Gene GPRK5 (Mouse)

GPRK5

Species: Mouse
Alias: Gprk5, GPRK5
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: AGC
Family: GRK
Subfamily: GRK

Sequence

Name Sequence Type Origin Length Description Download
GPRK5.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 263 Kinase domain by global Sugen HMM Fasta, JSON
GPRK5.AA Protein Sugen 590 None Fasta, JSON
GPRK5.NA RNA Sugen 3182 None Fasta, JSON

Protein domain

Protein domains of GPRK5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RGS GPRK5.AA RGS 52-171 26 5.6e-38 133.41 SMART 1-121 (121) Show / Hide 
Range on Protein: 52-171
Range on HMM: 1-121/121
Sequence Identity: 26% (32 aa)

DYYSLCDKQPIGRLLFRQFCETRPGL-ECYIQFLDLVAEYEITPDENLGAKGKEIMTKYLTPKSPV-FIAQVGQDLVSQTEKKLLQSPCKELFSACAQSV
.. .|||..||||..||.|....... . ...|.. . |.. ..|| . .|..||. ||. |..|  .  .. .....|... | . |....|  . . |
SFHHLCDNDPIGRRYFREFLKQEFCEYKENLEFWLACEEFKKMEDEERRQKAREIYDKYISPNAPCEHCVNIDHHTREQCQQCLCN-PHPDCFDEAQRHV

HDYLKGDPFHEYLDSMYFDRFL
......|.....| |.|..|.|
YQLMEKDSYPRFLRSDYYKRYL
RGS GPRK5.AA RGS 52-170 28 2.3e-35 118.64 Pfam 1-124 (124) Show / Hide 
Range on Protein: 52-170
Range on HMM: 1-124/124
Sequence Identity: 28% (36 aa)

DYYSLCDKQPIGRLLFRQFCET-RPGLECYIQFLDLVAEYEIT---PDENLGAK-GKEIMTKYLTPKSPVFIAQVGQDLVSQTEKKLLQ-SPCKELFSAC
.. .||..|||||.|||||.|.  ...  .|.|.. . ... .   .|| . .| ..||. ||..|.|| .....  |........| | .|....| ..
SFHHLCNDQPIGRRLFRQFLESEFCEY-ENIEFWLACEDFKKMFSDSDEKMHQKDAREIYNKYIAPDSPCECHNIDHDTREHCQDNLEQAQPTPDCFDEA

AQSVHDYLKGDPFHEYLDSMYFDRF
 . .......|.. ..|.|.|..||
QRHIYTLMEKDSYPRFLKSDYYQRF
Kinase GPRK5.AA GRK 186-448 76 2.1e-231 737.15 In-house 1-272 (272) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-272/272
Sequence Identity: 76% (208 aa)

FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ---FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGN--
||||||||||||||||||||||||||||||.|.||||||||||.||||||||||||.|.   |.|..|||||||||||||.||||||||..|||||||  
FRQYRVLGKGGFGEVCACQVRATGKMYACKCLDKKRIKKRKGETMALNEKQILEKVHSRDCPFIVCMAYAYETKDALCLVMTIMNGGDLHYHIYNMGNNE

PGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD-LIRGRVGTVGYMAPEVLNNQR-YGLSPDYWGLGCLIYEM
|||.|||..||||||.||||..||.. ||||||||||||||.||.||||||||..||||.  |.|||||.||||||||.|.| |  |||.|.|||.||||
PGFDEERMRFYAAEICCGLEHMHRRRIVYRDLKPENILLDDHGHVRISDLGLACEIPEGQPMIHGRVGTHGYMAPEVLQNERAYDFSPDWWSLGCMIYEM

IEGQSPFRGRKEKVKREEVDRRVLETEEVYSSKFSEEAKSICNMLLTKDSKQRLGCQEE--GAAEVKRHPFF
|||.|||| .|||||||||||||.|... |..|||||||.||.|||.|| .|||||...  ||.|||.||||
IEGHSPFRQHKEKVKREEVDRRVKEDPVKYPDKFSEEAKDICEMLLQKDPEQRLGCRGGTCGAQEVKEHPFF
Kinase GPRK5.AA GRK 186-448 84 1e-228 766.15 In-house 1-265 (265) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-265/265
Sequence Identity: 84% (223 aa)

FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMG-NPGFE
||||||||||||||||||||||||||||||.||||||||||||.||||||||||||.|.|||.||||||||||||||.|||||||||||||||| ||||.
FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEQMALNEKQILEKVHSRFVVSLAYAYETKDALCLVMTIMNGGDLKFHIYNMGENPGFD

EERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSP
||||.||||||.||||.||||..||||.|||||||||.||||||||||||.||||. |||||||||||||||..|.|| .|||.|||||||||||||.||
EERAIFYAAEICCGLEHLHRERIVYRDMKPENILLDDHGHIRISDLGLAVEIPEGQMIRGRVGTVGYMAPEVVKNERYTFSPDWWGLGCLIYEMIEGRSP

FRGRKEKVKREEVDRRVLETEEVYS-SKFSEEAKSICNMLLTKDSKQRLGCQEEGAAEVKRHPFF
|| ||||||||||||||.|..| || .|||||||.||.|||.||..|||||.|||..||..||||
FRQRKEKVKREEVDRRVKEDPEKYSHEKFSEEAKDICRMLLHKDPEQRLGCREEGCDEVRQHPFF
Kinase GPRK5.AA AGC 186-448 29 8.20000000001e-159 414.21 In-house 1-395 (395) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-395/395
Sequence Identity: 29% (116 aa)

FRQYRVLGKGGFGEVCACQVR------ATGKMYACKRLEKKR-IKKRK--GESMALNE------------KQILEKVN----------SQFVVN-LAYAY
|. ..|.|||.||.|. .. .      .|||.||.| |.||. |...|   . ....|            ..||||.|          ..|.|. | |..
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETKDA--LCLVLTIMN---------GG-DLKFHIYNM-GNPGFEEERALFYAAE-------ILCGLEDLHR-ENTVYRD-LKPENILLDDYGHIRISDLG
..||   |..|.  |.         || .| .|.... ..  |.|||| |||||       |...|| ||.  . ..|| |||||||||. |||...| |
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LAVKIP---------------------------------------------------EGDLIRGRVG--TVGYMAPEVLNNQRYGLSPDYWG--LGCLIY
|. ...                                                   ..|.    .|  |  |||||.|    || . |.|.  ||||.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMIEGQSPFRG------------RKEKVKREEVDRRVLETEEVYS----------SKFSEEAKSICNMLLTKDSKQRLGCQEE-----GAAEVKRHPFF
||. |..||.|            ..|. .. . .|.... .. .           ..||.|||.....||.|| ..||||...     || |.|.||.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase GPRK5.AA BARK 186-448 48 9.6e-95 321.06 In-house 1-264 (264) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-264/264
Sequence Identity: 48% (131 aa)

FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ----FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNP
|   |..|.||||||  |    |||||| | |.||||| ..|| .||||. .|. |       |.| ..||..| | || .| .|||||| .|.   |  
FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGQDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGV-

GFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNN-QRYGLSPDYWGLGCLIYEMIE
 | |.   ||||||. ||| .|. . ||||||| |||||..||.||||||||    .       ||| ||||||||.    |  | |.. |||..| .. 
-FSEQEMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDENGHVRISDLGLACDFSK-KKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLYKLLR

GQSPFRGRKEKVKREEVDRRVLETEEVYSSKFSEEAKSICNMLLTKDSKQRLGCQEEGAAEVKRHPFF
| ||||  | | | .|.||  |  .     .||.| ... ..|| .| ..||||. .|| ||| ||||
GHSPFRQHKTKDK-HEIDRMTLTMNVELPDSFSKEMRDLLEGLLQRDVSKRLGCMGRGAQEVKEHPFF
Kinase GPRK5.AA S_TKc 186-448 33 5.8e-86 292.81 SMART 1-231 (231) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-231/231
Sequence Identity: 33% (91 aa)

FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNG--GDLKFHIYNMGNPG-
..  |..|||.||.|. |. . ||. .|.|..            ....| |||.| .  ..|.| ..... | |..|.  ..|  |||. .| ..| .| 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGL-SPDYWGLGCLIYEM
   | | .| ||...|.|.|| .|. . ..|||||||||||.  || |.| ||| ..      .  .||  |||||||    ||  . | | .||..|||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

IEGQSPFRGRKEKVKREEVDRRVLETEEVYSSKFSEEAKSICNMLLTKDSKQRLGCQEEGA--AEVKRHPFF
. |. ||.   ... .  .               |.|||.. . .|.|| ..|... |  .   ..| ||.|
LCGYPPFP-QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GPRK5.AA RSK 189-448 36 3e-85 289.54 In-house 1-278 (278) Show / Hide 
Range on Protein: 189-448
Range on HMM: 1-278/278
Sequence Identity: 36% (101 aa)

YRVLGKGGFGEVCACQVR---ATGKMYACKRLEKKRIKKR-KGESMALNEKQILEKVN-SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPG-
 .|||.||.|.|  |.     .||. || | |.|. |..| |    .. | .||| .. ..|.|.| ||..|.. | |..  ..||.|  |... .  | 
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDD---YGHIRISDLGLAVK-IPE-GDLIRGRVGTVGYMAPEVLN---NQR-YGLSPDYWGLGC
| |..| ||.||| . .| ||    ..|||||||||.||    |||...| |.. .  .. . .    ..|. |||||.|.    |. .. . |.| ||.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LIYEMIEGQSPFRGRKEKVKREEVDRRVLETE--EVYS--SKFSEEAKSICNMLLTKDSKQRLGCQEEGAAEVKRHPFF
|.|||  |..||.|  ..  |.|. .|... .        .. |.|||.. ...|..| ..||||  ..|.|.|.||.|
LMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase GPRK5.AA AktR 186-448 36 2.6e-82 279.75 In-house 1-268 (268) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-268/268
Sequence Identity: 36% (100 aa)

FRQYRVLGKGGFGEVCACQVR-ATGKMYACKRLEKKRIKKRKGESMALNEKQILE-KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGF
|. |..||||.||.|  .| .  ..|.|| | . || |..|. .. ...|..|.| ..|  | |.| |. .||. | ... .. ||.| .|. . .   |
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKK--F

EEERALFYAAEILCGLEDLHRE-NTVYRDLKPENILLDDYGHIRISDLGLAV---KIPEGDLIRGRVGTVGYMAPEVLNN-QRYGLSPDYWGLGCLIYEM
.||.|.||.|.|| .|| || . | .||||||||||||  ||..|.| ||.    .. . .. .  .||. |||||.... . .. | |.| .|..||||
SEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEM

IEGQSPFRG--RKEKVKREEVDRRVLETEEVYSSKFSEEAKSICN-MLLTKDSKQRLGCQEEGAAEVKRHPFF
. |. ||    ........   .  .. .  |.|.||...|....  || |. ..||| . .|. |.|.||.|
VTGCPPFYHKNQNQMFQKIKIKQ-QNKFP--YPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase GPRK5.AA SGK 186-448 35 1.8e-79 244.96 In-house 1-283 (283) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-283/283
Sequence Identity: 35% (104 aa)

FRQYRVLGKGGFGEVCACQVRAT------------------GKMYACKRLEKKRIK-------KRKGESMALNEK-QILEKVNSQFVVNLAYAYETKDAL
|.   |.|||.||.|   .  ..                  .|.|| | | |. |        |.| .   . |.  || .... | ||| ||  ||. |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

CLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAV-KIPEGDLIRGRVGTVGYMAPEVLN
 .|.  .|||.. .|.   .   | | || |||||| | || ||  ...||||||||||||. ||... | ||.  .| . |      ||. |.|||||.
YFVMDYVNGGEMFYHLQREKH--FPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLR

NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSSKFSEEAKSICNMLLTKDSKQRLGCQEEGAAEVKRHPFF
 | .. . | | |||. |||. |  ||    .   ...     .  .      .| .|... . ||.|| |.|||   ....|.|.||||
KQPHDRTVDWWCLGCVLYEMMYGLPPF----YSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTK-RDFMEIKNHPFF
Kinase GPRK5.AA Pkinase 186-448 31 2.6e-73 254.65 Pfam 1-293 (293) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-293/293
Sequence Identity: 31% (94 aa)

FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMAL-NEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGG----DLKFHIYNMGN
..  |..|.|.||.|. |. . |||..|.|...|...|. | .. .. .| ||. ..|. ..| | ...|.|| ...|.  ..||    ||. .|  . .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

PGF--EEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHI----RISDLGLAVK--IPEGDLIRGRVGTVGYMAPEVLN-NQRYGLSPDYWGL
 .|  .|. . ||. .||.||| .|... ..|||||||||.|. |||    .|.| ||| .  .  .    ...|| .||||||.. .| || . | |..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCLIYEMIEGQSPFRGR---KEKVKREEVDRRVLE--TEEVYSSKFS-------------------EEAKSICNMLLTKDSKQRLGCQEEGAAEVKRHPF
||..|||. |. ||.|.   .. .   .. .|...  ... .. . |                   ||.|.... .|.|| |.|..     |.... ||.
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHPW

F
|
F
Kinase GPRK5.AA PKC 186-448 41 5.1e-73 235.97 In-house 1-262 (262) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-262/262
Sequence Identity: 41% (111 aa)

FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK-VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFE
|.  .||||| || |     . | ..|| | | |  | .      ...|| .|.   .  | ..|     |.| |  |.   ||||| ||| ...   |.
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRR--FK

EERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLA-VKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQS
||.| ||||||.|.|  ||. . .||||| .|.|||  |||.| | |..   . .||  .   ||  |.|||.|  | || | |.| .| | |||  |||
EEHARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQS

PFRGRKEKVKREEVDRRVLETEEVYSSKFSEEAKSICNMLLTKDSKQRLGC---QEEGAAEVKRHPFF
|| |  |    .|. . ... . .|   .|.||.|||  ..||. ..||||   ||||. ....||||
PFHGEDE----DELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase GPRK5.AA Ciliate-E2 186-448 23 3e-67 229.71 In-house 1-365 (365) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-365/365
Sequence Identity: 23% (90 aa)

FRQYRVLGKGGFGEVCACQVRATGKM-----------------------YACKRLEKKRIKKRKGESMAL----------NEKQILEKVNSQFVVNLAYA
.   ...|.|.|| |. |.|. ..|.                       || |...|. |.  | |   .          |||.|||..|. ..... ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YE--TKDALCLVLTIMNGGDLKFHIYNM----------GNPGFEEERAL---------------FYAAEILCGLEDLHREN-TVYRDLKPENILLDDYGH
..  ... . ||.   .||||. .|.|.          .   | |. ..               ||.|.|...|| || .|  ..||.||||||.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

IRISDLGLAVKIPEG--------------------------------DLIRGRVGTVGYMAPEVLNNQR---------YGLSPDYWGLGCLIYEMIEGQS
| |.|.||. |. .                                 ....  .|| ||||||.||..          |. . |.| ||...|||. |. 
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFRGRKEKVKREEVDRR----------VLETEEV-YSSKFSEEAKSICNM----LLTKDSKQRLGCQEEGAAEVKRHPFF
||    .. |  ..| .          . .  ..    | |.|.| ...     .| || ..|..    |. ... ||.|
PF---QQQIKQCKIDFPCPEWQKDTQCI-Q-CKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF
Kinase GPRK5.AA Akt 186-385 42 1e-66 212.27 In-house 1-203 (264) Show / Hide 
Range on Protein: 186-385
Range on HMM: 1-203/264
Sequence Identity: 42% (87 aa)

FRQYRVLGKGGFGEVCACQVRATGKMY-ACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFE
|.  .||||| || |  ..  .|.|.| | | | |..| ...    .. |. ||...|..|.||| |.  |.| |..|.  .|||.| .|..  .   | 
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKR--RFS

EERALFYAAEILCGLEDLHRENTVYRD-LKPENILLDDYGHIRISDLGLAV-K-IPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWG-LGCLIYEMIE
|.|| ||.||| ...| ||  | .||| |||||||.|  |||.. | ||.    | ..|      ||  |.|||.||.. .. . | || |||..|||. 
EDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMC

GQSPF
|. ||
GRPPF
Kinase GPRK5.AA Akt 410-448 46 6.2e-15 44.1 In-house 226-264 (264) Show / Hide 
Range on Protein: 410-448
Range on HMM: 226-264/264
Sequence Identity: 46% (18 aa)

SKFSEEAKSICNMLLTKDSKQRLGCQEEGAAEVKRHPFF
...| |.|.. . ||.|| |.|||  ...| |.||||.|
DWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase GPRK5.AA TyrKc 186-419 22 7.4e-14 1.33 SMART 1-280 (280) Show / Hide 
Range on Protein: 186-419
Range on HMM: 1-280/280
Sequence Identity: 22% (65 aa)

FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV--NSQFVVNLAYAYETK-------DALCLVLTIMNGGDLKFHIY
 .  ..|| | ||||. .. .    . | | | .        . . ..| .|. |.  . . .|.|  .  ..       . |..|.  | .|||| .. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

NMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEG-------DLIR------GR-VGTVGYMAPEVLNNQRY
. ..  .  .  | ..  | || | ||. | . |||   |.|... ....||| ||. .| ..       | .|      |. .  .  ||||..|  ..
KHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

GLSPDYWGLGCLIYEMIE-GQSPFRGR----------KEKVKREEVDRRVLE---------TEEVYS-------------SKFSEEAKSI
    | |  | ...|.   ||.|  |            |.||. .  ..  .         ..|.|.               |||  . .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase GPRK5.AA S_TK_X 449-528 20 6e-12 46.95 SMART 1-79 (79) Show / Hide 
Range on Protein: 449-528
Range on HMM: 1-79/79
Sequence Identity: 20% (18 aa)

RNMNFKRLEA--GMLDPPFVPDPRAVYCKDVLDIEQFS--TVKGVNLDHTDDDFYSKFSTGSVPIPWQNEMIETE----CFKELNVFG
|. ....|..  ... |||.|....||  .  |...|     ...         .. ........ |||| .|||    .| ... . 
RGIDWDKLYNQQKEIEPPFKPKIKEVYA-SPTDTSNFDPEFTEETPM-------LTPDDPPLSNSMWQNE-METEIPPDPFRGFTYVF