Gene FYN (Mouse)

FYN

Species: Mouse
Alias: Fyn, FYN
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Src
Subfamily: SrcA

Sequence

Name Sequence Type Origin Length Description Download
FYN.AA Protein Sugen 537 None Fasta, JSON
FYN.NA RNA Sugen 3242 None Fasta, JSON
FYN.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 250 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of FYN.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 FYN.AA SH3 85-142 43 1.7e-26 95.25 SMART 1-58 (58) Show / Hide 
Range on Protein: 85-142
Range on HMM: 1-58/58
Sequence Identity: 43% (25 aa)

TLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVD
  ..|||||.|...|.|||.||.....|. ....||..|  .||..|..|||||...|
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 FYN.AA SH3_1 88-135 46 2.1e-26 91.86 Pfam 1-49 (49) Show / Hide 
Range on Protein: 88-135
Range on HMM: 1-49/49
Sequence Identity: 46% (23 aa)

VALYDYEARTEDDLSFHKGEKFQILNSSEG-DWWEARSLTTGETGYIPS
||||||.|...|.||| ||....... |.. |||..|...||..|..||
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH3_2 FYN.AA SH3_2 86-141 19 5.3e-15 55.42 Pfam 1-68 (68) Show / Hide 
Range on Protein: 86-141
Range on HMM: 1-68/68
Sequence Identity: 19% (13 aa)

LFVALYDYEA-RTEDD-----LSFHKGEKFQIL---NSSEGDWWEA-RSLTTGET--GYIPSNYVAPV
..... ||.. . ...     |.|.||... ..   . . ..||.. .....|..  |..||..|...
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC
SH2 FYN.AA SH2 149-231 60 1.4e-52 156.21 Pfam 1-81 (81) Show / Hide 
Range on Protein: 149-231
Range on HMM: 1-81/81
Sequence Identity: 60% (50 aa)

WYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHY
||.||. |..|||.|.. |||.||||.||||.|.| |.|| ||...  ||.||||.|...||||||||.| .|..||.||.||
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGP--GDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 FYN.AA SH2 147-237 41 6.7e-36 126.5 SMART 1-87 (87) Show / Hide 
Range on Protein: 147-237
Range on HMM: 1-87/87
Sequence Identity: 41% (39 aa)

EEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITT--RAQFETLQQLVQHYSERAAG
..||.|.. |..||. |.. |.| |.||.|.||...|.|.||.|.      ..||||.||..|.|.|||..  | .|..| .||.||.  . |
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK-----GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase FYN.AA SrcA 271-520 90 2.7e-225 719.58 In-house 1-250 (250) Show / Hide 
Range on Protein: 271-520
Range on HMM: 1-250/250
Sequence Identity: 90% (225 aa)

LQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKDGEGRALKLPNLVDM
..|..|||.|.|||||||||||.||||||||||||||||.|||||||||||.|||||||||||||||||||||||.||||||||||.||..||||.||||
IRLERRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVVSEEPIYIVTEYMCKGSLLDFLKDEEGKYLKLPQLVDM

AAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGM
|||||.||||.|||||||||||.||||||. |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
AAQVAEGMAYMERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGM

NNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQGFL
|||||||||||||.||||||||.||||||..||.|||||||||||||.||
NNREVLEQVERGYHMPCPQDCPESLHELMCQCWRKDPEERPTFEYLQSFL
Kinase FYN.AA Src 271-520 76 2e-204 685.41 In-house 1-255 (255) Show / Hide 
Range on Protein: 271-520
Range on HMM: 1-255/255
Sequence Identity: 76% (196 aa)

LQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLK-DGEGRALKLPNLV
..|...||.|||||||||.||||||||.||||||||||| ||.||||||||.|.||||||||.|.| ||||||||||.|||||.|| |||||.|.||.|.
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

DMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIE--DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVP
|||||||.||||.|.||||||||. .|.|||....||.|||||||||.  |.||.||.|||||||||||||..|||||||||||||||||||.||.||||
DMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVP

YPGMNNREVLEQVERGYRMPCPQDCPISLHE-LMIHCWKKDPEERPTFEYLQGFL
||||.|.|||.|||||||||||. || .|.| .| .||.||||.|||||||| ||
YPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase FYN.AA SFK-Src 271-524 61 3.5e-188 563.41 In-house 1-259 (259) Show / Hide 
Range on Protein: 271-524
Range on HMM: 1-259/259
Sequence Identity: 61% (158 aa)

LQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAV-VSEEPIYIVTEYMSKGSLLDFLKDGEGRALKLPNLVD
 .| |.|| ||||.|| |.||. | ||.||||||.|| | ||.|||.||||.|..|.|||||    |||||.|| |  |||||.|.. .||.|..| |||
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLVD

MAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIE-DNE-YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPY
||||||.|||| |  |..||||   |.|||.  .||..|||..| .. |.| |||..|||||||||||||... || |||||||||||..|.|| ||.||
MAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPY

PGMNNREVLEQVER--GYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQGFLEDYF
||| | ||| ||.|  |||||||. ||  ....|. ||.. |..||||| |.  .||.|
PGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase FYN.AA SrcB 271-521 71 5.4e-169 567.72 In-house 1-251 (251) Show / Hide 
Range on Protein: 271-521
Range on HMM: 1-251/251
Sequence Identity: 71% (179 aa)

LQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKDGEGRALKLPNLVDM
|.|.|.|| |||||||||..|...|||.||.|.|||||| ||.|| .||.|.||.||.|||||. |||||.|||| ||.||||||  ||  |.|| |.||
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKEPIYIITEYMAKGCLLDFLKTDEGSKLSLPKLIDM

AAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGM
.||.| |||||||||||||||| ||||| . |.||||||||||.||||||||| |||||||||||||  .| ||||||||||||||.|.|| ||.|||||
SAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYPGM

NNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQGFLE
 | ||....|||||||.|. ||  | ..|..|||. |||||||.|||  |.
TNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase FYN.AA Src-Unclassified 271-520 52 4.7e-155 521.4 In-house 1-284 (284) Show / Hide 
Range on Protein: 271-520
Range on HMM: 1-284/284
Sequence Identity: 52% (148 aa)

LQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPG---TMSPESFL--------EEAQIMKKLKHDKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKDGE
..|.. || ||||||| | | |   ||.||..||   ||||| ||        .|||||||..| .||.|||| | |||.||.||||..||||..|. | 
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

GRALKLPNL------------VDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGL-----ICKIADFGLA--RLIEDNEYTARQGAKFPIKWTAPEAAL
|. | .. .            ||.||||| || | |   |.||||   |.|.|        . |..|||||  .|..| .| .|.||.||.||.|||...
GQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECFI

YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCP--QDCPISLHE-LMIHCWKKDPEERPTFEYLQGFL
|| |.|||||||.|||| |. |||..||||| ||||||.|||||||| |  . || .. | .|  || |||. ||||. |  ..
YGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase FYN.AA Pkinase_Tyr 271-520 48 4.5e-153 519.06 Pfam 1-270 (270) Show / Hide 
Range on Protein: 271-520
Range on HMM: 1-270/270
Sequence Identity: 48% (131 aa)

LQLIKRLGNGQFGEVWMGTWN-----GNTKVAIKTLKPGTMSP----ESFLEEAQIMKKL-KHDKLVQLYAVVS--EEP--IYIVTEYMSKGSLLDFLKD
....| || |.||||..|||.     ....||.|.||.|.|..    |.|..||.|||.| .|...|.||.|..  .||  ||||.||| .|.|||.|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

G--EGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLI-EDNEY-TARQGAKFPIKWTAPEAALYGRFTIKSDVWSF
   ....|... |..|..|.|.||.| |..|.|||||.  |.||......||.||||||.| .| .| ..|.|.|.||||.|||.  ||.||.|||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GILLTELVTKGRVP-YPGMNNREVLEQV-ERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQGFL
|.|. |..| |. | |||| | ||.|.. |.|||||||..||  ...|| .||..|||.||||.... .|
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase FYN.AA Frk 271-524 66 1.5e-149 503.14 In-house 1-260 (260) Show / Hide 
Range on Protein: 271-524
Range on HMM: 1-260/260
Sequence Identity: 66% (174 aa)

LQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLK--DGEGRALKLPNL
.|||.||| ||||||| | || .| ||.|||||||| |. || ||||||||.| ||.|||||   ||||||.|| | .|||...|.  ...|| .... |
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

VDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLAR-LIEDNE--YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGR
|||||||||||||.| .|||||||   |.|||...||||||||||| |. |||  | .|.||.||||||||||| | .||||||||||||||||..| ||
VDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGR

VPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQGFLEDYF
.||||| |.|||..|..|||||.| .||  | |.|..||..||..||||| ||  |||||
MPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase FYN.AA Src-Echino1 271-520 61 3.1e-143 482.17 In-house 1-252 (252) Show / Hide 
Range on Protein: 271-520
Range on HMM: 1-252/252
Sequence Identity: 61% (155 aa)

LQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKDGEGRALKLPNLVD
|.. |..|.|..|||| | |||||.||.||||..||||  || || .|||..|. .||.||| |.. ||||||| ||.|.|.|.||.|... .|.. |.|
LRMDKKIGKGHCGEVWKGVWNGNTPVAVKTLKEKTMSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHVKMTTLID

MAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPG
| |..|.|| |... |..||||   |.|||.| .||||||||||......| ..||||.|||||||||||||||||||||||||||.||.|| ||.||||
MGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFGRYPYPG

MNNREVLEQVERGYRMPCPQDCPISLHEL-MIHCWKKDPEERPTFEYLQGFL
| |||||.||.|||||| ...|| ||... |. || |||  |||||.|  |.
MMNREVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF
Kinase FYN.AA TyrKc 271-520 41 3.3e-136 459.71 SMART 1-280 (280) Show / Hide 
Range on Protein: 271-520
Range on HMM: 1-280/280
Sequence Identity: 41% (119 aa)

LQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKL--KHDKLVQLYAVVSE--------EPIYIVTEYMSKGSLLDFLKDGEGR
..|.| ||.|.||||. |||.  ..||.|.||...   | |..||.||.||  .|. .|.||.|...        ||..||.|||..|.|.|.|.. ...
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDN--------EYTARQ--GAK--FPIKWTAPEAALYGRFTIKSD
 |... |.... |.|.||.|....|.|||||   |.|||.....||.||||.| |.|          |....  |.|  .||.|.|||.  ||.||.|||
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

VWSFGILLTELVTKGRVPYPG-----MNNREVLEQVERGYRMPCPQD--------CPISLHELMIHCWKKDPEERPTFEYLQGFL
|||||... |. | |  ||||     |.|.||.|.|..|||||.|..        ||  ....|  ||. |||.||||. .  ..
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase FYN.AA SRM 271-521 51 2e-127 428.39 In-house 1-253 (253) Show / Hide 
Range on Protein: 271-521
Range on HMM: 1-253/253
Sequence Identity: 51% (131 aa)

LQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGT-MSPESFLEEAQIMKKLKHDKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKDGEGRALKLPNLV
  | ..|| | ||||| | | |  .||||  |    |  . .  | | |||| | ... |.||.|  .|.||.|| | ||.|. .|.| ...||..|.|.
FTLCRKLGEGYFGEVWEGLWKGQVHVAIKVIKRDNLMHQHMLQKEIQAMKKLRHKHIIRLHAVCSVGDPVYIITELMRKGNLQQYLRDSDEKALPIPHLL

DMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYP
|.| ||| ||.| |  |||||||   |.|||....||..|||||||| |  |    . . |.|||||||| |. . .||||||||||| |. |.| .|||
DFACQVAEGMCYLEEQNYIHRDLAARNVLVGDNNLCKVGDFGLARLIKDDIYSPSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILLHEMFTYGQCPYP

GMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQGFLE
|| | | . |..||||||||  || . | ||. ||..|||.||.|  |   | 
GMTNHETFQQIDRGYRMPCPAECPPEVHKLMLECWCRDPEQRPCFKDLREKLT
Kinase FYN.AA TK 271-520 26 3.2e-121 408.37 In-house 1-486 (486) Show / Hide 
Range on Protein: 271-520
Range on HMM: 1-486/486
Sequence Identity: 26% (128 aa)

