HLYFIFEYMKENLYQLIKERN---------------------------KLFPESAIRNIMYQILQGLA--FI
|||..... ..                 |||..||||  .|||.||. .                           | |.  .|| .|||||.||.  ..
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYC

HKHG--FFHRDLKPENLLCMGPELV--------------------KIADFGLAR--EIRSRP--------------------PYTDYVSTRWYRAPEVLL
|.|.  ..||||||||.|      .                    ||.||||||  ...|..                    |||.||.||||||||.||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

RSTNYS---------SPIDIWAVGCIMAEVYT--------LRPLFPGASE-----------IDTIFKICQVLGTPK---------------KTDWPE---
....|.         .|||.|.||||.|| ||        ..||||| ||           || .|||..|||||                . .||.   
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

----------------------GYQLSSAMNFLWPQCIPNNLKTLIPN-----------------------------------ASSEAIQLLRDLLQWDP
                      ....   .|.  |.. |...| |.|.                                   ....|| ||  .||.||
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

KKRPTASQALRYPYF
.||.||.|||. |||
DKRITAEQALQHPYF
Kinase ICK.AA CDK 4-284 35 1.1e-113 365.16 In-house 1-284 (284) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-284/284
Sequence Identity: 35% (114 aa)

YTTIKQLGDGTYGSVLLGRSIESG-----ELIAIKKMK------RKFYSWEECMNLREVKSLKKLNHANIVKLKEVIREN-----------DHLYFIFEY
|  ....| |||| |  .|. ..|     ...|.|| .      ..      .  .||.. ||.| |.|||||..|.  .             ||..|||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

MKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPEL-----VKIADFGLAREIRS-------RPPYTDYVSTRWYRAPE
|   |.....          |...|.|.|.||...|.... |||||| |.| .         .|||||||||.  .       . .||  | |.||||||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

VLLRSTNYS--SPIDIWAVGCIMAEVYT---LRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFLWPQCIPNNLKTLIPNASSEAIQLLRDL
.|| |..||   |||.|.||||.|| .|    .||||| |||| .|||....|||   .||.  .|                            .||  .
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------DLLNKM

LQWDPKKRPTASQALRYPYF
|. ||||| .|.|||  |||
LCYDPKKRISAEQALQHPYF
Kinase ICK.AA Pkinase 4-284 33 7.79999999999e-112 382.64 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-293/293
Sequence Identity: 33% (101 aa)

YTTIKQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLR---EVKSLKKLNHANIVKLKEVIRENDHLYFIFEYMKE-----NLYQLIK-ERN
|......| |..|.| ... . .|.. |.|..|..  ........|   |.. .|.||| |||.|... ...||.|...||.        |. .|. .|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KLF--PESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELV----KIADFGLARE--IRSRPPYTDYVSTRWYRAPEVLLRSTNYSSPIDIWAV
. |  .|  ....|||||.||...|..|. ||||||||.|.     .    ||.|||||.   . . . .|... |.||.||||.. .. |....|.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCIMAEVYTLRPLFPGA----SEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFLWPQCIPNNLKTLIPNASSEAIQLLRDLLQWDPKKRPTASQALRYP
|||..|... ||.|||.    . .| ...||...|.| . |||. .  |  . |   .     ..|. .|.|.|........|..|||||||| |.|  |
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

YF
.|
WF
Kinase ICK.AA CDC2 4-284 40 9.40000000001e-106 326.05 In-house 1-301 (301) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-301/301
Sequence Identity: 40% (123 aa)

YTTIKQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEE---CMNLREVKSLKKLN-HANIVKLKEVIRENDHLYFIFEYMKENLYQLIK---ERNKL
|. |. .| |||| |  ..  ......|.|| . .  . ..      .||   ||.|. | |||||..|| .   || .|||.  .| .. .     || 
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

FPESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIADFGLAREIRS-RPPYT--DYVSTRWYRAPEVLLRSTNYSSPIDIWAVGCIMAEV
.|.......|||||||..| | .. .|||||| |.|      .||||||||| .     .||    | |.||||||.||..  || |.|.|..|||.|| 
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---YTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLS-SAMNFLWPQCIPNNLKTLIPN---------ASSEAIQLLRDLLQWDPKKRPTASQALR
    | .|||.| |||| .||| ..||||.  .||. .||    . |  |.  |..|....||         .  |.|.||. .|| || || .| .||.
FMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTF--PRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQ

YPYF
 |||
HPYF
Kinase ICK.AA S_TKc 4-284 33 1.6e-104 354.47 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-231/231
Sequence Identity: 33% (100 aa)

YTTIKQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHANIVKLKEVIRENDHLYFIFEYMKE---NLYQLIKERNKL----
|. ....| |..|.| ..| ...|.. |||..|        .. .||.. ||| .| |||||..|... ||||...||.     .|...||.|..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-FPESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIADFGLAREIRSRPPYTDYVSTRWYRAPEVLLRSTNYSS-PIDIWAVGCIMAEVY
 |||  .| .||||...|...|.||. ||||||||.|.     .||.||||||..      | .. |.||.|||||     |.  ..|.|..|||..| .
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEML

TLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFLWPQCIPNNLKTLIPNASSEAIQLLRDLLQWDPKKRPTASQALR-------YPYF
. .|.||   .....||..                                        |.||....| .||.||.||||| .||.        |.|
CGYPPFP---QMQMMFKKIG---------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ICK.AA CDK7 4-284 34 1.7e-101 271.09 In-house 1-288 (288) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-288/288
Sequence Identity: 34% (102 aa)

YTTIKQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMN------LREVKSLKKLNHANIVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLF
|..||..| |... | ...  ..|. .|||| | |  . .|         .||.| |. . | |.. |  ..   . .. .|..|   |   ||    ..
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIK-KLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIIL

PESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIADFGLAREIRS-RPPYTDYVSTRWYRAPEVLLRSTNYSSPIDIWAVGCIMAEVYTL
  . | ..| ..|||| . |..   |||||| |||      .||||||||| . |    ||  | |||||||| |     | . .|.|.||||.||    
TPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLR

RPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFLWPQCIPN----NLKTLIPNASSEAIQLLRDLLQWDPKKRPTASQALRYPYF
 | .|| |.|| . .|.| ||||   .||.   ... |...  .  |      |. .   || ... |.  ..  .| || |..|.|  |||
VPYLPGDSDIDQLTRIFQTLGTPTEEEWPN---MCCMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase ICK.AA MOK 4-284 40 2.9e-94 295.81 In-house 1-283 (283) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-283/283
Sequence Identity: 40% (115 aa)

YTTIKQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLN-HANIVKLKEVI--RENDHLYFIFEYMKENLYQLIKERNKLFPES
| .| ..|.||.  |.  .|.  |.  | |.||..| | |.  ||||.. ...|| |.||..|.||.  |    |  | | |  |.| ||. |    |. 
YKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQHFESIEQVNNLREIQAMRRLNPHPNILMLHEVVFDRKTGNLALICELMDMNIYELIRGRRHYLPQK

AIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIADFGLAREIRSRPPYTDYVSTRWYRAPEVLLRSTNYSSPIDIWAVGCIMAEVYTLRPLF
 |.. |||... |  .|. | |||| ||||.|    . .|.||||  | . |. |||.|.||||||||| ||    |.  .|.|.|||.  |.  |.|||
KIMHYMYQLCKSLDHMHRNGIFHRDVKPENILIKQ-DHLKLADFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGYYTYQMDMWSVGCVFYEIASLHPLF

PGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFLWPQCIPNNLKTLIPNASSEAIQLLRDLLQWDPKKRPTASQALRYPYF
||. |.| | ||  |.|||...      . | |||. .|      .. |.||..  .....  .  .||  | || |... |||
PGVNEVDQISKIHDVMGTPCQKILNKFKNQSRAMNYDFPFKKGSGIEKLTPNLTKQCLEIMHKMCTYDPDERITAHQVIQHPYF
Kinase ICK.AA MAPK 4-284 34 1.4e-85 290.58 In-house 1-328 (328) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-328/328
Sequence Identity: 34% (115 aa)

YTTIKQLGDGTYGSVLLGRSIE------SGELIAIKKMKRKFYSWEECMN-LREVKSLKKL-NHANIVKLKEVIRE------NDH-----LYFIFEYMKE
|. .|..| | || |   .  .      .|. .||||. | | .   |   .||.| |. . .| ||.||.....       |..     .|...|.|  
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

NLYQLIKERNKLFPESAIRNIMYQILQG--LAFIHKHGFFHRDLKPENLLCMGPELVKIADFGLAREIRSRPPY---------------TDYVSTRWYRA
.|.|.|| ..    .  |. .||||| |  | .||  .  ||||||.|.|.    ..||.|||||| | .   .               |.||.||||||
DLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRA

PEVLLR--STNYSSPIDIWAVGCIMAEVYT-LRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQ-LSSAMNFLW-----PQCIPNNLKTLIPN----AS
||..|   ...|.  .|.|.||||.|| .|  .||||| . || ...| .|||||.. .. .  .  ..| |..      |.. . ......||    |.
PEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFI-QCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNAN

SEAIQLLRDLLQWDPKKRPTASQALRYPYF
..|| ||  .|..||.|| |. .||. |||
PQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase ICK.AA CDK5 4-284 37 4.6e-83 262.23 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-287/287
Sequence Identity: 37% (109 aa)

YTTIKQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEE---CMNLREVKSLKKLNHANIVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPES
|  .  .|.|||| |  .|  |..|..|.|.   .  |  |   .  .||.  || | | ||| |  ||  .  |  .||.. . |   . ..|      
YEKMEKIGEGTYGTVYKARNKETHEIVALKRV--RLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMH

AIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIADFGLARE--IRSRPPYTDYVSTRWYRAPEVLLRSTNYSSPIDIWAVGCIMAEVY-TLR
 |. .||| |.|||| |.|   |||||| |||       | |||||||   |  |  |.  | | |||.| ||. |  || .||.| .|||.||.  ..|
IIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVR-CYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGR

PLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAM--NFLWPQCIPNN-LKTLIPNASSEAIQLLRDLLQWDPKKRPTASQALRYPYF
|||||... |  ..| ...|||    ||   .|.        .|   ..  .. ..|. ...   ||  .|| .|..| .| .||. |||
PLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase ICK.AA CDKL 4-218 43 1.6e-76 260.51 In-house 1-218 (286) Show / Hide 
Range on Protein: 4-218
Range on HMM: 1-218/286
Sequence Identity: 43% (95 aa)

YTTIKQLGDGTYGSVLLGRSIESGELIAIKKMKR-KFYSWEECMNLREVKSLKKLNHANIVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAI
| ..  .| | || |.  |  |.|...|||| |  .    .    .||.| || | | ||| |.|| | .  |.  |||.  ..  . .|. .  .|. .
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHELEEYPNGVDEHVV

RNIMYQILQGLAFIHKHGFFHRDLKPENLLCM-GPELVKIADFGLAREIRSRPP--YTDYVSTRWYRAPEVLLRSTNYSSPIDIWAVGCIMAEVYTLRPL
|..|.|||....| |||   ||| ||||.|       ||. |||.|| . . |   ||||| |||||||| |.  | |..|.||||.||.|||  .  ||
RKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFAR-MLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPL

FPGASEIDTIFKICQVLGT
.|| |.||  ..| ..||.
WPGQSDIDQLYHIQKCLGP
Kinase ICK.AA Pkinase_Tyr 4-196 26 2.2e-20 69.66 Pfam 1-210 (270) Show / Hide 
Range on Protein: 4-196
Range on HMM: 1-210/270
Sequence Identity: 26% (57 aa)

YTTIKQLGDGTYGSVLLGRSI----ESGELIAIKKMKRKFYSWEE---CMNLREVKSLKKL-NHANIVKLKEVIR-ENDH--LYFIFEYMKE-NLYQLIK
 | .|.|| | .|.| .|.      . .   |.|.. .  .. |.    . .||.| .|.| .| |||.|  |.  . ..  .| ..|||.  .|.   .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

ER---NKLFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIADFGLAREIRSRPPYTDYVST------RWYRAPEVLLRSTNYSSPID
..   .. .. . . .. .|| .|... . ... ||||   | |   .  |||.|||||| | .   |  ....      .|. |||..  .  ...  |
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWM-APECINYGK-FTTKSD

IWAVGCIMAEVYTL
.|. |  | |..|.
VWSFGVLMWEIFTY
Kinase ICK.AA TyrKc 4-284 21 2.8e-16 40.4 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-280/280
Sequence Identity: 21% (69 aa)

YTTIKQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKL--NHANIVKLKEVIREN-------DHLYFIFEYMKE-NLYQLIKER
 | .|.|| | .| | .|. .   .  |.|..|       . . .|| . ..||  .| |||.|  |...        . |. ..|||.  .| . ....
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

NKLFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIADFGLAREIRSR-------PPYT------DY--VSTRWYRAPEVLLRSTNYS
 . .. .   ....|| .| ...|.... ||||   | |   .  |||.||||.|.| .          |.          .  ||. |||.. .   ..
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKFT

SPIDIWAVGCIMAEVYTL-RPLFPG---ASEIDTIFKICQVLGTPKKTDWPEG----YQLSSAMNFLWPQCIPNNLKTLIPNASSEAIQLLRDLLQWDPK
.  |.|. |  | |..|.  .  ||        . . . . . . .  . |.                            . ...|  |. ..  . ||.
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMS---------------------FVCCPDEMYQIMKQCWHEDPE

KRPTASQALRYPYF
.||| |.   . .|
DRPTFSEI--HECF
Kinase ICK.AA CDKL 243-284 32 1.1e-10 32.79 In-house 244-286 (286) Show / Hide 
Range on Protein: 243-284
Range on HMM: 244-286/286
Sequence Identity: 32% (14 aa)

PNNLKTLIPNAS-SEAIQLLRDLLQWDPKKRPTASQALRYPYF
...|.   ||.| ..|. ... .|. || .|.|..|... |||
MEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF