Gene GAK (Mouse)

GAK

Species: Mouse
Alias: Gak, GAK
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Other
Family: NAK
Subfamily: GAK

Sequence

Name Sequence Type Origin Length Description Download
GAK.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 274 Kinase domain by global Sugen HMM Fasta, JSON
GAK.NA RNA Sugen 5290 None Fasta, JSON
GAK.AA Protein Sugen 1306 None Fasta, JSON

Protein domain

Protein domains of GAK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GAK.AA GAK 40-313 69 6.5e-236 790.02 In-house 1-277 (277) Show / Hide 
Range on Protein: 40-313
Range on HMM: 1-277/277
Sequence Identity: 69% (193 aa)

LRVRRVLAEGGFAFVYEAQDLGSGREYALKRLLSNEEEKNRAIIQEVCFLKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKG-QLVEFLKRVE
.|||.|.|||||||||.|||...||||||||.||.....|||||.|.|..|||.||.||||||.|..|..|||...|||.|||.|.||. |||..|||.|
YRVRCVIAEGGFAFVYVAQDVQTGREYALKRMLSHDMQANRAIINEICMMKKLQGHENIVQFCDASYISREESNQSQAEYLLLMEYCKFSQLVDCLKRME

CKGPLSCDSILKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQKRAMVEEEITRNTTPMYRTPEIVDLYSNF
|..|.|||..|.||||.||||||||.|||||||||.|.||.|..||.||||||||||||.|||||||||||||.|||.|..|.||||||.||..|||||.
CYKPFSCDCVLRIFYQMCRAVQHMHSQKPPIIHRDIKIENFLIGNQKTIKLCDFGSATTKSHYPDYSWSAQKRSMVEDEMFRHTTPMYRSPEMCDLYSNW

PIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYS--IPVNDTRYTVFHDLIRAMLKVNPEERLSIAEVVRQL
|||.||||||.||.||..|.|||||||||||||.||.|.  ||..|..|..|||||||.|.|||.|||.||.||...
PIGHKQDIWAMGCMLYFMCYRQHPFEDGAKLRIINGNYMKPIPPQDNQYMCFHDLIRACLQVNPDERLDIAMVVEYM
Kinase GAK.AA NAK 40-313 44 6.8e-163 547.45 In-house 1-299 (299) Show / Hide 
Range on Protein: 40-313
Range on HMM: 1-299/299
Sequence Identity: 44% (134 aa)

LRVRRVLAEGGFAFVYEAQDL---------GSGREYALKRLLSN-EEEKNRAIIQEVCFLKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQ
..|...||||||..|| .||.          .|..|||||.... .|....|...|....|||..|.||||.....  ....|......|||....|.|.
YTVEKYLAEGGFSYVYLVQDNYINHPDNPNSNGEKYALKRMICHSDEQDLNACKREIEMMKKLQHHNNIVQYIDSHINERDDSNGTWEVFLLMEYCCHGS

LVEFL-KRVE-CKGPLSCDSILKIFYQTCRAVQHMHRQKP--PIIHRDLKVENLLLS---NQGTIKLCDFGSATTISHYPDYSWSAQKRAMVEEEITRNT
|.... || . .......| ||.||...|..||.||...|  ||||||.|.||.|||   ..|..|||||||.||....|...|.||.|.||...| ..|
LWDLMNKRLMDKGTCFTEDEILQIFCDVCEGVQAMHQCQPPKPIIHRDIKIENILLSESHHDGNYKLCDFGSMTTAIIQPENRWEAQYRSMVQDWINKYT

TPMYRTPEIVDLYSNFPIGEKQDIWALGCILYLLCFRQHPFED------GAKLRIVNGKYS--IPVNDTRYTVFHDLIRAMLKVNPEERLSIAEVVRQL
||||| ||..|||||.||.||.|||||||.|| .||..|||||      ..||.|.||.|.  ||.|.. .  .|||||.||...||.|..|..|. ||
TPMYRAPEMCDLYSNCPIDEKVDIWALGCMLYKMCFYTHPFEDCYQRHDSSKLAIQNGNYKYSIPDNSRYSQQMHDLIRYMLTPDPEQRPNIYQVLNQL
Kinase GAK.AA NAK-Unclassified 40-315 25 3.1e-75 256.28 In-house 1-405 (405) Show / Hide 
Range on Protein: 40-315
Range on HMM: 1-405/405
Sequence Identity: 25% (103 aa)

LRVRRVLAEGGFAFVYEAQ--------D------LGSGREYALKRLLSNEEEKNRAIIQEVCFLKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTEL
 .. | ||||||.||| ..        |      .  .  |.||| .  .||   .   |.   |.. .|||||.     .| .|   ..  | ..| |.
YTIVRYLAEGGFSFVYLVKFSKYINPPDNTASVPHSNSNMYCLKRMICQDEESLNTMKREIDVMKRFRNHPNIVKYI-DHHIMRENHNNQSYEVFMLMEY

CK-GQLVEFLK------RVECKGPLSCDS-ILKIFYQTCRAVQHMHRQKP--------------------------------------------PIIHRD
|. | |..|        .   ....  .. .|.|....|...| || . |                                            |.||||
CSRGSLQDFMNNQRTIYQRLTEQTRFHEQECLQIMSDVCQGIQCMHQHQPRQDNATSRVNVDAVSMTYSDETAMLLEDTPLEMDMLSSNSAGSIPLIHRD

LKVENLLLS----------------------------------------------------------NQGTIKLCDFGSATTISHYPDYSWSAQKRAMVE
.|.|| |..                                                          . |  |||||||....   .     .| .. ..
IKIENVLFCNLRRPSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSEDSEHNGIYKLCDFGSCCECIITIE---NRQEMQYLQ

EEITRNTTPMYRTPEIVDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLR-------IVN--GKYSIPVNDTRYTVFHDLIRAMLKVNPEERLSI
..| ..||| || ||..|||.. || || ||||||| || .||   |||..  |        | .  |||..|.| .    .| ||. || ..| .|..|
DWINMHTTPQYRAPEMIDLYRCCPIDEKIDIWALGCFLYKMCFYTTPFEMCGQLHNASVTYKILHGLGKYEFPSNHNYSNQLHNLIKIMLNEDPIQRPNI

AEVVRQLQE
 .|  .. .
YQVLNHICQ
Kinase GAK.AA BIKE 40-312 39 7.3e-74 251.7 In-house 1-267 (267) Show / Hide 
Range on Protein: 40-312
Range on HMM: 1-267/267
Sequence Identity: 39% (110 aa)

LRVRRVLAEGGFAFVYEAQDLGSGREYALKRLLSNEEEKNRAIIQEVCFLKKLSGHPNIVQF--CSAASIGKEESDTGQAEFLLLTELCKGQLVEFL-KR
  |  .||||||| |. ..| .    .||||   | |.   .   |. ..|..||| ||| .  |.  .||      |  | ..|.| |..|.|. . .|
VTVEEQLAEGGFAMVFLVRDHKG-NKCALKRMYVNNEHDLNVCCREHQIMKQCSGHKNIVGYVDCYINCIGN-----GVWECMILMEYCRHQVVNMMNQR

VECKGPLSCDSILKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQG--TIKLCDFGSATTISHYPDYSWSAQKRAMVEEEITRNTTPMYRTPEIVDL
..    .  . .|.||  .| ||  .|  . ||||||||||| ||...|     ||||||||.    |     ..   .|..|| ..||  || || .||
LQQGQYFTEQEVLQIFCDVCEAVSRLHHCQTPIIHRDLKVENILLHDHGPPHYVLCDFGSATNKFLNPQ----KHGVNYVKDEIEKYTTMCYRAPEMIDL

YSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPVNDTRYTVFHDLIRAMLKVNPEERLSIAEVVRQ
||  .|. | |||||||.|| |||   ||.   .| | .|...|| |       | ||| || . .| | .|  |   
YSGKEITTKADIWALGCMLYKLCFFCLPFGE-SQLAICDGNFTIPDNSKYSREMHCLIRYMLEPDMEKRPDIYQVSHV
Kinase GAK.AA S_TKc 40-317 25 2.8e-54 187.58 SMART 1-231 (231) Show / Hide 
Range on Protein: 40-317
Range on HMM: 1-231/231
Sequence Identity: 25% (73 aa)

LRVRRVLAEGGFAFVYEAQDLGSGREYALKRLLSNEEEKNRAIIQEVCFLKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKG---QLVEFLKR
 .. |.. .|.|. || ... ..||..|.|..        . |..|.  |||  .|||||..  .             .. . .|.| |    | ...|.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD---------DHLYMVMEYCDGDLGDLFDYIKK

VECKGP---LSCDSILKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQKRAMVEEEITRNTTPMYRTPEIVD
  ..|.   ..   . ...||.|.|....|..   ||||||| ||.||..  .||.||||.|. .                    |   || |. ||.. 
RGRHGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL-------------------TTFCGTPWYMAPEVL-

LYSNFPIGE-KQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPVNDTRYTVFHDLIRAMLKVNPEERLSIAEVVR-----QLQEIA
     . |  | |.|..||||| .. .. ||.     .. .              . |.|| .|...||.|... |. .      . .  
-----GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GAK.AA Pkinase 40-313 21 1.3e-50 179.23 Pfam 1-293 (293) Show / Hide 
Range on Protein: 40-313
Range on HMM: 1-293/293
Sequence Identity: 21% (69 aa)

LRVRRVLAEGGFAFVYEAQDLGSGREYALKRLLSNEEEKNRAIIQ----EVCFLKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKG-----QL
... |.. .|.|. ||.... |.|...|.|..   .|...  ..     |.. .|.| .|||||..  .             .  . .|.| |      |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------KDHIYMVMEYCEGGLYVMDL

VEFLKRVECKGPL--SCDSILKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTI----KLCDFGSATTISHYPDYSWSAQKRAMVEEEITRNTTP
 ..... . .|..  | . . ...||..|.....|..   ||||||| ||.|..|.|.|    |.||||.|  ..          .. |     |..   
FDYIST-WRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-------Y-NNS-MTTFCGTPW---

MYRTPEIVDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDG------AKLRIVNGKYSIPVNDTRY-----------------------TVFHDLIRAM
 |. ||..   .. ..| | |.|..||||| ..... || .        .. ... . . |.   ..                         . |.|. .
-YMAPEVIR--GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC

LKVNPEERLSIAEVVRQ--L
|...|..|.......    .
LCKDPKKRPTAEQILQHPWF
Kinase GAK.AA CAMK 45-309 17 6e-45 142.32 In-house 1-419 (425) Show / Hide 
Range on Protein: 45-309
Range on HMM: 1-419/425
Sequence Identity: 17% (76 aa)

VLAEGGFAFVYEAQDLGSG------------REYALKRLLSN----------------------------EEEKNRAIIQEVCFLKKLSG------HPNI
.| .|.|. |.....  ..            ...| | .  .                            .... . . .|.. .|||.|      ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQFCSAASIGK------EESDTGQA-------EFLLLT---ELCKGQ-----LVEFLKRVEC------------KGPLSCDSILKIFYQTCRAVQHMHRQ
...  .   ..      . ..| .        .. . .   |.| |      | ..... .|            .| .. .   ..| | | ||...| .
IKLYEVYEDPHYFKNTND-YET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

KPPIIHRDLKVENLLLSNQ-----------------GTIKLCDFGSATTISHYPDYSWSAQKRAMVEEEITRNT----------------TPMYRT-PEI
.  |.||||| ||.||..                  ..||..||| |. . .  ..    ... . ..|   ..                || |   ||.
N--IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNF---MCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEV

VDLYS-----------NFPIGEKQDIWALGCILYLLCFRQHPFEDG-----------------AKLRIVNGKYSIPVNDTRYTV----------------
.   .           . ..|.| |.|..|.||| .     ||..                   . .| .|||. |      .                 
LNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFH

------FHDLIRAMLKVNPEERLSIAEV
        |||| ||.|.||.|..|...
HFVSQECKDLIRKMLQVDPEKRMTIEQC
Kinase GAK.AA TKL-ciliate1 119-313 25 3.7e-38 128.2 In-house 74-279 (279) Show / Hide 
Range on Protein: 119-313
Range on HMM: 74-279/279
Sequence Identity: 25% (55 aa)

FLLLTELC-KGQLVEFLKRVEC-KGPLSCDSILKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATT-ISHYPDYSWSAQKRAMVE
| . .|.| || ... . |      ... . .... .   . .|..|  ..|.||||||..|.|..     | |.|.. ..   |      .    . . 
FYIIMEHCHKGTMFDICHRKHSQIYMIKWQHRMRWCKDIAQGMQYLHMRQNPLIHRDLKMQNILYDEPYQYKICNFPHVKIADFHR----IRNCSFQDMQ

EEITRNTTPMYRTPEIVD--LYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPVND------------TRYTVFHDLIRAMLKVNPE
.|. ||||.... ||. |  ...| || || ||.|.| ..| ||||  ||.   |.  .|.   ..                    ||.|.  ..  || 
NEMQRNTTFHWMAPEQMDPHIFPNYPINEKIDIYAYGIVMYILCFRKTPFQQ--KMSVINIMCYWCEFPGRPNLGPQFIHFDCPQNFHNLMMRCWCQNPN

ERLSIAEVVRQL
 | .  |.   |
KRPNFNEIIQIL
Kinase GAK.AA TKL 46-313 19 1e-36 128.31 In-house 1-364 (364) Show / Hide 
Range on Protein: 46-313
Range on HMM: 1-364/364
Sequence Identity: 19% (73 aa)

LAEGGFAFVYEAQDLG--------SGREYALKRLLS------------------------NEEEKNRAIIQEVCFLKKLSG--HPNIVQFCSAASIGKEE
. .|||. || ..  |        .|.. | |.. |                        |..|  ..  .|.  .. .|   |||||||  ..  ..  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

SDTGQA-----EFLLLTELC-KGQLVEFLKRVECKGPLSCDSILKIFYQTCRAVQHMHRQK------PPIIHRDLKVENLLLSNQGT-------------
   ..      .. . .|.| .| | ..|           . .... ....|.....| ..      ||||||||| .|.|. . .|             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-IKLCDFGSATTISHYPDYSWSAQKRAMVE---------EEITRNTTPMYRTPEIVD---LYSN----------FPIGEKQDIWALGCILYLLCFRQHPF
 .|.|||| ....|.  .   .... .| |           .|.  || .  ||. .    |..          |.  || |... | .|. .. |..|.
CCKICDFGLSRFMSQSGNM--NDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPY

EDGA--------------KLRIVNG-KYSIP---------VNDTRY-TVFHDLIRAMLKVNPEERLSIAEVVRQL
.|                ......| .  ||         .. .   . . .|.    . .||.|.|  |.. .|
YDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase GAK.AA Ciliate-E2 40-309 19 5.3e-36 121.06 In-house 1-359 (365) Show / Hide 
Range on Protein: 40-309
Range on HMM: 1-359/365
Sequence Identity: 19% (74 aa)

LRVRRVLAEGGFAFVYEAQDLGSGR-----------------------EYALKRLLSNEEEKNRAIIQEV----CF--------LKKLSGHPNIVQFCSA
  . ... .|.|. ||....   ..                       .||.|..  |. |    .|..     ||        ....  ||||...  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

ASIGKEESDTGQAEFLLLTELCKGQLVEF------LKRVEC---KGPLSCDSILKIFYQTCR---------------AVQHMHRQKPPIIHRDLKVENLL
     .| |.    . | .|.|.|.  .       .|| ..   ......  |..|..| ..               |....| ... |||||.| ||.|
----FQEKDDNN--IYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENIL

LSNQGTIKLCDFGSATTIS-HYPDYSWSAQKRAMVEEEI--------------TRNT------TPMYRTPEIVDLYS------NFPIGEKQDIWALGCIL
.     ||..||| .. ..  . ...   | . .  .                  |.      ||.|  |||.   .        . ..| |||.||.||
F-----IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL

YLLCFRQHPFEDGAKLRIVNGKYSIP----------------VNDTRYTVFHDLIRA----MLKVNPEERLS-IAEV
| ..| ..||       | ..|...|                 ..       |||.     ||...||.|.. . ..
YEMLFGKPPF----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQI
Kinase GAK.AA CMGC 40-254 18 3.1e-33 105.87 In-house 1-326 (513) Show / Hide 
Range on Protein: 40-254
Range on HMM: 1-326/513
Sequence Identity: 18% (62 aa)

LRVRRVLAEGGFAFVYEAQD--------------LGSGREYALKRLLSNEEEKNRAI------------IQEVCFLKKLS----------------GHPN
  . ... || .. ||...|                .....|.|.. ... ... |             . |. .||.|.                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVQ---FCSAASIGKEESDTGQA------EFLLLTELCKGQLVEFLKRVE--CKG----PLSCDS------------ILKIF------YQTCRAVQ--HM
||.   ..      ..|... .       .. | .|..   | ...|.     .|    |||               | ...      || .|..   ..
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HRQKPPIIHRDLKVENLLLSNQ--------------------GTIKLCDFGSATTISHYPDYSWSAQK-------------RAMVEEEITRNTTPMYRTP
|...  ||||||| ||.|....                    |..|.||||.|. .....|   . |.             |.. ..  ||     || |
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRW----YRAP

EIVDLYSNFP-------IGEKQDIWALGCILY
||   ...          ... |.|..|||..
EILLGWKHYTNHNYSMHYTTPIDMWSVGCIFA
Kinase GAK.AA CAMKL 121-198 29 8.3e-22 66.24 In-house 98-179 (297) Show / Hide 
Range on Protein: 121-198
Range on HMM: 98-179/297
Sequence Identity: 29% (25 aa)

LLTELCKGQ---LVEFLKRVECKG-PLSCDSILKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQG--TIKLCDFGSATTI
| .|.| |    | ..... .... ... .   ..| | . ||...|...  |.|||.| ||.||...|  .||..||| .. .
LVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG--IVHRDIKPENILLDENGNNNIKIIDFGFSNMY
Kinase GAK.AA Pkinase_Tyr 40-193 24 4.7e-14 48.21 Pfam 1-156 (270) Show / Hide 
Range on Protein: 40-193
Range on HMM: 1-156/270
Sequence Identity: 24% (40 aa)

LRVRRVLAEGGFAFVYEAQDL----GSGREYALKRL--LSNEEE-KNRAIIQEVCFLKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKG-QLV
..  ..| || |  ||..       . . . | | |   . .|. . .. ..|.  .|.|  |||||..  . .  .| .     . .. .|....  | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-----QIYIVMEYMPHGDLL

EFLKRV-ECKGPLSCDSILKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFG
..|..  | |.||.   .|.. .| ... .. ....  .|||||   | |.......| ||||
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFG
Kinase GAK.AA CAMKL 241-311 34 1.1e-12 36.61 In-house 214-293 (297) Show / Hide 
Range on Protein: 241-311
Range on HMM: 214-293/297
Sequence Identity: 34% (28 aa)

GEKQDIWALGCILYLLCFRQHPFEDGA-----------KLRIVNGKYSIPVNDTRYTVFHDLIRAMLKVNPEERLSIAEVVR
| | |||..| ||| . . . ||.|             ...|  | | .|.        .|||| ||.||||.| .| ....
GPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMN
Kinase GAK.AA TyrKc 40-313 18 3e-12 -24.74 SMART 1-280 (280) Show / Hide 
Range on Protein: 40-313
Range on HMM: 1-280/280
Sequence Identity: 18% (56 aa)

LRVRRVLAEGGFAFVYEAQDLGSGREYALKRLLSNEEEKNRAIIQEVCFLKKL-SGHPNIVQFCSAASIGKEESDTGQ---AEFLLLTELCK-GQLVEFL
..  ..| || |  ||...     .. | | | ..     .....|   ..||   |||||..  ... ...            ....|... | | ..|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN----FMYIEPLMIVMEYMPHGDLKDYL

KRVECKGPLSCDSILKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHY---PDYSWSAQKRAMVEEEITRNTT-PMYRT--
.. . |  |. .  |.. .| ..  .. |..  ..|||||   | |.....|.| .||| .  | ..               ....  | ..    .|  
RKHRPK--LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-----------ESKDYYRKKEHKGGKTML

------PEIVDLYSNFPIGEKQDIWALGCILY-LLCFRQHPFED---------GAKLRIVNGKYSIPVND--------TRYTVFHDLIRAMLKVNPEERL
      ||    |. |   .| |.|. |  .. .. . | | ..          .  .. .|..  .  .            ..  ...   . .||.| 
PIRWMAPECI-NYGKF--TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRP

SIAEVVRQL
. .|.....
TFSEIHECF
Kinase GAK.AA CAMKL 40-101 22 6.2e-09 24.5 In-house 1-80 (297) Show / Hide 
Range on Protein: 40-101
Range on HMM: 1-80/297
Sequence Identity: 22% (18 aa)

LRVRRVLAEGGFAFVYEAQD-LGSGREYALKRLL----SNEEEKNRA-----------IIQEVCFLKKLS--GHPNIVQF
 |. ..| .|.|. |  |.. .  |...| | .     .|.. ...            | .|.. .|.|.  .||||...
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKL
Kinase GAK.AA CMGC 290-308 31 0.010399 3.69 In-house 488-506 (513) Show / Hide 
Range on Protein: 290-308
Range on HMM: 488-506/513
Sequence Identity: 31% (6 aa)

DLIRAMLKVNPEERLSIAE
||.  ||. .|..|.....
DLLKKMLQYDPDKRITAEQ
Kinase GAK.AA Pkinase_Tyr 299-313 40 3.526237 1.23 Pfam 256-270 (270) Show / Hide 
Range on Protein: 299-313
Range on HMM: 256-270/270
Sequence Identity: 40% (6 aa)

NPEERLSIAEVVRQL
.||.| . .|...||
DPEDRPTFSEIHEQL
PTEN_C2 GAK.AA PTEN_C2 568-707 27 3.6e-38 137.91 Pfam 1-141 (141) Show / Hide 
Range on Protein: 568-707
Range on HMM: 1-141/141
Sequence Identity: 27% (40 aa)

PHSKPMLVKSVVM-TPVPLFSKQRNGC-RPFCEVYVGEERVTTTSQEYDRMKEF-KIEDGKAVIPLGVTVQGDVLIIIYHAR-ATLGGRLQAKMASMKMF
|..||  .....|  ..| | ||..|| ||....| ... | .|...|  .|.  . .... ..| ...|||||.| .|| .  .| . .  ..    ||
PPPKPLFLHCIIMDHGIPNF-KQGGGCWRPYIQIYQNDQKVFYTCKKYWHCKKYKQQKCCIFKFPQPCPVQGDVKIQCYHKGPSDL-PWMYEEC----MF

QIQFHTGFVPRNATTVKFAKYDLDACDIQ---EKYPDLFQVNLEVEV
...|.|.|...| ....| |..|| .. .   ...|. |.| .  . 
RFWFNTCFIEHNNNRLTFPKNELDKAWKDKKWKRFPPDFKVEVVFSE
DnaJ GAK.AA DnaJ 1241-1302 20 9.4e-07 29.68 SMART 1-72 (72) Show / Hide 
Range on Protein: 1241-1302
Range on HMM: 1-72/72
Sequence Identity: 20% (15 aa)

ESRWTPVSMADLVTPEQVKKQYRRAVLVVHPDKATGQPY----------EQYAKMIFMELNDAWSEFENQGS
.  .         .....||.||. .. .|||| .| |           .. |.  |.|.| |..   .. .
RDYYEILGVPRDADDDEIKKAYRKLAKKYHPDKNPGDPERSCWKLCWEEKEEAEEKFKEINEAYEVLSDPEK
DnaJ GAK.AA DnaJ 1254-1295 38 2.5e-05 22.97 Pfam 13-53 (65) Show / Hide 
Range on Protein: 1254-1295
Range on HMM: 13-53/65
Sequence Identity: 38% (16 aa)

TPEQVKKQYRRAVLVVHPDKATGQPYEQYAKMIFMELNDAWS
..|..||.||. .| .||||  . |    |.  |.|.| |..
SDEEIKKAYRKLALKYHPDKNPDDPE-EEAEEKFKEINEAYE