LQLIKRLGNGQFG---EVWMGTWNGN--------------------------TKVAIKTLKPG-TMSPES--------------FLEEAQIMKKLK----
..|.| || ||||   ||..|.|.|                           |.||.|.||.| .||.|               |||||..||...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HDKLVQLYAVVSEE-------------PIYIVTEYMSKGS----LLDFLK--DGEGRA-----------------------------------------
 |. .|.||.|....             |..||.|||..|.    |.|.|.  .....                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LKLPNLVDMAAQVAAGMAYIERM------NYIHRDLRSANILVGNGLI-----------CKIADFG---
                               | .. |. |..|.|.||.|....      |..||||   |.|||....           |||||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARLI-EDNEYTARQ------------------------GAKFPIKWTAPEAAL---------YGRFTIKSDVWSFGILLTELVTKGRVPYPG-M
     ||| | .| .|....                        |.|.||.|.|||. .         ||.||.||||||||.|. |..| |..||.| |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

NN---------REVLEQVERG--------------YRMPCPQDCP--------------ISLHELMIHCWKKDPEERPTFEYLQGFL
.|         .||.|...||              .|||.|..||                ...||  ||..|||.||||. |. .|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase FYN.AA Tec 271-522 47 1.4e-113 383.59 In-house 1-254 (254) Show / Hide 
Range on Protein: 271-522
Range on HMM: 1-254/254
Sequence Identity: 47% (120 aa)

LQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKDGEGRALKLP-NLV
| ..| ||.|||| | .| | .. .||||..| |.|| | |.|||..|.|| | |||||| | |.. |||||||||..|.||..|.  ...  |    | 
LTFMKELGSGQFGVVHLGKWRHQYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQKNMAILL

DMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYP
.|  .|  |||| || ..|||||   | |||   . |..|||..| . | .||   |.|||.|| .||   | |.  |||||.||.|  |  . |..||.
EMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPYE

GMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQGFLED
 | | || |.| .|.|.  |. |. .. . | |||.  |||||||. |   ...
NMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase FYN.AA S_TKc 271-524 25 2.6e-57 197.62 SMART 1-231 (231) Show / Hide 
Range on Protein: 271-524
Range on HMM: 1-231/231
Sequence Identity: 25% (69 aa)

LQLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMSK--GSLLDFLKDGEGRA----LK
 .... .| | ||.|. ..... . .|||| .|      |... | ||.|| .|. .|.|| |  .. .|.|.||..   |.|.|..|.  ..     . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

LPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI-KSDVWSFGILLTELVTK
      ...|.. ...|. ... |||||  .|||. .    ||.||||||..                . |||      ..  |.|.||.|..| |... 
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-

GRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQG-----FLEDYF
|. |.|  .  ......            . .. ... .|..||||.|||   .        .  .|
GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase FYN.AA Pkinase 271-520 25 1.1e-46 166.19 Pfam 1-293 (293) Show / Hide 
Range on Protein: 271-520
Range on HMM: 1-293/293
Sequence Identity: 25% (77 aa)

LQLIKRLGNGQFGEVWMGTWNGNTK-VAIKTLKPGTMSPESFLE-----EAQIMKKLKHDKLVQLYAVV-SEEPIYIVTEYMSKG----SLLDFLKDGEG
.......| | ||.|. ... |. | ||.|..|  . ...   .     |.||||.|.|.  |.|| .. ..  ||.|.||. .|    .| |...  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RAL--KLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLIC----KIADFGLARL--IEDNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVW
...      . ... |.. |..|. .|. ||||| ..|||. |   .    ||.|||||..  .  |..| . |  .   . |||  . .   . |.|.|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPW---YMAPEVIRGGQYYGPKVDMW

SFGILLTELVTKGRVPYPGM------NNREVLEQVER-GYRMPCPQDCP-------------------ISLHELMIHCWKKDPEERPTFEYLQGF--L
|.|..| |... || |.||       . ....... .  .. ..|..|.                    .. ...  |..|||..|||.| .     .
SCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF